AuPS 2013 Geelong Programme

Author index

Sunday 8th December 2013
GalleryCostaPercy BaxterLittle Percy Baxter
14:00 The flipped classroom in physiology education
Chairs: Yvonne Hodgson & David Saint
17:00 Registration
Location: Gallery
17:30 AuPS Invited Lecture
Chair: David Allen
17:30 G.S. Lynch: The role of physiology in understanding muscle wasting, adaptation and plasticity1P
Welcome Reception


Monday 9th December 2013
GalleryCostaPercy BaxterLittle Percy Baxter
08:30 Roberts Lecture
08:30 D.A. Saint: Learning and teaching: The rear view mirror, and the road ahead2P
09:00 Symposium: PPE - the use of Peers in Physiology Education
Chairs: Deanne Skelly & Arianne Dantas
09:00 R.A. Mulder: How does student peer review influence perceptions, engagement and academic outcomes? A case study3P
09:30 K. Tangalakis: Improving learning experience through student peer mentoring in laboratory classes4P
10:00 K. Colthorpe: Use of peer feedback to enhance engagement in a physiology cohort5P
10:30 D.H. Hryciw: Peer assisted study sessions to develop understanding of physiology in a mature age cohort6P
Symposium: Molecular physiology of inherited heart diseases
Chair: Jamie Vandenberg
09:00 M.J. Perrin: Clinical overview of inherited heart disease7P
09:20 C. Semsarian: Hypertrophic cardiomyopathy and contractile proteins8P
09:40 G.A. Robertson: IPSC-derived cardiomyocytes as a model for studying mechanisms of repolarization and disease in the developing heart: focus on hERG isoforms9P
10:20 D. Fatkin: Dilated cardiomyopathy and structural proteins11P
10:40 D.R. Laver: Catecholaminergic polymorphic ventricular tachycardia and calcium handling proteins12P
Free communications: Muscle metabolism and cell signalling
Chair: Victoria Foletta
09:00 D.J. Ham: Citrulline protects muscle cells from wasting in an mTOR independent manner in vitro13P
09:15 O.D. Robertson: Genetic over-expression of a dominant negative activin receptor preserves muscle mass in a model of muscle wasting14P
09:30 C.H. Ly: Despecification of myogenic C2C12 cells via metabolic reprogramming15P
09:45 N. Stupka: Role of selenoprotein S (SEPS1) in regulating skeletal muscle metabolic stress responses16P
10:00 M.A. Wallace: STARS increases skeletal muscle cell proliferation and differentiation17P
10:15 C.E. Winbanks: Bone Morphogenetic Protein (BMP) signalling is a positive regulator of skeletal muscle mass18P
11:00 Morning Tea
Location: Gallery
11:30 Symposium: Molecular control of skeletal muscle health in exercise and disease
Chairs: Rod Snow & Aaron Russell
11:30 A. Kralli: Estrogen-related receptors and their role in skeletal muscle metabolism19P
12:00 A.P. Russell: PGC-1/ERRα regulation of muscle growth20P
12:30 G.E.O. Muscat: The nuclear receptor, Nor-1, in skeletal muscle effects expression of Z-disk/sarcomeric binding proteins, and intracellular recycling21P
13:00 S.L. McGee: Class IIa histone deacetylase control of muscle metabolism22P
Symposium: Epithelial membrane transport
Chairs: Stefan Bröer & Peter Thorn
11:30 M. Levi: Regulation of intestinal phosphate transport23P
12:00 D.I. Cook: Regulation of the epithelial Na+ channel (ENaC) by kinases24P
12:30 A. Mather: Reabsorption of glucose in the proximal tubule occurs predominantly via the sodium glucose cotransporter25P
13:00 S. Broer: Regulation of epithelial function by protein diet26P
Free communications: Applied exercise physiology
Chairs: Aaron Peterson & Glenn McConell
11:30 G.K. McConell: Sheep as a large mammal model for investigating insulin sensitising effects of exercise27P
11:45 J.L. Areta: Depressd resting myofibrillar protein synthesis induced by short-term energy deficit is up-regulated by resistance exercise and post-exercise protein ingestion28P
12:00 V.L. Wyckelsma: High-intensity interval training in older adults does not upregulate the Na+,K+-ATPase isoforms measured in whole muscle homogenate, but shows fibre type specific upregulation when analysed in single fibres29P
12:15 B.D. Perry: The effects of short-term unloading and re-training on skeletal muscle function and Na+,K+-ATPase abundance in humans30P
12:30 C.W. Twaddell: Heart rate kinetics as an indicator of recovery from cold water immersion – An investigation of both sprint and endurance exercise31P
12:45 S.U. Jayasinghe: Reactivity to psychological stress in premenopausal women: Impact of cardiorespiratory fitness and cardio-metabolic risk32P
13:00 J. Yamauchi: Exercise duration and blood lactate concentrations in moderate and low intensity of cycle ergometry33P
13:15 A.C. Petersen: Skeletal muscle heat shock protein response to lower limb unloading and reloading in humans34P
13:30 Posters and Lunch
Location: Gallery
Odd poster board authors in attendance.
1 35PR.J. Lang: Nicotinic receptors on capsaicin-sensitive sensory afferents modulate peristalsis in the mouse renal pelvis
2 36PJ.P. Rao: Transports of phosphate and arsenate by everted gut sacs: a comparison
3 37PM.J. Nguyen: Sub-urothelial KCNQ+ interstitial cells modulate peristalsis in the mouse renal pelvis
4 38PE.Y. Cao: Enhancing mesenteric lymphatic transport to target the sphingosine-1-phosphate receptor
5 39PK.F. Howlett: Glucose homeostasis regulation: reversible lysine acetylation of GAPDH
6 40PC.R. Brandner: Perceptual responses to blood flow restriction resistance exercise
7 41PY. Jiang: Understanding the role of neutral amino acids in insulin resistance
8 42PA.K. May: The acute haemodynamic responses of young and older men to resistance and aerobic modes of blood-flow restriction exercise
9 43PE. Kheradpezhouh: H2O2 and paracetamol-induced oxidative stress initiates TRPM2 channel trafficking to the plasma membrane in rat hepatocytes
10 44PJ.R. Bell: Augmented CaMKII recruitment despite less reperfusion arrhythmias in female hearts – a matter of differential post-translational modification of CaMKII splice variants?
11 45PY. Li: Investigating involvement of store-operated channel in stretch-induced axonal injury
12 46PC. Chandramouli: Elevated cardiac AngII exacerbates structural and mechanical diabetic myocardial pathology in normotensive mice
13 47PL. Li: In vitro characterization of interactions between junctin and ryanodine receptors
14 48PY. Abdulla: Quantitative assessment of lymphatic function by near infrared imaging technique
15 49PG.A. Steele: CLIC-2, FKBP12.0 and FKBP12.6 association with ryanodine receptor calcium release channels
16 50PA. Sadrieh: Developing novel high performance computing approaches to cardiac simulation
17 51PK. Walweel: Inhibition of RyR2 from healthy and failing human hearts by calmodulin
18 52PS.J. Etherington: Looking beyond the laboratory: Finding time to develop global perspective in a content-driven physiology unit
19 53PS. Allami: Heat therapy effects on skeletal muscle heat shock proteins in the elderly
20 54PN.T. Frankenberg: Protein expression and localization of αB-crystallin in muscles of mdx dystrophic mice
21 55PN. Andreacchio: The effect of a yearly dose of vitamin D on skeletal muscle function
22 56PR.G. Barker: Taurine supplementation can improve tibialis anterior force production and muscle architecture: A comparison between the 28 and 70 day old mdx mouse model of Duchenne muscular dystrophy
23 57PN.L. McRae: Glucocorticoids regulate extracellular matrix gene expression of the ADAMTS5-versican enzyme-substrate axis in C2C12 skeletal muscle cells
24 58PG. Ravenscroft: KLHL41, a BTB-Kelch protein, is critical for skeletal muscle function
25 59PJ.E. Church: Serum miRNAs as potential biomarkers for assessing skeletal muscle regeneration
26 60PX. Yan: BRSK1 is required for myogenic differentiation of muscle precursor cells
27 61PT.R. Cully: Ca2+ uptake by the tubular (t-) system membrane of rat fast-twitch muscle
28 62PJ. Lam: The contractile properties of slow and fast skeletal muscle from protease activated receptor-2 null mice
29 152PT.M. Farr: Effects of contracting muscle mass on arterial plasma [K+] and fatigue during exercise
15:30 Afternoon Tea
Location: Gallery
16:00 Symposium: Intricacies of type 2 diabetes
Chair: Robyn Murphy
16:00 P. Thorn: Identification of targeted insulin secretion in pancreatic beta cells: evidence for an endocrine synapse63P
16:30 S. Andrikopoulos: Islet β cell dysfunction in type 2 diabetes – can we save the β cell?64P
17:00 A.J. Hoy: Liver insulin resistance and ceramides65P
17:30 G.D. Wadley: Skeletal muscle and insulin resistance – a focus on mitochondria66P
Symposium: Aquaporin channels in the nervous system as therapeutic targets
Chair: Andrea Yool
16:00 M.A. Stoodley: Role of aquaporin channels in spinal cord and implications for treatment of syringomyelia67P
16:30 R.J. Turner: A novel approach to the treatment cerebral oedema following trauma: modulation of Aquaporin 4 water channels68P
17:00 T.G. Johns: Blocking aquaporins inhibits brain cancer cell migration69P
17:30 A.J. Yool: Advances in drug discovery for aquaporin channels70P
Free communications: Muscle/sarcoplasmic reticulum
Chair: David Allen
16:00 C.A. Timpani: The effects of increasing extramitochondrial calcium concentration on mitochondrial function in dystrophic muscle71P
16:15 E.D. Hanson: The effect of dietary vitamin D manipulation on skeletal muscle function in mice72P
16:30 G.J. Pinniger: Stretch-induced force enhancement studied with myosin inhibitors and by varying temperature73P
16:45 S.I. Head: Properties of regenerated EDL mouse muscle following notexin injury74P
17:00 M.S. Imtiaz: An experimentally derived Ca2+ model for the studying effects of drugs on cardiac myocytes75P
17:15 C.R. Lamboley: Sarcoplasmic reticulum Ca2+ leak in human skeletal muscle fibres is not altered with age76P


Tuesday 10th December 2013
GalleryCostaPercy BaxterLittle Percy Baxter
08:30 Symposium: Releasing pattern of pituitary hormones
Chair: Chen Chen
08:30 C. Chen: Pulsatile GH secreting profiles in positive energy balance in mice77P
09:00 P. Mollard: Navigating pituitary structure and function - defining a roadmap for hormone secretion78P
09:30 I.J. Clarke: Patterns of secretion of hypothalamic hormones79P
10:00 D.R. Grattan: Plasticity in neuroendocrine circuits controlling prolactin secretion: changing patterns of secretion to meet physiological demand80P
Symposium: Sarcoplasmic reticulum proteins in myopathy
Chair: Angela Dulhunty
08:30 S. Treves: Mapping domains and functional effect of mutations in the skeletal muscle ryanodine receptor calcium release channel81P
09:00 P.P. Jones: Cardiac ryanodine receptor mutations linked to arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+ release82P
09:30 K.N. North: Diagnosis of inherited myopathies: next generation sequencing in action83P
10:00 N.A. Beard: Stress-induced thiol modification and phosphorylation in striated muscle disorders84P
Free communications: Exercise physiology and signalling
Chairs: Stuart Warmington & Catherine Winbanks
08:30 B.P. Frankish: Single muscle fibre analysis of proteins important for glycogen metabolism in skeletal muscle from trained cyclists following varying bouts of exercise85P
08:45 S.G. Wette: Characterizing the expression of Muscle Ankyrin Repeat Proteins at rest and in response to high intensity power resistance exercise in trained human muscle86P
09:00 E. Zacharewicz: Regulation of skeletal muscle microRNAs in young and old adults following acute resistance exercise87P
09:15 D.M. Camera: Effects of protein ingestion on muscle protein synthesis and mRNA expression following consecutive resistance and endurance exercise88P
09:30 D.J. Bishop: Ammonium chloride ingestion increases resting mRNA content, but blunts exercise-induced mRNA levels in human skeletal muscle89P
09:45 S. Lamon: The role and regulation of skeletal muscle microRNAs in response to exercise90P
10:00 N.A. Strobel: Altering the redox state of skeletal muscle by glutathione depletion increases the exercise-activation of PGC-1α91P
10:15 P.A. Della Gatta: Effect of ageing and exercise training on myokine expression responses to acute exercise93P
10:30 Morning Tea
Location: Gallery
11:00 Symposium: High intensity intermittent exercise and training
Chair: Nigel Stepto
11:00 J.A. Hawley: High-intensity interval training for health and performance: A polarized perspective94P
11:30 M.J. Gibala: Application of HIT to people with metabolic disorders95P
12:00 N.K. Stepto: Acute physiological responses to a single bout of high-intensity intermittent exercise: Implications for health promotion in obesity, Polycystic Ovary Syndrome (PCOS) and cardiovascular disease96P
12:30 C.S. Shaw: High intensity interval training and intramuscular lipid metabolism in healthy and obese humans97P
Symposium: Gastrointestinal Function and Metabolism
Chair: Mark Sleeman
11:00 Mark Sleeman - No abstract provided
11:30 C. Feinle-Bisset: Gastrointestinal fat sensing – implications for appetite regulation and disorders of impaired GI nutrient sensing98P
12:00 N.L. Trevaskis: Intestinal lymphatic transport of lipids and drugs are promoted by systemic and dietary triglyceride: implications for health and disease99P
12:30 D.J. Keating: Enteroendocrine cell signalling: implications in the GI tract and beyond100P
Free communications: Cardiovascular
Chair: Graham Lamb
11:00 G.B. Bernasochi: Impaired postischemic contractile recovery in male mice overexpressing aromatase101P
11:15 L.A. Bienvenu: Cardiac functional recovery post ischemia/reperfusion is impaired by cardiomyocyte mineralocorticoid receptor activation in male and female hearts102P
11:30 U. Varma: Insulin-induced glycogen accumulation is associated with increased glycogen-autophagy in hyperglycaemic cardiomyocytes103P
11:45 E.K. Fletcher: Loss of the peripheral molecular clock blunts the cardiac response to mineralocorticoid induced cardiovascular disease104P
12:00 Y.K. Ju: The involvement of TRPC3 channels in sinoatrial arrhythmias105P
12:15 A.P. Hill: Systems analysis of clinical variability in cardiac electrical phenotypes106P
12:30 D.H. Hryciw: Altered cardiac leptin signalling in offspring born small for gestational age107P
12:45 M.E. Reichelt: Impacts of experimental type-1 diabetes on cardiac function are not the same in male and female STZ-treated mice108P
13:00 Posters and Lunch
Location: Gallery
See Monday for list. Even board authors in attendance.
15:00 Afternoon Tea
Location: Gallery
15:30 Symposium: Dietary protein in health and disease
Chair: Rene Koopman
15:30 V.G. Coffey: Nutrient-training interactions for maximising adaptation in skeletal muscle109P
16:00 L.J.C. van Loon: Dietary protein to attenuate muscle loss in the older population110P
16:30 R. Koopman: Specific amino acids that regulate muscle mass in health and disease111P
17:00 I.B. Nyulasi: Nutritional support in the ICU112P
Symposium: Physiological roles of noncoding RNA in muscle
Chairs: Enzo Porrello & Paul Gregorevic
15:30 M. Giacca: Can we achieve cardiac regeneration in humans?113P
16:00 B.C. Bernardo: Regulation of physiological cardiac hypertrophy by microRNAs115P
16:30 P. Gregorevic: microRNAs as regulators of myogenic differentiation and cell size116P
17:00 E.R. Porrello: MicroRNA control of cardiac regeneration117P
Free communications: Neuroscience
Chair: Tony Luff
15:30 M.J. Watt: Fatty acid metabolism in the hypothalamic parenchyma of mice is limited by transport across the blood brain barrier118P
15:45 N.J. Spencer: Identification of the different types of spinal afferent nerve ending that underlie pain perception from the large intestine using a novel anterograde tracing technique119P
16:00 K.E. Froud: Dynamic regulation of the cochlea amplifier in response to contralateral noise120P
16:15 A.C.Y. Wong: Differential cochlear afferent neuron response to BDNF in postnatal mouse lacking canonical transient receptor potential channel subtype 3 (TRPC3) expression121P
16:30 J.M.E. Cederholm: Analysis of the gene expression response to a temporary reduction in hearing sensitivity122P
16:45 R. Rajan: Progesterone treatment does not appear to ameliorate sensory cortical responses or behaviour in diffuse traumatic brain injury123P
17:00 A.M. Goodwill: Corticospinal plasticity and motor performance in older adults following alternate tDCS electrode arrangements124P
17:15 A.T. Weier: Age related changes in corticospinal excitability and motor function125P
19:00 Awards and AuPS Conference Dinner
Location: Hopetoun Room, The Pier, Geelong


Wednesday 11th December 2013
GalleryCostaPercy BaxterLittle Percy Baxter
09:00 Plenary Lecture
09:00 B.C. Knollmann: Calcium and arrhythmia: from genes to teens to better drugs126P
Morning Tea
Location: Gallery
Symposium: Neuro control: Exercise and disease
Chairs: Rod Snow & Dawson Kidgell
10:45 M.I. Garry: Motor cortex plasticity and the influence of menstrual phase127P
11:15 D.J. Kidgell: Transcranial stimulation, exercise and motor cortex plasticity128P
11:45 W.P. Teo: Brain-computer interface robotic training and non-invasive brain stimulation for stroke rehabilitation: possibility or virtual reality?129P
12:15 A.J. Pearce: The long-term effects of sports concussion on motor cortex plasticity in retired Australian football players130P
Free communications: Autonomic, GI and Kidney
Chair: Rick Lang
10:45 D.F. van Helden: Topical agents that inhibit lymphatic transport – a first aid against snakebite131P
11:00 S.W. White: The cyanosed myocardium: evolutionary defence against reflex coronary vasoconstriction in vertebrates including man132P
11:15 K. Fatima Shad: In vitro effects of hypolipidemic drugs on oxidative stress133P
11:30 Y.F. Lim: Are villi rigid structures during lumen flow?134P
11:45 S.J. Fairweather: Collectrin forms a functional transport unit with SLC6 amino acid 2 transporters135P
12:00 J.F. Briffa: Acute leptin exposure alters the expression of fibrotic mediators in renal proximal tubule cells in vitro136P
12:15 K.A. Jenkin: Elevated CB1 and GPR55 cannabinoid receptor expression in proximal tubule cells and whole kidney exposed to diabetic conditions137P
Free communications: Muscle and cell signalling
Chair: Kirsten Howlett
10:45 T.D. Colgan: Combinatorial gene therapy using viral vector technology to treat Duchenne muscular dystrophy138P
11:00 T. Kennedy: Investigating the effect of Heat Shock Protein 72 Induction on the Dystrophic Pathology of mdx and dko Mice139P
11:15 E.L. Brown: PGC-1α and PGC-1β regulate creatine uptake via ERRα/CrT140P
11:30 A. Hagg: AAV mediated over-expression of the β2-Adrenoceptor promotes skeletal muscle hypertrophy141P
11:45 M. Morsch: Synaptic failure and muscle weakness in anti-MuSK-Myasthenia gravis are exacerbated by cholinesterase inhibition142P
12:00 K. Anderson: The overexpression of Ndrg2 promotes C2C12 myoblast proliferation143P
Location: Gallery
13:30 AuPS AGM
Location: Percy Baxter
14:30 Symposium: Of mice and men - translating biological signals into functional regulation
Chair: Robert Lee-Young
14:30 D.H. Wasserman: Integrated control of muscle glucose uptake in health and disease - insights from transgenic mice144P
15:00 C.R. Bruce: Time course of diet-induced hepatic and skeletal muscle insulin resistance - examining the mechanisms145P
15:30 R.S. Lee-Young: Skeletal muscle glucose metabolism in health and metabolic disease146P
16:00 J.R. Davey: Generation of follistatin overexpressing db/db mice by AAV delivery ameliorates hyperglycemia and preserves pancreatic β-cell function147P
Symposium: Cardiac injury and stress
Chair: Lea Delbridge
14:30 J.R. Erickson: Hyperglycemic stress induces cardiac arrhythmia via O-linked glycosylation of CaMKII148P
15:00 L.C. Hool: The role of the cytoskeleton in regulating mitochondrial function in cardiomyopathic states149P
15:30 L.M.D. Delbridge: Myocardial responses to metabolic stress – myocyte attrition and adaptation151P
16:00 J.R. Bell: Sex steroid balance plays a role in ischemic vulnerability150P
16:30 Afternoon Tea
Location: Gallery
17:00 End of Meeting

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