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ISSN 0067-2084

Volume 43



AuPS/ASB 2010 Adelaide Meeting

Symposium: Fatigue mechanisms limiting exercise performance
Significance of group III and IV muscle afferents for the endurance exercising human
M. Amann 1
Fatigue during intermittent-sprint exercise
D.J Bishop 9
Symposium: Emerging leaders in developmental physiology
Mechanism of alcohol-induced impairments in renal development: Could it be reduced retinoic acid?
S.P. Gray, L.A. Cullen-McEwen, J.F. Bertram & K.M. Moritz 17
Effects of intrauterine infection/inflammation on fetal lung development
A.J. Westover & T.J.M. Moss 25
Early origins of heart disease: Low birth weight and determinants of cardiomyocyte endowment
K.J. Botting, K.C.W. Wang, M. Padhee, I.C. McMillen, B. Summers-Pearce, L. Rattanatray, N. Cutri, G.S. Posterino, D.A. Brooks & J.L. Morrison 33
The developmental origins of obesity-related hypertension
S.L. Henry, B. Barzel, R.J. Wood-Bradley, S.L. Burke, G.A. Head & J.A. Armitage 47

AuPS/ASCEPT/HBPRCA 2011 Perth Meeting

Symposium: Being a small baby or being born preterm: Which is worse is for your health?
Short and long term effects of exposure to natural and synthetic glucocorticoids during development
R.R. Singh, J.S.M. Cuffe & K.M. Moritz 57
Early origins of heart disease: Low birth weight and the role of the insulin-like growth factor system in cardiac hypertrophy
K.C.W. Wang, K.J. Botting, M. Padhee, S. Zhang, I.C. McMillen, C.M. Suter, D.A. Brooks & J.L. Morrison 71
Preterm neonatal cardiovascular instability: does understanding the fetus help evaluate the newborn?
L. Bennet, L.C. Booth, P.P. Drury, J.S.L. Quaedackers & A.J. Gunn 81
Early life programming of cardiometabolic disease in the Western Australian pregnancy cohort (Raine) study
R.C. Huang, T.A. Mori & L.J. Beilin 93
Can exercise training rescue the adverse cardiometabolic effects of low birth weight and prematurity?
A.L. Siebel, A.L. Carey & B.A. Kingwell 101
Symposium: Elucidating abnormalities in cardiac metabolism
Myocardial insulin resistance, metabolic stress and autophagy in diabetes
K.M. Mellor, J.R. Bell, R.H. Ritchie & L.M.D. Delbridge 117

AuPS/PSNZ/ASB 2012 Sydney Meeting

AuPS Invited Lecture - Prof Joe Lynch
The glycine receptor – a new therapeutic target for chronic inflammatory pain
H. Lu, Q. Wang, Q. Shan & J.W. Lynch1P
Symposium: New insights into cardiac Ca2+ handling and excitability
P21 activated kinase-1 as a key regulator of cardiac automaticity and excitability
M. Lei, X. Wang, Y. Ke & R.J. Solaro2P
Involvement of calcium in pacemaker firing
D.G. Allen, J. Liu, M.S. Imtiaz & Y.K. Ju3P
Role of intracellular Ca2+ in sinoatrial node pacemaking
M.S. Imtiaz, D.G. Allen, D.F. van Helden & D.R. Laver4P
Effects of redox environment on calcium alternans in isolated rabbit cardiomyocytes
J.N. Edwards & L.A. Blatter5P
Plasma membrane Ca2+ channel handling and arrhythmogenesis
L.C. Hool, D. Longman, T. Mahzabin, H.M. Viola & E. Ingley6P
Symposium: Assessment in physiology - Changing philosophy and practice
Changing assessment: shifting the emphasis to learning and use
D. Boud7P
Students assessing each other - why and how?
Y.M. Hodgson8P
Assessment - What, why and how?
D.A. Saint, D. Horton & A. Elliott9P
Developing assessment as a collaborative endeavour
P. Poronnik10P
Symposium: Advances in methods for intestinal motility
Mapping and modelling human gastric slow wave activation in health and disease
G. O'Grady, P. Du & L.K. Cheng11P
Multimodal recordings of intestinal motor activity
P.G. Dinning12P
Computational modelling of enteric motor patterns
J.D. Chambers, E.A. Thomas & J.C. Bornstein13P
Spatio-temporal maps of intestinal motor patterns
M. Costa14P
Free Communications - Exercise Physiology
Calcium-dependent proteolysis of junctophilin-1 and junctophilin-2 in skeletal and cardiac muscle
G.D. Lamb, T.L. Dutka, D. Horvath, J.R. Bell, L.M.D. Delbridge & R.M. Murphy15P
Interpolated twitches decline progressively during a tetanic contraction of human adductor pollicis
S.C. Gandevia, C.J. McNeil, T.J. Carroll & J.L. Taylor16P
Effects of high intensity power resistance exercise and feeding on mechanosensing and stress-related gene expression in human skeletal muscle
S.G. Wette, M. Soop, N.P. Birch & H.K. Smith17P
Functional sympatholysis is a time- and intensity-dependent process in the contracting human calf muscle
E. Cameron & S. Green18P
Acute cardiac responses to blood flow restriction strength exercise
C.R. Brandner, D.J. Kidgell & S.A. Warmington19P
Neural control of blood flow to a contracting muscle: roles of central command and metaboreceptors
D. Boulton, C.E. Taylor, V.G. Macefield & S. Green20P
The effects of exercise duration on cerebral oxygenation in the human prefrontal cortex at moderate exercise intensity
J. Yamauchi & K. Kobayashi21P
Team Based Learning to undergraduates at Deakin University
G.D. Wadley, I. Story, M. Wallace & R.J. Snow22P
Symposium: Molecular insight via advanced fluorescence microscopy
New flow cytometry tricks to view protein conformations in cells and their subcellular localization
D.M. Hatters, Y.M. Ramdzan, A.R. Ormsby, S. Polling & K. Jovanoski23P
Imaging transcription factors in the living mouse embryo
N. Plachta25P
Evidence for, and function of, sub-resolution ordered membrane domains
D.M. Owen, D.J. Williamson, A. Magenau & K. Gaus26P
Symposium: Cystic fibrosis: Today and tomorrow
Fluorogen activating proteins report corrector-mediated restoration of mutant CFTR trafficking to the cell surface and its regulated peripheral recycling
J.P. Holleran, S.C. Watkins & R.A. Frizzell27P
Hypertonic saline nebulisation for pulmonary disease in people with cystic fibrosis
P.T.P. Bye, R. Dentice, T. Dwyer, C. Moriarty & M. Elkins28P
Early lung disease in cystic fibrosis
C.E. Wainwright29P
Developing a gene therapy for cystic fibrosis airway disease
D. Parsons30P
Symposium: Bridging the gap between molecular reductionism and physiology- the usefulness of ‘omics’
Using targeted mass spectrometry-based metabolomics to dissect metabolic flux in health and disease
T.R. Koves31P
Identification of factors secreted from the fatty liver: impact on metabolic function in other tissues
R.C. Meex, A. Morris, A.J. Hoy, R. Brown, P.J. Meilke, M.P. Molloy & M.J. Watt32P
Muscle secretory factors - where are we at a decade later?
M.A. Febbraio33P
A gene expression signature for insulin resistance
K. Walder34P
Free Communications - General Physiology
The role of TRPM2 channels in paracetamol overdose-induced Ca2+ entry in hepatocytes
E. Kheradpezhouh, G.J. Barritt & G.Y. Rychkov35P
Gestational age at time of the initial exposure to lipopolysaccharide determines the severity of diaphragmatic contractile dysfunction in preterm lambs
K. Karisnan, J.J. Pillow, A.J. Bakker, C. Berry, P. Noble & G.J. Pinniger36P
Anthracycline-induced dysfunction of cardiac SR Ca2+ handling: a potential pathway to anthracycline-induced cardiotoxicity
A.D. Hanna, A. Lam, A.F. Dulhunty & N.A. Beard37P
Calcium binding to the EF hand motif regulates polycystin 2 function
I.Y. Kuo, C. Keeler, M.E. Hodsdon & B.E. Ehrlich38P
The role of a newly discovered pancreatic islet peptide in the control of insulin secretion
K.W. Stewart, A.R.J. Phillips, L. Whiting & G.J.S. Cooper39P
Huntingtin-associated protein 1 (HAP1) regulates exocytosis, vesicle localization and interacts with multiple vesicle proteins
D.J. Keating, K.D. Mackenzie & X.F. Zhou40P
Anabolic effect of formoterol administration on skeletal muscle is not impaired by co-treatment with the β1-adrenoceptor antagonist CGP-20712A
V. Zaitsev, J.E. Church, T. Naim, P. Gregorevic, R. Koopman & G.S. Lynch41P
Endogenous and maximal sarcoplasmic reticulum calcium content in human vastus lateralis muscle fibres is decreased with ageing
C.R. Lamboley, R.M. Murphy, M.J. McKenna & G.D. Lamb42P
Human aging and expression of proteins interacting with the ryanodine receptor in skeletal muscle
H. Willemse, P.N. Smith, P.G. Board, M.G. Casarotto & A.F. Dulhunty43P
The pathogenesis of inflammation in knee osteoarthritis and its effect on muscle function
C. van der Poel, P. Levinger, I. Levinger & N.C. Walsh44P
Calpastatin and m-calpain have different cellular localizations in rat skeletal muscle: implications for function
J.P. Mollica, R.M. Murphy & G.D. Lamb45P
Online feedback assessments in introductory physiology courses: effects on students’ learning experience and outcomes
N.Y. Marden, L.G. Ulman & G.M. Velan46P
Taurine improves tibialis anterior force production and muscle architecture in the 28 day old mdx mouse model of Duchenne muscular dystrophy
R.G. Barker, C. van der Poel, R.M. Murphy & D. Horvath47P
SR pump function and fatigue characteristics of fast fibres from α-actinin-3-deficient speed gene knockout mice
S. Chan, P.J. Houweling, K.N. North & S.I. Head48P
The oxidative profile of white adipose tissue is not related to intrinsic exercise capacity or whole-body metabolic health
E.J. Stephenson, S.J. Lessard, D.A. Rivas, B.B. Yaspelkis III, L.G. Koch, S.L. Britton & J.A. Hawley49P
Contraction induces a cyclic promoter hypomethylation in mouse skeletal muscle
C.A. Lucas, A.J. Kee, G. Chen, J.T. Treebak, R. Barres, P.W. Gunning & E.C. Hardeman50P
The effect of amylase treatment on the detection of glycogenin, glycogen debranching enzyme and glycogen phosphorylase proteins in rat fast-twitch skeletal muscle
H. Xu, D. Stapleton & R.M. Murphy51P
The role of epigenetic modifications in the long term memory of cancer treatment
V. Nylander, M. Aznar, L. Specht, J. Zierath & R. Barres52P
Acute neural responses to blood flow restriction strength exercise
C.R. Brandner, S.A. Warmington & D.J. Kidgell53P
A photothrombosis-induced ischaemic infarct model for study of hind brain stroke
A.J. Craig, A. Krishnan & G.D. Housley54P
Understanding the molecular gates of KirBac3.1
S. El-Ajouz, A.P. Hill, J.M. Gulbis & J.I. Vandenberg55P
Influence of cell morphology in computational models of on and off retinal ganglion cells
T. Guo, D. Tsai, G.J. Suaning, N.H. Lovell & S. Dokos56P
Binding site of Scorpion toxin HsTx1 to the potassium channel Kv1.1 and Kv1.3 from Molecular Dynamics simulations
M.H. Rashid & S. Kuyucak57P
Identification and characterization of novel synthetic variabilin analogues targeting the glycine receptor Cl channels
S. Talwar, X. Xiao, R. Islam, A. Keramidas, R. J. Capon & J.W. Lynch58P
Computational investigation of μ-conotoxin binding to voltage gated sodium channels
S. Mahdavi & S. Kuyucak59P
Olivocochlear reflex strength and the auditory attentional filter
C. Bester, D. Robertson, M. Atlas & G. Hammond60P
Further measurements of liquid junction potentials, and their implications, using a refined freshly-cut 3M KCl reference salt-bridge methodology
P.H. Barry, T.M. Lewis & A.J. Moorhouse61P
Probenecid, a gout treatment, blocks the human P2X7 receptor
A. Bhaskaracharya, P. Dao-Ung, I. Jalilian, M. Spildrejorde, K. Skarratt, S. Fuller, R. Sluyter & L. Stokes62P
Agonist selectivity of neuronal glycine receptors
J.R. Lawson, H.-S. Tae & B.A. Cromer63P
Cannabinoid receptor 2 expression in proximal tubule cells exposed to elevated glucose and albumin
K.A. Jenkin, A.J. McAinch & D.H. Hryciw64P
Identifying key amino acid residues for α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors
H. Cuny, A.A. Grishin, A. Hung, R.J. Clark, K.B. Akondi, A. Brust, P.F. Alewood, D.J. Craik & D.J. Adams65P
Pharmacological characterization of individual subtypes of α4β3δ GABAA receptor, include the novel description of β3δ GABAA receptor subtype
H.J. Lee, N.L. Absalom, J. Hanrahan & M. Collins66P
Melittin-membrane interaction follows lipid-specific multi-step mechanism
T.K.H. Nguyen & A. Mechler67P
Using artificial synapses to investigate GABAA receptor kinetics
C.L. Dixon, A. Keramidas, P. Sah & J.W. Lynch68P
A salt-bridge network determines agonist size selectivity in ρ1 GABAC receptor
H.-S. Tae & B.A. Cromer69P
Mixed antagonistic effects of the ginkgolides at recombinant human ρ1 GABAC receptors
S.H. Huang, T.M. Lewis, S.C.R. Lummis, A.J. Thompson, M. Chebib, G.A.R. Johnston & R.K. Duke70P
Are the putative N-terminal α-helix and preceding residues important in GABAA/C receptor function?
L.W. Wong, H.-S. Tae & B.A. Cromer71P
Membrane trafficking and localization, residence time and degradation of KCa3.1 in a polarized epithelium
S.-L. Lee, B. Winter, D.C. Devor & K.L. Hamilton72P
Structural insight into the CLIC1 integral membrane structure by fluorescence resonance energy transfer and electron microscopy
J.E. Hare, S.C. Goodchild, R.D. Willows & L.J. Brown74P
Effects of new human startle disease mutations on glycine receptor function and structure
A. Bode, S.K. Chung, A. Keramidas, M.I. Rees & J.W. Lynch75P
The ATP-bound state of P-glycoprotein is closed towards the cell exterior
T. Stockner, Y. Dönmez & P. Chiba76P
TRPC3c (high activity) transient receptor potential channel expression in the mouse brain
Y. Kim, M. Klugmann, A.J. Moorhouse, P.P. Bertrand & G.D. Housley77P
Determining a link between XLID and missense mutations in Chloride Intracellular Ion Channel Protein 2 (CLIC2): a biophysical approach
E.L. Daniel, J.E. Hare & L.J. Brown78P
Differential movement of M4 transmembrane segments during activation of α1 and α3 glycine receptors
L. Han, S. Talwar & J.W. Lynch79P
Insights into voltage gated sodium channel NavAb function from multi-microsecond molecular dynamics simulations
C. Boiteux, I. Vorobyov & T.W. Allen80P
Modulation of GlyT2 by endogenous lipid based compounds occurs through interactions with EL3
L.J. Munro, R.M. Ryan & R.J. Vandenberg81P
Molecular Dynamics simulations on a bacterial homolog of the human glutamate transporters
G. Heinzelmann & S. Kuyucak82P
Characterization of the muscle-motor neuron topography of the mouse forelimb
A.P. Tosolini, R. Mohan & R. Morris83P
The binding of morphine and nicardipine to the multidrug transporter P-glycoprotein
N. Subramanian, M.L. O'Mara & A.E. Mark84P
Characterization of the muscle-motor neuron topography of the mouse hindlimb
R. Mohan, A.P. Tosolini & R. Morris85P
Timecourse of development of hyperactivity in the auditory midbrain after cochlear trauma
D. Robertson & W. Mulders86P
Evaluation of auditory nerve fibre recruitment by eABR via cochlear implant stimulation in the guinea-pig model
J.L. Pinyon & G.D. Housley87P
Electrical restitution properties of rabbit atrial tissue
A. Al Abed, N.H. Lovell & S. Dokos88P
Acute effects of insulin on the endothelium-dependent dilation of rat cremaster muscle arteries
G. Ivanov, S. Senadheera, S.L. Sandow & T.V. Murphy89P
Three-dimensional modeling of Ca2+ dynamics in single cardiac cells
M.S. Imtiaz, D.F. van Helden & D.R. Laver90P
Calcium waves alter dendritic spine morphology in basolateral amygdala projection neurons
J.M. Power & P. Sah91P
The importance of cardiac ion channels on the electrocardiogram - partial least squares regression as a new tool in computational biology
S.A. Mann, A. Sadrieh, J.I. Vandenberg & A.P. Hill92P
Atorvastatin-induced changes in micro-vascular smooth muscle function
X.H. Chan & S.J. Potocnik93P
Symposium: Spectral imaging in physiology – a highlight of techniques
Combining microelectrode recordings from human peripheral nerves with functional magnetic resonance imaging of the brain
V.G. Macefield, C. James & L.A. Henderson94P
AMP-activated protein kinase β subunit requires internal motion for optimal carbohydrate binding
P.R. Gooley, M. Bieri, A. Koay, J.I. Mobbs, D. Neumann & D. Stapleton95P
The how and why of glycogen ultrastructure - implications for physiology and disease
D. Stapleton, P.R. Gooley & R.M. Murphy96P
Single muscle fibre analysis reveals differential fibre type, localization and stimulation responses of enzymes important for glycogen metabolism: insights into muscle glycogen structure and function
R.M. Murphy, H. Xu, H. Latchman, N.T. Larkins, P.R. Gooley & D. Stapleton97P
Free communications - Channels: Molecular Interactions
Salt concentration effects on the viscoelasticity of supported bilayers
A. Mechler & T.K.H. Nguyen98P
Combining experiment and simulations to characterize the interactions of a sea-anemone toxin with the analgesic target acid-sensing ion channel 3
E. Deplazes, L.D. Rash, R. Gamsjaeger, A.K. Malde, A.E. Mark & G.F. King99P
The S4 domain is directly involved in determining the voltage sensitivity of Kv11.1 channel inactivation
M.D. Perry, S. Wong, C.A. Ng & J.I. Vandenberg100P
Molecular mechanisms for agonist selectivity in inhibitory Cys-loop ligand-gated ion channels
H.-S. Tae, J.R. Lawson & B.A. Cromer101P
Orientation of the bacterial mechanosensitive channel MscS in liposomal membranes
T. Nomura & B. Martinac102P
Ion selectivity of the mechanosensitive channel MscS is determined by charged residues within the cytoplasmic vestibulum
C.D. Cox, C.S. Ziegler, A.K. Campbell, K.T. Wann & B. Martinac103P
Free communications - Cardiac Physiology
Mechanisms contributing to angiotensin II induced increases in nerve-evoked contractions of mouse tail artery
T.F. Reardon & J.A. Brock104P
Asian immigrants to Australia show a lower sympathetic component to the baro-reflex than resident caucasians, as measured by heart rate variability analysis
D.A. Saint, L. Casey & A. Elliott105P
Propofol selectively modifies the arterial chemoreflex during severe hypoxia in the rabbit
A.W. Quail, D.B. Cottee, R. Roach & S.W. White106P
The serotonin pathway – a therapeutic target for pulmonary hypertension? Assessing vascular function using synchrotron radiation microangiography
D.O. Schwenke, E.A. Gray, J.T. Pearson, T. Sonobe, K. Umetani & M. Shirai107P
An augmented CaMKII response in the post-ischemic female heart is not proarrhythmic – towards understanding the sex-specificity of CaMKII pathophysiology
J.R. Bell, A.J.A. Raaijmakers, M.E. Reichelt, C.L. Curl & L.M.D. Delbridge108P
A cardiac troponin I mutation that causes familial dilated cardiomyopathy
A. Li, D. King, E. Kable, D. Dooijes, P.S. Macdonald, F. Braet, S. Ishiwata & C.G. dos Remedios109P
Free Communcations - Neuro-signalling
Modulation of cochlear amplifier performance by contralateral suppression
K.E. Froud, A.C.Y. Wong & G.D. Housley110P
Enterochromaffin cells release 5-HT with synaptic kinetics
R. Raghupathi, L. Zelkas, M. Duffield, N. Spencer & D.J. Keating111P
Transcriptional responses to noise stress in mice
J.M.E. Cederholm, K.E. Froud, W.  Kaplan & G.D. Housley112P
Septal glucagon-like peptide 1 receptors (GLP-1Rs) mediate the behavioural effects of cocaine
A.E. Harasta, M. Schneider, R. Spanagel, G.D. Housley & M. Klugmann113P
Human amniotic epithelial cell therapy for preterm perinatal asphyxia
L.G.T. van den Heuij, M. Fraser, A.J. Gunn & L. Bennet114P
Pre-synaptic pH changes and vesicle fusion at the Drosophila neuromuscular junction
L. Caldwell, P. Harries, S. Sydlik & C.J. Schwiening115P
Symposium: Perinatal asphyxia: adaptation and consequences
Making birth safer
A.J. Gunn116P
Resuscitating the asphyxic infant at birth
S.B. Hooper, K.S. Sobotka, T. Ong, G.R. Polglase & C. Klingenberg117P
Brain inflammation and injury resulting from chorioamnionitis is exacerbated by resuscitation in preterm lambs
G.R. Polglase, S.K. Barton, S.B. Hooper, S.L. Miller, T.J.M. Moss, F. Wong, K.C. Crossley, A.W. Gill, M. Kluckow & M. Tolcos118P
New strategies to protect the newborn brain
J.D. Aridas, T. Yawno, M. Ditchfield, M. Fahey, F. Wong, E.M. Wallace, G. Jenkin & S.L. Miller119P
Maternal glucocorticoids: timing is everything for the fetal brain
L. Bennet120P
Symposium: A vignette of TRP ion channel physiology
TRPC channels: An overview
L. Birnbaumer121P
Multiple roles for transient receptor potential (TRP) non-selective cation channels in liver function
G.J. Barritt125P
TRPM2 channels in oxidative stress-induced cell death
G.Y. Rychkov, E. Kheradpezhouh & G.J. Barritt126P
Proteolytic regulation of TRP channels: implications for pain and neurogenic inflammation
N.W. Bunnett127P
Myoendothelial microdomains and TRPC3: anatomical links to function
S.L. Sandow, T.H. Grayson, Y. Kim, G.D. Housley, P.P. Bertrand, T.V. Murphy, L. Birnbaumer, S.P. Marrelli, M. Tare & S. Senadheera129P
Free Communications: ASB Young Investigator & Spectroscopy
Quantification and detection of DNA in eukaryotic cells using Fourier transform infrared spectroscopy
D.R. Whelan, K.R. Bambery, L. Puskar, D. McNaughton & B.R. Wood130P
Super-resolution imaging of cells using a home built dSTORM microscope costing less than A$100k
T.D.M. Bell & D.R. Whelan131P
dSTORM super-resolution made cheap and easy
T. Holm, S. Wolter, T. Klein, A. Loeschberger, S. van de Linde & M. Sauer132P
Antimicrobial peptide activity in a competitive lipid environment
M.-A. Sani, T.C. Whitwell, J.D. Gehman & F. Separovic133P
Tethered Bilayer Lipid Membranes (tBLMs) to measure pore formation by antimicrobial peptide (AMP) insertion
C.G. Cranfield, B. Cornell, S. L. Grage, P. Duckworth, S. Carne, A. S. Ulrich & B. Martinac134P
Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels
P.S. Tan, M.D. Perry, C.A. Ng, J.I. Vandenberg & A.P. Hill135P
Characterizing various inward rectifier potassium channels
T.A. Hilder & S.H. Chung136P
Kinetic comparisons of heart and kidney Na+,K+-ATPases
A. Garcia, H.H. Rasmussen, H.-J. Apell & R.J. Clarke137P
Free Communications - Muscle Metabolism/Signalling
Regulation of plasma ceramide levels with fatty acid oversupply - evidence that the liver detects and secretes de novo synthesized ceramide
A.J. Hoy, A.C. Barnett, C.R. Bruce, S. Schenk, J.F. Horowitz & M.J. Watt138P
Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis
A.P. Russell, S. Wada, L. Vergani, S. Lamon, T. Ushida, G.D. Wadley, G. Soraru, C. Angelini & T. Akimoto139P
A switch in metabolism underlies the initiation of MyoD transcription in satellite cells
J.G. Ryall, S. Dell'Orso, A. Derfoul, A. Juan, M. Fulco, G. Gutierrez-Cruz, Y. Gu & V. Sartorelli140P
Glycine, a pharmaco-nutrient that protects muscle cells from cachectic stimuli in vitro and in vivo
R. Koopman, D.J. Ham, A. Chee, K.T. Murphy & G.S. Lynch141P
Suppression of NDRG2, a novel PGC-1α and PGC-1β target gene, contributes to the metabolic profile and protein synthesis rates of skeletal muscle cells
V.C. Foletta, E.L. Brown & A.P. Russell142P
Citrulline protects muscle cells from cachectic stimuli and preserves protein metabolism in vitro
D.J. Ham, D.I. Stapleton, G.S. Lynch & R. Koopman143P
Role of glycogen depletion in muscle fatigue
S. Trajanovska, D.K. Chong & D.G. Allen144P
Local sensitivity analysis of GLUT4 translocation in response to insulin
C.W. Gray & A.C.F. Coster145P
AuPS Plenary Lecture - Scandinavian Exchange Lecturer - Prof Håkan Westerblad
Muscle fatigue
H. Westerblad146P
Symposium: Calcium signalling in microdomains essential to normal cell function
Imaging the motility of inositol trisphosphate receptors in intact mammalian cells using single particle tracking photoactivated localization microscopy (sptPALM)
I.F. Smith, D. Swaminathan & I. Parker147P
Three-dimensional analysis of the tubular networks in mammalian and amphibian skeletal muscle fibres
I.D. Jayasinghe, D. Baddeley, C. Soeller & B.S. Launikonis148P
Specialization of the skeletal muscle junctional membranes allow rapid activation of store-operated calcium entry, tightly controlled by [Ca2+]SR
B.S. Launikonis149P
Focal secretion of insulin within intact islets of langerhans
J. Low, J. Mitchell, J. Bax & P. Thorn150P
Symposium: Science at the high performance computing frontier
Genomics Virtual Laboratory
M. Pheasant, E. Afgan, C. Sloggett & A. Lonie151P
Long time scale molecular simulations for understanding ion channel function
B. Corry153P
Sharing physiological models
P.M.F. Nielsen154P
Massive parallelization of cardiac simulations using unconventional processing architectures
A. Sadrieh155P
Free communications - Transporters
Mapping the chloride permeation pathway of a human glutamate transporter
R.J. Cater, R.J. Vandenberg & R.M. Ryan156P
Molecular determinants for functional differences between the neutral amino acid transporter ASCT1 and acidic amino acid transporters of the EAAT family
A.J. Scopelliti, R.M. Ryan & R.J. Vandenberg157P
γ hydroxybutyrate activates specific GABAA receptor subtypes
N.L. Absalom, L. Eghorn, N. Karim, I. Villamusen, A. Kobryn, P. Wellendorph & M. Chebib158P
Oleoyl L-carnitine inhibits glycine transport by GLYT2
J.E. Carland, R.E. Mansfield, R.M. Ryan & R.J. Vandenberg159P
Using N-modified aspartate analogues to probe the ‘open-to-inside’ structure of the bacterial aspartate transporter, GltPh
R.M. Ryan, B.C. McIlwain, M. Salim & R.J. Vandenberg160P
Conformational dynamics of an archaeal aspartate transporter are determined by the lipid bilayer
B.C. McIlwain, R.J. Vandenberg & R.M. Ryan161P
Benzamil, but not triamterene, reduces mechanosensitive 5-HT release from EC cells of guinea pig intestine
K.E. Polglaze, R.L. Bertrand & P.P. Bertrand162P
Enhanced T-type calcium channel function, but not L-type or TRPC3 channels, augments uteroplacental arterial vascular tone in late pregnancy
S. Senadheera, M. Tare, L. Leader, P.P. Bertrand, T.V. Murphy & S.L. Sandow163P
Symposium: Muscular adaptations to exercise: mechanisms at play
Adaptations to exercise: the role of epigenetic changes
R. Barres164P
AMPK signaling and exercise
B.E. Kemp, J.S. Oakhill, J.W. Scott, M.D. Fullerton, S. Galic, H.M. O'Neill & G.R. Steinberg165P
Sending the message: Training-nutrient interactions to stimulate mitochondrial biogenesis
J.A. Hawley166P
Exercise central haemodynamics: mechanisms and relation to end organ damage
J.E. Sharman167P
Symposium: Integrative physiology of the heart
Multi-scale cardiac energetics
S. Goo, T. Pham, J.-C. Han, A.J. Taberner, P.M.F. Nielsen, A. Hickey & D.S. Loiselle168P
Cardiac ischemia - different contexts and different consequences
L.M.D. Delbridge, S.B. Harrap, C.L. Curl & J.R. Bell169P
Cardiomyocyte group architecture and electrical activation pathways in the heart
M.L. Trew, G.B. Sands, I.J. LeGrice & B.H. Smaill170P
Computational analysis of the contribution of ionic conductances to ECG parameters
A. Sadrieh, S.A. Mann, R.N. Subbiah, J.I. Vandenberg & A.P. Hill171P
Free communications - Molecular Dynamics
Rational drug design from toxins - how rational can one get?
S. Kuyucak172P
Binding of scorpion toxins to the voltage sensors of Na+ channels: molecular dynamics studies
R. Chen & S.H. Chung173P
Brownian dynamics simulation of ion channel block by polypeptide toxins
D. Gordon & S.H. Chung174P
Biological channel mimics for use as desalination membranes
M. Thomas & B. Corry175P
Catalysis in silico
H. Yu176P
The effect of ATP binding on the conformation of P-glycoprotein
M.L. O'Mara & A.E. Mark177P
The effect of environment on the recognition and binding of vancomycin to native and resistance forms of lipid II
Z. Jia, M.L. O'Mara, J. Zuegg, M.A. Cooper & A.E. Mark178P
Long molecular dynamics simulations to explore ion channel function
I. Vorobyov, C. Boiteux & T.W. Allen179P
Free communications - Gene for Speed
Overcoming the barrier of sample size: The ACTN3 R577X polymorphism across three groups of elite European athletes
N. Eynon, D.J. Bishop, V.P. Pushkarev, P. Cieszczyk & A. Lucia180P
Deficiency of a fast twitch muscle fibre protein alters muscle adaptation in response to denervation and immobilization
F. Garton, J.T. Seto, P.J. Houweling, K.G. Quinlan, N. Yang & K.N. North181P
α-Actinin-3: a novel genetic modifier of Duchenne muscular dystrophy
M.W. Hogarth, P.J. Houweling, H. Gordish-Dressman, E.P. Hoffman, S.I. Head & K.N. North182P
Alterations in Ca2+ transients and SR function in isolated fast fibres from α-actinin-3-deficient speed gene knockout mice
S.I. Head, S. Chan, P.J. Houweling, R.M. Murphy, K.G. Quinlan & K.N. North183P
Metabolic consequences of α-actinin-3 deficiency – more than a structural muscle protein!
P.J. Houweling, Y. Berman, N. Turner, K.G. Quinlan, N. Yang, G. Cooney & K.N. North184P
Mutations in the α-tropomyosin-slow gene (TPM3) cause sarcomeric dysfunction in slow muscle fibres
M. Kreissl, C. Ottenheijm, K.N. North & N.F. Clarke185P
Free Communications - Cardiac Physiology
Functional analyses of a cluster of CCD mutations reveals a gating module within TM6 of RyR1
A.F. Dulhunty, L. Groom, S. Goonasekera, S. Mirza, A.D. Hanna, E.M. Gallant, C. Segovis, R.T. Rebbeck, M.G. Casarotto & R.T. Dirksen186P
Regulation of human RYR2 by intracellular Ca2+ and Mg2+
K. Walweel, N.A. Beard, J. Li, D.F. van Helden, M.S. Imtiaz, P. Molenaar & D.R. Laver187P
Adrenergic stimulation increases RYR2 activity via intracellular Ca2+ and Mg2+ regulation
J. Li, M.S. Imtiaz, N.A. Beard, A.F. Dulhunty, R. Thorne, D.F. van Helden & D.R. Laver188P
Role of cardiac Na+ channel blockers and Mg2+ in inhibiting the cardiac calcium release channel
D. Mehra, D.F. van Helden & D.R. Laver189P
Store-operated calcium entry activity revealed by confocal live cell calcium imaging in isolated mouse pacemaker cells
J. Liu, D.G. Allen & Y.K. Ju190P
Autonomic functions and serum leptin levels in normal and obese, a comparative study
A. Gogoi, M. Gogoi & A. Khasag191P
PSNZ - John Hubbard and Mary Bullivant Student Prize Competition
Does the heart really operate at 'isoefficiency'?
J.-C. Han, A.J. Taberner, P.M.F. Nielsen & D.S. Loiselle192P
Sympathetic modulation of cardiac function in diabetes - in vivo and ex vivo study
H.P.A. Thaung, J.C. Baldi, D.O. Schwenke & R.R. Lamberts193P
Inflammation of the proximal colon of IL10−/− mice induced by Helicobacter typhlonius infection reduces anion secretion and expression of the NaHCO3 cotransporter, NBCe1
S. Fan, M. Schultz & A.G. Butt194P
Invited Lecture - Prof Lutz Birnbaumer
TRPC channels: on-going discovery of molecular physiological function in relation to store operated Ca2+ entry and Orai proteins
L. Birnbaumer & Y. Zhang195P
Symposium: Brain dysfunction and translational neurophysiology
Optogenetical approach to reveal the regulatory mechanism of instinctive behaviors by the hypothalamic neurons
A. Yamanaka & T. Tsunematsu196P
Glia and neuron interactions: their role in synapse remodeling in vivo
J. Nabekura, K.S. Kim, H. Inada, K. Eto & H. Wake197P
Membrane transporters regulating inhibitory neurotransmitter signaling in health and disease
A.J. Moorhouse, M. Watanabe & J. Nabekura198P
Traumatic brain injury and sensory cortex: using barrel cortex to understand functional changes in the injured brain
R. Rajan, D. Alwis, V. Johnstone & E. Yan199P
Excitability and action potential in human axons
D. Burke200P
Central assessment of motor dysfunction using transcranial magnetic stimulation
M.C. Kiernan201P
Symposium: Autonomic physiology - nutrient sensing in the GI tract
Nutrient-sensing in the GI tract: fat, the gut microbiota and obesity
H.E. Raybould202P
Dysregulation of intestinal glucose sensing and transport in critical illness
R.L. Young203P
Iron sensing by the intestine: A new model for iron-induced changes to GI motility
P.P. Bertrand, K. Wang, C.H. Koo, S. Senadheera, T.V. Murphy, S.L. Sandow, L. Liu, J.C. Bornstein & R.L. Bertrand204P
Nutrient sensing in the human gastrointestinal lumen - role in appetite regulation and implications for obesity
C. Feinle-Bisset205P
Symposium: Skeletal muscle in health and disease
Mitochondrial myopathies
H. Westerblad206P
Insights into and therapies for nemaline myopathy
E. Hardeman207P
Tackling muscle wasting in cancer
K.T. Murphy208P
Uncovering the genetics of neuromuscular foetal akinesias using next generation sequencing
G. Ravenscroft & N.G. Laing209P
Symposium: Developments in auditory and vestibular physiology
Nanomechanical mechanisms of cochlear amplification
A.W. Gummer210P
Neurohumoral mechanisms for regulating sound transduction
G.D. Housley, K.E. Froud, A.C.Y. Wong, J.M.E. Cederholm & A.F. Ryan211P
Spreadsheet analysis of ion transport in epithelia
R.B. Patuzzi212P
Factors affecting clinical outcomes in adult patients with cochlear implants
P. J. Blamey & D. S. Lazard213P
The other part of the ear – a ‘balanced’ view
R. Lim, R.J. Callister & A.M. Brichta214P
The sensitive response of irregular otolithic vestibular afferents to bone conducted vibration and air conducted sound underpins fast, simple, safe clinical testing of otolithic function
I.S. Curthoys, V. Vulovic, L. Sokolic, J. Pogson, M. Robins & A.M. Burgess215P
Symposium: Ion Channels as drug targets
Exploiting toxins to probe pain pathways
D. Julius, C.J. Bohlen, A.T. Chesler & A. Priel216P
Spider-venom peptides that target the human Nav1.7 channel: potential analgesics for the treatment of chronic pain
G.F. King217P
Conotoxins targeting voltage-gated sodium channels: harnessing nature’s analgesics
R.S. Norton, K.K. Khoo, Z. Kuang, B.R. Green, K. Gupta, M.J. Wilson, M. Zhang, J.E.F. Rivier, P. Balaram, D. Yoshikami, B.M. Olivera & G. Bulaj218P
Modulation of Cys-loop receptors to address CNS disorders
M. Chebib219P
Correlating functional models of channel activation with subunit specific GABAA receptors
A. Keramidas, S. Talwar & J. W. Lynch220P
Free Communications - Muscle Diseases
Targeting activin to counteract muscle wasting and cachexia
J.L. Chen, K.L. Walton, S.L. Al-Musawi, K.T. Murphy, G.S. Lynch, C.A. Harrison & P. Gregorevic221P
Calpain-3 deficiency results in the perturbation of specific Ca2+-handling proteins in skeletal muscle of mice
B.P. Frankish & R.M. Murphy222P
Adeno-associated virus directed expression of Orai1 to examine store operated calcium entry in wild-type and dystrophic skeletal muscle
T.R. Cully, R.M. Murphy, B.W. Purdue, W.G. Thomas, P. Gregorevic & B.S. Launikonis223P
Combinatorial gene therapy using AAV technology to treat Duchenne muscular dystrophy
T.D. Colgan, K.T. Murphy, G.S. Lynch & P. Gregorevic224P
Altered expression of heat shock proteins in Duchenne muscular dystrophy
T. Kennedy, K. Swiderski, S.M. Gehrig, K.T. Murphy, R. Koopman & G.S. Lynch225P
Time-course of decline in the size of neuromuscular synaptic contacts with sedentary aging in mice
A. Cheng, M. Morsch & W.D. Phillips226P
A new view of fibre type transformations in elderly skeletal muscles
P.W. Sheard, N. Lal & J. Cornwall227P
Patient autoantibodies reveal the role of muscle specific kinase in maintaining the mature neuromuscular junction
M. Morsch, S.W. Reddel, N. Ghazanfari, K.V. Toyka & W.D. Phillips228P
Endogenous phosphorylation of the dystrophin protein modulates protein function
K. Swiderski, S. Shafer, B. Gallis, G.L. Odom, A.L. Arnett, J.S. Edgar, K.T. Murphy, T. Naim, D.M. Baum, D. Goodlett, G.S. Lynch & J.S. Chamberlain229P
Free communications 8


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