PROCEEDINGS OF THE
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ISSN 0067-2084 |
Volume 43 |
2012 |
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CONTENTS |
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AuPS/ASB/PSNZ Sydney 2012 Meeting |
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| Symposium: Fatigue mechanisms limiting exercise performance | |
| Significance of group III and IV muscle afferents for the endurance exercising human | |
| M. Amann | 1 |
| Fatigue during intermittent-sprint exercise | |
| D.J Bishop | 9 |
| Symposium: Emerging leaders in developmental physiology | |
| Mechanism of alcohol-induced impairments in renal development: Could it be reduced retinoic acid? | |
| S.P. Gray, L.A. Cullen-McEwen, J.F. Bertram & K.M. Moritz | 17 |
| Effects of intrauterine infection/inflammation on fetal lung development | |
| A.J. Westover & T.J.M. Moss | 25 |
| Early origins of heart disease: Low birth weight and determinants of cardiomyocyte endowment | |
| K.J. Botting, K.C.W. Wang, M. Padhee, I.C. McMillen, B. Summers-Pearce, L. Rattanatray, N. Cutri, G.S. Posterino, D.A. Brooks & J.L. Morrison | 33 |
| The developmental origins of obesity-related hypertension | |
| S.L. Henry, B. Barzel, R.J. Wood-Bradley, S.L. Burke, G.A. Head & J.A. Armitage | 47 |
AuPS/ASCEPT/HBPRCA 2011 Perth Meeting |
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| Symposium: Being a small baby or being born preterm: Which is worse is for your health? | |
| Short and long term effects of exposure to natural and synthetic glucocorticoids during development | |
| R.R. Singh, J.S.M. Cuffe & K.M. Moritz | 57 |
| Early origins of heart disease: Low birth weight and the role of the insulin-like growth factor system in cardiac hypertrophy | |
| K.C.W. Wang, K.J. Botting, M. Padhee, S. Zhang, I.C. McMillen, C.M. Suter, D.A. Brooks & J.L. Morrison | 71 |
| Preterm neonatal cardiovascular instability: does understanding the fetus help evaluate the newborn? | |
| L. Bennet, L.C. Booth, P.P. Drury, J.S.L. Quaedackers & A.J. Gunn | 81 |
| Early life programming of cardiometabolic disease in the Western Australian pregnancy cohort (Raine) study | |
| R.C. Huang, T.A. Mori & L.J. Beilin | 93 |
| Can exercise training rescue the adverse cardiometabolic effects of low birth weight and prematurity? | |
| A.L. Siebel, A.L. Carey & B.A. Kingwell | 101 |
| Symposium: Elucidating abnormalities in cardiac metabolism | |
| Myocardial insulin resistance, metabolic stress and autophagy in diabetes | |
| K.M. Mellor, J.R. Bell, R.H. Ritchie & L.M.D. Delbridge | 117 |
AuPS/PSNZ/ASB 2012 Sydney Meeting |
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| AuPS Invited Lecture - Prof Joe Lynch | |
| The glycine receptor – a new therapeutic target for chronic inflammatory pain H. Lu, Q. Wang, Q. Shan & J.W. Lynch | 1P |
| Symposium: New insights into cardiac Ca2+ handling and excitability | |
| P21 activated kinase-1 as a key regulator of cardiac automaticity and excitability M. Lei, X. Wang, Y. Ke & R.J. Solaro | 2P |
| Involvement of calcium in pacemaker firing D.G. Allen, J. Liu, M.S. Imtiaz & Y.K. Ju | 3P |
| Role of intracellular Ca2+ in sinoatrial node pacemaking M.S. Imtiaz, D.G. Allen, D.F. van Helden & D.R. Laver | 4P |
| Effects of redox environment on calcium alternans in isolated rabbit cardiomyocytes J.N. Edwards & L.A. Blatter | 5P |
| Plasma membrane Ca2+ channel handling and arrhythmogenesis L.C. Hool, D. Longman, T. Mahzabin, H.M. Viola & E. Ingley | 6P |
| Symposium: Assessment in physiology - Changing philosophy and practice | |
| Changing assessment: shifting the emphasis to learning and use D. Boud | 7P |
| Students assessing each other - why and how? Y.M. Hodgson | 8P |
| Assessment - What, why and how? D.A. Saint, D. Horton & A. Elliott | 9P |
| Developing assessment as a collaborative endeavour P. Poronnik | 10P |
| Symposium: Advances in methods for intestinal motility | |
| Mapping and modelling human gastric slow wave activation in health and disease G. O'Grady, P. Du & L.K. Cheng | 11P |
| Multimodal recordings of intestinal motor activity P.G. Dinning | 12P |
| Computational modelling of enteric motor patterns J.D. Chambers, E.A. Thomas & J.C. Bornstein | 13P |
| Spatio-temporal maps of intestinal motor patterns M. Costa | 14P |
| Free Communications - Exercise Physiology | |
| Calcium-dependent proteolysis of junctophilin-1 and junctophilin-2 in skeletal and cardiac muscle G.D. Lamb, T.L. Dutka, D. Horvath, J.R. Bell, L.M.D. Delbridge & R.M. Murphy | 15P |
| Interpolated twitches decline progressively during a tetanic contraction of human adductor pollicis S.C. Gandevia, C.J. McNeil, T.J. Carroll & J.L. Taylor | 16P |
| Effects of high intensity power resistance exercise and feeding on mechanosensing and stress-related gene expression in human skeletal muscle S.G. Wette, M. Soop, N.P. Birch & H.K. Smith | 17P |
| Functional sympatholysis is a time- and intensity-dependent process in the contracting human calf muscle E. Cameron & S. Green | 18P |
| Acute cardiac responses to blood flow restriction strength exercise C.R. Brandner, D.J. Kidgell & S.A. Warmington | 19P |
| Neural control of blood flow to a contracting muscle: roles of central command and metaboreceptors D. Boulton, C.E. Taylor, V.G. Macefield & S. Green | 20P |
| The effects of exercise duration on cerebral oxygenation in the human prefrontal cortex at moderate exercise intensity J. Yamauchi & K. Kobayashi | 21P |
| Team Based Learning to undergraduates at Deakin University G.D. Wadley, I. Story, M. Wallace & R.J. Snow | 22P |
| Symposium: Molecular insight via advanced fluorescence microscopy | |
| New flow cytometry tricks to view protein conformations in cells and their subcellular localization D.M. Hatters, Y.M. Ramdzan, A.R. Ormsby, S. Polling & K. Jovanoski | 23P |
| Imaging transcription factors in the living mouse embryo N. Plachta | 25P |
| Evidence for, and function of, sub-resolution ordered membrane domains D.M. Owen, D.J. Williamson, A. Magenau & K. Gaus | 26P |
| Symposium: Cystic fibrosis: Today and tomorrow | |
| Fluorogen activating proteins report corrector-mediated restoration of mutant CFTR trafficking to the cell surface and its regulated peripheral recycling J.P. Holleran, S.C. Watkins & R.A. Frizzell | 27P |
| Hypertonic saline nebulisation for pulmonary disease in people with cystic fibrosis P.T.P. Bye, R. Dentice, T. Dwyer, C. Moriarty & M. Elkins | 28P |
| Early lung disease in cystic fibrosis C.E. Wainwright | 29P |
| Developing a gene therapy for cystic fibrosis airway disease D. Parsons | 30P |
| Symposium: Bridging the gap between molecular reductionism and physiology- the usefulness of ‘omics’ | |
| Using targeted mass spectrometry-based metabolomics to dissect metabolic flux in health and disease T.R. Koves | 31P |
| Identification of factors secreted from the fatty liver: impact on metabolic function in other tissues R.C. Meex, A. Morris, A.J. Hoy, R. Brown, P.J. Meilke, M.P. Molloy & M.J. Watt | 32P |
| Muscle secretory factors - where are we at a decade later? M.A. Febbraio | 33P |
| A gene expression signature for insulin resistance K. Walder | 34P |
| Free Communications - General Physiology | |
| The role of TRPM2 channels in paracetamol overdose-induced Ca2+ entry in hepatocytes E. Kheradpezhouh, G.J. Barritt & G.Y. Rychkov | 35P |
| Gestational age at time of the initial exposure to lipopolysaccharide determines the severity of diaphragmatic contractile dysfunction in preterm lambs K. Karisnan, J.J. Pillow, A.J. Bakker, C. Berry, P. Noble & G.J. Pinniger | 36P |
| Anthracycline-induced dysfunction of cardiac SR Ca2+ handling: a potential pathway to anthracycline-induced cardiotoxicity A.D. Hanna, A. Lam, A.F. Dulhunty & N.A. Beard | 37P |
| Calcium binding to the EF hand motif regulates polycystin 2 function I.Y. Kuo, C. Keeler, M.E. Hodsdon & B.E. Ehrlich | 38P |
| The role of a newly discovered pancreatic islet peptide in the control of insulin secretion K.W. Stewart, A.R.J. Phillips, L. Whiting & G.J.S. Cooper | 39P |
| Huntingtin-associated protein 1 (HAP1) regulates exocytosis, vesicle localization and interacts with multiple vesicle proteins D.J. Keating, K.D. Mackenzie & X.F. Zhou | 40P |
| Posters | |
| Anabolic effect of formoterol administration on skeletal muscle is not impaired by co-treatment with the β1-adrenoceptor antagonist CGP-20712A V. Zaitsev, J.E. Church, T. Naim, P. Gregorevic, R. Koopman & G.S. Lynch | 41P |
| Endogenous and maximal sarcoplasmic reticulum calcium content in human vastus lateralis muscle fibres is decreased with ageing C.R. Lamboley, R.M. Murphy, M.J. McKenna & G.D. Lamb | 42P |
| Human aging and expression of proteins interacting with the ryanodine receptor in skeletal muscle H. Willemse, P.N. Smith, P.G. Board, M.G. Casarotto & A.F. Dulhunty | 43P |
| The pathogenesis of inflammation in knee osteoarthritis and its effect on muscle function C. van der Poel, P. Levinger, I. Levinger & N.C. Walsh | 44P |
| Calpastatin and m-calpain have different cellular localizations in rat skeletal muscle: implications for function J.P. Mollica, R.M. Murphy & G.D. Lamb | 45P |
| Online feedback assessments in introductory physiology courses: effects on students’ learning experience and outcomes N.Y. Marden, L.G. Ulman & G.M. Velan | 46P |
| Taurine improves tibialis anterior force production and muscle architecture in the 28 day old mdx mouse model of Duchenne muscular dystrophy R.G. Barker, C. van der Poel, R.M. Murphy & D. Horvath | 47P |
| SR pump function and fatigue characteristics of fast fibres from α-actinin-3-deficient speed gene knockout mice S. Chan, P.J. Houweling, K.N. North & S.I. Head | 48P |
| The oxidative profile of white adipose tissue is not related to intrinsic exercise capacity or whole-body metabolic health E.J. Stephenson, S.J. Lessard, D.A. Rivas, B.B. Yaspelkis III, L.G. Koch, S.L. Britton & J.A. Hawley | 49P |
| Contraction induces a cyclic promoter hypomethylation in mouse skeletal muscle C.A. Lucas, A.J. Kee, G. Chen, J.T. Treebak, R. Barres, P.W. Gunning & E.C. Hardeman | 50P |
| The effect of amylase treatment on the detection of glycogenin, glycogen debranching enzyme and glycogen phosphorylase proteins in rat fast-twitch skeletal muscle H. Xu, D. Stapleton & R.M. Murphy | 51P |
| The role of epigenetic modifications in the long term memory
of cancer treatment V. Nylander, M. Aznar, L. Specht, J. Zierath & R. Barres | 52P |
| Acute neural responses to blood flow restriction strength exercise C.R. Brandner, S.A. Warmington & D.J. Kidgell | 53P |
| A photothrombosis-induced ischaemic infarct model for study of hind brain stroke A.J. Craig, A. Krishnan & G.D. Housley | 54P |
| Understanding the molecular gates of KirBac3.1 S. El-Ajouz, A.P. Hill, J.M. Gulbis & J.I. Vandenberg | 55P |
| Influence of cell morphology in computational models of on and off retinal ganglion cells T. Guo, D. Tsai, G.J. Suaning, N.H. Lovell & S. Dokos | 56P |
| Binding site of Scorpion toxin HsTx1 to the potassium channel Kv1.1 and Kv1.3 from Molecular Dynamics simulations M.H. Rashid & S. Kuyucak | 57P |
| Identification and characterization of novel synthetic variabilin analogues targeting the glycine receptor Cl− channels S. Talwar, X. Xiao, R. Islam, A. Keramidas, R. J. Capon & J.W. Lynch | 58P |
| Computational investigation of μ-conotoxin binding to voltage gated sodium channels S. Mahdavi & S. Kuyucak | 59P |
| Olivocochlear reflex strength and the auditory attentional filter C. Bester, D. Robertson, M. Atlas & G. Hammond | 60P |
| Further measurements of liquid junction potentials, and their implications, using a refined freshly-cut 3M KCl reference salt-bridge methodology P.H. Barry, T.M. Lewis & A.J. Moorhouse | 61P |
| Probenecid, a gout treatment, blocks the human P2X7 receptor A. Bhaskaracharya, P. Dao-Ung, I. Jalilian, M. Spildrejorde, K. Skarratt, S. Fuller, R. Sluyter & L. Stokes | 62P |
| Agonist selectivity of neuronal glycine receptors J.R. Lawson, H.-S. Tae & B.A. Cromer | 63P |
| Cannabinoid receptor 2 expression in proximal tubule cells exposed to elevated glucose and albumin K.A. Jenkin, A.J. McAinch & D.H. Hryciw | 64P |
| Identifying key amino acid residues for α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors H. Cuny, A.A. Grishin, A. Hung, R.J. Clark, K.B. Akondi, A. Brust, P.F. Alewood, D.J. Craik & D.J. Adams | 65P |
| Pharmacological characterization of individual subtypes of α4β3δ GABAA receptor, include the novel description of β3δ GABAA receptor subtype H.J. Lee, N.L. Absalom, J. Hanrahan & M. Collins | 66P |
| Melittin-membrane interaction follows lipid-specific multi-step mechanism T.K.H. Nguyen & A. Mechler | 67P |
| Using artificial synapses to investigate GABAA receptor kinetics C.L. Dixon, A. Keramidas, P. Sah & J.W. Lynch | 68P |
| A salt-bridge network determines agonist size selectivity in ρ1 GABAC receptor H.-S. Tae & B.A. Cromer | 69P |
| Mixed antagonistic effects of the ginkgolides at recombinant human ρ1 GABAC receptors S.H. Huang, T.M. Lewis, S.C.R. Lummis, A.J. Thompson, M. Chebib, G.A.R. Johnston & R.K. Duke | 70P |
| Are the putative N-terminal α-helix and preceding residues important in GABAA/C receptor function? L.W. Wong, H.-S. Tae & B.A. Cromer | 71P |
| Membrane trafficking and localization, residence time and degradation of KCa3.1 in a polarized epithelium S.-L. Lee, B. Winter, D.C. Devor & K.L. Hamilton | 72P |
| Structural insight into the CLIC1 integral membrane structure by fluorescence resonance energy transfer and electron microscopy J.E. Hare, S.C. Goodchild, R.D. Willows & L.J. Brown | 74P |
| Effects of new human startle disease mutations on glycine receptor function and structure A. Bode, S.K. Chung, A. Keramidas, M.I. Rees & J.W. Lynch | 75P |
| The ATP-bound state of P-glycoprotein is closed towards the cell exterior T. Stockner, Y. Dönmez & P. Chiba | 76P |
| TRPC3c (high activity) transient receptor potential channel expression in the mouse brain Y. Kim, M. Klugmann, A.J. Moorhouse, P.P. Bertrand & G.D. Housley | 77P |
| Determining a link between XLID and missense mutations in Chloride Intracellular Ion Channel Protein 2 (CLIC2): a biophysical approach E.L. Daniel, J.E. Hare & L.J. Brown | 78P |
| Differential movement of M4 transmembrane segments during activation of α1 and α3 glycine receptors L. Han, S. Talwar & J.W. Lynch | 79P |
| Insights into voltage gated sodium channel NavAb function from multi-microsecond molecular dynamics simulations C. Boiteux, I. Vorobyov & T.W. Allen | 80P |
| Modulation of GlyT2 by endogenous lipid based compounds occurs through interactions with EL3 L.J. Munro, R.M. Ryan & R.J. Vandenberg | 81P |
| Molecular Dynamics simulations on a bacterial homolog of the human glutamate transporters G. Heinzelmann & S. Kuyucak | 82P |
| Characterization of the muscle-motor neuron topography of the mouse forelimb A.P. Tosolini, R. Mohan & R. Morris | 83P |
| The binding of morphine and nicardipine to the multidrug transporter P-glycoprotein N. Subramanian, M.L. O'Mara & A.E. Mark | 84P |
| Characterization of the muscle-motor neuron topography of the mouse hindlimb R. Mohan, A.P. Tosolini & R. Morris | 85P |
| Timecourse of development of hyperactivity in the auditory midbrain after cochlear trauma D. Robertson & W. Mulders | 86P |
| Evaluation of auditory nerve fibre recruitment by eABR via cochlear implant stimulation in the guinea-pig model J.L. Pinyon & G.D. Housley | 87P |
| Electrical restitution properties of rabbit atrial tissue A. Al Abed, N.H. Lovell & S. Dokos | 88P |
| Acute effects of insulin on the endothelium-dependent dilation of rat cremaster muscle arteries G. Ivanov, S. Senadheera, S.L. Sandow & T.V. Murphy | 89P |
| Three-dimensional modeling of Ca2+ dynamics in single cardiac cells M.S. Imtiaz, D.F. van Helden & D.R. Laver | 90P |
| Calcium waves alter dendritic spine morphology in basolateral amygdala projection neurons J.M. Power & P. Sah | 91P |
| The importance of cardiac ion channels on the electrocardiogram - partial least squares regression as a new tool in computational biology S.A. Mann, A. Sadrieh, J.I. Vandenberg & A.P. Hill | 92P |
| Atorvastatin-induced changes in micro-vascular smooth muscle function X.H. Chan & S.J. Potocnik | 93P |
| Symposium: Spectral imaging in physiology – a highlight of techniques | |
| Combining microelectrode recordings from human peripheral nerves with functional magnetic resonance imaging of the brain V.G. Macefield, C. James & L.A. Henderson | 94P |
| AMP-activated protein kinase β subunit requires internal motion for optimal carbohydrate binding P.R. Gooley, M. Bieri, A. Koay, J.I. Mobbs, D. Neumann & D. Stapleton | 95P |
| The how and why of glycogen ultrastructure - implications for physiology and disease D. Stapleton, P.R. Gooley & R.M. Murphy | 96P |
| Single muscle fibre analysis reveals differential fibre type, localization and stimulation responses of enzymes important for glycogen metabolism: insights into muscle glycogen structure and function R.M. Murphy, H. Xu, H. Latchman, N.T. Larkins, P.R. Gooley & D. Stapleton | 97P |
| Free communications - Channels: Molecular Interactions | |
| Salt concentration effects on the viscoelasticity of supported bilayers A. Mechler & T.K.H. Nguyen | 98P |
| Combining experiment and simulations to characterize the interactions of a sea-anemone toxin with the analgesic target acid-sensing ion channel 3 E. Deplazes, L.D. Rash, R. Gamsjaeger, A.K. Malde, A.E. Mark & G.F. King | 99P |
| The S4 domain is directly involved in determining the voltage sensitivity of Kv11.1 channel inactivation M.D. Perry, S. Wong, C.A. Ng & J.I. Vandenberg | 100P |
| Molecular mechanisms for agonist selectivity in inhibitory Cys-loop ligand-gated ion channels H.-S. Tae, J.R. Lawson & B.A. Cromer | 101P |
| Orientation of the bacterial mechanosensitive channel MscS in liposomal membranes T. Nomura & B. Martinac | 102P |
| Ion selectivity of the mechanosensitive channel MscS is determined by charged residues within the cytoplasmic vestibulum C.D. Cox, C.S. Ziegler, A.K. Campbell, K.T. Wann & B. Martinac | 103P |
| Free communications - Cardiac Physiology | |
| Mechanisms contributing to angiotensin II induced increases in nerve-evoked contractions of mouse tail artery T.F. Reardon & J.A. Brock | 104P |
| Asian immigrants to Australia show a lower sympathetic component to the baro-reflex than resident caucasians, as measured by heart rate variability analysis D.A. Saint, L. Casey & A. Elliott | 105P |
| Propofol selectively modifies the arterial chemoreflex during severe hypoxia in the rabbit A.W. Quail, D.B. Cottee, R. Roach & S.W. White | 106P |
| The serotonin pathway – a therapeutic target for pulmonary hypertension? Assessing vascular function using synchrotron radiation microangiography D.O. Schwenke, E.A. Gray, J.T. Pearson, T. Sonobe, K. Umetani & M. Shirai | 107P |
| An augmented CaMKII response in the post-ischemic female heart is not proarrhythmic – towards understanding the sex-specificity of CaMKII pathophysiology J.R. Bell, A.J.A. Raaijmakers, M.E. Reichelt, C.L. Curl & L.M.D. Delbridge | 108P |
| A cardiac troponin I mutation that causes familial dilated cardiomyopathy A. Li, D. King, E. Kable, D. Dooijes, P.S. Macdonald, F. Braet, S. Ishiwata & C.G. dos Remedios | 109P |
| Free Communcations - Neuro-signalling | |
| Modulation of cochlear amplifier performance by contralateral suppression K.E. Froud, A.C.Y. Wong & G.D. Housley | 110P |
| Enterochromaffin cells release 5-HT with synaptic kinetics R. Raghupathi, L. Zelkas, M. Duffield, N. Spencer & D.J. Keating | 111P |
| Transcriptional responses to noise stress in mice J.M.E. Cederholm, K.E. Froud, W. Kaplan & G.D. Housley | 112P |
| Septal glucagon-like peptide 1 receptors (GLP-1Rs) mediate the behavioural effects of cocaine A.E. Harasta, M. Schneider, R. Spanagel, G.D. Housley & M. Klugmann | 113P |
| Human amniotic epithelial cell therapy for preterm perinatal asphyxia L.G.T. van den Heuij, M. Fraser, A.J. Gunn & L. Bennet | 114P |
| Pre-synaptic pH changes and vesicle fusion at the Drosophila neuromuscular junction L. Caldwell, P. Harries, S. Sydlik & C.J. Schwiening | 115P |
| Symposium: Perinatal asphyxia: adaptation and consequences | |
| Making birth safer A.J. Gunn | 116P |
| Resuscitating the asphyxic infant at birth S.B. Hooper, K.S. Sobotka, T. Ong, G.R. Polglase & C. Klingenberg | 117P |
| Brain inflammation and injury resulting from chorioamnionitis is exacerbated by resuscitation in preterm lambs G.R. Polglase, S.K. Barton, S.B. Hooper, S.L. Miller, T.J.M. Moss, F. Wong, K.C. Crossley, A.W. Gill, M. Kluckow & M. Tolcos | 118P |
| New strategies to protect the newborn brain J.D. Aridas, T. Yawno, M. Ditchfield, M. Fahey, F. Wong, E.M. Wallace, G. Jenkin & S.L. Miller | 119P |
| Maternal glucocorticoids: timing is everything for the fetal brain L. Bennet | 120P |
| Symposium: A vignette of TRP ion channel physiology | |
| TRPC channels: An overview L. Birnbaumer | 121P |
| Multiple roles for transient receptor potential (TRP) non-selective cation channels in liver function G.J. Barritt | 125P |
| TRPM2 channels in oxidative stress-induced cell death G.Y. Rychkov, E. Kheradpezhouh & G.J. Barritt | 126P |
| Proteolytic regulation of TRP channels: implications for pain and neurogenic inflammation N.W. Bunnett | 127P |
| Myoendothelial microdomains and TRPC3: anatomical links to function S.L. Sandow, T.H. Grayson, Y. Kim, G.D. Housley, P.P. Bertrand, T.V. Murphy, L. Birnbaumer, S.P. Marrelli, M. Tare & S. Senadheera | 129P |
| Free Communications: ASB Young Investigator & Spectroscopy | |
| Quantification and detection of DNA in eukaryotic cells using Fourier transform infrared spectroscopy D.R. Whelan, K.R. Bambery, L. Puskar, D. McNaughton & B.R. Wood | 130P |
| Super-resolution imaging of cells using a home built dSTORM microscope costing less than A$100k T.D.M. Bell & D.R. Whelan | 131P |
| dSTORM super-resolution made cheap and easy T. Holm, S. Wolter, T. Klein, A. Loeschberger, S. van de Linde & M. Sauer | 132P |
| Antimicrobial peptide activity in a competitive lipid environment M.-A. Sani, T.C. Whitwell, J.D. Gehman & F. Separovic | 133P |
| Tethered Bilayer Lipid Membranes (tBLMs) to measure pore formation by antimicrobial peptide (AMP) insertion C.G. Cranfield, B. Cornell, S. L. Grage, P. Duckworth, S. Carne, A. S. Ulrich & B. Martinac | 134P |
| Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels P.S. Tan, M.D. Perry, C.A. Ng, J.I. Vandenberg & A.P. Hill | 135P |
| Characterizing various inward rectifier potassium channels T.A. Hilder & S.H. Chung | 136P |
| Kinetic comparisons of heart and kidney Na+,K+-ATPases A. Garcia, H.H. Rasmussen, H.-J. Apell & R.J. Clarke | 137P |
| Free Communications - Muscle Metabolism/Signalling | |
| Regulation of plasma ceramide levels with fatty acid oversupply - evidence that the liver detects and secretes de novo synthesized ceramide A.J. Hoy, A.C. Barnett, C.R. Bruce, S. Schenk, J.F. Horowitz & M.J. Watt | 138P |
| Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis A.P. Russell, S. Wada, L. Vergani, S. Lamon, T. Ushida, G.D. Wadley, G. Soraru, C. Angelini & T. Akimoto | 139P |
| A switch in metabolism underlies the initiation of MyoD transcription in satellite cells J.G. Ryall, S. Dell'Orso, A. Derfoul, A. Juan, M. Fulco, G. Gutierrez-Cruz, Y. Gu & V. Sartorelli | 140P |
| Glycine, a pharmaco-nutrient that protects muscle cells from cachectic stimuli in vitro and in vivo R. Koopman, D.J. Ham, A. Chee, K.T. Murphy & G.S. Lynch | 141P |
| Suppression of NDRG2, a novel PGC-1α and PGC-1β target gene, contributes to the metabolic profile and protein synthesis rates of skeletal muscle cells V.C. Foletta, E.L. Brown & A.P. Russell | 142P |
| Citrulline protects muscle cells from cachectic stimuli and preserves protein metabolism in vitro D.J. Ham, D.I. Stapleton, G.S. Lynch & R. Koopman | 143P |
| Role of glycogen depletion in muscle fatigue S. Trajanovska, D.K. Chong & D.G. Allen | 144P |
| Local sensitivity analysis of GLUT4 translocation in response to insulin C.W. Gray & A.C.F. Coster | 145P |
| AuPS Plenary Lecture - Scandinavian Exchange Lecturer - Prof Håkan Westerblad | |
| Muscle fatigue H. Westerblad | 146P |
| Symposium: Calcium signalling in microdomains essential to normal cell function | |
| Imaging the motility of inositol trisphosphate receptors in intact mammalian cells using single particle tracking photoactivated localization microscopy (sptPALM) I.F. Smith, D. Swaminathan & I. Parker | 147P |
| Three-dimensional analysis of the tubular networks in mammalian and amphibian skeletal muscle fibres I.D. Jayasinghe, D. Baddeley, C. Soeller & B.S. Launikonis | 148P |
| Specialization of the skeletal muscle junctional membranes allow rapid activation of store-operated calcium entry, tightly controlled by [Ca2+]SR B.S. Launikonis | 149P |
| Focal secretion of insulin within intact islets of langerhans J. Low, J. Mitchell, J. Bax & P. Thorn | 150P |
| Symposium: Science at the high performance computing frontier | |
| Genomics Virtual Laboratory M. Pheasant, E. Afgan, C. Sloggett & A. Lonie | 151P |
| Long time scale molecular simulations for understanding ion channel function B. Corry | 153P |
| Sharing physiological models P.M.F. Nielsen | 154P |
| Massive parallelization of cardiac simulations using unconventional processing architectures A. Sadrieh | 155P |
| Free communications - Transporters | |
| Mapping the chloride permeation pathway of a human glutamate transporter R.J. Cater, R.J. Vandenberg & R.M. Ryan | 156P |
| Molecular determinants for functional differences between the neutral amino acid transporter ASCT1 and acidic amino acid transporters of the EAAT family A.J. Scopelliti, R.M. Ryan & R.J. Vandenberg | 157P |
| γ hydroxybutyrate activates specific GABAA receptor subtypes N.L. Absalom, L. Eghorn, N. Karim, I. Villamusen, A. Kobryn, P. Wellendorph & M. Chebib | 158P |
| Oleoyl L-carnitine inhibits glycine transport by GLYT2 J.E. Carland, R.E. Mansfield, R.M. Ryan & R.J. Vandenberg | 159P |
| Using N-modified aspartate analogues to probe the ‘open-to-inside’ structure of the bacterial aspartate transporter, GltPh R.M. Ryan, B.C. McIlwain, M. Salim & R.J. Vandenberg | 160P |
| Conformational dynamics of an archaeal aspartate transporter are determined by the lipid bilayer B.C. McIlwain, R.J. Vandenberg & R.M. Ryan | 161P |
| Benzamil, but not triamterene, reduces mechanosensitive 5-HT release from EC cells of guinea pig intestine K.E. Polglaze, R.L. Bertrand & P.P. Bertrand | 162P |
| Enhanced T-type calcium channel function, but not L-type or TRPC3 channels, augments uteroplacental arterial vascular tone in late pregnancy S. Senadheera, M. Tare, L. Leader, P.P. Bertrand, T.V. Murphy & S.L. Sandow | 163P |
| Symposium: Muscular adaptations to exercise: mechanisms at play | |
| Adaptations to exercise: the role of epigenetic changes R. Barres | 164P |
| AMPK signaling and exercise B.E. Kemp, J.S. Oakhill, J.W. Scott, M.D. Fullerton, S. Galic, H.M. O'Neill & G.R. Steinberg | 165P |
| Sending the message: Training-nutrient interactions to stimulate mitochondrial biogenesis J.A. Hawley | 166P |
| Exercise central haemodynamics: mechanisms and relation to end organ damage J.E. Sharman | 167P |
| Symposium: Integrative physiology of the heart | |
| Multi-scale cardiac energetics S. Goo, T. Pham, J.-C. Han, A.J. Taberner, P.M.F. Nielsen, A. Hickey & D.S. Loiselle | 168P |
| Cardiac ischemia - different contexts and different consequences L.M.D. Delbridge, S.B. Harrap, C.L. Curl & J.R. Bell | 169P |
| Cardiomyocyte group architecture and electrical activation pathways in the heart M.L. Trew, G.B. Sands, I.J. LeGrice & B.H. Smaill | 170P |
| Computational analysis of the contribution of ionic conductances to ECG parameters A. Sadrieh, S.A. Mann, R.N. Subbiah, J.I. Vandenberg & A.P. Hill | 171P |
| Free communications - Molecular Dynamics | |
| Rational drug design from toxins - how rational can one get? S. Kuyucak | 172P |
| Binding of scorpion toxins to the voltage sensors of Na+ channels: molecular dynamics studies R. Chen & S.H. Chung | 173P |
| Brownian dynamics simulation of ion channel block by polypeptide toxins D. Gordon & S.H. Chung | 174P |
| Biological channel mimics for use as desalination membranes M. Thomas & B. Corry | 175P |
| Catalysis in silico H. Yu | 176P |
| The effect of ATP binding on the conformation of P-glycoprotein M.L. O'Mara & A.E. Mark | 177P |
| The effect of environment on the recognition and binding of vancomycin to native and resistance forms of lipid II Z. Jia, M.L. O'Mara, J. Zuegg, M.A. Cooper & A.E. Mark | 178P |
| Long molecular dynamics simulations to explore ion channel function I. Vorobyov, C. Boiteux & T.W. Allen | 179P |
| Free communications - Gene for Speed | |
| Overcoming the barrier of sample size: The ACTN3 R577X polymorphism across three groups of elite European athletes N. Eynon, D.J. Bishop, V.P. Pushkarev, P. Cieszczyk & A. Lucia | 180P |
| Deficiency of a fast twitch muscle fibre protein alters muscle adaptation in response to denervation and immobilization F. Garton, J.T. Seto, P.J. Houweling, K.G. Quinlan, N. Yang & K.N. North | 181P |
| α-Actinin-3: a novel genetic modifier of Duchenne muscular dystrophy M.W. Hogarth, P.J. Houweling, H. Gordish-Dressman, E.P. Hoffman, S.I. Head & K.N. North | 182P |
| Alterations in Ca2+ transients and SR function in isolated fast fibres from α-actinin-3-deficient speed gene knockout mice S.I. Head, S. Chan, P.J. Houweling, R.M. Murphy, K.G. Quinlan & K.N. North | 183P |
| Metabolic consequences of α-actinin-3 deficiency – more than a structural muscle protein! P.J. Houweling, Y. Berman, N. Turner, K.G. Quinlan, N. Yang, G. Cooney & K.N. North | 184P |
| Mutations in the α-tropomyosin-slow gene (TPM3) cause sarcomeric dysfunction in slow muscle fibres M. Kreissl, C. Ottenheijm, K.N. North & N.F. Clarke | 185P |
| Free Communications - Cardiac Physiology | |
| Functional analyses of a cluster of CCD mutations reveals a gating module within TM6 of RyR1 A.F. Dulhunty, L. Groom, S. Goonasekera, S. Mirza, A.D. Hanna, E.M. Gallant, C. Segovis, R.T. Rebbeck, M.G. Casarotto & R.T. Dirksen | 186P |
| Regulation of human RYR2 by intracellular Ca2+ and Mg2+ K. Walweel, N.A. Beard, J. Li, D.F. van Helden, M.S. Imtiaz, P. Molenaar & D.R. Laver | 187P |
| Adrenergic stimulation increases RYR2 activity via intracellular Ca2+ and Mg2+ regulation J. Li, M.S. Imtiaz, N.A. Beard, A.F. Dulhunty, R. Thorne, D.F. van Helden & D.R. Laver | 188P |
| Role of cardiac Na+ channel blockers and Mg2+ in inhibiting the cardiac calcium release channel D. Mehra, D.F. van Helden & D.R. Laver | 189P |
| Store-operated calcium entry activity revealed by confocal live cell calcium imaging in isolated mouse pacemaker cells J. Liu, D.G. Allen & Y.K. Ju | 190P |
| Autonomic functions and serum leptin levels in normal and obese, a comparative study A. Gogoi, M. Gogoi & A. Khasag | 191P |
| PSNZ - John Hubbard and Mary Bullivant Student Prize Competition | |
| Does the heart really operate at 'isoefficiency'? J.-C. Han, A.J. Taberner, P.M.F. Nielsen & D.S. Loiselle | 192P |
| Sympathetic modulation of cardiac function in diabetes - in vivo and ex vivo study H.P.A. Thaung, J.C. Baldi, D.O. Schwenke & R.R. Lamberts | 193P |
| Inflammation of the proximal colon of IL10−/− mice induced by Helicobacter typhlonius infection reduces anion secretion and expression of the NaHCO3 cotransporter, NBCe1 S. Fan, M. Schultz & A.G. Butt | 194P |
| Invited Lecture - Prof Lutz Birnbaumer | |
| TRPC channels: on-going discovery of molecular physiological function in relation to store operated Ca2+ entry and Orai proteins L. Birnbaumer & Y. Zhang | 195P |
| Symposium: Brain dysfunction and translational neurophysiology | |
| Optogenetical approach to reveal the regulatory mechanism of instinctive behaviors by the hypothalamic neurons A. Yamanaka & T. Tsunematsu | 196P |
| Glia and neuron interactions: their role in synapse remodeling in vivo J. Nabekura, K.S. Kim, H. Inada, K. Eto & H. Wake | 197P |
| Membrane transporters regulating inhibitory neurotransmitter signaling in health and disease A.J. Moorhouse, M. Watanabe & J. Nabekura | 198P |
| Traumatic brain injury and sensory cortex: using barrel cortex to understand functional changes in the injured brain R. Rajan, D. Alwis, V. Johnstone & E. Yan | 199P |
| Excitability and action potential in human axons D. Burke | 200P |
| Central assessment of motor dysfunction using transcranial magnetic stimulation M.C. Kiernan | 201P |
| Symposium: Autonomic physiology - nutrient sensing in the GI tract | |
| Nutrient-sensing in the GI tract: fat, the gut microbiota and obesity H.E. Raybould | 202P |
| Dysregulation of intestinal glucose sensing and transport in critical illness R.L. Young | 203P |
| Iron sensing by the intestine: A new model for iron-induced changes to GI motility P.P. Bertrand, K. Wang, C.H. Koo, S. Senadheera, T.V. Murphy, S.L. Sandow, L. Liu, J.C. Bornstein & R.L. Bertrand | 204P |
| Nutrient sensing in the human gastrointestinal lumen - role in appetite regulation and implications for obesity C. Feinle-Bisset | 205P |
| Symposium: Skeletal muscle in health and disease | |
| Mitochondrial myopathies H. Westerblad | 206P |
| Insights into and therapies for nemaline myopathy E. Hardeman | 207P |
| Tackling muscle wasting in cancer K.T. Murphy | 208P |
| Uncovering the genetics of neuromuscular foetal akinesias using next generation sequencing G. Ravenscroft & N.G. Laing | 209P |
| Symposium: Developments in auditory and vestibular physiology | |
| Nanomechanical mechanisms of cochlear amplification A.W. Gummer | 210P |
| Neurohumoral mechanisms for regulating sound transduction G.D. Housley, K.E. Froud, A.C.Y. Wong, J.M.E. Cederholm & A.F. Ryan | 211P |
| Spreadsheet analysis of ion transport in epithelia R.B. Patuzzi | 212P |
| Factors affecting clinical outcomes in adult patients with cochlear implants P. J. Blamey & D. S. Lazard | 213P |
| The other part of the ear – a ‘balanced’ view R. Lim, R.J. Callister & A.M. Brichta | 214P |
| The sensitive response of irregular otolithic vestibular afferents to bone conducted vibration and air conducted sound underpins fast, simple, safe clinical testing of otolithic function I.S. Curthoys, V. Vulovic, L. Sokolic, J. Pogson, M. Robins & A.M. Burgess | 215P |
| Symposium: Ion Channels as drug targets | |
| Exploiting toxins to probe pain pathways D. Julius, C.J. Bohlen, A.T. Chesler & A. Priel | 216P |
| Spider-venom peptides that target the human Nav1.7 channel:
potential analgesics for the treatment of chronic pain G.F. King | 217P |
| Conotoxins targeting voltage-gated sodium channels: harnessing nature’s analgesics R.S. Norton, K.K. Khoo, Z. Kuang, B.R. Green, K. Gupta, M.J. Wilson, M. Zhang, J.E.F. Rivier, P. Balaram, D. Yoshikami, B.M. Olivera & G. Bulaj | 218P |
| Modulation of Cys-loop receptors to address CNS disorders M. Chebib | 219P |
| Correlating functional models of channel activation with subunit specific GABAA receptors A. Keramidas, S. Talwar & J. W. Lynch | 220P |
| Free Communications - Muscle Diseases | |
| Targeting activin to counteract muscle wasting and cachexia J.L. Chen, K.L. Walton, S.L. Al-Musawi, K.T. Murphy, G.S. Lynch, C.A. Harrison & P. Gregorevic | 221P |
| Calpain-3 deficiency results in the perturbation of specific Ca2+-handling proteins in skeletal muscle of mice B.P. Frankish & R.M. Murphy | 222P |
| Adeno-associated virus directed expression of Orai1 to examine store operated calcium entry in wild-type and dystrophic skeletal muscle T.R. Cully, R.M. Murphy, B.W. Purdue, W.G. Thomas, P. Gregorevic & B.S. Launikonis | 223P |
| Combinatorial gene therapy using AAV technology to treat Duchenne muscular dystrophy T.D. Colgan, K.T. Murphy, G.S. Lynch & P. Gregorevic | 224P |
| Altered expression of heat shock proteins in Duchenne muscular dystrophy T. Kennedy, K. Swiderski, S.M. Gehrig, K.T. Murphy, R. Koopman & G.S. Lynch | 225P |
| Time-course of decline in the size of neuromuscular synaptic contacts with sedentary aging in mice A. Cheng, M. Morsch & W.D. Phillips | 226P |
| A new view of fibre type transformations in elderly skeletal muscles P.W. Sheard, N. Lal & J. Cornwall | 227P |
| Patient autoantibodies reveal the role of muscle specific kinase in maintaining the mature neuromuscular junction M. Morsch, S.W. Reddel, N. Ghazanfari, K.V. Toyka & W.D. Phillips | 228P |
| Endogenous phosphorylation of the dystrophin protein modulates protein function K. Swiderski, S. Shafer, B. Gallis, G.L. Odom, A.L. Arnett, J.S. Edgar, K.T. Murphy, T. Naim, D.M. Baum, D. Goodlett, G.S. Lynch & J.S. Chamberlain | 229P |
| Free communications 8 | |
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