Author index

Monday 29th November 2010
	Hickinbotham	Broughton	Gallery
08:00			Education breakfast - to 0900
08:30	Symposium: Mechanisms of multidrug resistance - the role of transporters in human disease Chair: Megan O'Mara & Chris McDevitt 08:30 Introduction 08:35 A.M. George: Perspectives on multidrug resistance in membrane transporters 2P 08:55 S.P.C. Cole: Molecular determinants of MRP1/ABCC1 expression and transport 3P 09:25 R. Callaghan: Drug translocation by P-glycoprotein: how do topographical changes in transmembrane helices assist? 4P 09:45 R.E. Martin: The malaria parasite's chloroquine resistance transporter: a multidrug resistance carrier? 5P 10:10 M.H. Brown: Antimicrobial resistance in staphylococci: Molecular architecture of a multidrug binding site 6P	Free communications: Energy metabolism in exercise Chair: Rod Snow 08:30 N.K. Stepto: Reduced mitochondrial biogenesis activation during exercise after short-term training 7P 08:45 D.J. Bishop: 30 days of normobaric hypoxia increases mitochondrial respiration 8P 09:00 A. Trewin: 3-day oral N-acetyl-cysteine supplementation alters metabolism but not performance of high intensity aerobic exercise in trained cyclists 9P 09:15 A.C. Petersen: Actions of the antioxidant N-acetylcysteine on cell signaling response to exercise in human skeletal muscle 10P
09:00			Symposium: Physiology education Chair: Simon Potocnik & Ann Sefton 09:00 Introduction 09:05 P. Poronnik: Rigour or rigor mortis: a challenge for physiology 11P 09:30 Y.M. Hodgson: Using the Finapres to teach cardiovascular physiology to second year science students 12P 09:45 R. Guy: The KISS approach: How to develop an effective self directed e-learning application 13P 10:00 D.A. Saint: Lecture attendance, learning style and assessment outcome in physiology students 14P 10:15 S. Wiederman: The Human Physiology Writing Centre: Task-based building of student capacity 15P
09:30		Free communications: Systemic influences in skeletal muscle Chair: Rod Snow 09:30 S. Green: Effect of hypoxia on the dynamic response of leg blood flow during exercise 16P 09:45 R. Koopman: Citrulline supplementation does not prevent atrophy during limb-casting in mice 17P 10:00 K.T. Murphy: Inhibition of the renin-angiotensin system enhances whole body and skeletal muscle function in healthy and tumour-bearing mice 18P
10:00
10:30	Morning Tea
11:00	Symposium: Skeletal muscle: the coupling of excitation to contraction Chair: Nicole Beard 11:00 Introduction 11:05 B.S. Launikonis: Voltage-dependent and -independent Ca2+ entry into skeletal muscle during excitation-contraction coupling 19P 11:30 T.L. Dutka: Coupling and uncoupling of the DHPRs and Ca2+ release channels in skeletal muscle fibres 20P 11:55 R.T. Dirksen: One is enough: RyR1 allele-specific gene silencing in mouse models of central core disease (CCD) and malignant hyperthermia (MH) 21P	Free communications: Imaging and structural analysis of lipids and proteins Chair: Joe Shapter 11:00 S. Fraser: Small molecule diffusion in inverse cubic phase lipid systems 22P 11:15 R. Creasey: Detection of proteins in the pathological deposits in Pseudoexfoliation syndrome using Atomic Force Microscopy 23P 11:30 J.L. Flewellen: Visualisation of bacterial hydrodynamics 24P 11:45 A. Mechler: Shedding light on liposomes: Using lipid-mimetic metal complexes for fluorescent labeling 25P 12:00 C.C. Curtain: Shedding light on neurodegeneration: small angle X-ray scattering and misfolded proteins 26P	Symposium: Regulation of metabolic balance through co-ordination of central and peripheral signalling Chair: Chen Chen 11:00 Introduction 11:05 F.J. Steyn: Integrating peripheral and central mechanisms that regulate growth hormone (GH) secretion during periods of altered food consumption 27P 11:30 M.A. Cowley: Control of energy balance by nutrient sensing neurons 28P 12:00 J. Epelbaum: Regulation of hypothalamic GHRH neuronal activity by ghrelin and obestatin 29P
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12:30	Lunch & posters
13:00	Poster session Protein interactions 1 J.J. Lu: Electron microscopic study of the effect of p75NTR extracellular domain on the amyloid β protein assembly 30P 2 O. Barnes: Superoxide dismutase 2 in human brain: A marker for mitochondria and mitochondrial dysfunction in Parkinson’s disease and dementia with Lewy bodies 31P 3 Y. Lu: The relationship between fibrillin and Marfan’s syndrome 32P Fetal physiology and pregnancy 4 F.S. Gravina: Oxytocin depolarizes mitochondrial membrane in freshly isolated myometrial cells 33P 5 J.L. Morrison: Intrauterine growth restricted fetuses have increased blood flow to the adrenals and decreased blood flow to the heart but no difference in brain blood flow 34P Nervous system 6 D. Bongiorno: Nedd4 and Nedd4-2 heterozygosity leads to opposing anxiety behaviour in mice 35P 7 K.L. Jung: Parvalbumin-immunoreactive neurons in the rat ventral respiratory column receive close appositions from galanin-immunoreactive axons 36P 8 N.J. Spencer: Mechanism underlying distension-evoked peristalsis in guinea-pig distal colon: is there a role for enterochromaffin (EC) cells? 37P 9 L. Beech: Identification of the pacemaker mechanism underlying migrating motor complexes in mouse small intestine 38P 10 K. Smith: The affects of amyloid precursor protein (APP) trafficking, processing and interaction with p75 in the presence of amyloid-β 39P 11 K.L. Furber: Thiol-reactivity: A small molecule approach to identifying proteins involved in regulating the calcium sensing steps of native membrane fusion 40P 12 G.R. Kestell: Spinal projections of medium sized sensory neurons that express Calcitonin Gene-Related Peptide but not Substance P in mice 41P Metabolism and signalling 13 J.W. Leong: Activation of CB1 receptor inhibits fasting-induced increase in growth hormone (GH) secretion in mice 42P 14 T. Xie: Characterising the impact of lipid-rich diets on the endocrine profile of C57 mice during progressive weight gain resulting in the development of obesity 43P 15 K.W. Lee: Possible role of fatty acid GPCRs in endometrial cancer cell growth in vitro 44P 16 L. Bobrovskaya: The effect of maternal separation stress and high fat diet on tyrosine hydroxylase regulation in the rat adrenal gland 45P 17 M. Attardi: Fasting increases fat mobilisation and utilisation subsequent to high intensity intermittent exercise in healthy adults 46P 18 T. Gerber: Caffeine ingestion and high intensity intermittent exercise increases post exercise fat mobilisation and glycogenolysis in healthy individuals 47P 19 B.D. Perry: N-acetylcysteine decreases insulin sensitivity after moderate intensity exercise 48P Channels 20 K. Walweel: Role of phosphorylation in the Ca2+ regulation of Ca2+ release channels in skeletal muscle 49P 21 M.J. Landsberg: Ion channels as nanovalves for the controlled release of liposome-encapsulated particulates 50P 22 E.M. Campbell: The availability of Aquaporin 1 to function as a gated cation channel is regulated by tyrosine kinase signalling 51P 23 Q. Wang: Conformational changes associated with desensitisation in the ligand binding domain of the glyicne receptor 52P 24 S. Al Khazaaly: Modelling the response of ion transporters to hyperosmotic shock in cells of salt-sensitive Chara australis and salt-tolerant Lamprothamnium succinctum 53P 25 T. Lynagh: Ivermectin interacts with an intersubunit transmembrane domain of the glycine receptor 54P 26 Y. Ke: How do mutations in the cytoplasmic PAS domain of hERG affect channel structure? 55P 27 H-S. Tae: Charged residues involved in GABAC receptor agonist selectivity 56P 28 A.J. Scopelliti: Characterisation of ASCT-mediated transport at low pH 57P 29 S. Balkrishna: Rapid down-regulation of the rat glutamine transporter SNAT3 by a caveolin-dependent trafficking mechanism in Xenopus laevis oocytes 58P 30 S.W. Park: Characterization of tolaasin inhibitory factors for the suppression of brown blotch 59P 31 M-S. To: Ophiobolin A is an inhibitor of STIM1/Orai1-mediated current 60P 32 J. Heide: Characterization of a novel hERG potassium channel isoform upregulated in schizophrenia patients 61P 33 E. Deplazes: Modeling of the open-channel structure of MscL using restrained simulations 62P 34 L. Stokes: The Tyr-315 to Cys polymorphism in the P2X4 receptor causes loss of function and is associated with increased pulse pressure in humans 63P 35 S. Fairweather: Brush-border peptidases alter the kinetic properties of neutral amino acid transporters B0AT1 and B0AT3 64P 36 J. Pei: Inhibitory activity of plant extracts on Plasmodium falciparum aquaporin 65P 37 Y.B. Yoon: Characterization of microbial nitrate uptake for the treatment of agricultural wastewater 66P 38 M.P. Ween: Methodology strategies for the purification and biophysical characterization of bacterial ATP-binding cassette transporters 67P 39 S.C.E. Wong: Re-examining the role of the voltage sensor in hERG channel inactivation 68P 40 M.H. Kim: Facilitation of tolaasin-induced haemolysis by phospholipid composed of short length fatty acids 69P 41 M. Thomas: Mapping the importance of 4 factors in creating monovalent ion selectivity in biological molecules 70P 42 H. Cuny: GABAB receptor gene knockdown impairs inhibition of N-type calcium channels in rat sensory neurons by α-conotoxin Vc1.1 71P 43 B.P. Callaghan: Biological activity of α-conotoxins on N-type calcium channels in rat sensory neurons 72P 44 P.S.P. Tan: Illuminating the mechanism of hERG channel activators using voltage clamp fluorometry 73P 45 P.H. Barry: A new simple method for the experimental measurement of liquid junction potentials 74P 46 O. Knapp: Identification of Nav1.8 channel domains responsible for µO-conotoxin MrVIB binding and channel biophysical properties 75P 47 T. Nomura: Lipid and lyso-lipid effects on the behavior of liposome co-reconstituted MscS and MscL 76P 48 M.H. Rashid: Binding of sea anemone toxin Shk to the potassium channel Kv1.3 from molecular dynamics simulations 77P Biophysics 49 P.J. Smith: Stabilisation of quasi stable states by flash turnover of photosystem II core complexes from higher plants. Back reaction kinetics 78P 50 R. Nixon-Luke: Rapid characterization of bacterial motility using Dynamic Light Scattering (DLS) 79P Exercise physiology 51 T. Atanasovska: Arterial potassium regulation during a 2000 metre rowing trial 80P 52 D.M. Camera: Interaction of muscle glycogen status and nutrient supplementation on skeletal muscle adaptation following resistance exercise 81P 53 C.A. Machado-Moreira: The local dynamics of thermal sweat suppression following a systemic cholinergic blockade 82P 54 C.A. Machado-Moreira: Do non-cholinergic efferent pathways have a functional relevance during the thermal and non-thermal stimulation of human eccrine sweat glands? 83P Vesicular secretion 55 Y. Jang: The role of F-actin in vesicular secretion 84P 56 A. Banerjee: The role of dynamin in fusion pore closure and endocytosis in pancreatic acinar cells 85P Heart 57 A.D. Hanna: Multiple effects of anthracyclines on cardiac ryanodine receptors 86P 58 N.A. Beard: Ryanodine receptor phosphorylation in human heart failure 87P 59 D. Mehra: Inhibition of cardiac Ca2+ release channels as therapy for arrhythmia 88P 60 S.A. Mann: How additive effects of small changes in repolarising currents can increase the risk for atrial fibrillation – a modelling study 89P Biomolecular structure and dynamics 61 K. Hendy: Measuring receptor motility and filopodia dynamics 90P 62 S. Orgeig: Pulmonary surfactant membranes of hibernating ground squirrels possess increased fluidity but are capable of maintaining an ordered membrane structure at low temperatures 91P 63 M.A. Sani: Aggregation state of Aβ peptides in model membranes 92P 64 J.D. Gehman: Boltzmann statistics maximum entropy of solid-state NMR dipolar recoupling and magic angle spinning data 93P 65 I.L. Salvemini: Measuring the incorporation of fluorescently labelled lipid analogues into the membrane of giant unilamellar vesicles 94P 66 C.A. Ng: Which residues are important within the N-terminal helix of hERG PAS domain to maintain a functional channel? 95P Muscle 67 H.A. Rudayni: Kinetics of glucose transport across the surface membranes of single fast- and slow-twitch muscle fibres of the rat 96P 68 S.I. Head: Myotoxin induced regeneration of fast-twitch EDL skeletal muscles from aged mice results in fibre branching and increased susceptibility to dystrophic type eccentric damage 97P 69 E. Wium: Identifying the skeletal muscle ryanodine receptor activation domain of triadin 98P 70 H. Willemse: Possible contribution of SPRY2 and ASI regions of RyR1 to interdomain interaction 99P 71 R.T. Rebbeck: In vitro interactions between C-terminal residues of the β1a subunit of DHPR and RyR1 from skeletal muscle 100P 72 R.P . Hewawasam: GSTM2-2 C terminus modulates the contractility of cultured rat ventricular cardiomyocytes 101P 73 A.J.H. Hewson: Effects of membrane cholesterol depletion on excitation-contraction coupling in mammalian skeletal muscle 102P 74 K.A. Burlinson: The response of healthy and dystrophic mdx mouse muscle to prolonged elevations of cytoplasmic Ca2+ 103P 75 N. Capitanio: Muscle membrane permeability, damage and atrophy in Zucker obese rats 104P 76 J.E. Church: Stimulating the Notch signalling pathway does not improve muscle regeneration after myotoxic injury in dystrophic mice 105P 77 E. Zacharewicz: Influence of myo-inositol on protein turnover in C2C12 myotubes 106P 78 D.S. Hiam: Does folic acid supplementation during pregnancy reduce skeletal muscle mitochondrial biogenesis and insulin signalling in adult offspring? 107P 79 D.M. Horvath: The effect of taurine and β-alanine supplementation on taurine content and contractile properties of skeletal muscle in the mdx mouse 108P
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14:30	Symposium: New insights into the molecular architecture of the heart and their implications for heart disease Chair: Yue-kun Ju & David Allen 14:30 M.R. Boyett: The molecular architecture of the heart's conduction system in health and disease 109P 15:05 Y.K. Ju: Distribution and functional role of IP3R receptors in mouse sino-atrial node 110P 15:30 A.F. Dulhunty: Proteins in the lumen of the sarcoplasmic reticulum determine cardiac RyR channel activity, cardiac function and the structure of Ca2+ release units 111P 15:55 M.B. Cannell: A new twist in cardiac muscle: dislocated and helicoid arrangements of myofibrillar z-disks in mammalian ventricular myocytes 112P 16:20 D. Fatkin: Mechanisms of contractile dysfunction in lamin A/C-deficient hearts 113P	Free communications: Membrane transport Chair: Brett Cromer 14:30 R.J. Clarke: Hot and cold running ion pumps 114P 14:45 S. Bröer: Mapping the ion translocation pathway in the glutamine transporter SNAT3 115P 15:00 R.M. Ryan: Glutamate transporter loss-of-function mutations cause human dicarboxylic aminoaciduria 116P 15:15 M.L. O'Mara: Determining the physiological state of a membrane protein: investigating the P-gycoprotein crystal structure 117P 15:30 R. Jaiswal: Acquisition and dissemination of multidrug resistance in cancer via microparticles 118P 15:45 J. Gong: Microparticles confer multidrug resistance in breast cancer 119P	Symposium: Imaging and dynamic microscopy (imaging of biological and biophysical processes) Chair: Pierre Moens 14:30 A.S. Yap: Cadherin dynamics and the cytoskeleton 120P 15:00 E. Gratton: Detecting stem cell differentiation using fluorescence lifetime microscopy (FLIM) by the phasor approach 121P 15:30 L. Tilley: Light, x-rays or electrons for imaging malaria parasites? 122P 16:00 M.A. Digman: Molecular transport in cells by the pair correlation fluctuation method 123P 16:30 E. Hinde: In vivo pair correlation analysis of enhanced green fluorescent protein (EGFP) intra nuclear diffusion 124P
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16:00		Free communications: Calcium signalling in muscle Chair: Nicole Beard 16:00 J.E. Robinson: SPontaneous Oscillatory Contraction (SPOC): Quantifying contractile performance in isolated human cardiomyocytes under partial activation 125P 16:15 J.N. Edwards: The effects of membrane potential and cytoplasmic calcium concentration on calcium extrusion across the tubular system in mammalian skeletal muscle 126P 16:30 D.W. Williams: The effect of suramin (a calmodulin antagonist) on caffeine-induced Ca2+-release in mechanically skinned fast-twitch skeletal muscle fibres of the rat 127P
16:30
	Afternoon Tea
17:00
	Symposium: Calcium signalling Chair: Grigori Rychkov & Greg Barritt 17:15 Introduction 17:20 O.V. Gerasimenko: Calcium regulation of apoptosis in pancreatic acinar cells 128P 17:45 A.L. Miller: The application of complementary luminescent and fluorescent imaging techniques to visualize nuclear and cytoplasmic Ca2+ signaling during in vivo differentiation of slow muscle cells in zebrafish embryos 129P 18:15 R.S. Lewis: STIM:Orai stoichiometry and the trapping and activation of store-operated calcium channels 130P	Free communications: Neuronal development and pathology Chair: Louise Tierney 17:15 L.J. Turnbull: Peroxiredoxin 4 is confined to the endoplasmic reticulum in human brain and associated with Lewy body formation in Parkinson's disease and dementia with Lewy bodies 131P 17:30 Y. Sun: ProBDNF inhibits neurites outgrowth in neurons of mice by activating RhoA 132P 17:45 S.I. Head: Postsynaptic GABAA receptor number and enhanced gaboxadol induced change in holding currents in Purkinje cells of the dystrophin-deficient mdx mouse 133P 18:00 X.F. Zhou: Huntingtin associated protein 1 associates with amyloid precursor protein and regulates its trafficking and Aβ levels 134P 18:15 D.J. Keating: Huntingtin-associated protein 1 (HAP1) regulates exocytosis via multiple mechanisms 135P	Symposium: Lipid Metabolism and disease: new insights from the lab to the clinic Chair: Matthew Watt 17:15 M.J. Watt: Circulating ceramide, inflammation and insulin resistance 136P 17:30 G.I. Lancaster: Dual, but opposing, roles for the double stranded RNA-dependent protein kinase in metabolic homeostasis 137P 17:55 B.A. Kingwell: The emerging role of HDL in glucose metabolism 138P 18:20 L.K. Heilbronn: Calorie restriction versus exercise: which produces the best health outcomes? 139P
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19:30	Student dinner Location: The Stag - corner of Rundle St and East Tce
20:00
20:30
21:00

Tuesday 30th November 2010
	Hickinbotham	Broughton	Gallery
08:30	Symposium: Ion channel modulation by peptide toxins Chair: Ray Norton & David Adams 08:30 Introduction - David Adams 08:35 G.F. King: Probing the interaction between psalmotoxin 1 and acid sensing ion channel 1a, an analgesic drug target 140P 08:55 R.S. Norton: Conotoxins targeting voltage-gated sodium channels: Designing new analgesics 141P 09:15 R.J. French: Subverting the biological actions of Conus peptides to modulate physiological responses 142P 09:45 M. Chebib: Calcium, Vc1.1 and α9α10 nicotinic acetylcholine receptors 143P 10:05 D.J. Adams: Analgesic conotoxins: modulation of voltage-gated calcium channels in pain pathways 144P 10:25 Closing remarks - Ray Norton	Free comunications: Smooth muscle Chair: Nick Spencer 08:30 M. Costa: Temporal relationships between intraluminal manometry and actual gut movement in the isolated rabbit small intestine 145P 08:45 S.E. Carbone: Gap junction coupling between smooth muscle cells modulates responses to inhibitory motorneurons and exogenous ATP 146P 09:00 R.J. Lang: KV4 and ANO1 / TMEN16A chloride channel expression profiles distinguish between atypical and typical smooth muscle cells in the mouse renal pelvis 147P 09:15 H.C. Parkington: Controlling uterine contractions: the role of interstitial cells 148P	Symposium: Emerging leaders in developmental physiology Chair: Caroline McMillen & Helena Parkington 08:30 K.M. Moritz: Developmental programming following prenatal alcohol exposure: models and mechanisms of disease 149P 08:55 T.J.M. Moss: Intrauterine inflammation: effects on fetal lung development 150P 09:20 J.L. Morrison: Early origins of cardiovascular disease: The heart of the matter 151P 09:45 J.A. Armitage: Maternal diets rich in fat programme obesity, hypertension and altered sympathetic nervous system activity in adult offspring 152P 10:00 M. Tare: Early life environments and programming of the vascular phenotype 153P
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09:30		Free communications: Sensory Chair: Nick Spencer 09:30 V.P. Zagorodnyuk: Selective loss of visceral pain in the aganglionic rectum of lethal spotted mutant mice 154P 09:45 G.D. Housley: Purinergic signalling via ATP-gated ion channels mitigates noise-induced hearing loss 155P 10:00 T.J. Hibberd: Extracellular recording of viscerofugal neurons in guinea-pig colon 156P
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10:30	Morning Tea
11:00	Symposium: Stress, disease and Ca2+ management: the cardiovascular challenge. Chair: Lea M D Delbridge & David Saint 11:00 D.R. Laver: Cardiac SR Ca2+ release channels and adrenergic stimulation 157P 11:22 J.R. Bell: Cardiac ischemic stress: Ca2+ and sex scenarios 158P 11:44 M. Ward: Cardiomyopathies: When is Ca2+ the culprit? 159P 12:06 D.P. Wilson: Defining the roles of Ca2+ entry in endothelin-1 and thromboxane A2 receptor mediated vascular contractile responses 160P	Free communications: Regulation of skeletal muscle growth and repair Chair: Kate Murphy 11:00 C.R. Wright: The role of G-CSF in the growth and development of skeletal muscle cells in vitro 161P 11:15 J.E. Church: β2-adrenoceptors are the dominant subtype involved in early muscle regeneration after injury 162P 11:30 S.M. Gehrig: Muscle-specific heat shock protein 72 (HSP72) overexpression improves muscle structure and function in dystrophic mdx mice 163P 11:45 J.P. Mollica: Properties and proteolytic activity of m-calpain in rat skeletal muscle 164P 12:00 R.M. Murphy: Properties of AMP kinase (AMPK) β isoforms and glycogen related proteins in segments of single fibres from rat skeletal muscle 165P	Symposium: Molecular physiology and membrane dynamics Chair: Jens Coorssen & Peter Thorn 11:00 P. Dietl: Pre-, hemi- and postfusion stages of lamellar body (LB) exocytosis in the rat lung: mechanisms of regulation and implications for surfactant release 166P 11:30 B. Garner: Targeting membrane lipids to modulate amyloid precursor protein processing 167P 11:45 F. Separovic: The effect of membrane-active peptides on membrane dynamics and molecular order 168P 12:00 B. Martinac: Mechanisms of mechanosensation: Evolutionary origins of mechanosensitive ion channels 169P 12:15 I.L. Gibbins: Molecules in motion: imaging peptides, their receptors and diffusion models 170P
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12:30	Lunch & posters		ASB MacCauley-Hope Award Lecture 12:30 R. J. Clarke: Pumping ions 216P
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14:30	Symposium: Fatigue mechanisms limiting exercise performance Chair: Michael McKenna & Mark Hargreaves 14:30 Introduction 14:40 M. Amann: Neuromuscular fatigue: interactions between central and peripheral factors 171P 15:30 D.J. Bishop: Fatigue during intermittent exercise: novel insights and real-world applications 172P	Symposium: Fundamentals of Biophysics - development of mathematical and computational methods Chair: John Gehman 14:30 P.W. Kuchel: Erythrocyte shape, metabolism and membrane transport – computations 173P 14:55 M. Mobli: Fast acquisition of multidimensional NMR experiments by maximum entropy reconstruction of non-uniformly sampled data 174P 15:15 D. Szekely: Toward the virtual heart: graphics processor accelerated interactive simulations of cardiac function 175P 15:35 A.C.F. Coster: Vesicle docking and delivery: Life in the TIRF zone 176P	Free communications: Ion channel gating Chair: Angelo Keramidas 14:30 A.R. Battle: Lipid effects on the gating behaviour and reconstitution of MscL and MscS 177P 14:45 A.P. Hill: Mapping the sequence of conformational changes underlying selectivity filter gating in a potassium channel 178P 15:00 D. Gordon: Rigid body Brownian dynamics simulations of ion channels and channel blockers 179P 15:15 S.C. Goodchild: Metamorphic chloride intracellular channel proteins: evidence for transmembrane extension and membrane induced oligomerisation of CLIC1 180P 15:30 N.R. Scrimgeour: pH dependence of the Ca2+ release activated Ca2+ (CRAC) channel 181P
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16:00	Afternoon Tea
16:30	Plenary Chair: David Adams 16:30 R.S. Kass: The congenital Long QT Syndrome: broad lessons from a rare disease 182P
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17:30			ASB meeting
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19:00	Conference Dinner and Dance
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Wednesday 1st December 2010
	Hickinbotham	Broughton	Gallery
08:30	Plenary Chair: Angela Dulhunty 08:30 R.T. Dirksen: Molecular mechanism of store-operated calcium entry (SOCE) in skeletal muscle and potential role in fatigue resistance 183P
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09:30	Symposium: Skeletal muscle ROS: the good, the bad and the, well it kinda depends Chair: Glenn McConell 09:30 G.K. McConell: Skeletal muscle ROS and glucose uptake during contraction 184P 09:50 G.D. Lamb: Effects of S-glutathionylation, S-nitrosylation and oxidation on Ca-sensitivity and force: a balancing act 185P 10:10 T. Tiganis: Skeletal Muscle H2O2 and Insulin Sensitivity 186P 10:30 D.E. James: The role of ROS in insulin resistance 187P 10:50 Discussion	Free communications: Endocrine signalling Chair: Phil Poronnik 09:30 S. Lie: Periconceptional and early preimplantational undernutrition alters gene expression of metabolic and gluconeogenic regulating factors in the liver 188P 09:45 M. Tjongue: The effects of chronic moderate prenatal ethanol exposure on cardiovascular and renal artery function in adult rats 189P 10:00 J.S. Jacobi: Gonadotropin-inhibiting hormone (GnIH) regulates spontaneous action potentials in anorexigenic proopiomelanocortin neurons and orexigenic neuropeptide Y cells 190P 10:15 L.M. Nicholas: Maternal overnutrition during the periconceptional period and gender influences insulin signalling and glucose handling in lambs after birth 191P 10:30 H. Peiris: The role of regulator of calcineurin 1 (RCAN1) in the regulation of glucose homeostasis 192P	Free communications: Ion channels Chair: Peter Barry 09:30 B.A. Cromer: Agonist interactions and selectivity in GABAA/C receptors 193P 09:45 M.L. Tierney: Defining GABAA receptor pharmacology and physiologies through the disruption of receptor protein interactions 194P 10:00 A. Keramidas: Developing activation mechanisms for GABAA receptors 195P 10:15 N.L. Absalom: Understanding the molecular and pharmacological basis of selectivity of nicotinic acetylcholine receptor antagonists using reactive methyllycaconitine analogues 196P 10:30 L. Ma: Reciprocal regulation of expression of STIM1 and Orai1 proteins 197P
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11:00	Morning Tea
11:30	Free communications: Regulation of protein expression in skeletal muscle Chair: Matthew Watt 11:30 R.J. Stefanetti: Atrogin-1 regulation in human and mouse skeletal myotubes 198P 11:45 V.C. Foletta: NDRG2, a novel player in the control of skeletal muscle mass? 199P 12:00 P.A. Della Gatta: Multiple cell types express myokines following intense resistance exercise 200P 12:15 E.L. Brown: PGC-1α and PGC-1β regulate protein synthesis in C2C12 myotubes 201P 12:30 N.T. Larkins: Properties and amounts of heat shock proteins in skeletal muscle 202P 12:45 M.A. Wallace: Knockdown of STARS alters protein synthesis and degradation 203P	Free communications: Calcium signalling Chair: Yue-kun Ju 11:30 C.H. Wilson: Expression of STIM and Orai in liver disease 204P 11:45 E. Kheradpezhouh: Molecular mechanisms of paracetamol induced liver damage 205P 12:00 R.B. de Oliveira: Mitochondria-induced hyperpolarization in mouse locus coeruleus neurons is dependent on Ca2+ entry but not intracellular Ca2+ release 206P 12:15 J. Chaisakul: Calcium influx-activating action of P-EPTX-Ar1a: an isolated neurotoxin from the venom of Irian Jayan death adder 207P 12:30 J. Gerasimenko: Alcohol-induced pancreatic trypsinogen activation depends on calmodulin-sensitive inositol trisphosphate receptors types 2 and 3 208P	Symposium: Computational studies on biological and synthetic nanotubes Chair: Shin-Ho Chung 11:30 T.W. Allen: Selective ion binding and its role in potassium channel selectivity 209P 11:52 A.E. Mark: The induction and stabilization of transmembrane pores by peptides 210P 12:09 B. Corry: Monitoring the conformational changes involved in MscL channel gating using FRET microscopy and simulation 211P 12:26 S. Kuyucak: Free energy simulations of Asp/Glu transporter GltPh 212P 12:43 T.A. Hilder: Mimicking biological ion channels using nanotubes 213P
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13:00	Lunch Location: Hickinbotham
13:30	AuPS AGM Chair: David Allen
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14:30	Plenary Chair: B. Martinac 14:30 R. Callaghan: Multi-drug efflux by P-glycoprotein; why has this protein not been stopped yet? 214P
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15:30	Plenary Chair: M. Watt 15:30 E.A. Richter: Metabolic regulation in exercise: mechanisms and experimental models 215P
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16:30	Awards and Wine and Cheese
17:00	End of meeting

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