AuPS (AHMRC) Sydney 2004 Meeting

Programme

In the programme below, each presentation has, beside the time, the page number in volume 35 of the Proceedings. These numbers are links to the HTML versions of the pages. Each HTML page has a link to a corresponding PDF print version.

Links to the abstracts can also be found in the author index.

Wednesday 24 November 2004

Symposium - Stretch Activated Ion Channels
Wed 8:30am-10:30am
1P	F. Sachs, T. Suchyna & P. Gottlieb Channels are not proteins: lessons from mechanosensitive ion channels
2P	D.A. Saint, W. Liu & J. Tan Gene expression of stretch activated channels and mechanoelectric feedback in the heart
3P	J. Lansman Mechanosensitive ion channels in dystrophic muscle: Implications for channel gating and disease pathogenesis
4P	D.G. Allen Role of mechanosensitive channels in skeletal muscle damage and muscular dystrophy

Poster viewing - presenter in attendance
12:00-1:30pm
	Board
69P	1451	A.A. Lim, H.-.S. Lee & M.L. Day DNA damage pathways in mouse pre-implantation embryos
71P	1453	A.J. Moorhouse, S. Li, R.M. Vickery, M.A. Hill & J.W. Morley A patch-clamp investigation of membrane currents in a novel mammalian retinal ganglion cell line
75P	1457	C. Van Der Poel & D.G. Stephenson Source of superoxide production in mammalian skeletal muscle at elevated temperature
77P	1459	C.B. Neylon, C. Fowler, K. Nurgali, B. Hunne, H.L. Robbins, K. Ngui, S.E. Moore, M.X. Chen, I. Selmer & J.B. Furness Intermediate-conductance calcium-activated potassium channel expression and function in the enteric nervous system
79P	1461	D.W. Jame, P.C. Dooley, J.M. West & G.D. Stephenson Effects of amino acids bearing net charges on Ca²⁺-activation properties of skeletal muscle fibres
81P	1463	E.R. Porrello, C.E. Huggins, C.L. Curl, S.B. Harrap, W.G. Thomas & L.M.D. Delbridge Increased angiotensin AT₂ receptor expression is associated with neonatal cardiac growth restriction in a genetic model of adult cardiac hypertrophy
83P	1465	G.M. O'Brien Modelling the role of the brain in orgasm
86P	1468	H. Kiriazis, X. Feng, X.M. Gao & X.J. Du Effects of aging in mouse heart expressing constitutively active α1B-adrenergic receptors
88P	1470	M. Gozali, E. Patak & J.N. Pennefather Hemokinin-1 acts at the tachykinin NK₁ receptor in the oestrogen-treated mouse uterus
90P	1472	M.A. Matuszek & S.H. Boutcher Lipid profile, plasma cortisol, and fasting glucose levels of young adult normotensive males with and without a family history of hypertension
91P	1473	G.Y. Rychkov, T. Litjens, M.L. Roberts & G.J. Barritt Modulation of store-operated Ca²⁺ Channels in rat liver cells by arachidonic acid
94P	1476	N.A. Beard, L. Wei, O.J. Fiebig, M. Varsányi & A.F. Dulhunty Mutation within the C-terminus of skeletal calsequestrin disrupts calcium binding
95P	1477	P. Pouliquin, S. Pace, S.M. Curtis, P.J. Harvey, M.G. Casarotto & A.F. Dulhunty Modulation of ryanodine receptor's activity by homer and a ryanodine receptor C-terminal tail peptide
96P	1478	R. Henry, V.M. Tatham, M. Yeoh, A. Owen & P.L. McLennan Omega-3 polyunsaturated fatty acids decrease spontaneous beating rate in the rat isolated atria
98P	1480	R. Patel, R.H. Ritchie & I.R. Wendt 17β-oestradiol attenuates phenylephrine-induced hypertrophy in male neonatal rat cardiac myocytes
100P	1482	S.B. Park, G.J. Stuart, C.E. Hill & A.T. Gulledge Cholinergic modulation of pyramidal neuron excitability in the prefrontal cortex
104P	1486	Y.L. Zhang, J.E. Dalziel & J. Dunlop Functional expression of poly-histidine tagged voltage-gated sodium channels in insect cells
106P	1488	C.M. Woods, P. Sandstrom, M.E. Bond, M. Michael, J. Svanvik, J. Toouli & G.T.P. Saccone Selective iNOS inhibition enhances spontaneous gallbladder motility

Free Communications 1 – Gastrointestinal/Smooth muscle
Wed 1:30pm-3:00pm
5P	Y. Sonoda, J. Toouli & G.T.P. Saccone Acute intravenous ethanol reduces trans-sphincteric flow in the anaesthetised possum
6P	D.T. Nguyen, B. Exintaris & R.J. Lang Role of mitochondrial and IP₃ dependent Ca²⁺ release in the generation of slow wave activity in the guinea-pig prostate
7P	M.S. Imtiaz, J. Zhao, K. Hosaka & D.F. Van Helden Role of intracellular Ca²⁺ stores and L-type Ca²⁺ channels in vasospasm
8P	S. Potocnik, N. Jenkins & M.A. Hill Involvement of cholesterol-rich membrane domains in the arteriolar myogenic response
9P	J.H. Tan & J.A. Brock Inhibition of glybenclamide-sensitive K⁺ channels underlies noradrenergic depolarization of the rat tail artery in vitro

Free Communications 2 – Muscle/Exercise/Physiology
Wed 1:30pm-3:00pm
10P	J.N. Edwards, C. Van Der Poel & G.D. Stephenson Effects of Tempol and Tiron on tetanic force in skeletal muscle preparations from rat and mouse incubated at 37°C and 38°C
11P	E. Verburg, R.M. Murphy, G.D. Stephenson & G.D. Lamb Disruption of EC-coupling by physiological [Ca²⁺] is mediated by Ca²⁺-activated proteases
12P	R.M. Murphy, D.G. Stephenson & G.D. Lamb Effect of creatine on contractile force and Ca²⁺-sensitivity in mechanically-skinned single fibres from rat skeletal muscle
13P	S.I. Head & B. Greenaway Acute incubation with creatine protects against muscle fatigue in an isolated skeletal muscle preparation
14P	M.J. McKenna, S. Sostaric, C.A. Goodman, X. Gong, J. Aw, J. Leppik, C.H. Steward, S.F. Fraser, H. Krum, R.J. Snow & M.J. Brown Contracting muscle mass and inactive muscle effects on K⁺ dynamics during exercise

Symposium – Ghrelin – is it merely a growth hormone secretagogue
Wed 3:30pm-5:30pm
15P	M.A. Cowley Ghrelin from the gut and the brain regulates neural circuits in the brain
16P	L.K. Chopin, P.L. Jeffery, A. Yeh, J.F. McNamara, R. Wight & A.C. Herington Ghrelin and hormone dependent cancer
17P	I.J. Clarke, Y. Kurose & J. Iqbal Ghrelin physiology in a species (sheep) that has continuous gastric function
18P	C. Chen, J. Cao, X. Xu, J. Pang, R. Xu & M. Chen Ghrelin and its synthetic analogues, growth hormone secretagogues (GHS), act on GHS receptor to regulate the cardiac function and suppress cardiomyocyte apoptosis in chronic heart failure rats

Symposium – Integrative aspects of human muscle performance
Wed 3:30pm-5:30pm
19P	J. Dempsey Respiratory muscles, O₂ transport and fatigue
20P	G.D. Lamb & D.G. Stephenson EC coupling in skeletal muscle: implications for fatigue
21P	S.L. McGee & M. Hargreaves Exercise and skeletal muscle gene expression: molecular mechanisms
22P	J.L. Taylor Supraspinal mechanisms of fatigue
23P	G. Davis, J. Raymond & J.W. Middleton Central and peripheral limits to exercise: lessons from FES-evoked leg exercise in spinal cord-injured individuals

AuPS lecture
Wed 5:30pm-6:30pm
	D.I. Cook From Berlin to Sydney: 40 years of exocrine physiology

Thursday 25 November 2004

Symposium – Dendritic physiology and processing in the central nervous system
Thurs 8:30am-10:30am
24P	J.S. Isaacson Dendritic signaling in olfactory circuits
25P	G.J. Stuart Initiation and backpropagation of action potentials in central neurons
26P	C.A. Reid, S. Xu & D.A. Williams Inactivation of T-type calcium channels in the apical proximal dendrites of CA3 neurons; A role for the mossy fibre-CA3 synapse
27P	P. Sah & J.M. Power Synaptically activated calcium rises in amygdalar pyramidal neurons

Free Communications 3 - Cardiovascular/Fetal physiology
Thurs 8:30am-10:30am
28P	S. White, S. McIlveen, R. Bishop, D. McLeod, R. Blake, R. Gunther, J. Davis, L. Talken, D. Cottee, A. Quail & G. Parsons Mechanisms controlling airways circulation during exercise
29P	H. Vedam, D.J. Barnes, J. Hedner, C. Phillips & R.R. Grunstein The effect of sustained hypoxia on arterial stiffness
30P	J. Horiuchi, S. Wakabayashi & R.A.L. Dampney Role of 5-HT_1A receptors in the cardiovascular response elicited from the dorsomedial hypothalamic nucleus in the rat
31P	J.A. London, C.M. Woods, C.J. Carati, J. Toouli & G.T.P. Saccone Intragastric ethanol depresses pancreatic vascular perfusion (PVP) partly via an endothelin-mediated mechanism
32P	M. Bhandari, M.E. Brooke-Smith, C.J. Carati, J. Toouli & G.T.P. Saccone Galanin reduces pancreatic vascular perfusion (PVP) in the Australian possum
33P	E.R. Lumbers, D.H. Hershco, A.C. Boyce, K.J. Gibson, J.H. Burrell, J. Wu & K.M. Moritz Specific effects of cortisol on components of circulating and tissue renin angiotensin systems of fetal sheep
34P	A.C. Boyce, S. Chinchen & K.J. Gibson Is the renal haemodynamic response to amino acids present in sheep?
35P	A.E. O'Connell, A.C. Boyce, R.N. Douglas-Denton, J.F. Bertram & K.J. Gibson The long-term effects of a midgestational asphyxial episode in fetal sheep

Poster viewing - presenter in attendance
Thurs 12:00-2:00pm
	Board
70P	1452	A.B. Everitt, M. L. Tierney & P.W. Gage Increasing the surface density of recombinant GABA_A receptors increases channel conductance
72P	1454	B. Exintaris, D.T. Nguyen & R.J. Lang Role of potassium and chloride channels in the generation of spontaneous activity in the prostate gland
73P	1455	C.D. Haley, C.J. Gordon, N.A.S. Taylor & A.B. Jenkins Non-thermal mechanisms may modulate novel high-amplitude oscillations in skin blood flow
74P	1456	C. Kolbe, B. De Jong & H. Jelinek Is there a case for left ventricular hypertrophy screening?
76P	1458	C.J. Gordon, S. Van Den Broek, V. Van Wegberg & N.A.S. Taylor Thigh venous occlusion does not increase sudomotor drive during sinusoidal exercise
78P	1460	D. Feng & C. Chen Linoleic acid stimulates Ca²⁺ release from InsP₃-sensitive Ca²⁺ storage sites, leading to a reduction in voltage-gated Ca²⁺ currents in primary cultured rat pancreatic β-cells
80P	1462	K. Seluakumaran & D. Robertson Effects of olivocohlear efferent activation on responses of single inferior colliculus neurons to tones in noise
82P	1464	E. Patak, M. Gozali, S. Ventura & J.N. Pennefather Tachykinins and tachykinin receptors in the mouse bladder
84P	1466	D. Bersten, T. Kaczor & G.S. Posterino Inorganic phosphate reduces sarcoplasmic reticulum Ca²⁺ release in the presence and absence of cytoplasmic creatine phosphate in mammalian skeletal muscle
85P	1467	H. Kiriazis, X.M. Gao, K. Wang, A.M. Dart & X.J. Du Heart rate is related to the risk of heart failure in pressure-overload mice
87P	1469	J.H. Zhang & C.E. Hill Extensive connexin expression in preglomerular but not postglomerular vasculature
89P	1471	L. Wei, D.R. Laver, N.A. Beard & A.F. Dulhunty The response of the ryanodine receptor to reduced luminal Ca²⁺ concentrations is depressed by calsequestrin
92P	1474	M.E. Bond, M. Michael, C.M. Woods, J. Toouli, B.O. Al-Jiffry & G.T.P. Saccone Upregulation of inducible nitric oxide synthase in acute cholecystitis
93P	1475	N. Ozsarac, S. Gaul, L. Liu, R.H.A. Fink & P.W. Gage The conductance of extrasynaptic GABA_A channels in newborn rat hippocampal neurons is increased by alphaxalone and pregnanolone
97P	1479	R.J. Lang, J. Haynes, J. Kelly, J. Johnson, E. Mulholland, L. Baker & C. Pouton Electrophysiological characterization of mature neurons derived from mouse embryonic stem cells by Sox-1 Lineage selection and directed differentiation
99P	1481	S.L. Kueh, S.I. Head & J.W. Morley A new colony of mdx* dystrophic mice with genetically identical littermate controls*
101P	1483	T.M. Campbell & P.J. Johnson Characterisation of intestinal muscarinic acetylcholine receptors using selective antibodies and muscarinic toxins
102P	1484	V.A.L. Seymour, T. Luu, P.W. Gage & L. Tierney Is the cysteine-loop involved in the gating mecahism of the GABA_A receptor?
103P	1485	W. Qu, A.J. Moorhouse, T.M. Lewis, K.D. Pierce, P.R. Schofield & P.H. Barry Both cytoplasmic and extracellular dequalinium block olfactory CNGA2 channels
105P	1487	Y. Sonoda, M. Teng, J. Toouli & G.T.P. Saccone Sphincter of Oddi motility is stimulated by acute intravenous ethanol
107P	1489	C.R. Campbell, D.I. Cook & A. Dinudom Regulation of the epithelial sodium channel by phosphatidylinositol 4,5-bisphosphate
29P	514	H. Vedam, D.J. Barnes, J. Hedner, C. Phillips & R.R. Grunstein The effect of sustained hypoxia on arterial stiffness

British Physiology Society Lecture
Thur 2pm-3pm
	David Beech TRP channels: properties and importance in blood vessels

Symposium – Environmental and genetic influences on respiratory health
Thurs 3:30-5:30pm
36P	K.E. Pinkerton Air pollution and respiratory health
37P	S.B. Hooper Role of the physico-chemical environment in lung development
38P	T.J.M. Moss The respiratory consequences of preterm birth
39P	G.B. Marks Environmental factors and gene-environment interactions in the aetiology of asthma

Free Communications 4 – Muscle I
Thurs 3:30pm-5:30pm
40P	D.G. Stephenson, T.H. Pedersen, O.B. Nielsen & G.D. Lamb Intracellular acidosis increases t-system excitability in depolarised muscle fibres of the rat in the presence but not in the absence of chloride
41P	C.A. Goodman, R. Blazev & G.M.M. Stephenson Glycogen content and contractile responsiveness to T-system depolarization in skinned muscle fibres of the rat
42P	J.D. Schertzer & G.S. Lynch Optimizing methods for ectopic expression of protein in murine skeletal muscle
43P	R. Blazev, J.G. Kemp, D.G. Stephenson & G.M.M. Stephenson MHC composition and isometric tension in EDL muscle fibres from Zucker Obese and Zucker Lean rats
44P	J.G. Ryall, D.R. Plant & G.S. Lynch β₂-adrenoceptor agonist formoterol promotes slow-to-fast fibre transitions in rat skeletal muscle
45P	F. Beitzel, M.N. Sillence & G.S. Lynch The role of β₂-adrenoceptors in skeletal muscle regeneration after myotoxic injury
46P	N. Stupka, B.J. Michell, D.R. Plant, R.Bassel-Duby, E.N. Olson, B.E. Kemp & G.S. Lynch Increased calcineurin phosphatase activity improves fatigue resistance whilst maintaining specific force in diaphragm muscles from dystrophic mdx* mice*
47P	L.J. Harcourt, J.G. Ryall, D.R. Plant, M.N. Sillence & G.S. Lynch Low dose formoterol administration improves limb muscle function in dystrophic mdx* mice*

Poster viewing and drinks
Thurs 5:30-6:30pm

AuPS Dinner
∼7:00pm Mylos Greek Cuisine, 101 Glebe Point Road, Glebe (Bus leaves Congress site at 7:00pm)

Friday 26 November 2004

Symposium – Intracellular communication
Friday 8:30am-10:30am
48P	J.P. Santos Da Silva, C.G. Dotti & J. Abad-Rodriguez Polarized transport of the ganglioside sialidase protein in morphologically non-polarized neurons is a sufficient signal for axonal fate determination
49P	R.G. Parton & J.F. Hancock Ultrastructural analysis of caveolae and lipid raft domains
50P	A.S. Yap, R. Ali, M. Goodwin, F. Helwani, A. Paterson, S. Stehbens, J. Scott & A. Shewan To make and keep: diverse modes of cadherin-cooperativity determine contact formation and adhesive recognition
51P	I.A. Hendry, L. Harvey, M.W. Weible II, S.K. Kaasinen & A.J. Reynolds Has the multivesicular body containing the neurotrophin retrograde transport organelle other components?

Free Communications 5 – Ion channels
Friday 8:30am-10:30am
52P	H. Hu, P. Poronnik & D.I. Cook UTP inhibits store-activated Ca²⁺ influx in HT29 cells
53P	W. Wu, Y. He & P.W. Gage Blocking sodium current reduces the rise in intracellular calcium concentration during hypoxia in rat hippocampal neurons
54P	T.M. Lewis, N.L. Absalom, W. Kaplan & P.R. Schofield Conformational changes in extracellular loop 2 during activation of the α1 glycine receptor
55P	J.E. Dalziel, S.C. Finch, W. Imlach, N. Houssain & J. Dunlop Effects of lolitrems isolated from endophyte on human BK channels
56P	G.Y. Rychkov, E. Aromataris, M.L. Roberts & G.J. Barritt Glucagon activates calcium and chloride conductance in rat hepatocytes
57P	A.F. Dulhunty, Y. Karunasekara, S.M. Curtis, P.J. Harvey, P.G. Board & M.G. Casarotto Structural determination of interactions between the the ryanodine receptor and the recombinant DHPR II-III loop and synthetic “C” peptides

AuPS AGM
Friday 1:30pm-3:00pm

Symposium – Cardiac hypertrophy and failure - cellular and signalling defects
Friday 3:30pm-5:30pm
58P	L.M.D. Delbridge Cardiac hypertrophy and cardiomyocyte metabolic disturbances – cause and consequence
59P	A.J. Davidoff, M.W. Carmody, N. Dube & I. Pinz Convergence of glucose- and fatty acid-induced cardiomyocyte insulin resistance and abnormal E-C coupling
60P	L.C. Hool Role of reactive oxygen species in cardiac signaling – from mitochondria to plasma membrane ion channels
61P	C. Semsarian Molecular basis of hypertrophic cardiomyopathy

Free Communications 6 – Muscle II
Friday 3:30-5:30pm
62P	D.R. Plant, F. Beitzel & G.S. Lynch Length-tension relations are altered in regenerating fast- but not slow-twitch muscles of the rat
63P	T.L. Dutka, G.S. Posterino & G.D. Lamb Action potential mediated Ca²⁺ release in mechanically skinned fast-twitch muscle fibres of the rat is reduced by low [ATP] and by elevated [Mg²⁺]
64P	D.R. Laver & G.D. Lamb Regulation of coupled calcium release channels in bilayers by luminal Ca²⁺
65P	R. Blazev, C.A. Goodman & G.M.M. Stephenson Excitation-contraction coupling characteristics in mechanically skinned muscle fibres of the rat vary with age and strain
66P	S.K. Bortolotto, D.R. Plant, L.J. Harcourt, X. Han, W.A. Morrison, G.S. Lynch & A. Messina Functional and morphological recovery of skeletal muscles from mast cell depleted mice after ischaemia reperfusion injury
67P	B.N. Honen, G.D. Lamb & D.R. Laver Aberrant function of calcium releases channels underlying sudden cardiac death probed with RyR domain peptides
68P	G.S. Lynch, F. Colarossi & D.R. Plant Comparison of injury and repair in mouse skeletal muscle after treatment with the myotoxic agents, bupivacaine or notexin