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ISSN 0067-2084

Volume 38




AuPS/Combio Brisbane 2006 Meeting

Symposium: Development and Physiological Adaptions of Neuronal Circuits and Synapses I
Glutamate receptor plasticity at excitatory synapses in the brain
D. Genoux & J.M. Montgomery 1
Inhibitory interneurons in the piriform cortex
N. Suzuki & J.M. Bekkers 9
Does spike-timing-dependent synaptic plasticity underlie memory formation?
J.J. Letzkus, B.M. Kampa & G.J. Stuart 15
Functions of SK channels in central neurons
E.S.L. Faber & P. Sah 25
Symposium: The environment and genome in development: signalling from the beginning
Intracellular calcium in the fertilization and development of mammalian eggs
K.T. Jones 35
Symposium: Molecular determinants of calcium signalling
Ca2+ signaling and early embryonic patterning during zebrafish development
S.E. Webb and A.L. Miller 43
Symposium: Homeostatic control of calcium in the healthy and diseased heart
The roles of α1A- and α1B-adrenergic receptors in heart: insights from studies of genetically modified mice
E.A. Woodcock 53
Ca2+ stores regulate ryanodine receptor Ca2+ release channels via luminal and cytosolic Ca2+ sites
D.R. Laver 59
Plenary Lecture
Age-related changes in the structure and function of skeletal muscles
J.A. Faulkner, L.M. Larkin, D.R. Claflin and S.V. Brooks 69
Symposium: Endocrinology
Involvement of somatostatin receptor subtypes in membrane ion channel modification by somatostatin in pituitary somatotropes
S.-K. Yang & C. Chen 77
Symposium: Regulation of membrane transport
Evidence for the regulation of L-type Ca2+ channels in the heart by reactive oxygen species – mechanism for mediating pathology
L.C. Hool 87
Regulation of epithelial Na+ channels by aldosterone: Role of Sgk1
I-H. Lee, C.R. Campbell, D.I. Cook and A. Dinudom 95
Plenary Lecture
The epithelial brush-border Na/H Exchanger NHE3 associates with the actin cytoskeleton by binding to ezrin directly and via PDZ domain containing NHERF proteins
B. Cha and M. Donowitz 105

AuPS/ASB 2007 Newcastle Meeting Abstracts

AuPS Symposium: Physiology education
Developing research and inquiry though undergraduate education
S. Barrie 1P
Models of research-led learning and the theoretical and practical considerations in diverse contexts
R.W. Moni 2P
Research skill development in practical course work: a cost benefit view
D.A. Saint and L. Rogers 3P
Creating the student-research nexus in research-led learning
L.M.D. Delbridge 4P
U.S. National Institutes of Health program: Fostering research at predominantly undergraduate institutions
B.E. Goodman 5P
Plenary Lecture - Mike Sanguinetti
Modifiers of hERG K+ channel gating
M.C. Sanguinetti, D. Fernandez and M. Perry 6P
Symposium: Protein structure, interactions and dynamics
CLIC proteins: chameleon proteins at the interface between membranes and the cytoskeleton
D.R. Littler, S.J. Harrop, L.J. Brown, G,J, Pankhurst, A.V. Mynott, J. Phang, P. Luciani, R.A. Mandyam, M. Mazzanti, S. Tanda, M.A. Berryman, S.N. Breit and P.M.G. Curmi 7P
Interactions of human profilin-1 and phosphatidylinositol 4,5-bisphosphate in giant unilamellar vesicles
K. Krishnan, S.H. Cody, A.H.A. Clayton and P.D.J. Moens 8P
New twists in old tales. Conotoxins targetted to sodium channels
R.S. Norton 9P
Dimers are forever: New developments in the mechanism of the Na+,K+-ATPase
R.J. Clarke 10P
TRPC1 is increased in mdx muscle, binds to caveolin-3 and is regulated by Src kinase: implications for Duchenne muscular dystrophy
O.L. Gervasio, N.P. Whitehead and D.G. Allen 11P
In the presence of ATP, acidosis markedly inhibits ClC-1 skeletal muscle chloride channels
B. Bennetts, M.W. Parker and B.A. Cromer 12P
Free communications: Skeletal muscle 1
Properties of the tubular system network in twitch muscle
J.N. Edwards, P. Bhat, P. Thorn and B.S. Launikonis 13P
An action potential activated Ca2+ current in skeletal muscle
B.S. Launikonis, E. Rìos and D.G. Stephenson 14P
A slowing of relaxation in EDL muscle from the genetically obese mouse is associated with alterations in SR Ca2+ handling
R. Blazev, J.G. Kemp, D.G. Stephenson and G.M.M. Stephenson 15P
The effects of acute and chronic central leptin infusion on metabolism in peripheral tissues
R.C. Laker, G.D. Wadley, I.J. Clarke, B. Canny and G.K. McConell 16P
Effects of the inflammatory agent carrageenan on contractile function in mammalian skeletal muscle
G.J. Pinniger, J.E. Pelham and A.J. Bakker 17P
LDH isozyme profile of striated muscles and electrophoretically-typed single fibres from cane toad (Bufo marinus)
J.R. Babb, R. Blazev, J.G. Kemp and G.M.M. Stephenson 18P
MuRF1 and Nedd4 are differentially expressed in denervated rat fast- and slow-twitch muscles
J.G. Ryall and G.S. Lynch 19P
Local insulin-like growth factor binding proteins are required for successful skeletal muscle regeneration after injury
S.M. Gehrig, J.D. Schertzer and G.S. Lynch 20P
Symposium: Magnetic techniques in protein studies
Application of CW and pulsed EPR, MoSophe and DFT calculations in unravelling the electronic structure of the molybdenum(V) centre in dimethylsulfoxide reductase
C.J. Noble, S. Drew, I. Lane, S. Benson, A.G. McEwan, C.G. Young and G.R. Hanson 21P
Using NMR to study kinase regulation
G.F. King 22P
Boltzmann-statistics analysis of solid state NMR experiments
J.D. Gehman, F. Separovic and A.K. Mehta 23P
Chiral selection in metabolism studied by NMR of anisotropic media
P.W. Kuchel, C. Naumann, D. Szekely and W.A. Bubb 24P
Enhanced protein stability through disulfide engineering
T.D. Mulhern, T.W. Qiu, M.J. Bird, K. Ia, H.C. Cheng and O. Tan 25P
Dynamics of the troponin molecular switch in the thin filament using SDSL-EPR
J.A. Cooke, P.M.G. Curmi and L.J. Brown 26P
Symposium: Calcium channels, microdomains and muscle function
Store operated Ca2+ channels and microdomains of Ca2+ in liver cells
G.J. Barritt, T.L. Litjens, J. Castro, E. Aromataris and G.Y. Rychkov 27P
Store-operated Ca2+ entry and TRPC expression; possible roles in control of heart rate
Y-K. Ju and D.G. Allen 28P
What’s where and why at a vascular myoendothelial signaling complex?
S.L. Sandow 29P
Location of voltage dependent calcium channel subtypes controls different aspects of cerebrovascular function
C.E. Hill, M.F. Navarro-Gonzalez, K.R. Meaney and T.H. Grayson 30P
Imaging and modelling calcium microdomains around individual and clustered channels
I. Parker, A. Demuro, J.W. Shuai and I. Smith 31P
Student symposium: Life after a PhD
Establishing a career in science: the early postdoctoral years
M.J. Watt 32P
Life after the Ph.D.: applying for jobs and establishing your career
G.S. Lynch 33P
Symposium: Potassium channels
Location and function of SK channels in pyramidal neurons in the amygdala
P. Sah, L. Faber and A. Delaney 34P
Potassium channel gating
J. Gulbis and O. Clarke 35P
A link to two-pore domain potassium channel regulation
C.E. Clarke, E. Veale, A. Mathie, K. Wyse, A. Torres, G. Pages, P.W. Kuchel and J.I. Vandenberg 36P
Mapping the insectophore of κ-atracotoxins: insect-selective BKCa channel blockers that reveal a novel insecticide target
S.J. Gunning, F.J. Maggio, S.M. Valenzuela, G.F. King and G.M. Nicholson 37P
Symposium: Insulin signaling in health and disease
Molecular mechanisms underpinning enhanced insulin action by prior exercise
J.F.P. Wojtaszewski 38P
Planet Akt. Are there alternate life forms in the insulin action galaxy?
D.E. James 39P
The retinoic acid receptor-related orphan nuclear receptor α regulates adiposity and lipid homeostasis
P. Lau, R. Fitzsimmons, S. Suryaprakash and G.E.O. Muscat 40P
Skeletal muscle fat metabolism and insulin resistance: old targets, new players
M.J. Watt 41P
Symposium: Exercise, free radicals and skeletal muscle
Redox modulation of contractile function in skeletal muscle
M.B. Reid 42P
Influence of skeletal muscle ROS production on excitation-contraction coupling at physiological temperatures
C. van der Poel, J.N. Edwards, W.A. Macdonald and D.G. Stephenson 43P
Skeletal muscle Na+,K+-pump activity, reactive oxygen species and fatigue in exercising humans
M.J. McKenna 44P
Role of reactive nitrogen species in skeletal muscle glucose uptake and mitochondrial biogenesis
G.K. McConell 45P
Symposium: TRP and the other channels
A TR(I)P through the world of epithelial calcium and magnesium channels
R.J.M. Bindels 46P
Conformational variability of the glycine receptor M2 domain in response to activation by different agonists
J.W. Lynch, S.A. Pless, M.I. Dibas and H.A. Lester 47P
Molecular components of store-operated Ca2+ entry in liver cells
G.Y. Rychkov 48P
Free communications: Skeletal muscle 2
The variably spliced ASI region of RyR1 contains a basic α-helix domain that modifies EC coupling
A.F. Dulhunty, T. Kimura, J.D. Lueck, P.J. Harvey, S.M. Pace, N. Ikemoto, M.G. Casarotto and R.T. Dirksen 49P
Reduced Ca2+-activated force explains increased skeletal muscle fatiguability in heart failure
E. Verburg, M. Munkvik, P.K. Lunde, G.D. Lamb and O.M. Sejersted 50P
Transgenic expression of cardiac α-actin rescues the lethal phenotype of skeletal α-actin knockout mice
G. Ravenscroft, K.J. Nowak, C. Jackaman, E.M. Lim, P.J. Morling, L.M. Griffiths, V. Fabian, J.L. Lessard, A.J. Bakker, K.E. Davies and N.G. Laing 51P
Contractile and fatigue properties of α-actinin-3 knockout fast-twitch EDL muscle
S.I. Head, S. Chan, D.G. Mac Aurthur and K.N. North 52P
Higher expression of caveolin-3 in mechanically-skinned single fibres from slow-twitch muscle compared with fast-twitch muscle
R.M. Murphy and G.D. Lamb 53P
Contractile characteristics of permeabilized muscle fibres from dystrophic dogs
C. van der Poel, K.T. Murphy, J.C.S. Bizario, M.C.R. Costa, M.L. Pinto and G.S. Lynch 54P
Mitochondrial ATP production rate is severely impaired in dystrophic mdx skeletal muscle, and is not influenced by altered calcium concentration
E. Rybalka and A. Hayes 55P
Stretch-induced oxidative damage to mdx muscle: the role of NADPH oxidase
N.P. Whitehead, E.W. Yeung, C. Pham and D.G. Allen 56P
Free communications: Membrane transport
The effect of Ca2+ concentration on response to salinity stress in Chara australis
S. Al Khazaaly, M.J. Beilby and V.A. Shepherd 57P
Thermodynamics of ATP binding to the Na+,K+-ATPase
A.M. Pilotelle, F. Cornelius, H.-J. Apell, J.M. Matthews and R.J. Clarke 58P
A single residue controls the substrate-induced conductance in the glutamine transporter SNAT3 (slc38a3)
S. Bröer, H.-P. Schneider, A. Bröer and J.W. Deitmer 59P
Identification of early endocytic structures after stimulation of pancreatic acinar cells
A. Shukla and P. Thorn 60P
AKT and SGK-1 regulate albumin endocytosis via separate signalling pathways
D.H. Hryciw, C. Slattery, A. Bolithon, S-J. Conroy, A. Lee and P. Poronnik 61P
Regulation of the epithelial Na+ channel by caveolin
I.-H. Lee, A. Dinudom, C.R. Campbell, S. Kumar and D.I. Cook 62P
Determining albumin degradation rates in the proximal tubule
C. Slattery and P. Poronnik 63P
Carbonic anhydrase inhibition - a novel therapeutic strategy for renal disease
C. Slattery and P. Poronnik 64P
Free communications: Smooth muscle and general physiology
Baroreflex-autonomic control of regional coronary blood flow conductance in awake sheep
M. Hamut, A.W. Quail, D.B.F. Cottee, P. Seah, D. McLeod, R. Blake and S.W. White 65P
Evolutionary aspects of neural control of coronary blood flow
A.W. Quail, D.B.F. Cottee, M. Hamut, P. Seah, D. McLeod, R. Blake and S.W. White 66P
Integrated autonomic control of the bronchial circulation and 3rd generation airway dimensions during exercise in awake sheep
D. McLeod, R. Gunther, P. Seah, A.W. Quail, D.B.F. Cottee, G. Parsons and S.W. White 67P
Controversy: exercise-induced pulmonary haemorrhage in the horse
S.W. White, G. Parsons, G. Mactaggart, D. McLeod, M. Hamut, D.B.F. Cottee and A.W. Quail 68P
The effects of maternal renal insufficiency on glomerular haemodynamics and tubuloglomerular feedback in the ovine fetus
K.J. Gibson, A.J. Turner, R.D. Brown, A.C. Boyce and A.E.G. Persson 69P
Spontaneous Ca and electrical signals in the renal pelvis that drive pelviureteric peristalsis
R.J. Lang, H. Hashitani, M. Tonta, H.C. Parkington and H. Suzuki 70P
Mapping action potential initiation sites in corneal cold receptors
J.A. Brock and R.W. Carr 71P
Effect of hypoxia on evoked responses in cerebellar Purkinje cells of the mdx mouse
D.K. Chelvanayagan, S.I. Head and J.W. Morley 72P
Free Communications presented as Posters
Solvent dependence of the photochemistry of the voltage-sensitive fluorescent membrane probe RH421
T.H.N. Pham and R.J. Clarke 73P
Fitting light saturation curves measured using PAM fluorometry
R.J. Ritchie 74P
Seasonality of chlorophyll b presence in core complexes of photosystem II from higher plants. A role of photoprotection?
P.J. Smith, N. Cox, R. Steffen, J.L. Hughes, E. Krausz and R.J. Pace 75P
Towards the structure of the ectodomain of the β4 subunit of the human MaxiK K+ channel: Refolding, crystallisation and strategies for phasing
O.B. Clarke and J.M. Gulbis 76P
Monitoring reaction kinetics of starch by NMR spectroscopy
A.C. Dona 77P
Muscling in on Paramagnetic NMR
N.M. Cordina, J.A. Cooke, M.W. Howell, J.M. Mackay and L.J. Brown 78P
Rotation of some mutants of thermophilic F1-ATPase
M.D. Hossain, S. Furuike, Y. Maki, K. Adachi and K. Kinosita Jr. 79P
Ratchets: Rectifying Brownian motion for transport
S.J. Lade and Y.S. Kivshar 80P
Modelling Staphylococcus aureus-induced septicemia using NMR
R. Plummer, J. Bodkin, T.W. Yau, D. Power, N. Pantarat, T.J. Larkin, D. Szekely, W.A. Bubb, T.C. Sorrell, C.J. Garvey and P.W. Kuchel 81P
pH behaviour of the water chemical shift in 1H NMR of red cells with low transmembrane magnetic susceptibility difference
T.J. Larkin, W.A. Bubb and P.W. Kuchel 82P
The ability of the red blood cell to synthesise glutathione in type 2 diabetes mellitus, and the implications for disease management
S. Whillier, J.E. Raftos and P.W. Kuchel 83P
What are the roles of amino acid transporters B0AT1 and ASCT2 in kidney and intestine?
N. Tietze and S. Bröer 84P
What is the physiological role of the neurotransmitter transporter 4 (NTT4) in the central nervous system?
S. Balkrishna and S. Bröer 85P
The role of the EGF receptor in albumin-induced renal fibrosis
Y. Jang, C. Slattery and P. Poronnik 86P
Gonadotrophin hormones in flying-fox plasma during key reproductive stages
A.A. Macdonald, K.-A. Gray and G.M. O'Brien 87P
The effect of a selective α7-nicotinic acetylcholine receptor antagonist on endothelium-dependent relaxation in rat mesenteric arteries
P.S. Chadha, J.D. Moffatt and R. Lever 88P
Synchronization of sinoatrial node cells: the effect of gap junctions
S. Polwiang and A. Coster 89P
Regulatory volume decrease in isolated cardiomyocytes: differences between freshly isolated and cultured cells?
J.R. Bell, D. Lloyd and M.J. Shattock 90P
Expression of TRPC4 and desmonplakin in mouse hearts
Y. Chu, D.G. Allen and Y-K. Ju 91P
Cellular mechanisms of STZ-induced diabetic cardiomyopathy
M-L. Ward, L. Zhang, A.R.J. Phillips and G.J.S. Cooper 92P
Structural studies of the phosphorylation domain of cardiac myosin binding protein-C
J. Hwang, C.E. Oakley, M. Kekic, L.J. Brown and B.D. Hambly 93P
Electrophysiological properties of the hERG mutation E444K, found in familial atrial fibrillation
S.A. Mann, J.A. Bursill, T. Marciniec, G. Guo, R. Otway, D. Fatkin and J.I. Vandenberg 94P
Preparation of PCR-grade RNA from myocardial biopsy tissue of cardiac surgery patients
W.T.K. Ip, L.M.D. Delbridge and S. Pepe 95P
Protein trafficking defects as a cause of congenital long QT syndrome
J.T. Zhao, J. Skinner, A.P. Hill and J.I. Vandenberg 96P
Dynamics of inactivation of hERG potassium channels
P. Ju, A.P. Hill, T. Marciniec and J.I. Vandenberg 98P
The measurement of inactivation in the human ether-á-go-go related gene channel
M.J. Perrin, T.J. Campbell and J.I. Vandenberg 99P
Evidence for functional coupling between the mitochondria and the L-type calcium channel in the heart
H.M. Viola, P.G. Arthur and L.C. Hool 100P
The effect of high hydrostatic pressure and TMAO on gating of MscS of E. coli
E. Petrov, P.R. Rohde and B. Martinac 101P
Rapid incorporation of bacterial mechanosensitive ion channel proteins MscL and MscS into liposomes using a modified sucrose method
A.R. Battle, E. Petrov, P. Pal and B. Martinac 102P
Are α9α10 nicotinic acetylcholine receptors a pain target?
S.T. Nevin, R.J. Clark, H. Klimis, M.J. Christie, D.J. Craik and D.J. Adams 103P
FRET-ing over CLIC1 insertion into the membrane
S.C. Goodchild, P.M.G. Curmi and L.J. Brown 104P
Chloride conductance in the transverse tubular system of rat skinned skeletal muscle fibres
T.L. Dutka, D.G. Stephenson and G.D. Lamb 105P
The RyR1 SPRY2 domain binds to the DHPR α1S II-III loop and to the RyR1 binding site for the DHPR β1a subunit
H-S. Tae, M.G. Casarotto, P.G. Board and A.F. Dulhunty 106P
Effects of calmodulin on protein synthesis in mechanically skinned skeletal muscle fibres of the rat
D.W. Jame, M. Jois and D.G. Stephenson 107P
Contralateral strength gains following a 4-week progressive resistance exercise programme
J.A. Sampson, H. Groeller and G. Jacobs 108P
Curve fitting model to quantify the rate and extent of force loss during different phases of fatigue in isolated skeletal muscle
S.P. Cairns and D.S. Loiselle 109P
Isoform dependent properties of calsequestrin
L. Wei, N.A. Beard and A.F. Dulhunty 110P
Contractile and fatigue properties of aged fast-twitch EDL muscle from an α-actinin-3 knockout mouse
S. Chan, S.I. Head, J.T. Seto and K.N. North 111P
Exogenous administration of a PPARδ agonist to dystrophic mdx mice confers no protection from contraction-mediated muscle damage
S.M. Gehrig, J.D. Schertzer and G.S. Lynch 112P
Contraction-induced changes to intracellular signalling in skeletal muscle
C. van der Poel, S-A. Tan, S.L. McGee, J.G. Ryall, M. Hargreaves and G.S. Lynch 113P
Quantification of calsequestrin-1 and calsequestrin-2 in rat slow- and fast-twitch skeletal muscle
N.T. Larkins, R.M. Murphy and G.D. Lamb 114P
Protease-activated receptor mediated calcium signaling and cytokine production in cultured c2c12 skeletal muscle cells
A.J. Bakker, K.A. Burlinson, N. Asokananthan, G.A. Stewart and G.J. Pinniger 115P
TRPC3 and GLUT4 interact during insulin-mediated glucose uptake in adult skeletal muscle
H. Westerblad, J.T. Lanner, D. Severa, S.L. Zhang, Y. Assefaw-Redda and J.D. Bruton 116P
Whole-body cooling during hyperthermia: physiology versus physics
J.N. Caldwell, A.M.J. van den Heuvel, M.J. Patterson and N.A.S. Taylor 117P
Resistance training increases total AKT, but decreases basal AS160 phosphorylation in individuals with clusters of metabolic risk factors
C.A. Goodman, I. Levinger, K.F. Howlett, J. Peake, A. Garnham, D.L. Hare, G. Jerums and S. Selig 118P
Inhibitors of mitochondrial function disrupt uterine pacemaking
F.S. Gravina, K. Ryan, M.S. Imtiaz, S.L. Sandow, R. Smith, H.C. Parkington and D.F. van Helden 119P
Differential inhibitory signalling in the superficial and deep dorsal horn of the mouse spinal cord
W.B. Anderson, B.A. Graham, P. Jobling, P.A. Tooney, A.M. Brichta and R.J. Callister 120P
Maturation of neuron excitability and membrane conductances in the superficial dorsal horn of the mouse spinal cord
M.A. Walsh, B.A. Graham, A.M. Brichta and R.J. Callister 121P
Compensatory changes in rapid A-type potassium channel function in the superficial dorsal horn of the spastic mouse; studied in vitro and in vivo
B.A. Graham, P.R. Schofield, A.M. Brichta and R.J. Callister 122P
Voltage dependent currents in type I and II hair cells and calyx terminals of primary afferents in an intact vestibular preparation
A.E. Kindig, R. Lim, R.J. Callister and A.M. Brichta 123P
Vestibular effects of ionic and volume changes of inner ear fluid in an isolated preparation of a mouse labyrinth
E.G. LaMont, R. Lim, R.J. Callister and A.M. Brichta 124P
Inhibitory synaptic transmission in neurons of the medial vestibular nucleus after unilateral labyrinthectomy
R. Lim, R.J. Callister and A.M. Brichta 125P
A horizontal spinal cord slice preparation for studying descending synaptic inputs to neurons in the mouse spinal cord
J.R. Flynn, M.P. Galea, A.M. Brichta, R.J. Callister and B.A. Graham 126P
Effects of a cognitive task on sway and postural reflex activity during standing
B.L. Julien and A.P. Bendrups 127P
N-type calcium channels contribute to acetylcholine release from parasympathetic but not sympathetic preganglionic neurons in female mice
P. Jobling 128P
Symposium: Artificial photosynthesis
Redesigning photosynthetic charge separation
S.G. Boxer 129P
Artificial photosynthesis and the bio-mimetic production of hydrogen
R.J. Pace, R. Stranger and S. Petrie 130P
Water-soluble chlorophyll-binding proteins (WSCPs) as well-defined systems by which to probe and modify chlorophyll-chlorophyll and chlorophyll-protein interactions
E. Krausz, J.L. Hughes, A. Oakley, B. Conlan and T. Wydrzynski 131P
Symposium: Influencing factors in the fate of cardiac myocytes in heart disease
Spatial and temporal patterns of cAMP production in cardiovascular physiology and pathophysiology using FRET
R.D. Harvey 132P
Multiple gene mutations altering cell fate and severity of heart disease
T. Tsoutsman, M. Kelly, E. Tu, L. Lam, C.E. Seidman, J.G. Seidman and C. Semsarian 133P
Heart cell attrition early in life – the beginning of the end?
L.M.D. Delbridge 134P
RyR2 peptides mimic Ca2+ dysfunction associated with disease mutations and suggest greater susceptibility in atrial than ventricular myocytes
D.S. Steele and Z. Yang 135P
The effect of mechanical stimulation on cardiac myocytes: The acute and chronic effects of stress and strain
E. White 136P
AuPS Invited Lecture
Efferent control in mammalian hearing
D. Robertson 137P
Symposium: Endocrinology, reproduction and foetal development
New kids on the block: RF-amides and neuroendocrine control of reproduction
I.J. Clarke 138P
Involvement of TTX-resistant Na+ currents and protein kinase C in the action of GHRH on primary cultured somatotropes from GH-GFP transgenic mice
C. Chen, S-K. Yang, H.C. Parkington and I.C.A.F. Robinson 139P
Imaging and manipulating the growth hormone axis
I.C.A.F. Robinson 140P
Growth hormone precursor cells: identification, enrichment, transplantation and differentiation
D.A. Lepore, K.R. Knight, G.P.L Thomas, A.J. Hussey, I. Brinas, P. Simmons, W.A. Morrison, C. Chen and P.Q. Thomas 141P
Symposium: EC coupling and fatigue
Altered cellular Ca2+ handling in skeletal muscle fatigue
H. Westerblad 142P
Importance of the t-system chloride conductance in muscle excitability and fatigue
G.D. Lamb, T.L. Dutka, R.M. Murphy and D.G. Stephenson 143P
Control of skeletal RyR channels by proteins in the SR lumen
N.A. Beard, L. Wei and A.F. Dulhunty 144P
Molecular recognition of the disordered dihydropyridine receptor II-III loop by a conserved domain in the type 1 ryanodine receptor
Y. Cui, H-S. Tae, N.C. Norris, Y. Karunasekara, P. Pouliquin, P.G. Board, A.F. Dulhunty and M.G. Casarotto 145P
Symposium: Amino acid transport and signalling
Amino acid signaling to mRNA translation: Central role of mTOR
S.R. Kimball 146P
Class 3 GPCRs as broad-spectrum L-amino acid sensors
A.D. Conigrave 147P
Closing the GATs. Metabolic consequences of blocking GABA uptake
F.A. Nasrallah, V.J. Balcar, J.L. Griffin and C. Rae 148P
Neutral amino acid transporters of the kidney and intestine
S. Kowalczuk, D.N. Azmanov, J.A. Cavanaugh, H. Rogers, C.G. Bailey, J.E.J. Rasko and S. Bröer 149P
Free communications: Cardiac muscle
Hyperinsulinaemia and elevated levels of phosphorylated Akt/PKB in the neonatal Hypertrophic Heart Rat (HHR) precede the onset of cardiac hypertrophy
E.R. Porrello, J.D. Schertzer, C.L. Curl, W.F. Meeker, K.M. Mellor, G.S. Lynch, S.B. Harrap, W.G. Thomas and L.M.D. Delbridge 150P
Regulation of ryanodine receptors from cardiac muscle by luminal Ca2+ and Mg2+
D.R. Laver 151P
In vitro modulation of the cardiac ryanodine receptor (calcium release channel) activity by human homer 1b
P. Pouliquin, S.M. Pace and A.F. Dulhunty 152P
Visualization of the 3-D distribution of proteins involved in cardiac excitation-contraction coupling using a novel optical approach
I.D. Jayasinghe, M.B. Cannell and C. Soeller 153P
Analysis of ryanodine receptor clusters in rat and human cardiac myocytes at high optical resolution
C. Soeller, R. Gilbert, D. Crossman and M.B. Cannell 154P
Angiotensin II mediates cardiomyocyte growth signalling via ErbB4
H. Chan, N.J. Smith, A. Agrotis, R.D. Hannan and W.G. Thomas 155P
Hypertrophic cardiomyopathy causing mutations in myosin binding protein-C alter PKA phosphorylation
C.E. Oakley, J. Hwang, L.J. Brown, M. Kekic, P.G. Fajer and B.D. Hambly 156P
Novel actin/tropomyosin filaments that regulate glucose uptake and insulin secretion
A.J. Kee, R. Szokolai, N. Vlahovich, R.G. Parton, D.E. James, G.J. Cooney, P.W. Gunning and E.C. Hardeman 157P
Free communications: Ion channels
Relative counter-ion permeation in anion-selective glycine receptor channels did not vary between two different anions, supporting an ion pair mechanism
S. Sugiharto, A.J. Moorhouse, T.M. Lewis, P.R. Schofield and P.H. Barry 158P
External divalent ions decrease counter-ion permeation in anion-selective glycine receptor channels without changing the minimum pore diameter of the channel
S. Sugiharto, T.M. Lewis, A.J. Moorhouse, P.R. Schofield and P.H. Barry 159P
MA-stretch residues are critical for ion conduction of 5-HT3A receptors
J.E. Carland, M.A. Cooper, M.R. Livesy, T.Z. Deeb, T.G. Hales, J.J. Lambert and J.A. Peters 160P
Function of the conserved cystine-loop in Cys-loop ligand-gated ion channels
M.L. Tierney and T. Luu 161P
Functional characterisation of ten myotonia-associated mutations of the hClC-1 chloride channel
A.H. Bretag, L.L. Ma, G.Y. Rychkov and P.L.Y. Fung 162P
The effect of mutation E232Q and clofibric acid derivatives on gating in the human skeletal muscle chloride ion channel, ClC-1
J.M.E. Cederholm, G.Y. Rychkov and A.H. Bretag 163P
Novel modulation of Nav channels in dorsal root ganglion neurons by veratridine
J. Ekberg, D.J. Adams, S. Kumar and P. Poronnik 164P
Structural features of the lolitrem family of fungal alkaloids important for inhibition of large conductance calcium-activated potassium (BK) channels
J.E. Dalziel, W.I. Imlach, J. Dunlop and S.C. Finch 165P
Free communications: Exercise physiology
Effect of high-intensity, interval exercise on signalling proteins and gene expression in human skeletal muscle
M. Hargreaves, S.L. McGee, K.F. Howlett, R.J. Snow, A. Garnham and M.J. Gibala 166P
The effects of hydration and aerobic fitness on physiological strain and endurance performance
T.L. Merry, P.N. Ainslie and J.D. Cotter 167P
nNOS is necessary for normal increases in glucose uptake during contraction of skeletal muscle
K. Linden, J.G. Ryall, C. van der Poel, J.D. Schertzer, G.S. Lynch and G.K. McConell 168P
Rat skeletal muscle 3-O-MFPase activity is not decreased by fatiguing in vitro electrical stimulation
C.A. Goodman, A. Hayes and M.J. McKenna 169P
Iron accelerates skeletal muscle fatigue at 37°C
T.F. Reardon and D.G. Allen 170P
Intra-segmental distribution of emotional sweating
C.A. Machado-Moreira and N.A.S. Taylor 171P
Free communications: Biophysics & spectroscopy
‘remedi’: Meeting the measurement needs of regenerative medicine
M.L. Mather, J.A. Crowe and S.P. Morgan 172P
X-ray diffraction as a tool to study the arrangement of cellulose molecules in plant cell walls
C.J. Garvey, O. Paris and R. Gillespie 173P
Novel signalling in mouse embryonic stem cells alters the pluripotent state
A.C. Lonic, F. Felquer, N. Hamra and M.B. Morris 174P
Does N-acetylcysteine act as an intracellular cysteine precursor in human erythrocytes?
J.E. Raftos, S. Whillier and P.W. Kuchel 175P
Free energy simulations of potassium channels - KcsA, Shaker and HERG
S. Kuyucak and T. Bastug 176P
In vivo measurement of hepatic lipid composition by proton magnetic resonance spectroscopy
N.A. Johnson, D.W. Walton, T. Sachinwalla, C.H. Thompson, K. Smith, P. Ruell, S.R. Stannard and J. George 177P
Free communications: Cardiovascular/heart
Evidence for direct regulation of the cardiac L-type Ca2+ channel during changes in thiol redox state
W.A. Macdonald, H.M. Viola, B. Martinac and L.C. Hool 178P
“Battle of the Clocks” – Sinoatrial pacemaking through plasmalemmal ionic currents or intracellular Ca2+ release
M.S. Imtiaz and D.F. van Helden 179P
Impaired post-ischemic functional recovery in primary cardiac hypertrophy is accentuated in female rats
J.R. Bell, E.R. Porrello, S.B. Harrap and L.M.D. Delbridge 180P
Diet high in N6 PUFA lowers cardiac membrane N3:N6 fatty acid ratio and increases atrial mass and cardiomyocyte size
S.E. Miller, C.E. Huggins, M.L. Theiss, P.L. McLennan, S. Pepe and L.M.D. Delbridge 181P
Effect of hexarelin on transient outward potassium current in rat ventricular myocytes
Q. Sun and C. Chen 182P
Antibody Microarrays: A new tool for testing leukocytes for inflammation
A. Brown, J-D. Lattimore, M. McGrady, D. Sullivan, W. Dyer, F. Braet and C.G. dos Remedios 183P
Congenital hyperinsulinism: from bench to bedside .... and back?
M.J. Dunne, R.M. Shepherd and K.E. Cosgrove 184P

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