APPS/PSNZ Sydney 2003 Meeting

Programme

In the programme below, each presentation has, beside the time, the page number in volume 33 of the Proceedings. These numbers are links to the HTML versions of the pages. Each HTML page has a link to a corresponding PDF print version.

A PDF file of the abstracts for each platform and poster session can be accessed by clicking on the PDF symbol in the upper right of the programme block.

Links to the abstracts can also be found in the author index.

Monday 29 September 2003

Chemistry Theatre 1

Symposium 1: Stretch-induced muscle damage in sport and disease

Chair: David Allen

0830		Introductory remarks: David Allen
0835	5P	The role of Dystrophin in muscle maintenance within the zebrafish embryo and the identification of zebrafish models of human muscular dystrophy P.D. Currie, Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst NSW 2010, Australia. (Introduced by David Allen)
0900	1P	Popping sarcomere hypothesis explains stretch induced muscle damage D.L. Morgan and U. Proske, Monash University, Clayton, Vic 3800, Australia.
0925	2P	Training with eccentric exercise to prevent hamstring strains U. Proske¹, P. Percival² and D.L. Morgan², ¹Department of Physiology, and ²Department of Electrical and Computer Systems Engineering, Monash University, Clayton, VIC 3800, Australia.
0950	3P	Stretch-activated channels in stretch-induced muscle damage - role in muscular dystrophy E.W. Yeung¹ and D.G. Allen², ¹Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hong Kong, and ²Institute for Biomedical Research and Department of Physiology, University of Sydney, NSW 2006, Australia.
1015	4P	Mechanisms of muscle damage in muscular dystrophy G.S. Lynch, Department of Physiology, The University of Melbourne, Victoria 3010, Australia.
1040		Close

Chemistry Theatre 2

Symposium 2: Potassium channels and endothelium-derived hyperpolarising factor: Physiological and clinical roles

Chair: Caryl Hill

0830		Opening remarks: Caryl Hill
0835	6P	Endothelium-derived hyperpolarising factor and cell coupling: Factors and fiction? S.L. Sandow, Division of Neuroscience, John Curtin School of Medical Research, ANU, Canberra, ACT 0200, Australia.
0905	7P	Endothelial potassium channels in the regulation of vascular tone in health and in disease H.A. Coleman, M. Tare and H.C. Parkington, Department of Physiology, Monash University, Vic 3800, Australia.
0935	8P	Changes in endothelium-derived hyperpolarising factor in ageing and hypertension: response to chronic treatment with renin-angiotensin system blockers K. Goto, K. Fujii, Y. Kansui and M. Iida, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan. (Introduced by Prof. Caryl Hill)
1005	9P	Potassium channels in the cerebral circulation in health and vascular disease C.G. Sobey, Department of Pharmacology, The University of Melbourne, Parkville, Victoria 3010, Australia. (Introduced by C.E. Hill)
1035		General disussion
1040		Close

Morning Tea

Free Communications 1: Skeletal Muscle

Chair: Gordon Lynch

1115	10P	Near-membrane cytosolic [Ca²⁺] levels and Ca²⁺ transients measured in myotubes grown from normal and dystrophic (mdx) mice using the Ca²⁺ indicator FFP-18 A.J. Bakker¹, R. Han¹ and M.D. Grounds², ¹School of Biomedical & Chemical Sciences and ²School of Anatomy & Human Biology, The University of Western Australia, Crawley, WA 6009, Australia.
1130	11P	Elevated temperature effects on sarcoplasmic reticulum function in mammalian skeletal muscle fibres C. van der Poel and D.G. Stephenson, School of Zoology, Faculty of Science and Technology, La Trobe University, Victoria 3086, Australia.
1145	12P	Effect of low ATP concentrations on action potential-induced Ca²⁺ release in mechanically-skinned EDL fibres of the rat T. Dutka and G.D. Lamb, Department of Zoology, La Trobe University, Victoria 3086, Australia.
1200	13P	Magnesium inhibition of skeletal RyRs modified by DIDS, ryanodine and ATP E.R. O'Neill¹, G.D. Lamb² and D.R. Laver¹, ¹School of Biomedical Sciences, University of Newcastle, Australia and ²Department of Zoology, LaTrobe University, Australia.
1215	14P	Nitric oxide alters the rate and sensitivity of sarcoplasmic reticulum calcium uptake in ovine skeletal muscle J.J. Cottrell¹, R.D. Warner¹, F.R. Dunshea¹, M.B. McDonagh¹ and R. Kuypers², ¹Department of Primary Industries, Research and Development Division, 600 Sneydes Rd, Werribee, 3030, Victoria, Australia and ²R. Kuypers, Food Science Australia, P.O. Box 3312, Tingalpa, 4173, Queensland, Australia.
1230	15P	Phosphorylation status of calsequestrin does not alter its ability to regulate native ryanodine receptors N.A. Beard¹, M.G. Casarotto¹, D.R. Laver² and A.F. Dulhunty¹, ¹John Curtin School of Medical Research, Australian National University, Canberra, ACT, and ²School of Biomedical Science, Faculty of Health, University of Newcastle, NSW, Australia.

Free Communications 2: Ion channels and biophysics

Chair: Trevor Lewis

1115	16P	NO donors increase persistent sodium current in HEK293 cells transfected with the human cardiac Na⁺ channel α-subunit W. Wu, F. Leves and P.W. Gage, Membrane Biology Program, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, ACT 2601, Australia.
1130	17P	Aphidicolin-induced stress pathway in pre-implantation embryos H.-S. Lee and M.L. Day, Department of Physiology, University of Sydney, NSW 2006, Australia.
1145	18P	Distinct expression of intermediate-conductance calcium-activated potassium (IK) channels in intrinsic primary afferent neurons of the rat gastrointestinal tract C.B. Neylon¹, H.L. Robbins¹, B. Hunne¹, S.E. Moore² and J.B. Furness¹, ¹Department of Anatomy & Cell Biology, and Centre for Neuroscience, University of Melbourne, Parkville, Victoria 3010, Australia. and ²Neurology and GI CEDD, GlaxoSmithKline, New Frontiers Science Park, Harlow CM19 5AW, U.K.
1200	19P	Inhibition of human large conductance calcium-activated potassium channels by a fungal toxin J.E. Dalziel¹, S.C. Finch² and J. Dunlop¹, ¹AgResearch Limited, Grasslands Research Centre, Private Bag 11008, Palmerston North, New Zealand and ²Ruakura Research Centre, Private Bag 3123, Hamilton, New Zealand.
1215	20P	Estimations of relative anion-cation permeabilities deduced from reversal (dilution) potential measurements, as in glycine receptor channel studies, are essentially model independent P.H. Barry¹, A. Keramidas¹, A.J. Moorhouse¹ and P.R. Schofield², ¹School of Medical Sciences, University of New South Wales, NSW 2052 and ²Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
1230	21P	Role of charged residues in coupling ligand binding and channel activation in the extracellular domain of the glycine receptor N.L. Absalom¹, T.M. Lewis², W. Kaplan³, K.D. Pierce¹ and P.R. Schofield¹, ¹Neurobiology Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, ²Department of Physiology and Pharmacology, School of Medicine, University of New South Wales, NSW 2052 and ³Peter Wills Bioinformatics Centre, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia.

Lunch

Chemistry Theatre 1

APPS Lecture - David Allen

Chair: Max Bennett

1345

22P

Skeletal muscle function: the role of ionic changes in fatigue, damage and disease D.G. Allen, Department of Physiology, University of Sydney (F13), NSW 2006, Australia.

Chemistry Theatre 1

Free Communications 3: Cardiac Muscle

Chair: Lea Delbridge

1445	23P	Tolerance of male and female rat papillary muscles to acute metabolic compromise I.R. Wendt and B. Zoltkowski, Department of Physiology, Monash University, Victoria 3800, Australia.
1500	24P	The rate of reactivation of the cardiac sodium hydrogen exchanger following inhibition with cyanide J.M. Tipene and D.G. Allen, Department of Physiology, University of Sydney (F13), NSW 2006, Australia.
1515	25P	Activity of the cardiac Na⁺-H⁺ exchanger during ischaemia X.-H. Xiao and D.G. Allen, Department of Physiology F13, University of Sydney, NSW 2006, Australia.
1530	26P	The effect of polyunsaturated fatty acids on cardiac ryanodine and inositol triphosphate receptors B. Honen¹, D. Saint² and D.R. Laver¹, ¹Department of Human Physiology, School of Biomedical Science, The University of Newcastle, Callaghan, NSW 2308 and ²Department of Physiology, School of Molecular and Biomedical sciences, The University of Adelaide, Adelaide, SA 5005, Australia.
1545	27P	ATP modulates intracellular Ca²⁺ and firing rate through a P2Y₁ purinoceptor in cane toad pacemaker cells Y.K. Ju, W. Huang, L. Jiang, J. Barden and D.G. Allen, Departments of Physiology and Anatomy, University of Sydney F13, NSW 2006, Australia.
1600	28P	Calcium loading properties of sarcoplasmic reticulum from rat ventricular myocardium L.M. Gibson¹ and D.G. Stephenson², ¹Pharmacy Department, School of Health and Environment, Faculty of Regional Development, La Trobe University Bendigo, Victoria 3552 and ²School of Zoology, Faculty of Science and Technology, La Trobe University, Bundoora, Victoria 3083, Australia.

Chemistry Theatre 2

Free Communications 4: Nervous system and special senses

Chair: John Miller

1445	29P	Temperature sensitivity of dopaminergic neurons in the Substantia Nigra pars compacta K.K. Chung and J. Lipski, Department of Physiology, University of Auckland, Private Bag 92019, Auckland 1020, New Zealand.
1500	30P	The nature of non-linear interaction between P2 purinergic and α₁ adrenergic receptors in hypoglossal motoneurons is determined by the temporal pattern of receptor activation R. Kanjhan^1,2, A. Jung¹, G.B. Miles¹, J. Lipski¹, G.D. Housley¹, M.C. Bellingham² and G.D. Funk¹, ¹Department of Physiology, University of Auckland, Auckland, New Zealand and ²School of Biomedical Sciences, University of Queensland, St. Lucia, QLD 4072, Australia.
1515	31P	Glutamate alters the morphology of dendritic spines in motoneurons A.J.C. McMorland¹, D.M. Robinson¹, C. Soeller¹, M.B. Cannell¹ and G.D. Funk², ¹Physiology, University of Auckland, New Zealand, and ²Physiology, University of Alberta, Canada.
1530	32P	μ and δ opioid receptor mRNA and protein expression in the cerebellum of the foetal, neonatal, and adult rat J.H. Miller, E.M. Mrkusich, B.M. Kivell and D.J. Day, School of Biological Sciences, Victoria University of Wellington, P.O. Box 600, Wellington, New Zealand.
1545	33P	Upregulation of ecto-nucleoside triphosphate diphosphohydrolases 1 and 2 in noise-exposed rat cochlea S.M. Vlajkovic¹, G.D. Housley¹, D.J.B. Munoz², S.C. Robson³, J. Sevigny⁴, C.J.H. Wang¹ and P.R. Thorne², ¹Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand, ²Discipline of Audiology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand, ³Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA and ⁴Centre de Recherche en Rhumatologie et Immunologie, CHUQ, Universit� Laval, Sainte-Foy, Qu�bec, Canada.
1600	34P	Quantifying local diffusion in the rat lens by two-photon flash photolysis M.D. Jacobs, C. Soeller, M.B. Cannell and P.J. Donaldson, Department of Physiology, The University of Auckland, Private Bag 92019, Auckland, New Zealand 92019.

Anderson Stuart Building

1615 - Poster Communications 1

1	35P	Motor unit discharge properties of respiratory muscles during quiet breathing J.P. Saboisky, J.E. Butler and S.C. Gandevia, Prince of Wales Medical Research Institute, Randwick, Sydney, NSW 2031, Australia.
2	36P	Block of the divalent anion channel in the SR of rabbit skeletal muscle by disulfonic stilbene derivatives K. Bradley and D.R. Laver, School of Biomedical Science, University of Newcastle, Australia.
3	37P	Aberrant splicing of ryanodine receptor in myotonic dystrophy T. Kimura^1,2, M.P. Tkahashi¹ and S. Sakoda¹, ¹Clinical Neuroscience (Neurology), Graduate School of Medicine, Osaka University, Suita, Osaka, Japan. and ²Present Address: Muscle Research, John Curtin School of Medical Research, Australian National University, Canberra ACT, Australia. (Introduced by A.F. Dulhunty)
4	38P	Glutathione transferase mu-2 modulation of the activity of muscle sarcoplasmic reticulum Y.A. Abdellatif, S. Watson, A.F. Dulhunty, P. Board and P.W. Gage, Muscle Research Group, John Curtin School of Medical Research, Australian National University, Mills Road, Acton, Canberra, ACT 2601, Australia.
5	39P	The effect of prolonged ischemia on the tonic stretch reflex of the tibialis anterior muscle and stiffness of the ankle joint J.A. Burne and A.R.N.M.H. Haque, School of Biomedical Science, University of Sydney, P0 Box 170, Lidcombe, NSW 2141, Australia. (Introduced by J. Lingard)
6	40P	The effect of background contraction and prolonged ischemia on the tendon reflex A.R.N.M.H. Haque and J.A. Burne, School of Biomedical Science, University of Sydney, P0 Box 170, Lidcombe, NSW 2141, Australia. (Introduced by J.M. Lingard)
7	41P	Acute incremental exercise, sprint exercise, as well as chronic intermittent hypoxia each decrease muscle Na⁺K⁺ATPase activity R.J. Aughey¹, J.A. Hawley², C.J. Gore³, A.G. Hahn³, D.T. Martin³, S.A. Clark², N.E. Townsend³, T. Kinsman³, M.J. Ashenden³, K.E. Fallon³, G.J. Slater³, A.P. Garnham⁴, C.M. Chow⁵ and M.J. McKenna¹, ¹Centre for Rehabilitation, Exercise and Sports Science, Victoria University of Technology, Melbourne, ²RMIT University, Melbourne, ³Australian Institute of Sport, Canberra, ⁴Deakin University, Melbourne, and ⁵University of Sydney, NSW 2006, Australia.
8	42P	A simple method for determining regional visual acuity in humans D.F. Davey¹ and W. Burke^1,2, ¹Department of Physiology and ²Department of Anatomy & Histology, Institute for Biomedical Research, University of Sydney, NSW 2006, Australia.
9	43P	ATP acts as both a competitive antagonist and a positive allosteric modulator at recombinant NMDA receptors A. Kloda¹, J.D. Clements², R. Lewis¹ and D.J. Adams¹, ¹School of Biomedical Sciences, University of Queensland, Brisbane, QLD 4072 and ²Synaptic Dynamics Lab, John Curtin School of Medical Research, Australian National University, Canberra ACT 0200, Australia.
10	44P	Inhibitory synaptic transmission in mouse type A and B medial vestibular nucleus neurones in vitro A.J. Camp, B.A. Graham, R.J. Callister and A.M. Brichta, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Callaghan, NSW 2308, Australia.
11	45P	Ryanodine receptor isoforms in the neonatal rat cochlea R.T. Whitehead, M.B. Cannell and G.D. Housley, Department of Physiology, Faculty of Medical Health Science, University of Auckland, Private Bag 92019, Auckland, New Zealand.
12	46P	Localisation of P2X6 receptor protein expression in the adult rat cochlea D. Greenwood, L.K. Yang, P.R. Thorne and G.D. Housley, Department of Physiology, University of Auckland, Private Bag 92 019, Auckland 1009, New Zealand.
13	47P	GABA_A receptor subunit composition in cultured hippocampal neurons from newborn rats N. Ozsarac¹, M.L. Tierney² and P.W. Gage¹, ¹John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, ACT 2601 and ²School of Biochemistry & Molecular Biology, Faculty of Science, Australian National University, Canberra, ACT 2601, Australia.
14	48P	Affinity purification of the skeletal muscle ryanodine receptor using a gluthatione-S-transferase-FKBP12 fusion protein P. Pouliquin, S. Pace and A. Dulhunty, Muscle Research Group, John Curtin School of Medical research, Australian National University, Mills Road, Acton, ACT 2601, Australia.
15	49P	The role of the Ether-�-go-go K⁺ channel in cellular proliferation in the mouse preimplantation embryo S.L. Jones and M.L. Day, Department of Physiology and Institute for Biomedical Research, University of Sydney, NSW 2006, Australia.
16	50P	The Cys-loop's role in ligand-binding and channel-gating in the GABA_A receptor V.A.L. Seymour¹, T. Luu¹, M.L. Tierney² and P.W. Gage¹, ¹Department of Molecular Biosciences, John Curtin School of Medical Research, Building 54 - ANU, Mills Rd, Acton, ACT 0200 and ²Biochemistry and Molecular Biology, Faculty of Science, Building 41 - ANU, Linnaeus Way, Acton ACT 0200, Australia.
17	51P	Expression of calcium release channels in rat arteries T.H. Grayson and C.E. Hill, Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia.
18	52P	Mineralocorticoid activates epithelial sodium channel via exocytosis in mouse renal collecting duct cells Y. Hosoda¹, M. Pedler², H. Hu¹, A. Beesley¹, C. Bailey², A. Dinudom¹, J.E.J. Rasko² and D.I. Cook¹, ¹Department of Physiology, University of Sydney, NSW 2006 and ²Centenary Institute of Cancer Medicine & Cell Biology, & Sydney Cancer Centre, Newtown, NSW 2042, Australia.

1800- Student Function - Anderson Stuart Building Courtyard

Tuesday 30th September 2003

Chemistry Theatre 1

Symposium 3: Role of neural angiotensin II in regulation of cardiovascular function

Chair: Roger Dampney and Simon Malpas

0830		Introductory remarks: Roger Dampney
0840	53P	Angiotensin in the ventrolateral medulla A.M. Allen, Howard Florey Institute, The University of Melbourne, Vic. 3010, Australia.
0900	54P	Brain angiotensin and body fluid homeostasis M.J. McKinley, T. Alexiou, P. Sinnayah and M. Mathai, Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria 3010, Australia. (Introduced by R.A.L. Dampney)
0920	55P	Superoxide mediates excitatory actions of angiotensin II in the rostral ventrolateral medulla during acute stress D.N. Mayorov, G.A. Head and R. De Matteo, Baker Heart Research Institute, PO Box 6492, St. Kilda Rd. Central, Melbourne, Victoria 8008, Australia.
0940	56P	Modulation of neurohumoral effector gain as a novel mechanism for the long term regulation of blood pressure G.A. Head and S.L. Burke, Baker Heart Research Institute, Commercial Road, Melbourne, Victoria 3004, Australia.
1000	57P	Role of angiotensin II in regulating long term levels of sympathetic activity S.C. Malpas, C.J. Barrett, S. Guild, R. Ramchandra and D. Budgett, Department of Physiology and Bioengineering Institute, University of Auckland, Auckland, New Zealand.
1020		General discussion on future directions led by Roger Dampney
1040		Close

Chemistry Theatre 2

Symposium 4: Regulation of ion transport

Chair: Peter Barry and Margot Day

0830	58P	Regulation of the epithelial sodium channels A. Dinudom, Department of Physiology, University of Sydney, NSW 2006, Australia.
0900	59P	Links between cell proliferation and K channel activity M.L. Day, Department of Physiology, University of Sydney, NSW 2006, Australia.
0930	60P	Regulation of the glutamine transporter SN1 (SNAT3) S. Br�er, School of Biochemistry & Molecular Biology, Australian National University, Linnaeus way 41, Canberra, ACT 0200, Australia. (Introduced by David Cook)
1000	61P	The familial intrahepatic cholestasis type 1 protein: a P-type ATPase influencing bile acid transporters M.J. Harris^1,2 and I.M. Arias², ¹ANZAC Research Institute, University of Sydney, Concord RG Hospital, Concord, NSW 2139 and ²Tufts University School of Medicine, Boston MA, USA. (Introduced by David Cook)
1030		General discussion
1040		Close

Morning Tea

Free Communications 5: Skeletal muscle

Chair: Graham Lamb

1100	62P	Variations in myosin expression along the length of orbital fibres in the rabbit extraocular muscle C.A. Lucas and J.F.Y. Hoh, Department of Physiology and Institute for Biomedical Research, School of Medical Sciences, Faculty of Medicine, The University of Sydney, NSW 2006, Australia.
1115	63P	Fibre types in rat laryngeal muscles and their transformations following denervation and reinnervation H.S. Rhee, C.A. Lucas and J.F.Y. Hoh, Department of Physiology and Institute for Biomedical Research, School of Medical Sciences, Faculty of Medicine, The University of Sydney, NSW 2006, Australia.
1130	64P	There is no difference in the net efficiency of fast- and slow-twitch mouse muscles C.J. Barclay and C.L. Weber, School of Physiotherapy & Exercise Science, Griffith University Gold Coast, PMB 50 Gold Coast Mail Centre, Gold Coast, Queensland 9726, Australia.
1145	65P	Treatment with the β₂-agonists formoterol or salmeterol produce greater muscle hypertrophy in rats than fenoterol J.G. Ryall, D.R. Plant and G.S. Lynch, Muscle Mechanics Laboratory, Department of Physiology, The University of Melbourne, Victoria 3010, Australia.
1200	66P	Ca²⁺ handling properties of mechanically skinned fibres from fast and slow muscles of adult and old rats following chronic fenoterol treatment D.R. Plant, J.G. Ryall, P. Gregorevic and G.S. Lynch, Muscle Mechanics Laboratory, Department of Physiology, The University of Melbourne, Victoria 3010, Australia.

Free Communications 6: Ion channels and membrane transport

Chair: David Saint

1100	67P	Involvement of a voltage-dependent calcium channel in signal transduction in the 2-cell embryo Y. Li¹, M.L. Day² and C. O'Neill¹, ¹Human Reproduction Unit, Royal North Shore Hospital, Department of Physiology, University of Sydney, NSW 2006 and ²Department of Physiology, University of Sydney, NSW 2006, Australia.
1115	68P	Negative feedback inhibition of Ca²⁺ influx during P_2Y2 receptor activation H. Hu¹, M.M. Cummins¹, Y. Hosoda¹, P. Poronnik², M. Day¹ and D.I. Cook¹, ¹Department of Physiology, University of Sydney, NSW 2006 and ²School of Biomedical Sciences, University of Queensland, QLD 4072, Australia.
1130	69P	Calcium release-activated calcium current in rat hepatocytes G.Y. Rychkov¹, T. Litjens¹, M.L. Roberts¹ and G.J. Barritt², ¹School of Molecular and Biomedical Sciences, University of Adelaide and ²Flinders Medical Centre, Flinders University of South Australia.
1145	70P	Characterisation of chloride currents in the mouse pre-implantation embryo I. Pons-Meneghetti¹, M.L. Day¹, D.I. Cook¹ and M.H. Johnson², ¹Laboratory of Developmental Physiology, Department of Physiology, Anderson Stuart Building (F13), University of Sydney, NSW 2006, Australia and ²Department of Anatomy, Dowlin St, Cambridge CB2 3DY, UK.
1200	71P	Clustering of recombinant GABA_A receptors alters channel properties A.B. Everitt, M.L. Tierney and P.W. Gage, Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.

Lunch

Chemistry Theatre 1

Invited Lecture - Julian Paton

Chair: Peter Gage

1300

72P

Signalling across the blood brain barrier: Implications for blood pressure control J.F.R. Paton, School of Medical Sciences, Department of Physiology, University of Bristol, Bristol BS8 1TD, UK.

Anderson Stuart Building

Poster Session 2

1	73P	Effect of oscillating airway smooth muscle length on bronchoconstriction — the role of the airway wall P.B. Noble, P.K. McFawn and H.W. Mitchell, School of Biomedical and Chemical Sciences, University of Western Australia, Crawley, WA 6009, Australia.
2	74P	Bronchial response to protease-activated receptor stimulation of airway lumenal and adventitial surfaces H.W. Mitchell, H.L. Goh, N. Asokananthan, R.S. Lan, G.A. Stewart and A. Sharma, School of Biomedical and Chemical Sciences, University of Western Australia, Nedlands, WA, Australia.
3	75P	Measurement of culture confluency and volume of human airway smooth muscle cells using quantitative phase microscopy C.L. Curl¹, C.J. Bellair², T. Harris³, B.E. Allman⁴, A. Roberts², K.A. Nugent², P.J. Harris¹, A.G. Stewart³ and L.M.D. Delbridge¹, ¹Department of Physiology, ²Department of Physics, and ³Department of Pharmacology, University of Melbourne, Parkville, Victoria 3010 and ⁴IATIA Ltd.,� Rutland Rd, Box Hill, Victoria 3128, Australia.
4	76P	Increases in renal angiotensinogen mRNA levels following a mixed amino acid infusion in late gestation fetal sheep A.C. Boyce, K.J. Gibson, J. Wu and E.R. Lumbers, Dept of Physiology & Pharmacology, School of Medical Sciences, University of New South Wales, Sydney 2052, Australia.
5	77P	Central program and ovarian feedback both influence LH secretion in flying-foxes G.M. O'Brien and K.-A. Gray, School of Biological, Biomedical and Molecular Sciences, University of New England, NSW 2351, Australia.
6	78P	The dorsomedial hypothalamic nucleus modulates the baroreceptor reflex L.M. McDowall, S. Killinger and R.A.L. Dampney, Department of Physiology F13, University of Sydney, NSW 2006 Australia.
7	79P	Renal sympathoexcitatory response evoked from the dorsomedial hypothalamic nucleus is mediated by presympathetic vasomotor neurons in the rostral ventrolateral medulla J. Horiuchi¹, S. Killinger¹, R.M. McAllen², A.M. Allen² and R.A.L. Dampney¹, ¹Department of Physiology, The University of Sydney, NSW 2006, Australia and ²Neurobiology Group, The Howard Florey Institute, The University of Melbourne, VIC 3010, Australia.
8	80P	Blockade of angiotensin type 1 (AT1) receptors in the rostral ventrolateral medulla increases renal sympathetic activity and arterial pressure under hypoxic conditions J. Sheriff, M.A.P. Fontes, S. Killinger and R.A.L. Dampney, Department of Physiology F13, University of Sydney, NSW 2006, Australia.
9	81P	Angiotensin II microinjections in the nucleus tractus solitarius has an inhibitory effect on the cardiac but not the non-cardiac sympathetic component of the baroreceptor reflex P. Tan and R.A.L. Dampney, Department of Physiology F13, University of Sydney, NSW 2006, Australia.
10	82P	Angiotensin II via AT₁ receptors may mediate apoptosis in the cardiac conduction system of rats U. Vongvatcharanon¹, S. Vongvatcharanon², N. Radenahmad¹, P. Kirirat¹, P. Intasaro¹, P. Sobhon³ and T. Parker⁴, ¹Department of Anatomy, Faculty of Science, Prince of Songkla University, Hat-Yai 90112, Thailand, ²Department of Oral Surgery, Faculty of Dentisty, Prince of Songkla University, Hat-Yai 90112, Thailand, ³Department of Anatomy, Faculty of Science, Mahidol University, Bangkok 10400, Thailand and ⁴School of Biomedical Science, Nottingham University, Nottingham NG7 2UH, UK.
11	83P	Effect of sinoaortic denervation on baroreflex sensitivity assessed with complex demodulation in the anaesthetised rat Tzeng, PD Larsen and DC Galletly, Department of Surgery and Anaesthesia, Wellington School of Medicine, PO Box 7343, Wellington, New Zealand.
12	84P	Change in baroreflex sensitivity during induction of anaesthesia with propofol P.D. Larsen, Y.C. Tzeng and D.C. Galletly, Department of Surgery & Anesthesia, Wellington School of Medicine, PO Box 7343, Wellington, New Zealand.
13	85P	Calbindin D-28K and parvalbumin calcium-binding proteins in SA and AV node of rat heart S. Vongvatcharanon¹ and U. Vongvatcharanon², ¹Department of Oral and Maxillofacial Surgery (Anesthesiology section), Faculty of Dentisty, Prince of Songkla University, Hat-Yai 90112, Thailand and ²Department of Anatomy, Faculty of Science, Prince of Songkla University, Hat-Yai 90112, Thailand.
14	86P	Cardiac remodelling contributes to altered ventricular mechanics in hypertensive cardiomyopathy A.P. Pope, B.H. Smaill and I.J. LeGrice, Department of Physiology/Bioengineering Institute, University of Auckland, Private Bag 92019 Auckland, New Zealand
15	87P	Autoperfused hindlimb as a physiologically relevant model to study skeletal muscle function and metabolism A.J. Hoy, G.E. Peoples and P.L. McLennan, Smart Foods Centre, Department of Biomedical Science, University of Wollongong, NSW, 2522.
16	88P	Vascular remodeling and changes in cellular coupling during vascular disease N.M. Rummery, S.L. Sandow, T.D. Brackenbury and C.E. Hill, Division of Neuroscience, John Curtin School of Medical Research, Australian National University Canberra, ACT 0200, Australia.
17	89P	Initiation and coordination of vasomotion in rat cerebral arteries R.E. Haddock, T.D. Brackenbury and C.E. Hill, Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.
18	90P	Functional remodeling in response to prolonged agonist exposure or elevated pressure delays arteriolar relaxation S.J. Potocnik¹, M.A. Hill¹, L.A. Martinez-Lemus² and G.A. Meininger², ¹Microvascular Biology Group, School of Medical Sciences, RMIT University, Melbourne, Vic. 3081 Australia and ²Department of Medical Physiology, College of Medicine, Texas A&M University, College Station, Texas 77843, USA.

Chemistry Theatre 1

Free communications 7: Exercise physiology

Chair: Tony Luff

urecognised line: TABLE_WIDTH=11.5

1500	91P	Opposing effects of acute and chronic high intensity exercise on Na⁺K⁺ATPase activity in skeletal muscle R.J. Aughey¹, K.T. Murphy¹, S.A. Clark², J. Christie², A.G. Hahn³, C.J. Gore³, A.P. Garnham⁴, C.M. Chow⁵, J.A. Hawley² and M.J. McKenna¹, ¹Centre for Rehabilitation, Exercise and Sports Science, Victoria University of Technology, Melbourne²RMIT University, Melbourne³Australian Institute of Sport, Canberra⁴Deakin University, Melbourne and ⁵University of Sydney, Sydney.
1515	92P	Acute intense exercise upregulates Na⁺,K⁺-ATPase isoform mRNA, but not protein expression in human skeletal muscle K.T. Murphy¹, R.J. Snow², A.C. Petersen¹, R.M. Murphy², J. Mollica², J.S. Lee¹, A.P. Garnham², R.J. Aughey¹, J.A. Leppik¹, I. Medved¹, D. Cameron-Smith² and M.J. McKenna¹, ¹Muscle, Ions and Exercise Group, School of Human Movement, Recreation and Performance, Centre for Rehabilitation, Exercise and Sports Science, Victoria University of Technology, PO Box 14428, MCMC Melbourne, Victoria, 8001 and ²Exercise, Muscle and Metabolism Unit, School of Health Sciences, Deakin University, Burwood, Victoria, 3125.
1530	93P	Increased Na⁺K⁺ATPase content is associated with improved potassium regulation during maximal exercise after sprint training in non-diabetics, but not in type 1 diabetes mellitus A.R. Harmer¹, P.A. Ruell¹, M.J. McKenna², D.J. Chisholm³, J.M. Thom¹, S.K. Hunter¹ and J.R. Sutton¹, ¹School of Exercise & Sports Science, The University of Sydney, New South Wales,²School of Human Movement, Recreation, and Performance, Centre for Rehabilitation, Exercise and Sports Science, Victoria University of Technology, Victoria, and ³Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
1545	94P	Effect of exercise on intracellular insulin signalling in human skeletal muscle K.F. Howlett¹, K. Sakamoto², H. Yu², L.J. Goodyear² and M. Hargreaves¹, ¹School of Health Sciences, Deakin University, Burwood, 3125, Australia and ²Joslin Diabetes Center, Harvard Medical School, Boston, 02215, USA.
1600	95P	Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle M. Hargreaves and S.L. McGee, School of Health Sciences, Deakin University, Burwood, VIC 3125, Australia.
1615	96P	Effect of exercise on Ca²⁺-sensitive protein kinases in human skeletal muscle A.J. Rose¹, B. Michell², B.E. Kemp¹ and M. Hargreaves¹, ¹Exercise, Muscle & Metabolism Unit, School of Health Sciences, Deakin University, Vic., 3125 and ²St. Vincent's Institute of Medical Research, Fitzroy, Vic., 3065, Australia.
1630	97P	The effect of repeated bouts of level and downhill treadmill walking on plasma interleukin-6 N.C. Bevan¹, P.M. Bergin¹, T.J. Connor^1,2 and S.A. Warmington¹, ¹Department of Physiology and ²Institute of Neuroscience, The University of Dublin, Trinity College, Dublin 2, Ireland.
1645	98P	Determinants of muscle buffer capacity D. Bishop and J. Edge, School of Human Movement and Exercise Science, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia.

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Chemistry Theatre 2

Symposium 5: Hormonal, metabolic and neural control of the kidney

Chair: Warwick Anderson

1500		Introductory remarks: Warwick Anderson
1500	99P	Activation of renal calcium and water excretion by novel activators of the calcium-sensing receptor A.D. Conigrave and H. Lok, School of Molecular and Microbial Biosciences (G08), University of Sydney, NSW 2006, Australia.(Introduced by M. Day)
1530	100P	Molecular changes in proximal tubule function in diabetes mellitus P. Poronnik¹ and C.A. Pollock², ¹School of Biomedical Sciences, University of Queensland, St Lucia, QLD 4072 and ²Department of Medicine, University of Sydney, Royal North Shore Hospital, St Leonards, NSW 2065, Australia. (Introduced by David J Adams)
1600	101P	Differential neural control of glomerular ultrafiltration K.M. Denton, S.E. Luff, A. Shweta and W.P. Anderson, Department of Physiology, Monash University, Victoria 3800, Australia.
1630	102P	Neural control of renal medullary perfusion R.G. Evans¹, G.A. Eppel¹, S.C. Malpas² and K.M. Denton¹, ¹Department of Physiology, PO Box 13F, Monash University, Victoria 3800, Australia and ²Department of Physiology, University of Auckland Medical School, Private Bag 92019, Auckland, New Zealand.
1700		General discussion
1710		Close

1900 Conference Dinner

Wednesday 1st October 2003

Chemistry Theatre 1

Symposium 6: Functional imaging

Chair: Mark Cannell and Paul Donaldson

0830	103P	Gaining new insights into physiological function from biophotonics M.B. Cannell, Department of Physiology, University of Auckland, PB92019, New Zealand.
0910	104P	Biosensors for investigating neuronal Ca²⁺ signalling D.A. Williams, M.L. Smart and C.A. Reid, Department of Physiology, University of Melbourne, Victoria 3010, Australia.
0930	105P	New views of lens structure and function P.J. Donaldson, A.C. Grey, B.R. Merriman-Smith, A.M.G. Sisley, C. Soeller, M.B. Cannell and M.D. Jacobs, Department of Physiology, School of Medical Sciences, University of Auckland, Auckland 006, New Zealand.
0950	106P	Quantitative phase microscopy - a new way to interrogate the structure and function of unstained viable cells C.L. Curl and L.M.D. Delbridge, Department of Physiology, University of Melbourne, Victoria 3010, Australia.
1010	107P	High throughput imaging of extended tissue volumes I.J. LeGrice, G. Sands, D. Hooks, D. Gerneke and B.H. Smaill, Bioengineering Institute & Physiology Department, University of Auckland, Auckland, New Zealand.
1030		Close

Chemistry Theatre 2

Symposium 7: Active Learning

Chair: Ann Sefton

0830		Introductory remarks
0835	108P	Active learning: If it works, why aren't we all doing it? J.A. Michael, Department of Molecular Biophysics and Physiology, Rush Medical College, 1750 W. Harrison St., Chicago, IL 60612, USA. (Introduced by M. Roberts)
0925	109P	Promoting active learning with a Generic Skills Guide M.I. Frommer, Department of Physiology, University of Sydney, NSW 2006, Australia. (Introduced by Ann Sefton)
0945	110P	Where should we focus, teaching or learning? M.L. Roberts, Discipline of Physiology, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia, 5005, Australia.
1005		General discussion
1030		Close

Morning Tea

Free communications 8: Skeletal muscle, microcirculation, and reproduction

Chair: Derek Laver

1045	111P	Role of the calcineurin signal transduction pathway in muscle regeneration in dystrophic mdx mice N. Stupka, D.R. Plant and G.S. Lynch, Muscle Mechanics Laboratory, Department of Physiology, The University of Melbourne, Vic. 3010, Australia.
1100	112P	Muscle damage in mdx mice is reduced after treatment with streptomycin N.P. Whitehead and D.G. Allen, Department of Physiology, University of Sydney (F13), NSW 2006, Australia.
1115	113P	Influence of lowered [Na⁺]_o on single and trains of action potentials in soleus muscle fibres of the mouse S.P. Cairns¹ and J.M. Renaud², ¹Division of Sport and Recreation, Faculty of Health, Auckland University of Technology, Private Bag 92006, Auckland 1020, New Zealand and ²Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada.
1130	114P	The effect of reactive oxygen species on muscle fatigue at room temperature compared to body temperature T.R. Moopanar and D.G. Allen, Department of Physiology and Institute for Biomedical Research, University of Sydney (F13), NSW 2006, Australia.
1145	115P	Nutritive and non-nutritive blood flow and oxygen consumption in active rat skeletal muscle A.J. Hoy, G.E. Peoples and P.L. McLennan, Smart Foods Centre, Department of Biomedical Science, University of Wollongong, NSW, 2522.
1200	116P	Glutathione synthesis in whole human red blood cells J.E. Raftos, Department of Biological Sciences, Macquarie University, NSW 2109, Australia.
1215	117P	Circadian gene expression in mouse uterus and liver A.A. Lim¹, M.H. Johnson² and M.L. Day¹, ¹Department of Physiology and Institute for Biomedical Research, University of Sydney, N.S.W. 2006, Australia and ²Department of Anatomy, University of Cambridge, CB2 3DY, United Kingdom.

Free communications 9: Fetal and renal physiology

Chair: Roger Evans

1045	118P	Effects of vitamin D insufficiency in the fetus and in early life on vascular reactivity in young adult rats H.C. Parkington¹, S.J. Emmett¹, R. Morley², C. Skordilis¹, H.A. Coleman¹ and M. Tare¹, ¹Department of Physiology, Monash University, Victoria 3800 and ²University of Melbourne Department of Paediatrics, Royal Children's Hospital, Victoria 3052, Australia.
1100	119P	Possible role of the brain angiotensin system in programming and maintaining hypertension in sheep prenatally exposed to dexamethasone A. McAlinden¹, A. Jefferies¹, M. Cock¹, E. Wintour¹, C. May² and M. Dodic¹, ¹Department of Physiology, Monash University, Clayton, Victoria 3800 and ²Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria 3010, Australia. (Introduced by M. Dodic)
1115	120P	The effects of maternal renal dysfunction and a high salt diet on the renin angiotensin systems of the pregnant ewe and her fetus K.J. Gibson, A.C. Boyce, B.M. Karime, C.L. Thomson, J. Wu, Y.P. Zhou and E.R. Lumbers, Department of Physiology and Pharmacology, School of Medical Sciences, University of New South Wales, NSW 2052, Australia.
1130	121P	The role of renal sympathetic nerve activity in the hypertension induced by chronic nitric oxide blockade R. Ramchandra, C.J. Barrett, S.J. Guild and S.C. Malpas, Circulatory Control Lab, Department of Physiology, University of Auckland, Private Bag 92019, Auckland, New Zealand.
1145	122P	Baroreflexes play a major role in regulating the long-term level of sympathetic nerve activity S.J. Guild, C.J. Barrett, R. Ramchandra and S.C. Malpas, Circulatory Control Laboratory, Department of Physiology, University of Auckland, Private Bag 921019, Auckland, New Zealand.
1200	123P	NO and α-adrenoceptor subtypes in regional renal vascular responses to renal nerve stimulation in rabbits G.A. Eppel¹, L.L. Lee¹, K.M. Denton¹, S.C. Malpas² and R.G. Evans¹, ¹Department of Physiology, Building 13F, Monash University, VIC 3800, Australia and ²Department of Physiology, University of Auckland, Auckland, New Zealand.
1215	124P	Do nitric oxide and prostaglandins protect the renal medullary circulation from ischaemia during renal nerve stimulation? N.W. Rajapakse¹, G.A. Eppel¹, K.M. Denton¹, S.C. Malpas² and R.G. Evans¹, ¹Department of Physiology, Monash University, Melbourne, Australia and ²Department of Physiology, University of Auckland, Auckland, New Zealand.

Lunch / AGM / Award of Prizes - Peter Bishop Laboratory, Anderson Stuart Building

Chemistry Theatre 1

Symposium 8: Integrating cardiac function: From molecules to man

Chair: David Allen

1415		Opening remarks: David Allen
1415	125P	Ion channelopathies: What have they taught us about arrhythmias and anti-arrhythmic therapy? J.I. Vandenberg and T.J. Campbell, Electrophysiology and Biophysics Program, Victor Chang Cardiac Research Institute, Level 9, 384 Victoria Street. Darlinghurst, NSW 2010 and Department of Medicine, St. Vincent's Hospital. University of NSW, NSW 2052, Australia.
1450	126P	Cardiac hypertrophy: comparing models and counting genes L.M.D. Delbridge, Department of Physiology, University of Melbourne, Parkville, Victoria 3010, Australia.
1515	127P	Modelling and imaging cardiac function during excitation-contraction coupling C. Soeller and M.B. Cannell, Department of Physiology, School of Medical Science, University of Auckland, Private Bag 92019, Auckland, New Zealand.
1550	128P	Cardiac structure and electrical activation: models and measurement B.H. Smaill, Bioengineering Institute and Department of Physiology, University of Auckland, Private Bag 92019 Auckland, New Zealand.
1605		General discussion
1615		Close

Chemistry Theatre 2

Symposium 9: Exocytosis and neurosecretion

Chair: David Adams

1315		Opening remarks: David Adams
1415	129P	Differential regulation of two modes of exocytosis by protein phosphatases A.T.R. Sim, School of Biomedical Sciences, The University of Newcastle, and Hunter Medical Research Institute, Callaghan, NSW 2308, Australia. (Introduced by D. Adams)
1445	130P	Coupling G protein-coupled receptors to exocytosis P.D. Marley, Department of Pharmacology, University of Melbourne, Vic. 3010, Australia. (Introduced by D.J. Adams)
1515	131P	PI-3 kinase type II C2&alpha is essential for ATP-dependent priming of neurosecretory granules prior to exocytosis Fr�d�ric A. Meunier¹, G. Hammond¹, P.J. Parker¹, G. Schiavo¹, F.T. Cooke² and J. Domin³, ¹Cancer Research UK, London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, UK,²Biochemistry and Molecular Biology, University of College, London, Darwin Building, Gower Street, W1E 6BT, London, UK, and ³Renal section, Faculty of Medicine, Imperial College School of Medicine, London W12 0NN, UK. (Introduced by Prof. D. J. Adams)
1545	132P	Pre- and postsynaptic factors controlling synaptic efficacy at central synapses M.C. Bellingham and M.L. Kerr, School of Biomedical Sciences, University of Queensland, St. Lucia, Queensland 4072, Australia. (Introduced by D.J. Adams)
1615		Close

Afternoon Tea