AuPS 2018 Sydney Programme

Author index

Sunday 25th November 2018
Law 101Law 106Carslaw 173Anderson Stuart N248
16:00 Registration
Location: Foyer outside Law 101
The registration desk will be open on Sunday from 16:00-18:00
17:00 AuPS Invited Lecture
17:00 L.C. Hool: Taming the beast: targeting the L-type calcium channel to reduce cardiovascular morbidity and mortality1P
18:00 Welcome Reception
Location: Anderson Stuart Building Courtyard


Monday 26th November 2018
Law 101Law 106Carslaw 173Anderson Stuart N248
08:00 Registration
Location: Foyer outside Law 101
Registration desk will remain open until 09:00
08:30 Symposium: Ion channel function
08:30 D.J. Beech: Piezo1 mechano-sensor in vascular physiology and disease2P
09:00 K. Poole: Mechanoelectrical transduction at the cell-substrate interface3P
09:22 C.D. Cox: A TRiP through the mechanical world of TRPP channels4P
09:44 I. Vetter: Ion channels in pain pathways: insight from venom peptides5P
10:06 Steve Petrou - No abstract provided
Symposium: Shift work: beneficial effects of exercise and the timing of meals
08:30 J.A. Hawley: Timing is everything: exercise & nutrition as ‘Zeitgebers’ that influence circadian biology6P
09:00 G.K. McConell: Can exercise overcome the negative metabolic effects of shift work?7P
09:30 S. Banks: Altering the timing of meals to improve metabolic and cognitive performance outcomes in shift workers8P
10:00 M.L. Jackson: Impact of shift work on sleep, alertness and cognitive function– can “splitting” sleep reduce the adverse effects of night shift work?9P
Free communications: Exercise physiology
Chairs: Michells Keske & Aaron Petersen
08:30 A.C. Petersen: Effects of hypoxia on skeletal muscle molecular adaptations to heavy resistance training10P
08:45 H. Dillon: MicroRNA expression in female skeletal muscle mitochondria following a single bout of endurance exercise11P
09:00 S. Green: Initial orthostatic hypotension: effects of tilt speed and hand position on finger arterial blood pressure during head-up tilt12P
09:15 S. Alexander: Investigating exosomal microRNA and lipidomic profile in response to acute endurance exercise in males and females13P
09:30 S.G. Wette: Expression of putative mechanosensing signalling proteins in skeletal muscle after power resistance exercise and feeding in resistance-trained men14P
09:45 J. Silver: MiRNA expression in skeletal muscle mitochondria following an acute bout of endurance exercise15P
10:30 Morning Tea
11:00 Symposium: Metabolic implications of vascular dysfunction
Chair: Renée Ross
11:00 M.A. Keske: Skeletal muscle microvascular blood flow and insulin action16P
11:30 S.J. Blackwood: The physiological importance of flowmotion19P
12:00 D. Premilovac: Metabolic-vascular coupling: pericytes regulate capillary blood flow18P
12:30 C.M. Kolka: The skeletal muscle endothelium: the barrier within17P
Free communications: Skeletal muscle and disease
Chairs: Bradley Launikonis & Zoe White
11:00 K.N. Roeszler: ACTN3 genotype influences androgen receptor signalling and skeletal muscle mass regulation in health and disease20P
11:15 A.L. Pascoe: Reproducibility and ethical concerns of Notexin as an acute animal injury model21P
11:30 J.P. Hardee: Therapeutic potential of slow muscle programming by low-frequency stimulation in dystrophic mice22P
11:45 B.P. Frankish: Dot blotting for fibre type identification of single muscle fibres: a fast, reliable and sample-sparing method23P
12:00 Z. White: Cholesterol lowering prevents ambulatory dysfunction in muscular dystrophy24P
12:15 C.R. Lamboley: Movements of calcium in skeletal muscle fibres in the absence of calsequestrin25P
12:30 D.P. Singh: Mechanisms of Ca2+ release in human and toad skeletal muscle in response to halothane26P
Free communications: Regulating cellular function
Chairs: Kayte Jenkin & Grigori Rychkov
11:00 G.Y. Rychkov: The mechanism of Orai channels dependence on intracellular pH27P
11:15 F.H. Zhou: TRPM2 channels contribute to liver ischemia and reperfusion injury28P
11:30 K.A. Jenkin: Human and non-human intestinal NHE3: Human NHE3 demonstrates increased susceptibility to inhibition and unique regulation by ubiquitin29P
11:45 A.J. Trewin: Mitochondrial ROS generated at the complex-II matrix or intermembrane space microdomain has distinct effects on redox signalling and stress sensitivity in C. elegans30P
12:00 M.S. Cameron: Different vasodilator mechanisms in intermediate- and small-sized arteries from the hindlimb vasculature of the toad, Rhinella marina31P
12:15 R.I. Siriwardhana: New insights into the regulation of uterine contractions in human labour32P
12:30 J.S.M. Cuffe: Gestational diabetes mellitus is associated with an altered placental glucocorticoid receptor isoform profile, increased human placental lactogen mRNA expression and placental glycogen accumulation33P
13:00 Lunch and posters
1 34PT.V. Lakeland: Exploring how compartment-specific changes in NAD biosynthesis influence the response to endurance training
2 35PL. Parker: Acute continuous moderate-intensity exercise, but not low-volume high-intensity interval exercise, attenuates postprandial suppression of circulating osteocalcin in young overweight and obese adults
3 36PG. Allsopp: The effect of hypoxia on older adults’ muscle strength and mass responses to resistance training
4 37PS.I. Head: Evidence from a mouse model that high levels of circulating dihydrotestosterone increases skeletal muscle mass and force production in isolated fast- and slow-twitch muscles in males and females but reduces recovery from fatigue in females
5 38PS. Landen: Sex-specific epigenetic adaptations to endurance exercise
6 39PB.S. Launikonis: Determination of heat production in human skeletal muscle from measurements of basal Ca2+ movements
7 40PC.Y. Tan: Miniature inhibitory postsynaptic current in cerebellar Purkinje cells of old dystrophic mdx mice
8 41PR. Koopman: Choline as a nutritional intervention to alleviate the dystrophic pathology in mdx mice
9 42PJ.L. Huang: Elevated MuSK expression restores dystrophin-associated proteins to the sarcolemma of mdx muscle fibres
10 43PA. Meizoso-Huesca: Free fatty acid receptor 4 activation induces lysophosphatidic acid receptor 1 (LPA1) desensitization independent of LPA1 internalization and heterodimerization
11 44PD. Ge: Evidence of neuromuscular junction remodelling during periods of prolonged muscle inactivity in amphibians
12 45PB.T. Tepper: The role of ADAMTS5 in extracellular matrix remodelling in diet-induced insulin resistance
13 46PD. Hiam: The influence of GWAS-based gene variants on the bone-remodelling marker Osteocalcin in the Gene SMART study
14 47PJ.Q. Zhang: Post-myocardial infarction exercise training improved calcium sensitivity and cardiac function
15 48PM.C. Renton: The role of protein kinase D in cardiac glucose metabolism in diabetic cardiomyopathy
16 49PA.C. Betik: Use of vibration platforms to increase total limb and skeletal muscle microvascular blood flow
17 50PT.V. Murphy: Effect of gestational diabetes on endothelium-dependent vasodilation of human myometrial and omental arteries
18 51PK. Roberts-Thomson: Family history of Type 2 diabetes alters muscle capillary perfusion after a meal
19 52PM.G. Morales-Scholz: Divergent autophagy responses in the liver and skeletal muscle of diabetic (db/db) mice
14:00 Posters
15:00 Afternoon Tea
15:30 Symposium: Metabolic and signalling dysregulation in cardiac stress
Chair: Kim Mellor
15:30 E.D. Abel: Novel mechanisms linking metabolic signaling and mitochondria to the pathophysiology of heart failure53P
16:00 L.M.D. Delbridge: Molecular mechanisms of cardiac metabolic stress pathology54P
16:30 R.R. Lamberts: Autonomic dysregulation in the diabetic heart55P
17:00 J.L.J. Coleman: Orphan G protein-coupled receptor GPR37L1 and the cardiovascular system: variability across methods and models56P
Free communications: Skeletal muscle and metabolism
Chairs: Adam Rose & Kirsten Howlett
15:30 X. Ren: MMP2 and MMP9 in wild-type and mdx mice with taurine supplementation57P
15:45 K.I. Watt: A metabolic role for the Hippo signalling pathway effector Yap in adult skeletal muscle fibres58P
16:00 R.J. Mills: Development of a human skeletal micro muscle platform with pacing capabilities59P
16:15 B.D. Perry: Metformin divergently regulates the unfolded protein response and reduces protein synthesis and autophagy in palmitate-treated myotubes60P
16:30 A.B. Addinsall: Inflammatory regulation by Selenoprotein S is not responsible for the loss of muscle performance61P
16:45 S.J. Blackwood: Isoproterenol enhances force production in mouse glycolytic and oxidative muscle via separate mechanisms62P
17:00 A.J. Rose: Liver one-carbon metabolism affects the integrated stress response and systemic metabolic control63P
17:30 ECR talk
18:30 Student/ECR mixer
Location: The Rose Hotel, Chippendale


Tuesday 27th November 2018
Law 101Law 106Carslaw 173Anderson Stuart N248
08:00 Registration
Location: Foyer outside Law 101
Registration desk will remain open until 09:00
08:30 Symposium: The genome and epigenome of the exercising skeletal muscle
Chair: Nir Eynon
08:30 N. Eynon: What do we know on the genome of the exercising muscle?64P
09:00 J.T. Seto: New insights into the influence of ACTN3 on muscle performance65P
09:30 J.M. Craig: Developing epigenetic biomarkers - applications for exercise66P
10:00 S. Voisin: Racing against the (epigenetic) clock: exercise training slows down epigenetic aging in skeletal muscle67P
Free communications: Cardiac physiology
Chairs: James Hudson & Richard Mills
08:30 M.E. Reichelt: Cardiomyocyte ErbB4 receptors are essential for neonatal cardiac hypertrophy and growth, and also maintain cardiac function in adult mouse hearts68P
08:45 L.J. Daniels: Glycogen dysregulation and cardiomyocyte dysfunction in a rat model of type 1 diabetes69P
09:00 J.E. Hudson: Functional screening in human cardiac organoids for new regenerative therapeutics70P
09:15 S.P. Wells: Acute oestradiol slows conduction and prolongs action potential duration in the left atrium, but not in cardiomyocyte cultures71P
09:30 N.A. Beard: Characterization of RyR2 function in failing human atria72P
09:45 E.J. Chan: STBD1 regulation of myocardial glycogen content73P
Free communications: Neural mechanisms
Chair: Gary Housley
08:30 J.M.E. Cederholm: Noise-induced hearing adaptation kinetics of the ‘cochlear amplifier’ maps to P2X2 receptor-dependent auditory brainstem response temporary threshold shift74P
08:45 N.L. Absalom: Concatenated GABAA receptors reveal diverse molecular phenotype of epilepsy-causing mutations75P
09:00 W.D. Phillips: Cannabinoids increase synaptic vesicle filling at the neuromuscular junction76P
09:15 P.G. Noakes: The neuromuscular junction - the hidden player in MND: studies from MND model mice and MND patients77P
09:30 L.G. Hall: The role of the Alzheimer's disease protein amyloid beta 42 in heart disease78P
10:30 Morning Tea
11:00 Symposium: The structural basis of electrical signalling: latest developments in the structural analysis of ion channels and transporters
11:00 J. Yang: Structural basis of function and regulation of endolysosomal TRPML channels79P
11:30 G.F. King: Cryo-EM structure of a gating modifier–sodium channel complex reveals the complex molecular basis of allosteric modulation of channel gating80P
11:52 C. Lau: Understanding the mechanisms of hERG channel gating and drug inhibition using cryo-EM81P
12:14 J.M. Gulbis: Investigating the role of conformational change of the pore in Kir channel gating82P
12:36 R.M. Ryan: The split personality of glutamate transporters: a chloride channel and a transporter83P
Symposium: Maternal Influences on fetal physiology
11:00 D.M. Sloboda: Maternal microbial and metabolic influences on programming reproductive and metabolic outcomes84P
11:30 Margaret J. Morris: Maternal effects on offspring metabolism and behaviour – impact of diet and stress85P
12:00 H. Chen: Impact of maternal cigarette smoke exposure on brain health, lessons learned from a mouse model86P
12:30 D.H. Hryciw: Elevated maternal linoleic acid reduces male fetal survival87P
13:00 Lunch
14:00 Plenary Lecture
14:00 W.F. Boron: Common principles across physiological systems112P
15:00 Afternoon Tea
15:30 Symposium: Rigor and reproducibility in physiological research
Chairs: Bill Phillips & Séverine Lamon
15:30 David Vaux - No abstract provided
16:00 S.C. Gandevia: Reproducibility: why you should be worried?88P
16:30 M.D. Grounds: Building rigour in exploratory rodent studies of neuromuscular disease89P
17:00 Panel discussion
19:00 Conference Dinner
Location: Dockside. Cockle Bay Wharf, Wheat Rd, Darling Harbour
Drinks served at 19:00 before dinner at 19:30. Doors close at 23:30.


Wednesday 28th November 2018
Law 101Law 106Carslaw 173Anderson Stuart N248
08:00 Registration
Location: Foyer outside Law 101
Registration desk will remain open until 09:00
08:30 Symposium: Enhancing student engagement: flipping, quizzes, study tools, condensed units and professional development
Chairs: Julia Choate & Yvonne Hodgson
08:30 K. Tangalakis: Revolutionizing first year: an innovative block model to improve student engagement and success90P
08:54 S. Flecknoe: Activating the classroom to enhance student engagement and learning91P
08:55 K. Carroll: Activating the classroom to enhance student engagement and learning
09:18 J. Choate: Engaging biomedical students with their course via in-curriculum professional development92P
09:42 K. Colthorpe: Biomedical science students’ active engagement in study tool creation and use93P
10:06 A.J. Moorhouse: Medical students engaging in physiology via a national quiz competition94P
Symposium: Immunometabolism and disease
08:30 S.L. Masters: NLRP1 exacerbates colitis-associated cancer through IL-18, with effects on butyrate producing Clostridiales95P
08:50 K.G.R. Quinlan: Eosinophils in adipose tissue energy expenditure96P
09:10 K. Schroder: New insights into inflammasome signalling and inhibition97P
09:30 M.A. Febbraio: The novel designer cytokine IC7Fc protects against obesity-induced metabolic disease98P
10:00 J.D. Schertzer: Microbiota components that improve endocrine control of metabolism in obesity and ageing99P
10:30 Morning Tea
11:00 Symposium: Adipose tissue - physiology and pathology
Chair: Lea Delbridge
11:00 M.J. Watt: Identification of metabolically distinct adipocyte progenitor cells in human adipose tissues101P
11:30 W.C. Boon: Effects of oestrogens on adipose tissues113P
12:00 J.R. Bell: Pericardial adipose accumulation and cardiac pathology – mechanistic insights102P
Education free communications
11:00 L. Ainscough: ‘Let’s not keep it private’: Schooling background and student preparedness transitioning into university103P
11:15 S. Orgeig: Improved student engagement and outcomes using a multi-purpose online platform – an alternative option for the one-on one tutor in large classes104P
11:30 H. Nagaraja: Matching teaching strategies to learning style preferences in an undergraduate physiology module105P
11:45 S. Lamon: Evaluating the redevelopment of a physiology online postgraduate unit106P
12:00 V. Hasa: Working as partners: a student-staff collaboration in the redesign of a major biomedical capstone course107P
12:15 C. Young: Lessons learnt from redesigning a major biomedical capstone course108P
12:30 S.J. Etherington: Tertiary physiology educators' perspectives on internationalisation of physiology education109P
12:45 D.H. Hryciw: Work integrated learning in the science curriculum110P
13:00 Lunch
13:30 Michael Roberts Lecture
13:30 G.D. Wadley: Adventures in flipping the classroom111P
14:00 AGM and award of prizes
15:00 Education Workshop - MCQs and SAQs in Australian Physiology Education
Chairs: Julia Choate & Andrew Moorhouse
17:00 End of Meeting

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