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Volume 36




AuPS/AHMRC Sydney 2004 Meeting

British Physiology Society Lecture
Emerging functions of 10 types of transient receptor potential (TRP) cationic channel in vascular smooth muscle
D.J. Beech 1
Symposium — Environmental and genetic influences on respiratory health
Influence of air pollution on respiratory health during perinatal development
K.E. Pinkerton and J.P. Joad 9
Role of the physico-chemical environment in lung development
S.B. Hooper and M.J. Wallace 15
The respiratory consequences of preterm birth
T.J.M. Moss 23
Environmental factors and gene-environment interactions in the aetiology of asthma
G.B. Marks 29
Symposium — Cardiac hypertrophy and failure - cellular and signalling defects
Cardiac hypertrophy, substrate utilisation and metabolic remodelling: cause or effect?
R.H. Ritchie & L.M.D. Delbridge 35
Convergence of glucose- and fatty acid-induced abnormal myocardial excitation-contraction coupling and insulin signalling
A.J. Davidoff 45
Reactive oxygen species in cardiac signalling – from mitochondria to plasma membrane ion channels
L.C. Hool 55
Genes, calcium and modifying factors in hypertrophic cardiomyopathy
T. Tsoutsman, L. Lam & C. Semsarian 63
Symposium — Integrative aspects of human muscle performance
Effects of exercise-induced arterial hypoxemia on limb muscle fatigue and performance
L.M. Romer & J.A. Dempsey 71
Exercise and skeletal muscle GLUT4 expression: molecular mechanisms
S.L. McGee & M. Hargreaves 77
Evidence for a supraspinal contribution to human muscle fatigue
J.L. Taylor, G. Todd & S.C. Gandevia 83
Symposium — Stretch Activated Ion Channels
Gene expression of stretch activated channels and mechano-electric feedback in the heart
D. Kelly, L. Mackenzie, P. Hunter, B. Smaill & D.A. Saint 91
Mechanosensitive ion channels in skeletal muscle: A link in the membrane pathology of muscular dystrophy
J.B. Lansman & A. Franco-Obregón 101
Muscle damage in mdx (dystrophic) mice: The role of calcium and reactive oxygen species
N.P. Whitehead, E.W. Yeung & D.G. Allen 111

AuPS/ASB 2005 Canberra Meeting Abstracts

Meeting Opening
How does the membrane electric field gate an ion channel open and close?
Francisco Bezanilla 1P
Symposium 1: Ion Channel Gating
The domains in the Na channel have specific functions
Francisco Bezanilla and Baron Chanda 2P
Modulation of potassium channel conformation and function by permeating ions
S.J. Korn 3P
The gating of mechanosensitive ion channels
B. Martinac 4P
The mechanism of fast gating in ClC chloride channels
B. Corry, D. Bisset and S.H. Chung 5P
Conformational changes associated with glycine receptor activation
J.W. Lynch and R.L. Hawthorne 6P
Symposium 2: Functional Roles of Potassium Channels in the Vasculature
Endothelium-dependent vasodilatation: Fundamental role of SKCa and IKCa potassium channels
C.J. Garland 7P
Functional effects of vascular KIR channels
C.G. Sobey 8P
Kv as a target for nitroxyl anion (NO)-mediated vasodilatation
B.K. Kemp-Harper and J.L. Favaloro 9P
The smooth muscle BKCa potassium channel and its interaction with arteriolar myogenic tone
T.V. Murphy, Y.T. Hwang, H. Ding, N. Kotecha and M.A. Hill 10P
Potassium channels in vascular dysfunction
C.R. Triggle, A. Ellis, L. Ceroni, W. Wiehler and H. Ding 11P
Free Communications 1: Exercise Physiology
Sudomotor responses during isometric exercise appear to be intensity- and muscle mass-dependent
C.J. Gordon, C.D. Haley, J.N. Caldwell and N.A.S. Taylor 12P
Hydration indices in exertional heat stress
A.T. Garrett, N.G. Goossens, N.J. Rehrer, M.J. Patterson and J.D. Cotter 13P
Plasma ammonia responses during heavy-intensity constant-load cycling in young and older individuals
S. Sabapathy, D.A. Schneider and N.R. Morris 14P
Abnormal muscle Na+,K+-pumps, plasma K+, and exercise limitation in renal failure patients
A.C. Petersen, M.J. Leikis, K.T. Murphy, J.A. Leppik, X. Gong, A.B. Kent, L.P. McMahon and M.J. McKenna 15P
The effect of eccentric exercise on plasma K+ regulation and skeletal muscle Na+,K+-ATPase activity and content
J.A. Bennie, C.A. Goodman, M.J. Leikis and M.J. McKenna 16P
N-acetylcysteine infusion enhances skeletal muscle Na+,K+-ATPase activity and plasma K+ regulation, and delays fatigue, during prolonged submaximal exercise in well-trained individuals
C.A. Goodman, I. Medved, M.J. Brown, A.R. Bjorksten, K.T. Murphy, A.C. Petersen, S. Sostaric, X. Gong and M.J. McKenna 17P
Free Communications 2: Ion channels
Investigating the mechanism of proton transfer through the bacterial ClC transporter
M. O\'Mara, J. Yin, M. Hoyles and S.H. Chung 18P
An electrostatic basis for valence selectivity in cationic channels
T. Vora, B. Corry and S.H. Chung 19P
A current source and a cation conductance are components of an electrical circuit connected across the plasma membrane of the malaria parasite Plasmodium falciparum
R.J.W. Allen, K.J. Saliba and K. Kirk 20P
Role of protein flexibility in gramicidin A channel permeability
Turgut Bastug 21P
Ca2+ influx through store-operated Ca2+ channel in mouse sinoatrial node
Y.K. Ju, H. Chaulet, R.M. Graham and D.G. Allen 22P
A hydrogen peroxide insult causes sustained alteration in the sensitivity of the L-type Ca2+ channel to β-adrenergic receptor stimulation in ventricular myocytes
L.C. Hool, H.M. Viola and P.G. Arthur 23P
Plenary Lecture - Nigel Unwin
Structure and gating mechanism of the nicotinic acetylcholine receptor
N. Unwin 24P
Free Communications 3: Ligand-Gated Ion Channels
Analysis of a GABAAγ2 (R43Q) knock-in mouse model of familial epilepsy
S. Petrou, H. Tan, P. Davies and S. Murphy 25P
The receptor-associated protein, rapsyn, and regulation of postsynaptic acetylcholine receptor packing density and turnover at the neuromuscular synapse
W.D. Phillips and O.L. Gervásio 26P
Functional consequences of clustering GABAA receptors
M.L. Tierney, T.L. Luu, A.E. Everitt and P.W. Gage 27P
The charge of the P-loop glutamate controls cation-anion selectivity in CNG channels
W. Qu, A.J. Moorhouse, M. Chandra, K.D. Pierce, T.M. Lewis and P.H. Barry 28P
Structure and dynamics of the periplasmic loop of the MscL mechanosensitive channel studied by electron paramagnetic resonance spectroscopy
G. Meyer, E. Perozo and B. Martinac 29P
Free Communications 4: Skeletal Muscle Regulation: From Molecular Mechanism to Physiology
Calcium-phosphate precipitation in the sarcoplasmic reticulum reduces action potential-mediated Ca2+ release in mammalian skeletal muscle
T.L. Dutka, L. Cole and G.D. Lamb 30P
Digoxin effects on muscle strength, fatigue and K+ fluxes during exercise in healthy young adults
M.J. McKenna, S. Sostaric, M.J. Brown, C.A. Goodman, X. Gong, A.C. Petersen, J. Aw, J.A. Leppik, C.H. Steward, S.F. Fraser, R.J. Snow and H. Krum 31P
The peak tetanic force-[K+]o relationship in mouse fast- and slow-twitch muscle: modulation with [Na+]o or [Ca2+]o
S.P. Cairns 32P
The effect of dithiothreitol (DTT) application on isolated mouse muscle fatigued at 37°C
T.R. Moopanar and D.G. Allen 33P
Cytoplasmic ATP-sensing CBS domains regulate gating of skeletal muscle ClC-1 chloride channels
B. Bennetts, G.Y. Rychkov, H-L. Ng, C.J. Morton, D. Stapleton, M.W. Paarker and B.A. Cromer 34P
Modelling diffusive O2 supply to isolated muscle preparations
C.J. Barclay 35P
Free Communications presented as Posters
Ion channel structure and function
Effects of gadolinium and static magnetic fields on MscL channel activity
E. Petrov, Z.-W. Liu and B. Martinac 36P
Conformational changes involved in MscL channel gating measured using FRET spectroscopy
B. Corry, P. Rigby and B. Martinac 37P
C-terminal charged cluster of the mechanosensitive channel MscL, RKKEE, functions as a pH sensor
A. Kloda and B. Martinac 38P
The effects of eriochrome cyanine R on the mechanosensitive channels of E. coli
T. Nguyen, B. Clare, L.C. Hool and B. Martinac 39P
Mutations within the selectivity filter of the NMDA receptor channel influence voltage-dependent block by extracellular 5-Hydroxytryptamine
A. Kloda and D.J. Adams 40P
Ion selectivity of glycine receptors with mutations of charged residues in the intracellular portals
T.M. Lewis,   Sugiharto, J.A. Peters, J.J. Lambert, P.H. Barry and A.J. Moorhouse 41P
A molecular determinant of tropisetron inhibition of the glycine receptor Cl- channel
Z. Yang, A.D. Ney and J.W. Lynch 42P
Subunit-specific inhibition of recombinantly expressed glycine receptors by ginkgolides and bilobalide
R.L. Hawthorne and J.W. Lynch 43P
Crosslinking of α1β1 GABAA receptor subunits via cysteines introduced into the transmembrane domain
T.I. Webb, Z. Yang and J.W. Lynch 44P
Etomidate alters the single-channel properties of GABAA receptors in newborn rat hippocampal neurons
V.A.L. Seymour, P.W. Gage and M.L. Tierney 45P
GABAA αβ receptors open spontaneously when the conserved M2 leucine 9′ residue is mutated to a threonine
T.L. Luu, M.L. Tierney and P.W. Gage 46P
GABARAP influences the conductance of recombinant GABAA channels
A.B. Everitt, M.L. Tierney and P.W. Gage 47P
C-Terminal peptide of M protein from dengue virus (DVM-C) forms ion channels
A. Premkumar, C.R. Horan and P.W. Gage 48P
The role of the M1-P1 loop in acid sensitive two-pore domain potassium (TASK) channel regulation
C.E. Clarke, A. Mathie and J.I. Vandenberg 49P
Structural studies of chloride intracellular ion channel proteins
A.V. Mynott, D.R. Littler, P.M.G. Curmi, L.J. Brown and S.N. Breit 50P
Biomolecular structure and dynamics
Photochemical behaviour and Na+,K+-ATPase sensitivity of voltage-sensitive styrylpyridinium fluorescent membrane probes
S. Amoroso, V.V. Agon, T. Starke-Peterkovic, M.D. McLeod, H.-J. Apell, P. Sebban and R.J. Clarke 51P
Applications of styrylpyridinium dyes in elucidating ion-transport mechanisms in plant cells
S. Amoroso, R.J. Clarke, A. Larkum and R. Quinnell 52P
The crystal structure of Pichia pastoris lysyl oxidase at 1.23Å reveals a lysine-lysine covalent cross-link, dehydrolysinonorleucine
A.P. Duff, A.E. Cohen, P.J. Ellis, D.B. Langley, D.M. Dooley, H.C. Freeman and J.M. Guss 53P
Molecular dynamics study of conformational changes in human serum albumin by binding of fatty acids
S. Fujiwara and T. Amisaki 54P
NMR probes of red cell deformation
P.W. Kuchel, B.E. Chapman, D.J. Philp and W.A. Bubb 55P
Current-voltage analysis of response to salt stress by salt-tolerant and salt-sensitive charophyte cells
M.J. Beilby and V.A. Shepherd 56P
Oxygen evolution in chimeric spinach photosystem II with cyanobacteria manganese stabilising protein
A. Williamson, W. Hillier, R. Razeghifard and T. Wydrzynski 57P
The role of an oil droplet lens in vision enhancement
L. Fischer, M. Vorobyev, A. Zvyagin and T. Plakhotnik 58P
Circular dichroic spectra of the N-terminal region of cardiac myosin binding protein – C
C.E. Oakley, L.J. Brown and B.D. Hambly 59P
Changes in mechanical properties of live cell wall during turgor regulation monitored by atomic force microscopy
E.M. Mahomudally, M.J. Beilby, V.A. Shepherd and A.R. Moon 60P
Cardiac muscle and Skeletal muscle
Effect of temperature on stretch-induced cardiac action potential shortening in the rat heart: involvement of TREK-1
D.R. Kelly, L. Mackenzie and D.A. Saint 61P
Immunohistochemical identification of stretch-sensitive two-pore-potassium (TREK) channels in the human heart
S.Y. Yuan, H.P. Zhu and D.A. Saint 62P
More than one type of stretch activated channel contributes to the action potential duration in guinea pig
L. Mackenzie, D.R. Kelly and D.A. Saint 63P
Fatty acid composition of red blood cell membranes as a marker of human heart membrane phospholipid fatty acids
M.L. Theiss, S. Pepe and P.L. McLennan 64P
Confocal Ca2+ imaging of mouse sinoatrial node
Y.K. Ju, D.G. Allen and M.B. Cannell 65P
Reactive oxygen species generated from the mitochondria and not NAD(P)H-oxidase regulate L-type Ca2+ channel function during acute hypoxia in ventricular myocytes
L.C. Hool, H.M. Viola, C.A. Di Maria and P.G. Arthur 66P
Eccentric damage is accentuated in aged dystrophin-deficient EDL muscles from dystrophic mice (MDX)
S. Chan and S.I. Head 67P
Phosphorylation of CSQ affects Ca2+ binding and interactions with anchoring protein junctin
N.A. Beard, S. Cheung, L. Wei, M. Varsànyi and A.F. Dulhunty 68P
A calsequestrin polymer is necessary for the Ca2+ binding protein to regulate RyR channels
L. Wei, N.A. Beard and A.F. Dulhunty 69P
Digoxin and exercise effects on Na+,K+-pump activity, content, isoform gene and protein expression in human skeletal muscle
X. Gong, A.C. Petersen, S. Sostaric, C.A. Goodman, D. Cameron-Smith, R.J. Snow, K.T. Murphy, K. Carey, J. Aw, H. Krum and M.J. McKenna 70P
Nervous system
Reduced long-term depression is recovered in aging mdx cerebellar Purkinje cells
J.L. Anderson, S.I. Head and J.W. Morley 71P
Differential action of ω-conotoxins CVID and CVIB on voltage-gated calcium channels in rat sensory neurons
L.M. Motin, R.J. Lewis and D.J. Adams 72P
Evidence from collision experiments that onset chopper neurons in the guinea pig cochlear nucleus receive excitatory input from centrifugal collaterals
D. Robertson and W.H.A.M. Mulders 73P
P2Y receptor activation inhibits the formation and proliferation of primary mouse sub-ventricular-derived neurospheres
M.R. Stafford, P.F. Bartlett and D.J. Adams 74P
Membrane transport and its regulation
Protein kinase A inhibits cell growth induced by overexpression of IK channels
C.J. Fowler, K. Ngui, B. Hunne, D. Poole, J.B. Furness and C.B. Neylon 75P
Post-transcriptional regulation of CFTR protein expression by 5′untranslated region encoded regulatory elements
S-J. Conroy, W.L Davies and A.E.O. Trezise 76P
Nedd4-2, CLC-5 and albumin endocytosis in the proximal tubule: a role for SGK-1?
D.H. Hryciw, J. Ekberg, A. Lee, I.L. Lensink, S. Kumar, W.B. Guggino, D.I. Cook, C.A. Pollock and P. Poronnik 77P
Na+ H+ exchanger regulatory factor 2 (NHERF-2) is a scaffold for the plasma membrane Ca2+ ATPase (PMCA)
W.A. Kruger, G.R. Monteith, L. Tongpao and P. Poronnik 78P
NHERF1 - a novel scaffold protein for the astroglial glutamate transporter GLAST
A. Rayfield, A. Lee, D. Pow, D.H. Hryciw, T.A. Ma, S. Bröer, C.H. Yun and P. Poronnik 79P
Molecular cloning and characterisation of the mouse ‘system IMINO’ transporter
S. Kowalczuk, A. Bröer, M. Munzinger, N. Tietze, K. Klingel and S. Bröer 80P
Increased acetaminophen hepatotoxicity in the NaS1 sulphate transporter null mouse
S. Lee, P.A. Dawson and D. Markovich 81P
The influence of dietary fish oil and exercise upon oxidative status biomarkers in a rat model
R. Henry, A.J. Owen and P.L. McLennan 82P
Simulation of visual processing in retinal ganglion cells
M. Watson, G. Holmes, T. Byrne and S. Cornford 83P
AuPS Invited Lecture - Angela Dulhunty
Excitation-contraction coupling from 1969 to 2005
A.F. Dulhunty 84P
Symposium 3: Physiology Teaching in the 21st Century: Trends, Challenges and Innovations
Challenges facing physiology educators in the 21st century
Ann Sefton 85P
Research led teaching and learning in physiology
R.E. Kemm 86P
Problem-based learning (PBL): A novel and effective approach for teaching research skills by addressing contemporary research problems in physiology
J. Schwartz and P. Buckley 87P
Improving learning outcomes for students in Clinical Physiology
C.R Dallemagne 88P
Symposium 4: Membrane Protein Structure and Interactions
Seeing spots: miscibility transitions in lipid/cholesterol membranes
S.L. Keller and S.L. Veatch 89P
Role of the plasma membrane in amyloid formation and toxicity
M.I. Aguilar, X. Hou, S. Subasinghe, A. Mechler, K. Hall, L. Martin and D.H. Small 90P
Are chloride intracellular ion channel proteins (CLICs) really channels? Exploring their membrane structure
L.J. Brown, D.R. Littler, A.V. Mynott, S.J. Harrop, S.N. Breit, M. Mazzanti and P.M.G. Curmi 91P
Structure and dynamics of cellular components using fluorescence and X-ray diffraction techniques
Leann Tilley and Nick Klonis 92P
Symposium 5: Regulation of Membrane Transport
The canonical transient receptor potential channel 1 is an essential structural component of the mechanosensitive calcium permeable channel in vertebrate cells
O.P. Hamill, R. Maroto, A. Kurosky, T.G. Wood, A. Raso and B. Martinac 93P
Sensing pressure with K2P channels
Eric Honore 94P
Varieties of mechanotransduction: the cytoskeletal stress fibre as a force transmitter and a mechanosensor
Masahiro Sokabe, Kimihide Hayakawa and Hitoshi Tatsumi 95P
Role of tryptophan residues in ion channel function
Amitabha Chattopadhyay 96P
Symposium 6: Membrane Associated Proteins that Regulate Muscle Contraction
From DHPR to RyR and back again: What lies along the way?
Kurt Beam 97P
Regulation of ryanodine receptors from skeletal and cardiac muscle by components of the cytoplasm and lumen
D.R. Laver 98P
Structural and functional characterisation of the interaction of the dihydropyridine receptor II-III loop with the ryanodine receptor
M.G. Casarotto, Y. Cui, Y. Karunasekara, P.J. Harvey, N. Norris, P.G. Board and A.F. Dulhunty 99P
ClC-1 chloride channel - matching its properties to a role in skeletal muscle
G.Y. Rychkov 100P
Plenary Lecture D. Peter Tieleman
Pores, channels and transporters: computational studies of membrane transport
Peter Tieleman 101P
Free Communications 5: Cardiac muscle
Does lignocaine increase the chance of survival from massive heart attack?
S.M. Weiss and P.W. Gage 102P
Acute application of n-3 polyunsaturated fatty acids modify calcium sparks in permeabilised rat cardiac myocytes
B. Honen, R. Dalton, D.F. van Helden and D.R. Laver 103P
Abnormal calcium transients and calcium handling protein expression in cardiomyocytes from mdx (dystrophic) mice
I.A. Williams and D.G. Allen 104P
Mechanisms underlying the stretch-dependent slow inotropic response in isolated mouse myocardium
M.L. Ward and D.G. Allen 105P
Salutary effects of pyruvate are more evident in female than male glut4-deficient mouse hearts
C.E. Huggins, J.L. Favaloro, J. Proietto, S. Pepe and L.M.D. Delbridge 106P
The angiotensin type 2 receptor prevents cell death in neonatal cardiomyocytes of the hypertrophic heart rat
E.R. Porrello, A. D'Amore, C.L. Curl, S.B. Harrap, W.G. Thomas and L.M.D. Delbridge 107P
Free Communications 6: Cellular signaling
Analyses of the actin cytoskeleton using fluorescence resonance energy transfer (FRET)
C.G. dos Remedios, D. Chhabra, I. Dedova, D. Safer and E DeLaCruz 108P
Profilin binding to sub-micellar concentration of polyphosphoinositides PI(4,5)P2 and PI(3,4,5)P3
P.D.J. Moens 109P
Phospholipase Cγ is essential for activation of store-operated Ca2+ channels in liver cells
T. Litjens, T. Nguyen, E. Aromataris, M. Roberts, G. Barritt and G.Y. Rychkov 110P
Distinct characteristics of exocytosis in mouse pancreatic acinar cells
Peter Thorn, Olga Larina and Ian Parker 111P
Synchronization of Ca2+ oscillations through interaction of intracellular Ca2+ stores and L-type Ca2+ channels
M.S. Imtiaz, J. Zhao, K. Hosaka and D.F. van Helden 112P
Characterization of the of the electrical activity underlying spontaneous contractions in the mouse ureteropelvic junction
R.J. Lang, B. Zoltkowoski, J. Hammer, W. Meeker, I. Wendt and H.C. Parkington 113P
Free Communications 7: Muscle physiology
Active metabolism of mouse papillary muscle
C. Widén and C.J. Barclay 114P
Functional and electrophoretic identification of two Troponin C isoforms in toad skeletal muscle fibres
B. O'Connell, R. Blazev and G.M.M. Stephenson 115P
X-ray diffraction analysis of the effects of myosin chain-2 phosphorylation on the structure of fast skeletal muscle fibres
J.F.Y. Hoh, M. Yamaguchi, M. Kimura, S. Takemori and N. Yagi 116P
Calpain-1 and calpain-3 are not autolysed with exhaustive exercise in humans
R.M. Murphy, R.J. Snow and G.D. Lamb 117P
Increased fatigue resistance in EDL muscle of the obese mouse is associated with an increase in the proportion of hybrid IIB+IID fibres
R. Blazev, J.G. Kemp, D.G. Stephenson and G.M.M. Stephenson 118P
Insulin-like growth factor-I gene transfer by electroporation enhances skeletal muscle regeneration and function after injury
J.D. Schertzer and G.S. Lynch 119P
Free Communications 8: Biophysics
Bicarbonate is not a physiological substrate of Photosystem II
I.L. McConnell, W. Hillier and T. Wydrzynski 120P
Spectra of reef fish – a physics approach to colourful patterns
M. Vorobyev and J. Marshall 121P
Resonances of the human vocal tract and some of their uses
John Smith and Joe Wolfe 122P
Free communications 9: Education
Enhancing the first-year experiences of undergraduate students enrolled in large classes
R.W. Moni, K.B. Moni, L. Lluka and P. Poronnik 123P
Creating an effective learning community in a large-class service teaching physiology course
H.G.G. Ernst and K.L. Colthorpe 124P
The place of physiology in an integrated medical curriculum
T.O. Neild 125P
Using a student-centred approach to enhance understanding of the physiology of metabolism and energy balance
K.L. Colthorpe and H.G.G. Ernst 126P
Student perceptions and use of pre-specified criteria in constructing complex concept maps in physiology
R.W. Moni, E. Beswick, A. Forrest and K.B. Moni 127P
The opinion editorial – a novel assessment task in final year physiology
D.H. Hryciw, P. Poronnik and R.W. Moni 128P
Free communications 10: Skeletal Muscle 1
Low dose formoterol treatment reverses sarcopenia and improves muscle function in fast- but not slow-twitch skeletal muscles of aged rats
G.S. Lynch and J.G. Ryall 129P
β-adrenergic signalling in skeletal muscle regeneration after myotoxic injury
F. Beitzel, M.N. Sillence and G.S. Lynch 130P
Streptomycin reduces stretch-induced membrane permeability in isolated muscles from mdx (dystrophic) mice
N.P. Whitehead, M. Streamer and D.G. Allen 131P
Muscle weakness in a mouse model of nemaline myopathy can be reversed with exercise and reveals a novel myofibre repair mechanism
A.J. Kee, J.E. Joya, V. Nair-Shalliker, M.-A. Nguyen, M. Ghoddusi and E.C. Hardeman 132P
Contraction-mediated damage in mdx dystrophic mouse tibialis anterior muscles is not affected by the membrane sealant poloxamer
D.R. Plant, J.G. Ryall and G.S. Lynch 133P
Aberrant splicing of ryanodine receptor reduces Ca2+ release via an inter-domain interaction in myotonic dystrophy type 1
T. Kimura, M. Nakamori, J.D. Lueck, P. Pouliquin, R.T. Dirksen, M.P. Takahashi, S. Sakoda and A.F. Dulhunty 134P
Free communications 11: Skeletal muscle 2
The effect of altering the rest period during interval training on adaptations to muscle metabolism, ion regulation and exercise performance
J. Edge, D. Bishop and C.A. Goodman 135P
Long lasting muscle fatigue: partial disruption of EC-coupling by the elevated cytosolic calcium during contractions
E. Verburg, T.L. Dutka and G.D. Lamb 136P
The role of reactive oxygen species on stretch-induced muscle damage in dystrophic mice
D.G. Allen and E.Y. Yeung 137P
Effects of raising the temperature from 25°C to 37°C on twitch responses in fast-twitch mechanically skinned muscle fibres of the rat
C. van der Poel, J. Edwards and D.G. Stephenson 138P
Exposure of mammalian skeletal muscle to sub-physiological temperatures reduces its ability to function at physiological temperatures
J. Edwards, C. van der Poel and D.G. Stephenson 139P
Free communications 12: Systems physiology
Novel nifedipine-insensitive high voltage activated calcium channels play a role in vascular tone of cerebral arteries
M.F. Navarro-Gonzalez and C.E. Hill 140P
Accentuation during diabetes of differential connexin expression between the preglomerular and postglomerular renal vasculature
J.H. Zhang and C.E. Hill 141P
High-amplitude oscillations in human skin blood flow are distinct from known cardiac or respiratory influences
C.D. Haley, C.J. Gordon, N.A.S. Taylor and A.B. Jenkins 142P
Activation of at least three classes of ion channels by β-adrenoceptor activation in pregnant uterine smooth muscle
H.C. Parkington, M.A. Tonta, S. Simon, S.A. Cohen, A. Satragno, R.J. Lang and H.A. Coleman 143P
Expression of a constitutively active K+ channel prevents cell division in the mouse preimplantation embryo
M.L. Day, C.G. Bailey, J.E. Rasko, M.H. Johnson and D.I. Cook 144P
Symposium 7: Function and Regulation of Ion Transport Membrane Proteins
The transition between gating states in inward rectifier K+ channels
J. Gulbis 145P
Channelrhodopsin 1,2, a new class of ion channels: functional description and cellular applications
Georg Nagel, Peter Hegemann, Suneel Kateriya and Ernst Bamberg 146P
Membrane lipid composition and its effect on Na+,K+-ATPase molecular activity: insights from mammals, birds and ectotherms
N. Turner, P.L. Else, B.J. Wu and A.J. Hulbert 147P
Testing the membrane pacemaker model of metabolism
P.L. Else, N. Turner, T.W. Mitchell, B.J. Wu and A.J. Hulbert 148P
Regulation of the Na,K-ATPase
Helge Rasmussen 149P
Symposium 8: Epithelial Transport of Ions and Metabolites
A systems biology approach to understanding the role of peptide transporters in biology
H. Daniel, B. Meissner, B. Spanier, D. Weitz and I. Frey 150P
Na+-H+ exchange regulatory factors NHERF-1 and NHERF-2: roles in albumin endocytosis in the proximal tubule
P. Poronnik, C. Ferguson, R. Parton, C.H. Yun and D.H. Hryciw 151P
Sulphate ions in mammalian physiology: lessons from sulphate transporter knock-out mice
P.A. Dawson, B. Gardiner, S. Lee, M.C. Ku, S.M. Grimmond and D. Markovich 152P
Regulation of epithelial Na+ channels
A. Dinudom, I.-H. Lee and D.I. Cook 153P
Disorders of neutral amino acid resorption in epithelial cells
S. Bröer 154P
Author indexes

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