AuPS/ASB Newcastle 2007 Meeting

In the programme below, each presentation has, beside the presentation time or poster board, the page number in volume 38 of the Proceedings. These numbers are links to the HTML versions of the pages. Each HTML page has a link to a corresponding PDF print version.

A PDF file of the abstracts for each platform and poster session can be accessed by clicking on the PDF symbol in the upper right of the programme block.

Links to the abstracts can also be found in the full author index and in the presenting author index.

Posters will be available for viewing througout the meeting. Presenting authors will be at their poster duing the poster session on Tuesday. Odd numbered posters will be manned from 1300-1400; even numbered ones from 1400-1500.

Sunday 2 December 2007

Concert Hall

AuPS Symposium: Physiology education

Chair: Kirsten Farrand

1400	1P	Developing research and inquiry though undergraduate education — S. Barrie, Institute for Teaching and Learning, The University of Sydney, NSW 2006, Australia.
1425	2P	Models of research-led learning and the theoretical and practical considerations in diverse contexts — R.W. Moni, Head of Educational Research Unit, School of Biomedical Sciences, The University of Queensland, St Lucia, QLD 4072, Australia.
1450	3P	Research skill development in practical course work: a cost benefit view — D.A. Saint and L. Rogers, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA 5005, Australia.
1515	4P	Creating the student-research nexus in research-led learning — L.M.D. Delbridge, Department of Physiology, The University of Melbourne, Parkville, VIC 3010, Australia.
1540		Afternoon tea/discussion
1600	5P	U.S. National Institutes of Health program: Fostering research at predominantly undergraduate institutions — B.E. Goodman, Sanford School of Medicine, University of South Dakota, 414 E. Clark St., Vermillion, SD 57069 USA.
1640		Close

Plenary Lecture - Mike Sanguinetti

Chair: David Adams

1700	6P	Modifiers of hERG K⁺ channel gating — M.C. Sanguinetti, D. Fernandez and M. Perry, CVRTI, University of Utah, 95 South 2000 East, Salt Lake City, Utah 84112, USA. (Introduced by David Adams)
1800		Close

1800-2000 Welcome reception - Balcony and Hunter Rooms

Monday 3 December 2007

Concert Hall

Poster viewing

Mulubinba Room

Symposium: Protein structure, interactions and dynamics

Chair: Pierre Moens

0830	7P	CLIC proteins: chameleon proteins at the interface between membranes and the cytoskeleton — D.R. Littler,^1,2 S.J. Harrop,^1,2 L.J. Brown,^2,3 G,J, Pankhurst,² A.V. Mynott,^1,2 J. Phang,^1,2 P. Luciani,⁴ R.A. Mandyam,³ M. Mazzanti,⁴ S. Tanda,⁵ M.A. Berryman,⁵ S.N. Breit² and P.M.G. Curmi,^1,2 ¹School of Physics, University of New South Wales, NSW 2052, Australia, ²Centre for Immunology, St Vincent’s Hospital and University of New South Wales, Sydney, NSW 2010, Australia, ³Department of Chemistry and Biomolecular Sciences, Macquarie University, NSW 2109, Australia, ⁴Department of Cellular and Developmental Biology, University of Rome “La Sapienza”, 00185 Rome, Italy and ⁵Department of Biomedical Sciences, Molecular and Cellular Biology Program, Ohio University College of Osteopathic Medicine, Athens, OH 45701, USA.
0850	8P	Interactions of human profilin-1 and phosphatidylinositol 4,5-bisphosphate in giant unilamellar vesicles — K. Krishnan,¹ S.H. Cody,² A.H.A. Clayton² and P.D.J. Moens,¹ ¹The University of New England, Armidale, NSW 2351, Australia and ²Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, VIC 3050, Australia.
0910	9P	New twists in old tales. Conotoxins targetted to sodium channels — R.S. Norton, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia.
0930	10P	Dimers are forever: New developments in the mechanism of the Na⁺,K⁺-ATPase — R.J. Clarke, School of Chemistry, University of Sydney, NSW 2006, Australia.
0950	11P	TRPC1 is increased in mdx muscle, binds to caveolin-3 and is regulated by Src kinase: implications for Duchenne muscular dystrophy — O.L. Gervasio, N.P. Whitehead and D.G. Allen, Bosch Institute, School of Medical Sciences, Anderson Stuart Building (F13), The University of Sydney, NSW 2006, Australia.
1010	12P	In the presence of ATP, acidosis markedly inhibits ClC-1 skeletal muscle chloride channels — B. Bennetts,¹ M.W. Parker¹ and B.A. Cromer,² ¹St. Vincent's Institute, Fitzroy, VIC 3065, Australia and ²Howard Florey Institute, University of Melbourne, VIC 3010, Australia.
1030		Close

Hunter Room

Free communications: Skeletal muscle 1

Chair: Nicole Beard

0830	13P	Properties of the tubular system network in twitch muscle — J.N. Edwards,^1,2 P. Bhat,² P. Thorn² and B.S. Launikonis,² ¹Department of Zoology, La Trobe University, Melbourne, Vic 3086, Australia and ²School of Biomedical Sciences, The University of Queensland, St Lucia, Qld 4072, Australia.
0845	14P	An action potential activated Ca²⁺ current in skeletal muscle — B.S. Launikonis,¹ E. Rìos² and D.G. Stephenson,³ ¹School of Biomedical Sciences, University of Queensland, QLD 4072, Australia, ²Dept of Biophysics & Physiology, Rush University Medical Centre, Chicago, IL 60612, USA and ³Department of Zoology, La Trobe University, VIC 3086, Australia.
0900	15P	A slowing of relaxation in EDL muscle from the genetically obese mouse is associated with alterations in SR Ca²⁺ handling — R. Blazev,¹ J.G. Kemp,^1,2 D.G. Stephenson³ and G.M.M. Stephenson,¹ ¹Muscle Cell Biochemistry Laboratory, School of Biomedical and Health Sciences, Victoria University, Vic 3011, Australia, ²School of Exercise Science, Australian Catholic University, Vic 3065, Australia and ³Department of Zoology, La Trobe University, Vic 3086, Australia.
0915	16P	The effects of acute and chronic central leptin infusion on metabolism in peripheral tissues — R.C. Laker,¹ G.D. Wadley,¹ I.J. Clarke,² B. Canny² and G.K. McConell,¹ ¹Department of Physiology, University of Melbourne, VIC 3010, Australia and ²Department of Physiology, Monash University, VIC 3800, Australia.
0930	17P	Effects of the inflammatory agent carrageenan on contractile function in mammalian skeletal muscle — G.J. Pinniger, J.E. Pelham and A.J. Bakker, School of Biomedical, Biomolecular and Chemical Sciences. The University of Western Australia Crawley, WA 6009, Australia.
0945	18P	LDH isozyme profile of striated muscles and electrophoretically-typed single fibres from cane toad (Bufo marinus) — J.R. Babb, R. Blazev, J.G. Kemp and G.M.M. Stephenson, Muscle Cell Biochemistry Laboratory, School of Biomedical and Health Sciences, Victoria University, P.O. Box 14428, Melbourne, VIC 8001, Australia.
1000	19P	MuRF1 and Nedd4 are differentially expressed in denervated rat fast- and slow-twitch muscles — J.G. Ryall and G.S. Lynch, Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, VIC 3010, Australia.
1015	20P	Local insulin-like growth factor binding proteins are required for successful skeletal muscle regeneration after injury — S.M. Gehrig, J.D. Schertzer and G.S. Lynch, Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, VIC 3010, Australia.
1030		Close

Morning Tea

Concert Hall

Poster Viewing

Mulubinba Room

Symposium: Magnetic techniques in protein studies

Chair: Louise Brown

1100	21P	Application of CW and pulsed EPR, MoSophe and DFT calculations in unravelling the electronic structure of the molybdenum(V) centre in dimethylsulfoxide reductase — C.J. Noble,^1,2 S. Drew,^1,2 I. Lane,^1,2 S. Benson,¹ A.G. McEwan,^2,3 C.G. Young⁴ and G.R. Hanson,^1,2 ¹Centre for Magnetic Resonance, The University of Queensland, St Lucia, QLD 4072, Australia, ²Centre for Metals in Biology, The University of Queensland, St Lucia, QLD 4072, Australia, ³School of Molecular and Microbial Sciences, The University of Queensland, St Lucia, QLD 4072, Australia and ⁴School of Chemistry, The University of Melbourne, Parkville, VIC 3052, Australia.
1130	22P	Using NMR to study kinase regulation — G.F. King, Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD 4072, Australia.
1200	23P	Boltzmann-statistics analysis of solid state NMR experiments — J.D. Gehman,¹ F. Separovic¹ and A.K. Mehta,² ¹School of Chemistry, Bio21 Institute, University of Melbourne, VIC 3010, Australia and ²Department of Chemistry, Emory University, Atlanta, GA 30322, USA.
1215	24P	Chiral selection in metabolism studied by NMR of anisotropic media — P.W. Kuchel, C. Naumann, D. Szekely and W.A. Bubb, School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia.
1230	25P	Enhanced protein stability through disulfide engineering — T.D. Mulhern, T.W. Qiu, M.J. Bird, K. Ia, H.C. Cheng and O. Tan, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, VIC 3010, Australia.
1245	26P	Dynamics of the troponin molecular switch in the thin filament using SDSL-EPR — J.A. Cooke,¹ P.M.G. Curmi² and L.J. Brown,¹ ¹Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, Australia and ²School of Physics, The University of New South Wales, Sydney, NSW 2052, Australia.
1300		Close

Hunter Room

Symposium: Calcium channels, microdomains and muscle function

Chair: Dirk van Helden, James Brock

1100	27P	Store operated Ca²⁺ channels and microdomains of Ca²⁺ in liver cells — G.J. Barritt,¹ T.L. Litjens,² J. Castro,¹ E. Aromataris² and G.Y. Rychkov,² ¹Department of Medical Biochemistry, School of Medicine, Flinders University, P.O.Box 2100, Adelaide, SA 5001, Australia and ²Department of Physiology, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA 5005, Australia.
1120	28P	Store-operated Ca²⁺ entry and TRPC expression; possible roles in control of heart rate — Y-K. Ju and D.G. Allen, School of Medical Sciences, University of Sydney F13, NSW 2006, Australia.
1140	29P	What’s where and why at a vascular myoendothelial signaling complex? — S.L. Sandow, Department of Pharmacology, School of Medical Sciences, University of New South Wales, NSW 2052, Australia.
1200	30P	Location of voltage dependent calcium channel subtypes controls different aspects of cerebrovascular function — C.E. Hill, M.F. Navarro-Gonzalez, K.R. Meaney and T.H. Grayson, Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Acton, ACT 2601, Australia.
1220	31P	Imaging and modelling calcium microdomains around individual and clustered channels — I. Parker, A. Demuro, J.W. Shuai and I. Smith, Departments of Neurobiology & Behavior and Physiology & Biophysics, University of California, Irvine, CA 92697, USA. (Introduced by Dirk van Helden)
1250		General discussion
1300		Close

1300-1400 Lunch

Student symposium: Life after a PhD

Chair: Enzo Porrello

1300	32P	Establishing a career in science: the early postdoctoral years — M.J. Watt, St Vincent's Institute, 9 Princes St, Fitzroy, VIC 3065, Australia.
1320	33P	Life after the Ph.D.: applying for jobs and establishing your career — G.S. Lynch, Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, VIC 3010, Australia.
1400		Close

1300-1400 Lunch

Concert Hall

Poster Viewing

Mulubinba Room

Symposium: Potassium channels

Chair: Jamie Vandenberg

1400	34P	Location and function of SK channels in pyramidal neurons in the amygdala — P. Sah, L. Faber and A. Delaney, Queensland Brain Institute, University of Queensland, St Lucia, QLD 4072, Australia.
1430	35P	Potassium channel gating — J.M. Gulbis, Structural Biology Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia.
1500	36P	A link to two-pore domain potassium channel regulation — C.E. Clarke,^1,2 E. Veale,³ A. Mathie,³ K. Wyse,¹ A. Torres,⁴ G. Pages,⁴ P.W. Kuchel⁴ and J.I. Vandenberg,^1,2 ¹University of New South Wales, NSW 2052, Australia, ²Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia, ³University of Kent, England, UK and ⁴University of Sydney, NSW 2006, Australia.
1530	37P	Mapping the insectophore of κ-atracotoxins: insect-selective BK_Ca channel blockers that reveal a novel insecticide target — S.J. Gunning,¹ F.J. Maggio,² S.M. Valenzuela,¹ G.F. King^2,3 and G.M. Nicholson,¹ ¹Department of Medical & Molecular Biosciences, University of Technology Sydney, Broadway, NSW 2007, Australia, ²Department of Molecular, Microbial & Structural Biology, University of Connecticut Health Center, Farmington, Connecticut 06032, USA and ³Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD 4072 Australia.
1600		Close

Hunter Room

Symposium: Insulin signaling in health and disease

Chair: Mark Febbraio

1400	38P	Molecular mechanisms underpinning enhanced insulin action by prior exercise — J.F.P. Wojtaszewski, Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, University of Copenhagen, 13 Universitetsparken, DK 2100, Copenhagen, Denmark. (Introduced by M. Febbraio)
1430	39P	Planet Akt. Are there alternate life forms in the insulin action galaxy? — D.E. James, Diabetes and Obesity Research Program 384 Victoria Street, Darlinghurst, NSW 2010, Australia. (Introduced by Mark Febbraio)
1500	40P	The retinoic acid receptor-related orphan nuclear receptor α regulates adiposity and lipid homeostasis — P. Lau, R. Fitzsimmons, S. Suryaprakash and G.E.O. Muscat, Institute for Molecular Bioscience, University of Queensland, Qld 4072, Australia. (Introduced by M. Febbraio)
1530	41P	Skeletal muscle fat metabolism and insulin resistance: old targets, new players — M.J. Watt, St Vincents Institute, 9 Princes St, Fitzroy, VIC 3065, Australia.
1600		Close

1600-1600 Afternoon Tea

Concert Hall

Bob Robertson Lecture

Chair: Brett Hambly

1630		Introduction
1730		Close

Mulubinba Room

ASB AGM

1730		Meeting starts
1830		Close

1900-2200 Student Mixer - M.J Finnegans - King & Darby Sts.

Tuesday 4 December 2007

Concert Hall

Poster viewing

Mulubinba Room

Symposium: Exercise, free radicals and skeletal muscle

Chair: Michael McKenna, Mark Hargreaves

0830	42P	Redox modulation of contractile function in skeletal muscle — M.B. Reid, Department of Physiology, University of Kentucky, 800 Rose St., Room MS-509, Lexington, KY 40536-0298, USA. (Introduced by Michael McKenna)
0915	43P	Influence of skeletal muscle ROS production on excitation-contraction coupling at physiological temperatures — C. van der Poel,¹ J.N. Edwards,¹ W.A. Macdonald² and D.G. Stephenson,¹ ¹Department of Zoology, La Trobe University, Bundoora, VIC 3083, Australia and ²Department of Physiology, Arhus University, Denmark.
0840	44P	Skeletal muscle Na⁺,K⁺-pump activity, reactive oxygen species and fatigue in exercising humans — M.J. McKenna, School of Human Movement Recreation and Performance, Centre for Ageing, Rehabilitation, Exercise & Sport, Victoria University PO Box 14428, Melbourne, VIC 8001, Australia.
1005	45P	Role of reactive nitrogen species in skeletal muscle glucose uptake and mitochondrial biogenesis — G.K. McConell, Department of Physiology, University of Melbourne, Parkville, VIC 3011, Australia.
1030		Close

Hunter Room

Symposium: TRP and the other channels

Chair: Anuwat Dinudom

0830	46P	A TR(I)P through the world of epithelial calcium and magnesium channels — R.J.M. Bindels, 286 Physiology, PO Box 9101, 6500 HB Nijmegen, The Netherlands. (Introduced by A. Dinudom)
0915	47P	Conformational variability of the glycine receptor M2 domain in response to activation by different agonists — J.W. Lynch,¹ S.A. Pless,¹ M.I. Dibas² and H.A. Lester,² ¹School of Biomedical Sciences, University of Queensland, Brisbane, QLD 4072, Australia and ²Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
0950	48P	Molecular components of store-operated Ca²⁺ entry in liver cells — G.Y. Rychkov, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA 5005, Australia.
1025		Close

1030-1100 Morning Tea

Concert Hall

Free communications: Skeletal muscle 2

Chair: Glenn McConell

1100	49P	The variably spliced ASI region of RyR1 contains a basic α-helix domain that modifies EC coupling — A.F. Dulhunty,¹ T. Kimura,² J.D. Lueck,³ P.J. Harvey,¹ S.M. Pace,¹ N. Ikemoto,⁴ M.G. Casarotto¹ and R.T. Dirksen,³ ¹JCSMR, ANU, PO Box 334, ACT, 2601, Australia, ²Hyogo College of Medicine, 1-1 Mukogawa-cho Nishinomiya, HYOGO 663-8501, Japan, ³University of Rochester Medical Center, PO Box 711, 601 Elmwood Avenue, Rochester, NY, 14642 USA and ⁴Boston Biomedical Research Institute, Watertown, MA, USA.
1115	50P	Reduced Ca²⁺-activated force explains increased skeletal muscle fatiguability in heart failure — E. Verburg,^1,2 M. Munkvik,¹ P.K. Lunde,¹ G.D. Lamb² and O.M. Sejersted,¹ ¹Institute for Experimental Medical Research, Ullevaal University Hospital, Oslo, Norway and ²Department of Zoology, La Trobe University, Bundoora, VIC 3086, Australia.
1130	51P	Transgenic expression of cardiac α-actin rescues the lethal phenotype of skeletal α-actin knockout mice — G. Ravenscroft,^1,2 K.J. Nowak,¹ C. Jackaman,¹ E.M. Lim,¹ P.J. Morling,³ L.M. Griffiths,³ V. Fabian,³ J.L. Lessard,⁴ A.J. Bakker,² K.E. Davies⁵ and N.G. Laing,¹ ¹University of Western Australia, Centre for Medical Research, B Block, QE II Medical Centre, Nedlands Western Australia, ²University of Western Australia, Department of Physiology, 35 Stirling Highway, Crawley Western Australia, ³Royal Perth Hospital, Neuropathology, PathWest Anatomical Pathology, Perth, Australia, ⁴Cincinnati Children's Hospital Medical Center, Division of Developmental Biology, Cincinnati, United States and ⁵MRC Functional Genetics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
1145	52P	Contractile and fatigue properties of α-actinin-3 knockout fast-twitch EDL muscle — S.I. Head,¹ S. Chan,¹ D.G. Mac Aurthur² and K.N. North,² ¹Department of Physiology, University of New South Wales, Sydney, NSW 2052, Australia and ²Faculty of Medicine, University of Sydney, The Children's Hospital at Westmead, Neurogenetics Research Unit Westmead, Westmead, NSW 2145, Australia.
1200	53P	Higher expression of caveolin-3 in mechanically-skinned single fibres from slow-twitch muscle compared with fast-twitch muscle — R.M. Murphy and G.D. Lamb, Department of Zoology, La Trobe University, VIC 3086, Australia.
1215	54P	Contractile characteristics of permeabilized muscle fibres from dystrophic dogs — C. van der Poel,¹ K.T. Murphy,¹ J.C.S. Bizario,² M.C.R. Costa,² M.L. Pinto² and G.S. Lynch,¹ ¹Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, VIC 3010, Australia and ²Associação de Amigos dos Portadores de Distrofia Muscular, University of Ribeirão Preto, São Paulo, Brasil.
1230	55P	Mitochondrial ATP production rate is severely impaired in dystrophic mdx skeletal muscle, and is not influenced by altered calcium concentration — E. Rybalka and A. Hayes, Exercise Metabolism Unit, Centre for Aging, Rehabilitation, Exercise & Sport and School of Biomedical & Clinical Sciences, Victoria University, PO Box 14428, Melbourne City MC, VIC 8001, Australia.
1245	56P	Stretch-induced oxidative damage to mdx muscle: the role of NADPH oxidase — N.P. Whitehead,¹ E.W. Yeung,² C. Pham¹ and D.G. Allen,¹ ¹Discipline of Physiology, Bosch Institute, University of Sydney, NSW 2006, Australia and ²Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hong Kong.
1300		Close

Mulubinba Room

Free communications: Membrane transport

Chair: Phil Poronnik, Stefan Bröer

1100	57P	The effect of Ca²⁺ concentration on response to salinity stress in Chara australis — S. Al Khazaaly, M.J. Beilby and V.A. Shepherd, Biophysics, School of Physics, The University of NSW, NSW 2052, Australia.
1115	58P	Thermodynamics of ATP binding to the Na⁺,K⁺-ATPase — A.M. Pilotelle,¹ F. Cornelius,² H.-J. Apell,³ J.M. Matthews⁴ and R.J. Clarke,¹ ¹School of Chemistry, University of Sydney, NSW 2006, Australia, ²Department of Biophysics, University of Aarhus, DK-8000 Aarhus C, Denmark, ³Department of Biology, University of Constance, D-78457 Constance, Germany and ⁴School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia.
1130	59P	A single residue controls the substrate-induced conductance in the glutamine transporter SNAT3 (slc38a3) — S. Bröer,¹ H.-P. Schneider,² A. Bröer¹ and J.W. Deitmer,² ¹School of Biochemistry & Molecular Biology, Australian National University, Building 41, Canberra, ACT 0200, Australia and ²Abteilung Allgemeine Zoologie, Fachbereich Biologie, Technical University Kaiserslautern, 67653 Kaiserslautern, Germany.
1145	60P	Identification of early endocytic structures after stimulation of pancreatic acinar cells — A. Shukla and P. Thorn, School of Biomedical Sciences, University of Queensland, QLD 4072, Australia.
1200	61P	AKT and SGK-1 regulate albumin endocytosis via separate signalling pathways — D.H. Hryciw, C. Slattery, A. Bolithon, S-J. Conroy, A. Lee and P. Poronnik, School of Biomedical Sciences, The University of Queensland, St Lucia, Qld 4067, Australia.
1215	62P	Regulation of the epithelial Na⁺ channel by caveolin — I.-H. Lee,¹ A. Dinudom,¹ C.R. Campbell,¹ S. Kumar² and D.I. Cook,¹ ¹Discipline of Physiology, Faculty of Medicine, University of Sydney, NSW 2006, Australia and ²Hanson Centre of Cancer Research, IMVS, SA 500, Australia.
1230	63P	Determining albumin degradation rates in the proximal tubule — C. Slattery and P. Poronnik, School of Biomedical Sciences, The University of Queensland, 4072 Queensland, Australia.
1245	64P	Carbonic anhydrase inhibition - a novel therapeutic strategy for renal disease — C. Slattery and P. Poronnik, School of Biomedical Sciences, The University of Queensland, QLD 4072, Australia.
1300		Close

Hunter Room

Free communications: Smooth muscle and general physiology

Chair: Dirk van Helden

1100	65P	Baroreflex-autonomic control of regional coronary blood flow conductance in awake sheep — M. Hamut, A.W. Quail, D.B.F. Cottee, P. Seah, D. McLeod, R. Blake and S.W. White, Cardiovascular Research Programme, Hunter Medical Research Institute, and Discipline of Human Physiology, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Callaghan, NSW 2308, Australia.
1115	66P	Evolutionary aspects of neural control of coronary blood flow — A.W. Quail, D.B.F. Cottee, M. Hamut, P. Seah, D. McLeod, R. Blake and S.W. White, Cardiovascular Research Programme, Hunter Medical Research Institute, and Discipline of Human Physiology, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Callaghan, NSW 2308, Australia.
1130	67P	Integrated autonomic control of the bronchial circulation and 3rd generation airway dimensions during exercise in awake sheep — D. McLeod,¹ R. Gunther,² P. Seah,¹ A.W. Quail,¹ D.B.F. Cottee,¹ G. Parsons² and S.W. White,¹ ¹University of Newcastle, and Cardiovascular Research Program, Hunter Medical Research Institute, Callaghan, NSW 2308, Australia and ²Pulmonary and Critical Care Medicine, UC Davis, Davis, CA 95616, USA.
1145	68P	Controversy: exercise-induced pulmonary haemorrhage in the horse — S.W. White,¹ G. Parsons,² G. Mactaggart,¹ D. McLeod,¹ M. Hamut,¹ D.B.F. Cottee¹ and A.W. Quail,¹ ¹Cardiovascular Research Programme, Hunter Medical Research Institute, and Discipline of Human Physiology, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Callaghan, NSW 2308, Australia and ²Pulmonary and Critical Care Medicine, University of California Davis, Davis, CA 95616, USA.
1200	69P	The effects of maternal renal insufficiency on glomerular haemodynamics and tubuloglomerular feedback in the ovine fetus — K.J. Gibson,¹ A.J. Turner,¹ R.D. Brown,² A.C. Boyce¹ and A.E.G. Persson,² ¹Dept of Physiology, School of Medical Sciences, University of New South Wales, NSW 2052, Australia and ²Dept of Physiology, Uppsala University, Uppsala, S-75123, Sweden.
1215	70P	Spontaneous Ca and electrical signals in the renal pelvis that drive pelviureteric peristalsis — R.J. Lang,¹ H. Hashitani,² M. Tonta,¹ H.C. Parkington¹ and H. Suzuki,² ¹Department of Physiology, School of Biomedical Sciences, Monash University, Clayton, VIC 3800, Australia and ²Department of Regulatory Cell Physiology, Nagoya City Graduate School of Medicine, Nagoya 467-8601, Japan.
1230	71P	Mapping action potential initiation sites in corneal cold receptors — J.A. Brock and R.W. Carr, Prince of Wales Medical Research Institute, Barker St, Randwick, NSW 2031, Australia.
1245	72P	Effect of hypoxia on evoked responses in cerebellar Purkinje cells of the mdx mouse — D.K. Chelvanayagan, S.I. Head and J.W. Morley, Department of Physiology, University of New South Wales, Sydney, NSW 2052, Australia .
1300		Close

Concert Hall

Lunch and Posters

1300		Session starts
		Presenting authors at odd numbered posters 1300-1400; at even numbered 1400-1500
1	73P	Solvent dependence of the photochemistry of the voltage-sensitive fluorescent membrane probe RH421 — T.H.N. Pham and R.J. Clarke, School of Chemistry, University of Sydney, Sydney NSW 2006, Australia.
2	74P	Fitting light saturation curves measured using PAM fluorometry — R.J. Ritchie, School of Biological Sciences, The University of Sydney, NSW 2006, Australia.
3	75P	Seasonality of chlorophyll b presence in core complexes of photosystem II from higher plants. A role of photoprotection? — P.J. Smith, N. Cox, R. Steffen, J.L. Hughes, E. Krausz and R.J. Pace, School of Chemistry, College of Science, Australian National University, Science Rd, Acton, ACT 2601, Australia.
4	76P	Towards the structure of the β4 subunit ectodomain of the human BK K⁺ channel — O.B. Clarke and J.M. Gulbis, The Walter and Eliza Hall Institute, 1G Royal Pde, Parkville 3050 VIC, Australia.
5	77P	Monitoring reaction kinetics of starch by NMR spectroscopy — A.C. Dona, School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia.
6	78P	Muscling in on Paramagnetic NMR — N.M. Cordina,¹ J.A. Cooke,¹ M.W. Howell,¹ J.M. Mackay² and L.J. Brown,¹ ¹Department of Chemical and Biomolecular Sciences, Macquarie University, North Ryde NSW 2109, Australia and ²School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia.
7	79P	Rotation of some mutants of thermophilic F₁-ATPase — M.D. Hossain,^1,2 S. Furuike,¹ Y. Maki,³ K. Adachi¹ and K. Kinosita Jr.,¹ ¹Department of Physics, Faculty of Science and Engineering, Waseda University, Okubo 3-4-1, Shinjuku-ku, Tokyo 169-8555, Japan, ²Department of Physics, School of Physical Sciences, Shahjalal University of Science and Technology, Sylhet-3114, Bangladesh and ³Department of Physics, Osaka Medical College, Osaka 569-8686, Japan. (Introduced by S. Bröer)
8	80P	Ratchets: Rectifying Brownian motion for transport — S.J. Lade and Y.S. Kivshar, Nonlinear Physics Centre, Research School of Physical Sciences and Engineering, The Australian National University, ACT 0200, Australia.
9	81P	Modelling Staphylococcus aureus-induced septicemia using NMR — R. Plummer,¹ J. Bodkin,² T.W. Yau,^1,4 D. Power,³ N. Pantarat,³ T.J. Larkin,¹ D. Szekely,¹ W.A. Bubb,¹ T.C. Sorrell,³ C.J. Garvey⁴ and P.W. Kuchel,¹ ¹School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia, ²School of Chemistry, University of New South Wales, NSW 2052, Australia, ³Centre for Infectious Diseases and Microbiology, University of sydney and Westmead Millennium Institute, Westmead, NSW 2145, Australia and ⁴Australian Nuclear Science and Technology Organisation, Menai, NSW 2234, Australia.
10	82P	pH behaviour of the water chemical shift in ¹H NMR of red cells with low transmembrane magnetic susceptibility difference — T.J. Larkin, W.A. Bubb and P.W. Kuchel, School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia.
11	83P	The ability of the red blood cell to synthesise glutathione in type 2 diabetes mellitus, and the implications for disease management — S. Whillier,¹ J.E. Raftos¹ and P.W. Kuchel,² ¹Department of Biological Sciences, Macquarie University, NSW 2109, Australia and ²School of Molecular and Microbial Biosciences, The University of Sydney, NSW 2006, Australia.
12	84P	What are the roles of amino acid transporters B⁰AT1 and ASCT2 in kidney and intestine? — N. Tietze and S. Bröer, School of Biochemistry and Molecular Biology, Australian National University, ACT 0200, Australia.
13	85P	What is the physiological role of the neurotransmitter transporter 4 (NTT4) in the central nervous system? — S. Balkrishna and S. Bröer, School of Biochemistry & Molecular Biology, Australian National University, ACT 0200, Australia.
14	86P	The role of the EGF receptor in albumin-induced renal fibrosis — Y. Jang, C. Slattery and P. Poronnik, School of Biomedical Sciences, The University of Queensland, Qld 4072, Australia.
15	87P	Gonadotrophin hormones in flying-fox plasma during key reproductive stages — A.A. Macdonald, K.-A. Gray and G.M. O'Brien, Human Biology and Physiology, University of New England, NSW 2351, Australia.
16	88P	The effect of a selective α7-nicotinic acetylcholine receptor antagonist on endothelium-dependent relaxation in rat mesenteric arteries — P.S. Chadha,^1,2 J.D. Moffatt³ and R. Lever,¹ ¹Department of Pharmacology, The School of Pharmacy, University of London, WC1N 1AX, UK, ²School of Medical Sciences, University of New South Wales, NSW 2052, Australia and ³Department of Physiology, St. George's, University of London, SW17 0RE, UK.
17	89P	Synchronization of sinoatrial node cells: the effect of gap junctions — S. Polwiang and A. Coster, School of Mathematics and Statistics, The University of New South Wales, NSW 2052, Australia.
18	90P	Regulatory volume decrease in isolated cardiomyocytes: differences between freshly isolated and cultured cells? — J.R. Bell, D. Lloyd and M.J. Shattock, Cardiovascular Division, King's College London, The Rayne Institute, St. Thomas' Hospital, London, SE1 7EH, U.K.
19	91P	Expression of TRPC4 and desmonplakin in mouse hearts — Y. Chu, D.G. Allen and Y-K. Ju, Displine of Physiology, School of Medical Science, University of Sydney, NSW 2006, Australia.
20	92P	Cellular mechanisms of STZ-induced diabetic cardiomyopathy — M-L. Ward,¹ L. Zhang,^1,2 A.R.J. Phillips^2,4,5 and G.J.S. Cooper,^2,3,5 ¹Department of Physiology, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand., ²School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand., ³Department of Medicine, FMHS, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand., ⁴Department of Surgery, FMHS, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand. and ⁵Protemix Corporation, Auckland, New Zealand..
21	93P	Structural studies of the phosphorylation domain of cardiac myosin binding protein-C — J. Hwang,¹ C.E. Oakley,² M. Kekic,¹ L.J. Brown³ and B.D. Hambly,¹ ¹Pathology and Bosch Institute, University of Sydney, NSW 2006, Australia, ²Molecular Biophysics, Florida State University, Tallahassee, Florida, USA and ³Chemistry and Biomolecular Sciences, Macquarie University, NSW 2109, Australia.
22	94P	Electrophysiological properties of the hERG mutation E444K, found in familial atrial fibrillation — S.A. Mann,¹ J.A. Bursill,¹ T. Marciniec,¹ G. Guo,² R. Otway,² D. Fatkin² and J.I. Vandenberg,¹ ¹Electrophysiology and Biophysics Programm, Victor Chang Cardiac Research Institute, Level 9, 384 Victoria Street, Darlinghurst, NSW 2010, Australia and ²Molecular Cardiology Program, Victor Chang Cardiac Research Institute, Level 6, 384 Victoria Street, Darlinghurst, NSW 2010, Australia.
23	95P	Preparation of PCR-grade RNA from myocardial biopsy tissue of cardiac surgery patients — W.T.K. Ip,^1,2 L.M.D. Delbridge¹ and S. Pepe,² ¹Cardiac Phenomics Laboratory, Department of Physiology, University of Melbourne, Parkville, VIC 3010, Australia and ²Department of Surgery, Alfred Hospital, Faculty of Medicine, Nursing and Health Sciences, Prahran, VIC 3181, Australia.
24	96P	Protein trafficking defects as a cause of congenital long QT syndrome — J.T. Zhao,¹ J. Skinner,² A.P. Hill¹ and J.I. Vandenberg,¹ ¹Mark Cowley Lidwill Research Program in Cardiac Electrophysiology, Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, NSW 2010, Australia and ²Paediatric and Congenital Cardiac Services, Auckland City Hospital Level 3, Building 32, Private Bag 92 189, Auckland 1030, New Zealand.
25		Abstract withdrawn
26	98P	Dynamics of inactivation of hERG potassium channels — P. Ju, A.P. Hill, T. Marciniec and J.I. Vandenberg, Mark Cowley Lidwill Cardiac Electrophysiology and Biophysics Program, Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia.
27	99P	The measurement of inactivation in the human ether-á-go-go related gene channel — M.J. Perrin,^1,2 T.J. Campbell² and J.I. Vandenberg,¹ ¹Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst, NSW, 2010, Australia and ²St Vincent's Clinical School, Level 5 DeLacey Building, St Vincent's Hospital, Victoria Street, Darlinghurst, NSW 2010, Australia.
28	100P	Evidence for functional coupling between the mitochondria and the L-type calcium channel in the heart — H.M. Viola, P.G. Arthur and L.C. Hool, Cardiovascular Electrophysiology Laboratory, School of Biomedical, Biomolecular and Chemical Sciences, M311, Physiology, The University of Western Australia, Crawley, WA 6009, Australia.
29	101P	The effect of high hydrostatic pressure and TMAO on gating of MscS of E. coli — E. Petrov, P.R. Rohde and B. Martinac, School of Biomedical Sciences, The University of Queensland, St Lucia, QLD 4072, Australia.
30	102P	Rapid incorporation of bacterial mechanosensitive ion channel proteins MscL and MscS into liposomes using a modified sucrose method — A.R. Battle, E. Petrov, P. Pal and B. Martinac, Department of Physiology and Pharmacology, School of Biomedical Sciences, The University of Queensland, St Lucia 4072, Australia.
31	103P	Are α9α10 nicotinic acetylcholine receptors a pain target? — S.T. Nevin,¹ R.J. Clark,² H. Klimis,³ M.J. Christie,³ D.J. Craik² and D.J. Adams,¹ ¹School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia, ²Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia and ³Pain Management Research Institute, Kolling Institute, University of Sydney at Royal North Shore Hospital, St Leonards, NSW 2065, Australia.
32	104P	FRET-ing over CLIC1 insertion into the membrane — S.C. Goodchild,¹ P.M.G. Curmi² and L.J. Brown,¹ ¹Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, Australia and ²School of Physics, The University of New South Wales, Sydney, NSW 2052, Australia.
33	105P	Chloride conductance in the transverse tubular system of rat skinned skeletal muscle fibres — T.L. Dutka, D.G. Stephenson and G.D. Lamb, Department of Zoology, La Trobe University, Melbourne, VIC 3086, Australia.
34	106P	The RyR1 SPRY2 domain binds to the DHPR α1S II-III loop and to the RyR1 binding site for the DHPR β1a subunit — H-S. Tae, M.G. Casarotto, P.G. Board and A.F. Dulhunty, Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, ACT 2601, Australia.
35	107P	Effects of calmodulin on protein synthesis in mechanically skinned skeletal muscle fibres of the rat — D.W. Jame, M. Jois and D.G. Stephenson, School of Life Sciences, La Trobe University, VIC 3086, Australia.
36	108P	Contralateral strength gains following a 4-week progressive resistance exercise programme — J.A. Sampson, H. Groeller and G. Jacobs, School of Health Sciences, University of Wollongong, NSW 2522, Australia.
37	109P	Curve fitting model to quantify the rate and extent of force loss during different phases of fatigue in isolated skeletal muscle — S.P. Cairns¹ and D.S. Loiselle,² ¹School of Sport and Recreation, Faculty of Health and Environmental Sciences, AUT University, Private Bag 92006, Auckland 1020, New Zealand and ²Department of Physiology, School of Medicine, University of Auckland, Auckland 92019, New Zealand.
38	110P	Isoform dependent properties of calsequestrin — L. Wei, N.A. Beard and A.F. Dulhunty, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia.
39	111P	Contractile and fatigue properties of aged fast-twitch EDL muscle from an α-actinin-3 knockout mouse — S. Chan,¹ S.I. Head,¹ J.T. Seto² and K.N. North,² ¹Department of Physiology, University of New South Wales, NSW 2052, Australia and ²Faculty of Medicine, University of Sydney, Neurogenetics Research Unit , The Children's Hospital at Westmead, Westmead, NSW 2145, Australia.
40	112P	Exogenous administration of a PPARδ agonist to dystrophic mdx mice confers no protection from contraction-mediated muscle damage — S.M. Gehrig, J.D. Schertzer and G.S. Lynch, Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, VIC 3010, Australia.
41	113P	Contraction-induced changes to intracellular signalling in skeletal muscle — C. van der Poel, S-A. Tan, S.L. McGee, J.G. Ryall, M. Hargreaves and G.S. Lynch, Department of Physiology, The University of Melbourne, VIC 3010, Australia.
42	114P	Quantification of calsequestrin-1 and calsequestrin-2 in rat slow- and fast-twitch skeletal muscle — N.T. Larkins, R.M. Murphy and G.D. Lamb, Department of Zoology, La Trobe University, Melbourne, VIC 3086, Australia.
43	115P	Protease-activated receptor mediated calcium signaling and cytokine production in cultured c2c12 skeletal muscle cells — A.J. Bakker, K.A. Burlinson, N. Asokananthan, G.A. Stewart and G.J. Pinniger, School of Biomedical, Biomolecular & Chemical Sciences, University of Western Australia, Crawley, WA 6009, Australia.
44	116P	TRPC3 and GLUT4 interact during insulin-mediated glucose uptake in adult skeletal muscle — H. Westerblad, J.T. Lanner, D. Severa, S.L. Zhang, Y. Assefaw-Redda and J.D. Bruton, Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden.
45	117P	Whole-body cooling during hyperthermia: physiology versus physics — J.N. Caldwell,¹ A.M.J. van den Heuvel,¹ M.J. Patterson² and N.A.S. Taylor,¹ ¹School of Health Sciences University of Wollongong Wollongong NSW 2522 Australia and ²Defence Science and Technology Organisation Melbourne VIC Australia.
46	118P	Resistance training increases total AKT, but decreases basal AS160 phosphorylation in individuals with clusters of metabolic risk factors — C.A. Goodman,¹ I. Levinger,¹ K.F. Howlett,² J. Peake,³ A. Garnham,² D.L. Hare,⁴ G. Jerums⁵ and S. Selig,¹ ¹School of Human Movement, Recreation and Performance, Victoria University, Melbourne, VIC 8001, Australia, ²School of Exercise and Nutrition Sciences, Deakin University, Melbourne, VIC 3125, Australia, ³School of Human Movement Studies, University of Queensland, Brisbane, QLD 4072, Australia, ⁴Department of Cardiology, Austin Health, University of Melbourne, VIC 3084, Australia and ⁵Department of Endocrinology, Austin Health, University of Melbourne, VIC 3084, Australia.
47	119P	Inhibitors of mitochondrial function disrupt uterine pacemaking — F.S. Gravina,¹ K. Ryan,¹ M.S. Imtiaz,¹ S.L. Sandow,² R. Smith,³ H.C. Parkington⁴ and D.F. van Helden,¹ ¹School of Biomedical Sciences, Faculty of Health, University of Newcastle, NSW 2308, Australia, ²Department of Pharmacology, University of New South Wales, NSW 2052, Australia, ³Mothers and Babies Research Centre, John Hunter Hospital & School of Medicine and Public health, University of Newcastle, NSW 2308, Australia and ⁴Department of Physiology, Monash University, VIC 3800, Australia.
48	120P	Differential inhibitory signalling in the superficial and deep dorsal horn of the mouse spinal cord — W.B. Anderson,^1,2 B.A. Graham,^1,2 P. Jobling,^1,2 P.A. Tooney,^1,2 A.M. Brichta^1,2 and R.J. Callister,^1,2 ¹School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia and ²Hunter Medical Research Institute (HMRI), Lookout Road, New Lambton, NSW 2310, Australia.
49	121P	Maturation of neuron excitability and membrane conductances in the superficial dorsal horn of the mouse spinal cord — M.A. Walsh,^1,2 B.A. Graham,^1,2 A.M. Brichta^1,2 and R.J. Callister,^1,2 ¹School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia and ²Hunter Medical Research Institute (HMRI), New Lambton, NSW 2305, Australia.
50	122P	Compensatory changes in rapid A-type potassium channel function in the superficial dorsal horn of the spastic mouse; studied in vitro and in vivo — B.A. Graham,¹ P.R. Schofield,² A.M. Brichta¹ and R.J. Callister,¹ ¹School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia and Hunter Medical Research Institute (HMRI), New Lambton, NSW 2305, Australia and ²Prince of Wales Medical Research Institute (POWMRI), Randwick, NSW 2031, Australia.
51	123P	Voltage dependent currents in type I and II hair cells and calyx terminals of primary afferents in an intact vestibular preparation — A.E. Kindig, R. Lim, R.J. Callister and A.M. Brichta, Hunter Medical Research Institute, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Callaghan, NSW 2308, Australia.
52	124P	Vestibular effects of ionic and volume changes of inner ear fluid in an isolated preparation of a mouse labyrinth — E.G. LaMont, R. Lim, R.J. Callister and A.M. Brichta, Hunter Medical Research Institute, School of Biomedical Science, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia.
53	125P	Inhibitory synaptic transmission in neurons of the medial vestibular nucleus after unilateral labyrinthectomy — R. Lim, R.J. Callister and A.M. Brichta, Hunter Medical Research Institute, School of Biomedical Sciences, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia.
54	126P	A horizontal spinal cord slice preparation for studying descending synaptic inputs to neurons in the mouse spinal cord — J.R. Flynn,¹ M.P. Galea,² A.M. Brichta,¹ R.J. Callister¹ and B.A. Graham,¹ ¹School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia and Hunter Medical Research Institute (HMRI), New Lambton, NSW 2305, Australia and ²School of Physiotherapy and Rehabilitation Sciences Research Centre, The University of Melbourne, Melbourne, VIC 3010, Australia.
55	127P	Effects of a cognitive task on sway and postural reflex activity during standing — B.L. Julien and A.P. Bendrups, School of Human Biosciences, La Trobe University, VIC 3086, Australia.
56	128P	N-type calcium channels contribute to acetylcholine release from parasympathetic but not sympathetic preganglionic neurons in female mice — P. Jobling, School of Biomedical Sciences and Hunter Medical Research Institute, University of Newcastle, Callaghan, NSW 2308, Australia.
1500		Close

Poster viewing

Mulubinba Room

Symposium: Artificial photosynthesis

Chair: Tony Collings

1500		Tony Collings - Update on Artificial Photosynthesis since the last symposium in 2003
1515	129P	Redesigning photosynthetic charge separation — S.G. Boxer, Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. (Introduced by A. Colling)
1600	130P	Artificial photosynthesis and the bio-mimetic production of hydrogen — R.J. Pace, R. Stranger and S. Petrie, Department of Chemistry, College of Science, ANU, Canberra, ACT 0200, Australia.
1630	131P	Water-soluble chlorophyll-binding proteins (WSCPs) as well-defined systems by which to probe and modify chlorophyll-chlorophyll and chlorophyll-protein interactions — E. Krausz,¹ J.L. Hughes,¹ A. Oakley,¹ B. Conlan² and T. Wydrzynski,² ¹Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia and ²Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia.
1700		Close

Hunter Room

Symposium: Influencing factors in the fate of cardiac myocytes in heart disease

Chair: Livia Hool, David Saint

1500	132P	Spatial and temporal patterns of cAMP production in cardiovascular physiology and pathophysiology using FRET — R.D. Harvey, Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106-4970, USA. (Introduced by Livia Hool)
1530	133P	Multiple gene mutations altering cell fate and severity of heart disease — T. Tsoutsman,^1,2 M. Kelly,¹ E. Tu,¹ L. Lam,¹ C.E. Seidman,^3,4 J.G. Seidman³ and C. Semsarian,^1,2,5 ¹Agnes Ginges Centre for Molecular Cardiology, Centenary Institute, Locked Bag No. 6, Newtown, NSW 2042, Australia, ²Central Clinical School, University of Sydney, NSW 2006, Australia, ³Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA, ⁴Cardiovascular Division, Brigham and Women’s Hospital, Boston, MA, USA and ⁵Department of Cardiology, Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia. (Introduced by L. Hool)
1550	134P	Heart cell attrition early in life – the beginning of the end? — L.M.D. Delbridge, Department of Physiology, The University of Melbourne, Parkville, VIC 3010, Australia.
1610	135P	RyR2 peptides mimic Ca²⁺ dysfunction associated with disease mutations and suggest greater susceptibility in atrial than ventricular myocytes — D.S. Steele and Z. Yang, Institute of Membrane and Systems Biology, University of Leeds, Leeds, LS29JT, UK. (Introduced by Derek Laver)
1630	136P	The effect of mechanical stimulation on cardiac myocytes: The acute and chronic effects of stress and strain — E. White, Institute of Membrane and Systems Biology, University of Leeds, Leeds LS29JT, UK. (Introduced by L. Hool)
1650		Close

Concert Hall

AuPS Invited Lecture &mdash Don Robertson

Chair: David Saint

1700	137P	Efferent control in mammalian hearing — D. Robertson, Discipline of Physiology, School of Biomedical Biomolecular and Chemical Sciences, The University of Western Australia, WA 6009, Australia.
1800		Close

1900-2300 Conference Dinner - Harbour View Function Centre at Queens Wharf

Wednesday 5 December 2007

Concert Hall

Poster viewing

Mulubinba Room

Symposium: Endocrinology, reproduction and foetal development

Chair: Chen Chen, Iain Robinson

0830	138P	New kids on the block: RF-amides and neuroendocrine control of reproduction — I.J. Clarke, Monash University, Department of Physiology, P O Box 13F, Monash University, VIC 3800, Australia.
0900	139P	Involvement of TTX-resistant Na⁺ currents and protein kinase C in the action of GHRH on primary cultured somatotropes from GH-GFP transgenic mice — C. Chen,^1,2 S-K. Yang,^1,2 H.C. Parkington² and I.C.A.F. Robinson,³ ¹Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, VIC 3168, Australia, ²Department of Physiology, Monash University, Clayton, VIC 3800, Australia and ³Molecular Neuroendocrinology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.
0930	140P	Imaging and manipulating the growth hormone axis — I.C.A.F. Robinson, Division of Molecular Neuroendocrinology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK. (Introduced by Chen Chen)
1000	141P	Growth hormone precursor cells: identification, enrichment, transplantation and differentiation — D.A. Lepore,¹ K.R. Knight,² G.P.L Thomas,² A.J. Hussey,² I. Brinas,¹ P. Simmons,³ W.A. Morrison,² C. Chen⁴ and P.Q. Thomas,⁵ ¹Pituitary Research Unit, Murdoch Children’s Research Institute, Royal Childrens Hospital Parkville, VIC 3052, Australia, ²Bernard O’Brien Institute of Microsurgery and Department of Surgery, The University of Melbourne, St. Vincent’s Hospital, Fitzroy, VIC 3065, Australia, ³Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Centre, Houston, Texas 77030, USA, ⁴Prince Henry’s Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia and ⁵School of Molecular & Biomedical Science, The University of Adelaide, SA 5005, Australia.
1030		Close

Hunter Room

Symposium: EC coupling and fatigue

Chair: Gordon Lynch, Angela Dulhunty

0830	142P	Altered cellular Ca²⁺ handling in skeletal muscle fatigue — H. Westerblad, Department of Physiology & Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden. (Introduced by G.D. Lamb)
0910	143P	Importance of the t-system chloride conductance in muscle excitability and fatigue — G.D. Lamb, T.L. Dutka, R.M. Murphy and D.G. Stephenson, Department of Zoology, La Trobe University, Melbourne, VIC 3086, Australia.
0935	144P	Control of skeletal RyR channels by proteins in the SR lumen — N.A. Beard, L. Wei and A.F. Dulhunty, Muscle Research Group, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 0200, Australia.
1005	145P	Molecular recognition of the disordered dihydropyridine receptor II-III loop by a conserved domain in the type 1 ryanodine receptor — Y. Cui, H-S. Tae, N.C. Norris, Y. Karunasekara, P. Pouliquin, P.G. Board, A.F. Dulhunty and M.G. Casarotto, John Curtin School of Medical Research, Australian National University, ACT 0200, Australia.
1030		Close

1030-1100 Morning Tea

Concert Hall

Symposium: Amino acid transport and signalling

Chair: Stefan Bröer

1100	146P	Amino acid signaling to mRNA translation: Central role of mTOR — S.R. Kimball, Department of Cellular & Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA. (Introduced by S. Bröer)
1130	147P	Class 3 GPCRs as broad-spectrum L-amino acid sensors — A.D. Conigrave, School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia.
1200	148P	Closing the GATs. Metabolic consequences of blocking GABA uptake — F.A. Nasrallah,¹ V.J. Balcar,² J.L. Griffin³ and C. Rae,¹ ¹Prince of Wales Medical Research Institute, Barker St, Randwick, NSW 2031, Australia, ² Dept of Anatomy and Histology, The University of Sydney, NSW 2006, Australia and ³Dept of Biochemistry, Tennis Court Rd, The University of Cambridge, Cambridge CB2 1QW, UK. (Introduced by S. Bröer)
1230	149P	Neutral amino acid transporters of the kidney and intestine — S. Kowalczuk,¹ D.N. Azmanov,² J.A. Cavanaugh,² H. Rogers,² C.G. Bailey,³ J.E.J. Rasko^3,4 and S. Bröer,¹ ¹School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia, ²Medical Genetics Research Unit, Medical School, Australian National University, Canberra ACT 0200, Australia, ³Centenary Institute of Cancer Medicine & Cell Biology, University of Sydney, NSW 2006, Australia and ⁴Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia.
1300		Close

Mulubinba Room

Free communications: Cardiac muscle

Chair: David Allen

1100	150P	Hyperinsulinaemia and elevated levels of phosphorylated Akt/PKB in the neonatal Hypertrophic Heart Rat (HHR) precede the onset of cardiac hypertrophy — E.R. Porrello,^1,2 J.D. Schertzer,¹ C.L. Curl,¹ W.F. Meeker,¹ K.M. Mellor,¹ G.S. Lynch,¹ S.B. Harrap,¹ W.G. Thomas² and L.M.D. Delbridge,¹ ¹Department of Physiology, The University of Melbourne, Parkville, VIC 3010, Australia and ²Baker Heart Research Institute, Prahran, VIC 3004, Australia.
1115	151P	Regulation of ryanodine receptors from cardiac muscle by luminal Ca²⁺ and Mg²⁺ — D.R. Laver, School of Biomedical Sciences, University of Newcastle and Hunter Medical Research Institute, Callaghan, NSW 2308, Australia.
1130	152P	In vitro modulation of the cardiac ryanodine receptor (calcium release channel) activity by human homer 1b — P. Pouliquin, S.M. Pace and A.F. Dulhunty, Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra ACT 0200, Australia.
1145	153P	Visualization of the 3-D distribution of proteins involved in cardiac excitation-contraction coupling using a novel optical approach — I.D. Jayasinghe, M.B. Cannell and C. Soeller, Department of Physiology, Faculty of Medical and Health Sciences, 85 Park Road, Grafton, Auckland, New Zealand.
1200	154P	Analysis of ryanodine receptor clusters in rat and human cardiac myocytes at high optical resolution — C. Soeller, R. Gilbert, D. Crossman and M.B. Cannell, Department of Physiology, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.
1215	155P	Angiotensin II mediates cardiomyocyte growth signalling via ErbB4 — H. Chan,^1,2 N.J. Smith,¹ A. Agrotis,¹ R.D. Hannan³ and W.G. Thomas,¹ ¹Baker Heart Research Institute, Melbourne, VIC 8008, Australia, ²Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia and ³Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia.
1230	156P	Hypertrophic cardiomyopathy causing mutations in myosin binding protein-C alter PKA phosphorylation — C.E. Oakley,^1,2 J. Hwang,¹ L.J. Brown,³ M. Kekic,¹ P.G. Fajer² and B.D. Hambly,¹ ¹Discipline of Pathology, University of Sydney, NSW 2006, Australia, ²Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA and ³Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, Australia.
1245	157P	Novel actin/tropomyosin filaments that regulate glucose uptake and insulin secretion — A.J. Kee,^1,2 R. Szokolai,^1,3 N. Vlahovich,^1,3 R.G. Parton,⁴ D.E. James,⁵ G.J. Cooney,⁵ P.W. Gunning^2,6 and E.C. Hardeman,^1,2 ¹Muscle Development Unit, Children’s Medical Research Institute, Westmead, NSW 2145, Australia, ²Faculty of Medicine, University of Sydney, NSW 2006, Australia, ³University of Western Sydney, NSW 1797, Australia, ⁴Institute for Molecular Biosciences, University of Queensland, QLD 4072, Australia, ⁵Diabetes and Obesity Program, Garvan Institute of Medical Research, NSW 2010, Australia and ⁶Oncology Research Unit, Children’s Hospital at Westmead, Westmead, NSW 2145, Australia.
1300		Close

Hunter Room

Free communications: Ion channels

Chair: Joe Lynch

1100	158P	Relative counter-ion permeation in anion-selective glycine receptor channels did not vary between two different anions, supporting an ion pair mechanism — S. Sugiharto,¹ A.J. Moorhouse,¹ T.M. Lewis,¹ P.R. Schofield² and P.H. Barry,¹ ¹Dept of Physiology and Pharmacology, School of Medical Sciences, University of NSW, NSW 2052, Australia and ²The Prince of Wales Medical Research Institute, Barker Street, Randwick, NSW 2031, Australia.
1115	159P	External divalent ions decrease counter-ion permeation in anion-selective glycine receptor channels without changing the minimum pore diameter of the channel — S. Sugiharto,¹ T.M. Lewis,¹ A.J. Moorhouse,¹ P.R. Schofield² and P.H. Barry,¹ ¹Department of Physiology, School of Medical Sciences, The University of New South Wales, NSW 2052, Australia and ²The Prince of Wales Medical Research Institute, Barker Street, Randwick, NSW 2031, Australia.
1130	160P	MA-stretch residues are critical for ion conduction of 5-HT_3A receptors — J.E. Carland,¹ M.A. Cooper,¹ M.R. Livesy,¹ T.Z. Deeb,² T.G. Hales,² J.J. Lambert¹ and J.A. Peters,¹ ¹Neurosciences Institute, The University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK and ²Dept of Pharmacology and Physiology, The George Washington University, Washington DC, USA.
1145	161P	Function of the conserved cystine-loop in Cys-loop ligand-gated ion channels — M.L. Tierney and T. Luu, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 0200, Australia.
1200	162P	Functional characterisation of ten myotonia-associated mutations of the hClC-1 chloride channel — A.H. Bretag,¹ L.L. Ma,¹ G.Y. Rychkov^1,2 and P.L.Y. Fung,¹ ¹Sansom Institute, University of South Australia, North Terrace, Adelaide SA 5000, Australia and ²Physiology Discipline, University of Adelaide, SA 5005, Australia.
1215	163P	The effect of mutation E232Q and clofibric acid derivatives on gating in the human skeletal muscle chloride ion channel, ClC-1 — J.M.E. Cederholm,¹ G.Y. Rychkov^1,2 and A.H. Bretag,¹ ¹Sansom Institute, University of South Australia, Adelaide, SA 5000, Australia and ²Discipline of Physiology, University of Adelaide, SA 5005, Australia.
1230	164P	Novel modulation of Na_v channels in dorsal root ganglion neurons by veratridine — J. Ekberg,¹ D.J. Adams,¹ S. Kumar² and P. Poronnik,¹ ¹School of Biomedical Sciences, The University of Queensland, St Lucia, QLD 4072, Australia and ²Institute and Institute of Medical and Veterinary Science, Frome Rd, Adelaide, SA 5000, Australia.
1245	165P	Structural features of the lolitrem family of fungal alkaloids important for inhibition of large conductance calcium-activated potassium (BK) channels — J.E. Dalziel,¹ W.I. Imlach,¹ J. Dunlop¹ and S.C. Finch,² ¹AgResearch, Grasslands Research Centre, Tennent Drive, Private Bag 11008, Palmerston North 4442, New Zealand and ²Ruakura Research Centre, East Street, Private Bag 3123, Hamilton 3240, New Zealand.
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Concert Hall

1300-1400 Lunch

Mulubinba Room

AuPS AGM (& lunch)

1300		Meeting starts
1400		Close

Concert Hall

Free communications: Exercise physiology

Chair: Gordon Lynch

1400	166P	Effect of high-intensity, interval exercise on signalling proteins and gene expression in human skeletal muscle — M. Hargreaves,¹ S.L. McGee,¹ K.F. Howlett,² R.J. Snow,² A. Garnham² and M.J. Gibala,³ ¹Department of Physiology, The University of Melbourne, VIC 3010, Australia, ²School of Exercise & Nutrition Sciences, Deakin University, Burwood, VIC 3125, Australia and ³Department of Kinesiology, McMaster University, Hamilton, ON, Canada.
1415	167P	The effects of hydration and aerobic fitness on physiological strain and endurance performance — T.L. Merry,¹ P.N. Ainslie² and J.D. Cotter,¹ ¹School of Physical Education, University of Otago, Dunedin, New Zealand and ²Department of Physiology, University of Otago, Dunedin, New Zealand Dunedin, New Zealand.
1430	168P	nNOS is necessary for normal increases in glucose uptake during contraction of skeletal muscle — K. Linden, J.G. Ryall, C. van der Poel, J.D. Schertzer, G.S. Lynch and G.K. McConell, Department of Physiology, The University of Melbourne, VIC 3010, Australia.
1445	169P	Rat skeletal muscle 3-O-MFPase activity is not decreased by fatiguing in vitro electrical stimulation — C.A. Goodman,^1,3 A. Hayes^2,3 and M.J. McKenna,^1,3 ¹School of Human Movement, Recreation and Performance, Victoria University, Melbourne, VIC 8001, Australia, ²School of Biomedical and Health Sciences, Victoria University, Melbourne, VIC 8001, Australia and ³Centre for Ageing, Rehabilitation, Exercise and Sport, Victoria University, Melbourne, VIC 8001, Australia.
1500	170P	Iron accelerates skeletal muscle fatigue at 37°C — T.F. Reardon and D.G. Allen, School of Medical Sciences (F13), Bosch Institute, The University of Sydney, NSW 2006, Australia.
1515	171P	Intra-segmental distribution of emotional sweating — C.A. Machado-Moreira and N.A.S. Taylor, School of Health Sciences, University of Wollongong, Wollongong, NSW 2522, Australia.
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Mulubinba Room

Free communications: Biophysics & spectroscopy

Chair: Brett Hambly

1400	172P	‘remedi’: Meeting the measurement needs of regenerative medicine — M.L. Mather, J.A. Crowe and S.P. Morgan, Applied Optics Group, School of Electrical & Electronic Engineering, University of Nottingham, Nottingham, NG7 2RD, UK. (Introduced by A. Collings)
1415	173P	X-ray diffraction as a tool to study the arrangement of cellulose molecules in plant cell walls — C.J. Garvey,¹ O. Paris² and R. Gillespie,³ ¹ANSTO, PMB 1, Menai, NSW 2234, Australia, ²Max Planck Institute of Colloids and Interfaces, Department of Biomaterials, 14424 Potsdam, Germany and ³Department of Archaelogy and Natural History, Australian National University, ACT 0200, Australia.
1430	174P	Novel signalling in mouse embryonic stem cells alters the pluripotent state — A.C. Lonic,¹ F. Felquer,² N. Hamra² and M.B. Morris,³ ¹Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia, ²School of Biomedical Science, Univeristy of Adelaide, Adelaide, SA 5000, Australia and ³Human Reproduction Unit, School of Medical Sciences, University of Sydney, NSW 2006, Australia. (Introduced by Derek Laver)
1445	175P	Does N-acetylcysteine act as an intracellular cysteine precursor in human erythrocytes? — J.E. Raftos,¹ S. Whillier¹ and P.W. Kuchel,² ¹Department of Biological Sciences, Macquarie University, NSW 2109, Australia and ²School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia.
1500	176P	Free energy simulations of potassium channels - KcsA, Shaker and HERG — S. Kuyucak and T. Bastug, School of Physics A28, University of Sydney, NSW 2006, Australia.
1515	177P	In vivo measurement of hepatic lipid composition by proton magnetic resonance spectroscopy — N.A. Johnson,¹ D.W. Walton,² T. Sachinwalla,² C.H. Thompson,³ K. Smith,¹ P. Ruell,¹ S.R. Stannard⁴ and J. George,⁵ ¹Discipline of Exercise and Sport Science, The University of Sydney, East Street, Lidcombe, NSW 2141, Australia, ²Department of Magnetic Resonance, Rayscan Imaging, 41-43 Goulburn Street Liverpool, NSW 2170, Australia, ³Department of Medicine, Flinders University, Bedford Park, SA 5042, Australia, ⁴Institute of Food, Nutrition and Human Health, Massey University, Palmerston North Private Bag 11222, New Zealand and ⁵Storr Liver Unit Westmead Millennium Institute, The University of Sydney, Westmead Hospital, Westmead, NSW 2145, Australia.
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Hunter Room

Free communications: Cardiovascular/heart

Chair: Saxon White

1400	178P	Evidence for direct regulation of the cardiac L-type Ca²⁺ channel during changes in thiol redox state — W.A. Macdonald,¹ H.M. Viola,¹ B. Martinac² and L.C. Hool,¹ ¹School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, WA 6009, Australia and ²School of Biomedical Sciences, The University of Queensland, St Lucia, Qld 4072, Australia.
1415	179P	“Battle of the Clocks” – Sinoatrial pacemaking through plasmalemmal ionic currents or intracellular Ca²⁺ release — M.S. Imtiaz and D.F. van Helden, The Neuroscience Group, School of Biomedical Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.
1430	180P	Impaired post-ischemic functional recovery in primary cardiac hypertrophy is accentuated in female rats — J.R. Bell, E.R. Porrello, S.B. Harrap and L.M.D. Delbridge, Department of Physiology, The University of Melbourne, VIC 3010, Australia.
1445	181P	Diet high in N6 PUFA lowers cardiac membrane N3:N6 fatty acid ratio and increases atrial mass and cardiomyocyte size — S.E. Miller,¹ C.E. Huggins,¹ M.L. Theiss,² P.L. McLennan,² S. Pepe¹ and L.M.D. Delbridge,¹ ¹Department of Physiology, University of Melbourne, VIC 3010, Australia and ²The University of Wollongong, NSW 2522, Australia.
1500	182P	Effect of hexarelin on transient outward potassium current in rat ventricular myocytes — Q. Sun and C. Chen, Endocrine Cell Biology, Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, VIC 3168, Australia.
1515	183P	Antibody Microarrays: A new tool for testing leukocytes for inflammation — A. Brown,¹ J-D. Lattimore,² M. McGrady,³ D. Sullivan,⁴ W. Dyer,⁵ F. Braet⁶ and C.G. dos Remedios,¹ ¹Muscle Research Unit Bosch Institute (F13) The University of Sydney NSW 2006, Australia, ²Cardiology Department, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia, ³Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia, ⁴Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Missenden Road, NSW 2050, Australia, ⁵Australian Red Cross Blood Service, 152 Clarence Street, Sydney 2000, Australia and ⁶Electron Microscope Unit, Australian Key Centre for Microscopy and Microanalysis, The University of Sydney, NSW 2006, Australia.
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Concert Hall

Prizes

1530

Awarding of AuPS and ASB student prizes

The Physiological Society (UK) Exchange Lecture - Mark Dunne

Chair: Graham Lamb

1530	184P	Congenital hyperinsulinism: from bench to bedside .... and back? — M.J. Dunne, R.M. Shepherd and K.E. Cosgrove, Faculty of Life Sciences, University of Manchester, Core Technology Facility, 46 Grafton Street, Manchester, M13 9NT, UK.
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1630 End of conference