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ISSN 0067-2084

Volume 49


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Professor William Burke
Dedicated to the Memory of
William (Liam) Burke (1922-2018)


AuPS 2018 Sydney Meeting

AuPS Invited Lecture
Taming the beast: targeting the L-type calcium channel to reduce cardiovascular morbidity and mortality
L.C. Hool
Symposium: Ion channel function
Piezo1 mechano-sensor in vascular physiology and disease
D.J. Beech
Mechanoelectrical transduction at the cell-substrate interface
K. Poole, S. Sianati, N. Bavi & J. Richardson
A TRiP through the mechanical world of TRPP channels
C.D. Cox, CA. Ng & B. Martinac
Ion channels in pain pathways: insight from venom peptides
I. Vetter, J.R. Deuis, M.R. Israel, A. Mueller & T. Durek
Symposium: Shift work: beneficial effects of exercise and the timing of meals
Timing is everything: exercise & nutrition as ‘Zeitgebers’ that influence circadian biology
J.A. Hawley
Can exercise overcome the negative metabolic effects of shift work?
G.K. McConell
Altering the timing of meals to improve metabolic and cognitive performance outcomes in shift workers
S. Banks
Impact of shift work on sleep, alertness and cognitive function– can “splitting” sleep reduce the adverse effects of night shift work?
M.L. Jackson
Free communications: Exercise physiology
Effects of hypoxia on skeletal muscle molecular adaptations to heavy resistance training
A.C. Petersen, J.J. Fyfe, M.W.H. Inness, L. Parker, F. Billaut & R.J. Aughey
MicroRNA expression in female skeletal muscle mitochondria following a single bout of endurance exercise
H. Dillon, J. Silver, S. Alexander, S. Lamon & G.D. Wadley
Initial orthostatic hypotension: effects of tilt speed and hand position on finger arterial blood pressure during head-up tilt
S. Green & D. Boulton
Investigating exosomal microRNA and lipidomic profile in response to acute endurance exercise in males and females
S. Alexander, S. Lamon, J. McMullen, Y.K. Tham & G.D. Wadley
Expression of putative mechanosensing signalling proteins in skeletal muscle after power resistance exercise and feeding in resistance-trained men
S.G. Wette, H.K. Smith, G.D. Lamb & R.M. Murphy
MiRNA expression in skeletal muscle mitochondria following an acute bout of endurance exercise
J. Silver, H. Dillon, S. Loke, S. Lamon & G.D. Wadley
Symposium: Metabolic implications of vascular dysfunction
Skeletal muscle microvascular blood flow and insulin action
M.A. Keske
The skeletal muscle endothelium: the barrier within
C.M. Kolka
Metabolic-vascular coupling: pericytes regulate capillary blood flow
D. Premilovac, E. Attrill, N. King, L. Brown & B. Sutherland
The physiological importance of flowmotion
S.J. Blackwood, R.M. Ross, S. Rattigan, R.D. Russell, S.M. Richards & M.A. Keske
Free communications: Skeletal muscle and disease
ACTN3 genotype influences androgen receptor signalling and skeletal muscle mass regulation in health and disease
K.N. Roeszler, F.C. Garton, L.R. Meehan, C.F. Tiong, P.J. Houweling, P. Gregorevic, J.T. Seto & K.N. North
Reproducibility and ethical concerns of Notexin as an acute animal injury model
A.L. Pascoe, A.J. Johnston, L. Jenkinson, C. van der Poel & R.M. Murphy
Therapeutic potential of slow muscle programming by low-frequency stimulation in dystrophic mice
J.P. Hardee, J.G. Ryall, T. Naim, K.J. Martins, S.M. Gehrig, R. Koopman, G.R. Steinberg & G.S. Lynch
Dot blotting for fibre type identification of single muscle fibres: a fast, reliable and sample-sparing method
D. Christiansen, M.J. MacInnis, E. Zacharewicz, H. Xu, B.P. Frankish & R.M. Murphy
Cholesterol lowering prevents ambulatory dysfunction in muscular dystrophy
Z. White, N. Milad & P. Bernatchez
Movements of calcium in skeletal muscle fibres in the absence of calsequestrin
C.R. Lamboley, L. Pearce, D.P. Singh & B.S. Launikonis
Mechanisms of Ca2+ release in human and toad skeletal muscle in response to halothane
D.P. Singh, L. Pearce, C.R. Lamboley & B.S. Launikonis
Free communications: Regulating cellular function
The mechanism of Orai channels dependence on intracellular pH
G.Y. Rychkov, F.H. Zhou, M. Adams, L. Ma & G.J. Barritt
TRPM2 channels contribute to liver ischemia and reperfusion injury
F.H. Zhou, J. De Haas, K. Kingma, J. Hua, E. Kheradpezhouh, A.D. Burt, G.J. Barritt & G.Y. Rychkov
Human and non-human intestinal NHE3: Human NHE3 demonstrates increased susceptibility to inhibition and unique regulation by ubiquitin
K.A. Jenkin, S. Lin, Y. Han, P. He & C.C. Yun
Mitochondrial ROS generated at the complex-II matrix or intermembrane space microdomain has distinct effects on redox signalling and stress sensitivity in C. elegans
A.J. Trewin, L.L. Bahr, A. Almast, A.Y. Wei, B.J. Berry & A.P. Wojtovich
Different vasodilator mechanisms in intermediate- and small-sized arteries from the hindlimb vasculature of the toad, Rhinella marina
M.S. Cameron & J.A. Donald
New insights into the regulation of uterine contractions in human labour
R.I. Siriwardhana, D. Sekali, C. Adams, M.A. Tonta, P.J. Sheehan, H.A. Coleman, S.P. Brennecke & H.C. Parkington
Gestational diabetes mellitus is associated with an altered placental glucocorticoid receptor isoform profile, increased human placental lactogen mRNA expression and placental glycogen accumulation
N.L. Kent, O.J. Holland, A.V. Perkins & J.S.M. Cuffe
Exploring how compartment-specific changes in NAD biosynthesis influence the response to endurance training
T.V. Lakeland, A.F. Samsudeen, L.K. Metcalfe, H. Govindaraju & N. Turner
Acute continuous moderate-intensity exercise, but not low-volume high-intensity interval exercise, attenuates postprandial suppression of circulating osteocalcin in young overweight and obese adults
L. Parker, C.S. Shaw, E. Byrnes, N.K. Stepto & I. Levinger
The effect of hypoxia on older adults’ muscle strength and mass responses to resistance training
G. Allsopp, S. Hoffmann, J. Pasco, A. Russell & C.R. Wright
Evidence from a mouse model that high levels of circulating dihydrotestosterone increases skeletal muscle mass and force production in isolated fast- and slow-twitch muscles in males and females but reduces recovery from fatigue in females
L. Kiriaev, S.I. Head, J.W. Morley, K. Walters & D.J. Handelsman
Sex-specific epigenetic adaptations to endurance exercise
S. Landen, S. Voisin, S. Lamon & N. Eynon
Determination of heat production in human skeletal muscle from measurements of basal Ca2+ movements
C.J. Barclay & B.S. Launikonis
Miniature inhibitory postsynaptic current in cerebellar Purkinje cells of old dystrophic mdx mice
C.Y. Tan, S.L.L. Kueh, S.I. Head & J.W. Morley
Choline as a nutritional intervention to alleviate the dystrophic pathology in mdx mice
R. Koopman, F. Alves, M.K. Caldow, M.K. Montgomery, J. Trieu, T. Naim, M.J. Watt & G.S. Lynch
Elevated MuSK expression restores dystrophin-associated proteins to the sarcolemma of mdx muscle fibres
J.L. Huang, J. Ban & W.D. Phillips
Free fatty acid receptor 4 activation induces lysophosphatidic acid receptor 1 (LPA1) desensitization independent of LPA1 internalization and heterodimerization
A. Meizoso-Huesca, S. Villegas-Comonfort, T. Romero-Avila & A. Garcia-Sainz
Evidence of neuromuscular junction remodelling during periods of prolonged muscle inactivity in amphibians
D. Ge, P.G. Noakes & N.A. Lavidis
The role of ADAMTS5 in extracellular matrix remodelling in diet-induced insulin resistance
B.T. Tepper, C. Swinton, S.T. Bond, T. Connor, M. Ellis, K. Aston-Mourney, C.S. Shaw, S.L. McGee & K.F. Howlett
The influence of GWAS-based gene variants on the bone-remodelling marker Osteocalcin in the Gene SMART study
D. Hiam, S. Voisin, X. Yan, S. Landen, M. Jacques, E. Byrnes, T.C. Brennan-Speranza, I. Levinger & N. Eynon
Post-myocardial infarction exercise training improved calcium sensitivity and cardiac function
J.Q. Zhang, E.A. Wason, M.A. Garza & E. Chung
The role of protein kinase D in cardiac glucose metabolism in diabetic cardiomyopathy
M.C. Renton, K.A. De Jong, L.G. Hall, T. Connor, S.D. Martin, G.M. Kowalski, C.R. Bruce, C.S. Shaw, S.L. McGee & K.F. Howlett
Use of vibration platforms to increase total limb and skeletal muscle microvascular blood flow
A.C. Betik, L. Parker, G. Kaur & M.A. Keske
Effect of gestational diabetes on endothelium-dependent vasodilation of human myometrial and omental arteries
T.V. Murphy, L.R. Leader & S.L. Sandow
Family history of Type 2 diabetes alters muscle capillary perfusion after a meal
K. Roberts-Thomson, A.C. Betik, L. Parker, G. Kaur, G.D. Wadley & M.A. Keske
Divergent autophagy responses in the liver and skeletal muscle of diabetic (db/db) mice
M.G. Morales-Scholz, C. Swinton, K.F. Howlett, R.M. Murphy, S.L. McGee & C.S. Shaw
Symposium: Metabolic and signalling dysregulation in cardiac stress
Novel mechanisms linking metabolic signaling and mitochondria to the pathophysiology of heart failure
E.D. Abel
Molecular mechanisms of cardiac metabolic stress pathology
L.M.D. Delbridge
Autonomic dysregulation in the diabetic heart
R.R. Lamberts
Orphan G protein-coupled receptor GPR37L1 and the cardiovascular system: variability across methods and models
J.L.J. Coleman, M.A. Mouat, K. Jackson, R. Smythe, D. Newington, C. Stanley, R.M. Graham, R. Stocker, G. Head & N.J. Smith
Free communications: Skeletal muscle and metabolism
MMP2 and MMP9 in wild-type and mdx mice with taurine supplementation
X. Ren, R.G. Barker, G.D. Lamb & R.M. Murphy
A metabolic role for the Hippo signalling pathway effector Yap in adult skeletal muscle fibres
K.I. Watt, D.C. Henstridge, M. Ziemann, M.K. Montgomery, D. Samocha-Bonet, N.A. Mellet, R.S. Lee-Young, R.E. Thomson, A. Hagg, J.R. Davey, H. Qian, A. El-Osta, J.R. Greenfield, P.J. Miekle, M.J. Watt, M.A. Febbraio, A.J. Cox, K.F. Harvey & P. Gregorevic
Development of a human skeletal micro muscle platform with pacing capabilities
R.J. Mills
Metformin divergently regulates the unfolded protein response and reduces protein synthesis and autophagy in palmitate-treated myotubes
B.D. Perry, J.A. Rahnert, Y. Xie, D. Espinoza, B. Zheng, P. Zhang & S.R. Price
Inflammatory regulation by Selenoprotein S is not responsible for the loss of muscle performance
A.B. Addinsall, C.R. Wright, T.L. Kotsiakos, C. van der Poel & N. Stupka
Isoproterenol enhances force production in mouse glycolytic and oxidative muscle via separate mechanisms
S.J. Blackwood & A. Katz
Liver one-carbon metabolism affects the integrated stress response and systemic metabolic control
T. Gantert, A. Maida, M. Warrier, S.H. Zeisel & A.J. Rose
Symposium: The genome and epigenome of the exercising skeletal muscle
What do we know on the genome of the exercising muscle?
N. Eynon
New insights into the influence of ACTN3 on muscle performance
J.T. Seto
Developing epigenetic biomarkers - applications for exercise
J.M. Craig
Racing against the (epigenetic) clock: exercise training slows down epigenetic aging in skeletal muscle
S. Voisin, N. Harvey, S. Lamon, J. Denham, D. Hiam, M. Jacques, S. Landen, J. Alvarez-Romero, K. Ashton, L. Haupt, M.E. Lindholm, F. Marabita, D. Rowlands, L. Griffiths & N. Eynon
Free communications: Cardiac physiology
Cardiomyocyte ErbB4 receptors are essential for neonatal cardiac hypertrophy and growth, and also maintain cardiac function in adult mouse hearts
M.E. Reichelt, Z. Lu, R. Cockburn, Z. Wang, T. Paravicini & W.G. Thomas
Glycogen dysregulation and cardiomyocyte dysfunction in a rat model of type 1 diabetes
L.J. Daniels, V.L. Benson, M. Annandale, L.M.D. Delbridge & K.M. Mellor
Functional screening in human cardiac organoids for new regenerative therapeutics
R.M. Mills, B.J. Parker, G.A. Quaife-Ryan, H.K. Voges, E.J. Needham, A. Bornot, M. Ding, H. Andersson, M. Polla, D.A. Elliott, L. Drowley, M. Clausen, A.T. Plowright, I.P. Barrett, Q.-D. Wang, D.E. James, E.R. Porrello & J.E. Hudson
Acute oestradiol slows conduction and prolongs action potential duration in the left atrium, but not in cardiomyocyte cultures
S.P. Wells, H.M. M Waddell, C. O'Shea, P. Kirchhof, D. Pavlovic, L.M.D. Delbridge & J.R. Bell
Characterization of RyR2 function in failing human atria
A.L. Denniss, A.F. Dulhunty, P. Molenaar & N.A. Beard
STBD1 regulation of myocardial glycogen content
E.J. Chan, U. Varma, C.L. Curl, P. Koutsifeli, K.M. Mellor & L.M.D. Delbridge
Free communications: Neural mechanisms
Noise-induced hearing adaptation kinetics of the ‘cochlear amplifier’ maps to P2X2 receptor-dependent auditory brainstem response temporary threshold shift
J.M.E. Cederholm, A.F. Ryan & G.D. Housley
Concatenated GABAA receptors reveal diverse molecular phenotype of epilepsy-causing mutations
N.L. Absalom, V. Liao, P.K. Ahring, D.C. Indurthi, M.T. Bowen, J.C. Arnold, I.S. McGregor & M. Chebib
Cannabinoids increase synaptic vesicle filling at the neuromuscular junction
M. Morsch, D.A. Protti, D. Cheng, F. Braet, R.S. Chung, S.W. Reddel & W.D. Phillips
The neuromuscular junction - the hidden player in MND: studies from MND model mice and MND patients
P.G. Noakes, S.T. Ngo, K.M. Lee, K. Chand, N.A. Lavidis, K. Kesavan, J. Kumar, E. Wimberger, T. Tracey, A. Russell, E. Wolvetang, P. McCombe, R. Henderson & L. Jeffree
The role of the Alzheimer's disease protein amyloid beta 42 in heart disease
L.G. Hall, J.K. Czeczor, T. Connor & S.L. McGee
Symposium: The structural basis of electrical signalling: latest developments in the structural analysis of ion channels and transporters
Structural basis of function and regulation of endolysosomal TRPML channels
M. Li, X. Zhou, K.W. Zhang, D. Su, N.M. Benvin, H. Li, S. Wang, I.E. Michailidis, X. Li & J. Yang
Cryo-EM structure of a gating modifier–sodium channel complex reveals the complex molecular basis of allosteric modulation of channel gating
G.F. King
Understanding the mechanisms of hERG channel gating and drug inhibition using cryo-EM
C. Lau, M. Hunter, A.G. Stewart, M. Clarke, E. Perozo & J.I. Vandenberg
Investigating the role of conformational change of the pore in Kir channel gating
J.M. Gulbis, K.A. Black, D.M. Miller, O.B. Clarke, A.P. Hill, J.R. Bolla, C.V. Robinson, B.J. Smith, D. Laver, R. Jin & S. He
The split personality of glutamate transporters: a chloride channel and a transporter
I. Chen, Q. Wu, R.J. Cater, R.J. Vandenberg, J. Font & R.M. Ryan
Symposium: Maternal Influences on fetal physiology
Maternal microbial and metabolic influences on programming reproductive and metabolic outcomes
D.M. Sloboda
Maternal effects on offspring metabolism and behaviour – impact of diet and stress
Margaret J. Morris
Impact of maternal cigarette smoke exposure on brain health, lessons learned from a mouse model
H. Chen, Y.L. Chan, N.M. Jones, S. Saad & B.G. Oliver
Elevated maternal linoleic acid reduces male fetal survival
N. Shrestha, J.S.M. Cuffe, O.J. Holland, A. Cox, A. Bulmer, A.V. Perkins, A.J. McAinch & D.H. Hryciw
Plenary Lecture
Common principles across physiological systems
W.F. Boron
Symposium: Rigor and reproducibility in physiological research
Reproducibility: why you should be worried?
S.C. Gandevia
Building rigour in exploratory rodent studies of neuromuscular disease
M.D. Grounds
Symposium: Enhancing student engagement: flipping, quizzes, study tools, condensed units and professional development
Revolutionizing first year: an innovative block model to improve student engagement and success
K. Tangalakis & S.T. Howe
Activating the classroom to enhance student engagement and learning
S. Flecknoe, C. Filby, A. Davies, R. Cooper, K. Schliephake & K. Carroll
Engaging biomedical students with their course via in-curriculum professional development
J. Choate, M. Demaria, M. Etheve, S. Cran & D. Carroll
Biomedical science students’ active engagement in study tool creation and use
K. Colthorpe, K.W. Lam & L. Ainscough
Medical students engaging in physiology via a national quiz competition
A.J. Moorhouse, M. Dunn, H. Suh, K. Parameshwaran, S. Muralidaran, M. Lim & H.M. Cheng
Symposium: Immunometabolism and disease
NLRP1 exacerbates colitis-associated cancer through IL-18, with effects on butyrate producing Clostridiales
S.L. Masters
Eosinophils in adipose tissue energy expenditure
A.J. Knights, E.J. Vohralik, P.J. Houweling, K.L. Hoehn, M. Crossley & K.G.R. Quinlan
New insights into inflammasome signalling and inhibition
K. Schroder, D. Boucher, M. Monteleone, R.C. Coll & K.W. Chen
The novel designer cytokine IC7Fc protects against obesity-induced metabolic disease
M.A. Febbraio
Microbiota components that improve endocrine control of metabolism in obesity and ageing
J.D. Schertzer
Symposium: Adipose tissue - physiology and pathology
Identification of metabolically distinct adipocyte progenitor cells in human adipose tissues
M.J. Watt & A. Raajendiran
Pericardial adipose accumulation and cardiac pathology – mechanistic insights
J.R. Bell
Effects of oestrogens on adipose tissues
W.C. Boon
Education free communications
‘Let’s not keep it private’: Schooling background and student preparedness transitioning into university
I. Rutenberg, L. Ainscough, K. Colthorpe, T. Langfield & J. Kibedi
Improved student engagement and outcomes using a multi-purpose online platform – an alternative option for the one-on one tutor in large classes
S. Orgeig, S.S. List, B.J. Mayo, G. Todd, A.M. Stringer & E.J. Parkinson-Lawrence
Matching teaching strategies to learning style preferences in an undergraduate physiology module
H. Nagaraja, G. Harrison, B.K. Anupama & M.A. Bunmi
Evaluating the redevelopment of a physiology online postgraduate unit
S. Lamon & I. Story
Working as partners: a student-staff collaboration in the redesign of a major biomedical capstone course
V. Hasa, I. Rutenberg, C. Panaretos, I. Tucker, O. Jordan Pearson, K. Colthorpe & C. Young
Lessons learnt from redesigning a major biomedical capstone course
C. Young, J. Bowles, L. Lluka, V. Hasa & K. Colthorpe
Tertiary physiology educators' perspectives on internationalisation of physiology education
S.J. Etherington
Work integrated learning in the science curriculum
D.H. Hryciw
Michael Roberts Lecture
Adventures in flipping the classroom
G.D. Wadley
Education Workshop - MCQs and SAQs in Australian Physiology Education


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