AuPS 2015 Hobart Programme

Author index

Sunday 29th November 2015
MS1MS2Rm 158
13:00 Education workshop: Designing assessments in physiology
Chairs: Yvonne Hodgson & Joel Michael
13:00 Welcome
13:10 J.A. Michael: Using MCQs to assess causal reasoning1P
13:30 C.P. Sevigny: Using EMQs and MCQs to assess higher order thinking and knowledge in physiology2P
13:45 A. Edwards: Should students be allowed to “play to their strengths” with flexible assessment?3P
14:00 G.M. Rayner: Student perceptions of a differentiated assessment model in large enrolment undergraduate science cohorts4P
14:15 K. Colthorpe: Progressive development of scientific literacy through assessment5P
14:30 Workshop activities - Participants discuss and work on assessment problems
16:00 End of workshop
17:00 Registration
Location: Foyer
17:30 Opening ceremony - AuPS Invited Lecture
Chair: Graham Lamb
17:45 S. Bröer: Amino acid transport - Translating basic discovery into improving health6P
Welcome reception


Monday 30th November 2015
MS1MS2Rm 158
08:30 Free communications: Muscle wasting disease
Chairs: Severine Lamon & Jessica Terrill
08:30 N.L. McRae: Genetic reduction of the extracellular matrix protein versican modulates the pathology and function of dystrophic mdx mouse hindlimb muscles7P
08:45 S. Chan: Fast-twitch muscle from old dystrophic mice contain complex branched fibres which are susceptible to contractile damage while slow-twitch are protected8P
09:00 A. Hayes: Effects of vitamin D supplementation on dystrophic (mdx) muscles during damage and repair9P
09:15 T.D. Colgan: Microdystrophin and follistatin combinatorial gene delivery to treat a severe mouse model of Duchenne muscular dystrophy10P
09:30 J.R. Terrill: Taurine homeostasis in Duchenne Muscular Dystrophy and the use of the amino acid as a therapeutic intervention11P
09:45 K. Swiderski: Dysfunction of the dystrophin-glycoprotein complex in cancer cachexia12P
10:00 J.L. Chen: Development of novel TGF-β-targeted therapeutics to treat cachexia13P
10:15 J.R. Davey: Integrated expression analysis of follistatin treatment identifies a novel E3 ubiquitin ligase in the regulation of muscle hypertrophy and sarcopenia14P
Free communications: Muscle and vascular
Chairs: Steve Richards & Tim Murphy
08:30 I. Heinonen: The effects of diabetic metabolic derangement on left ventricular structure and function15P
08:45 S.L. McGee: The Alzheimer’s disease protein Aβ42 is released from adipose tissue and alters cardiac glucose metabolism and function16P
09:00 J.R. Bell: Aromatase expression in human/rat myocardium and pericardial adipose – a potential mechanistic link between obesity and myocardial disease onset?17P
09:15 A. Das: Nicotinamide mononucleotide, an NAD+ precursor, reverses age-associated decline in exercise capacity by increasing skeletal muscle capillary density in a Sirt1-dependent manner18P
09:30 N. Kahlberg: Nitroxyl-mediated relaxation is preserved in the diabetic mesenteric artery despite endothelial dysfunction and increased axial stiffness20P
09:45 G.K. McConell: Local infusion of a nitric oxide synthase inhibitor reverses increases in leg insulin sensitivity after acute exercise in humans21P
10:00 S.J. Blackwood: Forearm blood flow distribution in healthy controls and T2D: Effect of exercise training23P
10:15 R.D. Russell: Restricted microvascular blood flow in skeletal muscle after an oral glucose challenge in healthy humans22P
Symposium: Education symposium: What do we want our physiology graduates to know and be able to do?
Chair: Yvonne Hodgson
08:30 J.A. Michael: The core concepts of physiology: What are they and how do we know if our students understand them?24P
09:15 S. Clarke: Online resources to support the teaching of physiology content and practicals25P
09:30 D.J. Watters: Teaching the core concept of gradient flow: application of Mathbench modules26P
09:45 K. Zimbardi: Milestones that evidence student progression from novice to an expert understanding of the nature of scientific knowledge27P
10:00 J. Choate: Using a course wide professional development program to enhance undergraduate career development and employability58P
10:30 Morning tea
11:00 Symposium: Sex-specific effects of programming: how your gender plays a role in determining your disease risk
Chair: Deanne Hryciw
11:00 K.M. Moritz: Sex, drugs and developmental programming of renal, cardiovascular and metabolic dysfunction28P
11:30 B.S. Muhlhausler: Sex-specific effects of programming: how your gender plays a role in determining your disease risk29P
12:00 K.G. Pringle: Fetal sex specific differences in the maternal renin-angiotensin system: implications for pregnancy outcome30P
12:30 M. Tare: Sex differences in the effects of early life Vitamin D deficiency on vascular regulation31P
Symposium: Stem cells & regenerative medicine
Chairs: James Ryall & Aaron Russell
11:00 T.H. Cheung: Molecular regulation of stem cell quiescence32P
11:30 E.R. Porrello: A functional genomics pipeline for mammalian heart regeneration33P
12:00 J.G. Ryall: Metabolic reprogramming in skeletal muscle stem cells34P
12:30 R.J. Bryson-Richardson: Determination of the mechanism of disease in myopathies utilizing zebrafish35P
Free communications: Drugs and channels
Chair: David Adams
11:00 N. Shah: Docking the B0AT: Identification of novel amino acid transport inhibitors36P
11:15 Q. Cheng: Screening of chemical compounds to identify specific inhibitors of the nutrient transporter B0AT1, a potential drug target to treat type 2 diabetes37P
11:30 M.J. Windley: Investigating the importance of temperature dependent hERG channel block in proarrhythmic risk assessment38P
11:45 C.A. Ng: Quantifying expression defects of LQT2 associated hERG mutations39P
12:00 L. Ma: Heat sensation of temperature sensitive TRPV1 channel supported by the transmembrane core domain40P
12:15 G. Rychkov: Curcumin and chlorpromazine are novel inhibitors of TRPM2 channel41P
12:30 S.J. Fairweather: Different location same story: Identification of a common binding site for membrane-anchored ancillary proteins in the SLC6 family of neural and epithelial transporters42P
12:45 N.L. Trevaskis: A biomimetic glyceride prodrug approach to promote drug delivery to the lymphatics, associated immune cells and tissues43P
13:00 Lunch
Roberts Lecture
Chair: Graham Lamb
13:45 D.H. Hryciw: Communicating science: how do we teach undergraduates to become scientists?44P
Free communications: Disease and signalling/muscle
Chairs: Craig Goodman & Sanket Joshi
14:15 S.S. Thakur: Differential expression of heat shock proteins in proliferating and differentiating skeletal muscle cells45P
14:30 J.A. Barbour: Anabolic metabolism and pro-survival signaling are engaged to rescue the phenotype of electron transport chain dysfunction in a cybrid cell model46P
14:45 A.J. Genders: A physiological drop in pH decreases mitochondrial respiration, and AMPK and Akt signalling, in L6 myotubes47P
15:00 N.T. Frankenberg: Mechanisms of insulin resistance in Type I and Type II muscle fibres from Type 2 diabetics48P
15:15 L.B. McMillan: The relationship between sarcopenic obesity, functional strength and bone mineral density49P
15:30 W.J. Gan: Cell polarity defines three distinct domains in pancreatic beta cells and is disrupted in type 2 diabetes50P
15:45 R. Taylor: Single cell transcriptome profiling of prostate epithelial cell types: monitoring androgen responsiveness51P
Free communications: Exercise Physiology/Metabolism
Chairs: Xu Yan & Nigel Taylor
14:15 N. Eynon: ACTN3 R577X variant influences mitochondrial-related gene expression following a bout of exercise52P
14:30 L. Parker: Acute high-intensity exercise-induced redox signalling is associated with enhanced insulin sensitivity in obese middle-aged men53P
14:45 H.M. Bowes: The scaling of human basal metabolic rate in adult males54P
15:00 F. Falcão-Tebas: Fit mum, fat dad: Can mum exercising during pregnancy overcome the detrimental effects on insulin sensitivity in offspring of a high fat eating dad?55P
15:15 Y. Asif: Long-term cardiac programming by short-term juvenile exercise training56P
15:30 S.R. Notley: Can variations in body morphology explain gender-related differences in heat loss?57P
15:45 L. Sylow: Rac1 and AMPK account for the major part of exercise-stimulated muscle glucose uptake170P
16:00 Posters and afternoon tea
Odd poster board authors in attendence.
1 59PS.L. Sandow: Endothelial BKCa, but not TRPV4 activity is altered in focal cerebral ischemic stroke
2 60PS.L. Sandow: α1-,α2-Na,K-ATPase and Kir 2.1 expression and their implications for cerebral artery function and migraine etiology in a mouse model of Familial Hemiplegic Migraine type 2
3 61PT.V. Murphy: Altered arterial mechanics and vasodilator function in an in vitro model of vascular insulin resistance
4 62PM.J. Christie: The effect of intrauterine growth restriction on the Ca2+-sensitivity and maximum Ca2+-activated force of β-escin skinned mesenteric arteries of 5-week old male Wistar-Kyoto rats
5 63PK. El Sayed: Exaggerated blood pressure responses to mental stress are associated with increases in muscle sympathetic nerve activity
6 64PC.T. Bussey: Individual contributions of isoflurane anaesthesia and surgical incision to haemodynamic regulation in Zucker Diabetic Fatty rats in vivo
7 65PK. Tadros: The effect of high glucose concentration and oxidative stress on transient receptor potential vanilloid 4 ion channel-mediated relaxation in rat carotid artery
8 66PS.M. Lee: (+)-naloxone and (+)-naltrexone transiently block cardioprotection in ischemic-preconditioned mouse hearts
9 67PT.H. Goh: Increased heart glucose uptake in Slc6a19 (-/-) mice appears to be independent of GLP-1 action
10 68PZ.B. Ma: Intramyocardial delivery of miR-29a improves cardiac function and prevents pathological remodeling following myocardial infarction
11 69PX. Ren: Characteristics of MMP-9 protein in rat skeletal muscle
12 70PE. Zacharewicz: MiR-499 reduces muscle protein synthesis in human primary myotubes
13 71PC.S. Shaw: Visualisation of intramuscular lipid droplet and perilipin 2 association in isolated human muscle fibres
14 72PC.R. Lamboley: Contractile properties of type I and type II skeletal muscle fibres are altered in aged men undergoing androgen deprivation therapy
15 73PS. Lamon: MicroRNA expression patterns in post-natal mouse skeletal muscle development
16 74PG.J. Pinniger: Gestational age at time of in utero lipopolysaccharide exposure influences the severity of inflammation-induced diaphragm dysfunction in lambs
17 75PX. Koenig: Examining the access to and handling of calcium by the t-tubular system in skinned rat fibres
18 76PN.A. Beard: Complex regulation of ryanodine receptors by calsequestrin in cardiac muscle: the effect of doxorubicin
19 77PC.A. Timpani: Adenylosuccinic acid therapy attenuates skeletal muscle histopathology in the dystrophin-deficient mdx mouse
20 78PR.G. Barker: The effect of age and taurine supplementation on glycogen associated protein abundance in mdx mice: A comparison between 28 and 70 d mdx mice, a model of Duchenne muscular dystrophy
21 79PG. Keefe: A reduction in Selenoprotein S (SEPS1) amplifies the inflammatory profile of fast twitch skeletal muscle in the mdx dystrophic mouse
22 80PJ. Kuang: The effects of normobaric hypoxia on mitochondrial function in humans
23 81PS.G. Wette: Single fibre responses of MARPs to an acute bout of resistance exercise in untrained individuals
24 82PH. Xu: Diffusibility and glycogen association of AMPK in rat skeletal muscle with and without in vitro stimulation
25 83PA. Selathurai: The role of mitochondrial derived phosphatidylethanolamine in regulating skeletal muscle structure and function
26 84PM. Zhang: Inorganic nitrate supplementation enhances skeletal muscle insulin sensitivity in nNOS null mice
27 85PA.C. Betik: Tocotrienols and Whey Protein Increase Exercise Capacity in Diet -Induced Obese Male Sprague-Dawley Rats
28 86PA.J. McAinch: Agonism of GPR120 regulates markers of skeletal muscle metabolism
29 87PK.F. Howlett: Role of insulin receptor substrate-2 serine phosphorylation in the regulation of liver metabolism
30 88PA.A. Brown: Inflammation is not a driving factor in the development of insulin resistance in diet induced obesity in rats
31 89PY. Jiang: Mice lacking amino acid transporter B0AT1 (Slc6a19) have improved glycaemic control
32 90PE. Rybalka: Idebenone therapy protects against Oxaliplatin-induced gastrointestinal dysfunction
33 91PE. Rybalka: Platinum accumulation and changes in mitochondrial function of the longitudinal muscle & myenteric plexus following oxaliplatin administration
34 92PW. Jing: Flippases and scramblases regulate phospholipid distribution in the plasma membrane during platelet activation and apoptosis
35 93PN.L. Absalom: GHB, THIP and NCS-382 activate a subset of GABAARs expressed in Xenopus oocytes
36 94PN.Y. Marden: Impact of ability-weighted team-based learning on performance in introductory physiology laboratory classes in year 2 tertiary education
37 171PD. Christiansen: Fibre-type specific changes to skeletal muscle Na+-K+-ATPase and FXYD1 following post-exercise cold-water immersion in humans
17:30 Plenary Lecture
Chair: Matthew Watt
17:30 B.H. Goodpaster: The impact of exercise on insulin resistance and type 2 diabetes95P
19:30 ECR & Student Event
Location: Brunswick Hotel


Tuesday 1st December 2015
MS1MS2Rm 158
08:30 Symposium: Cardiovascular metabolo-pathology
Chair: Kimberley Mellor
08:30 X. Hu: MG53 and diabetic cardiomyopathy96P
09:00 L.M.D. Delbridge: Myocardial energy mis-appropriation in metabolic stress97P
09:30 C.X. Qin: An alternative approach to protecting the heart under ischaemic stress98P
10:00 G.M. Kowalski: Dietary fuels and metabolic consequences are context specific99P
Symposium: Novel mechanisms that regulate the physiological attributes of muscle
Chair: Paul Gregorevic
08:30 K.A. Esser: Circadian rhythms, molecular clock and musculoskeletal health100P
09:00 D.E. James: Exercise regulated phosphoproteome reveals new AMPK substrates and signaling pathways101P
09:30 K.J. Nowak: A powerful mouse resource for mapping genetic traits, identifying modifying genes and unravelling gene networks102P
10:00 J.E. Hudson: Bioengineering human cardiac tissue103P
Free communications: Signal transduction/skeletal muscle
Chairs: Nicole Beard & Noni Frankenberg
08:30 B.S. Launikonis: The tubular (t-) system is a dynamic Ca2+-buffer in human skeletal muscle fibres104P
08:45 Y.W. Oo: Inhibitory effect of dantrolene on skeletal muscle RYR in the presence of calmodulin105P
09:00 R. Blazev: The effect of nitrate supplementation on sarcoplasmic reticulum Ca2+ handling in dystrophic skeletal muscle fibres106P
09:15 R.H. Choi: The effect of intracellular [Mg2+] on Ca2+ handling by the sarcoplasmic reticulum107P
09:30 A.D. Hanna: Cardiac-specific FKBP12 deficiency alters RyR2 calcium release and causes severe dilated cardiomyopathy in male and female mice108P
09:45 A. Addinsall: Role for selenoprotein S (SEPS1) in regulating skeletal muscle contractile function in fast twitch muscles109P
10:00 V.C. Foletta: The stress-responsive NDRG2 protein alters the redox state in C2C12 myoblasts and is protective against hydrogen peroxide-induced oxidative stress110P
10:15 G.D. Housley: Cochlear type II spiral ganglion afferent fibres are essential for medial olivocochlear reflex – mediated otoprotection from noise – induced hearing loss111P
10:30 Morning tea
11:00 Symposium: Physiological mechanisms controlling microvascular flow and muscle metabolism
Chair: Steve Rattigan
11:00 M.A. Keske: Regulation of muscle microvascular flow and metabolism: an overview113P
11:30 E.C. Eringa: Perivascular adipose tissue in control of organ perfusion and glucose metabolism112P
12:00 K.A. Sjøberg: The effects of GLP-1 on microvascular recruitment in human and rat muscle114P
12:30 R.M. Dwyer: Beneficial effects of exercise on regulation of microvascular flow115P
Symposium: The sarcoplasmic reticulum of skeletal muscle
Chair: Bradley Launikonis
11:00 T.R. Cully: The role of ryanodine receptor Ca2+ leak in t-system Ca2+ handling in skeletal muscle fibres116P
11:30 S.I. Head: α-actinin-3 and sarcoplasmic reticulum function117P
12:00 A.F. Dulhunty: Functional interactions within the skeletal ryanodine receptor calcium release complex118P
12:30 F. Protasi: Exercise-dependent formation of new SR-TT junctions containing STIM1 and Orai1119P
Pregnancy and fetal physiology
Chair: James Cuffe
11:00 J.L. Morrison: Differential effect of early versus late onset chronic hypoxemia on molecular mechanisms regulating lung maturation in the late gestation fetus127P
11:15 S.L. Sandow: IKCa-IP3R myoendothelial microdomains in the uterine radial arteriole are present in normal, and absent in gestational and pre-eclamptic hypertensive pregnancies: Targets for therapy?122P
11:30 D.H. Hryciw: F2 fetal nephron number and weight benefits of endurance exercise training for females born small on high fat diet123P
11:45 E.S. Dorey: Periconceptional alcohol exposure alters the mesolimbic reward pathway and behaviour in offspring124P
12:00 J.S.M. Cuffe: Maternal corticosterone exposure in the mouse programs dysregulation of plasma corticosterone levels and adrenal size in offspring in an age and sex specific manner125P
12:15 H.C. Parkington: Complex interacting mechanisms regulating contraction and inter-contraction relaxation in labouring human myometrium126P
12:30 G.R. Zosky: The mechanism(s) of vitamin D deficiency induced alterations in lung structure and function128P
12:45 T.J. Harvey: Maternal nutrient restriction alters Ca2+ handling properties and contractile function of isolated left ventricle bundles in male but not female rats121P
13:00 Lunch and Posters
See Monday for list. Even board authors in attendance.
  Student and ECR Lunchtime Discussion: Life, Balance and Gender Issues
15:00 Symposium: Controlling the excitable heart
Chair: Livia Hool
15:00 D.J. Paterson: Cyclic nucleotide coupled phosphodiesterase signalling in cardiac sympathetic neurons in heart disease: novel therapeutic targets129P
15:30 D.R. Laver: Calmodulin regulation of ryanodine receptors (RYR2) differs in failing and non-faling human hearts due to differences in RYR2 phosphorylation130P
16:00 P.P. Jones: Regulation of the cardiac ryanodine (RyR2) receptor by RyR2 associated proteins131P
16:30 L.C. Hool: Insights into adrenergic stimulation of calcium channels132P
Symposium: New insights into exercise-induced mitochondrial adaptations
Chair: David Bishop
15:00 D.J. Bishop: Factors influencing exercise-induced mitochondrial biogenesis133P
15:30 Z. Yan: Autophagy and exercise-induced mitochondrial adaptions134P
16:00 G.D. Wadley: Does antioxidant supplementation reduce skeletal muscle mitochondrial biogenesis?135P
16:30 J.S. Coombes: NRF-2 and mitochondrial biogenesis136P
Free communications: Muscle growth/development
Chairs: Emma Rybalka & Gavin Pinniger
15:00 D.J. Morrison: Assessing postprandial glucose using the triple tracer technique137P
15:15 S. Joshi: The NAD+ precursors, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), regulate exercise capacity in aged mice in a SIRT1-dependent manner138P
15:30 P.J. Houweling: The evolution of ACTN3: Why has α-actinin-3 deficiency become so common and why do we care?139P
15:45 N.J. Hoffman: Global phosphoproteomics reveals the skeletal muscle contraction signalling repertoire and novel regulation of sarcoplasmic reticulum calcium sensing machinery via AMPK140P
16:00 L.C. Butchart: The long and short of non-coding RNAs during post-natal growth of skeletal muscles in mice: a focus on lncRNA and miRNAs141P
16:15 J. Sorensen: Idebenone protects against chemotherapy-induced skeletal muscle wasting and mitochondrial dysfunction in mice142P
16:30 T.D. Colgan: Non-invasive characterisation of early disease progression in mouse models of Duchenne muscular dystrophy143P
16:45 C.A. Goodman: Insights into the role and regulation of the Translationally Controlled Tumor Protein in skeletal muscle144P
18:30 18:15 Ferry to Mona; Dinner; Midnight Ferry to city


Wednesday 2nd December 2015
MS1MS2Rm 158
09:00 Symposium: Lipid metabolism in health & disease - novel techniques to assess lipids
Chair: Matthew Watt
09:00 A.J. Hoy: Fatty acids and prostate cancer: a journey from the lab to the clinic172P
09:30 T.W. Mitchell: What has lipidomics done for me lately: insights, advances and limitations in the application of lipidomics to the study of lipid metabolism in health and disease146P
10:00 C.R. Bruce: Phospholipids and skeletal muscle function147P
10:30 M.F. Snel: Mass spectrometric imaging, a novel way of visualising lipid distribution in tissue148P
Symposium: Linking mitochondria with health and disease
Chairs: Nigel Tuner & Sean McGee
09:00 D.R. Thorburn: Understanding the landscape of inherited mitochondrial diseases149P
09:30 D.J. Marcinek: Mitochondrial redox in aging skeletal muscle150P
10:00 A.A. Cooper: Mitochondrial dysfunction in Parkinson’s disease151P
10:30 N. Turner: Distinct metabolic effects of elevated NAD biosynthesis in the nuclear or mitochondrial compartments152P
11:00 Morning tea
11:30 Symposium: Age, sex and cardiovascular protection strategies
Chair: Jim Bell
11:30 S.E. Howlett: Different cardioprotection strategies in ageing153P
12:00 C.G. Sobey: GPER pharmacotherapy in ischemic stroke154P
12:30 D.A. Saint: Manipulating the innate immune system as a cardioprotective strategy155P
13:00 B.K. Kemp-Harper: Nitroxyl (HNO) as a vasoprotective signalling molecule156P
Symposium: SERCA and NaK properties and regulation in skeletal muscle
Chair: Graham Lamb
11:30 R.M. Murphy: Furthering our insights into the ATPases in muscle157P
12:00 A.R. Tupling: The diverse roles of phospholamban and sarcolipin in skeletal muscle: From adaptive thermogenesis to muscle myopathy158P
12:30 G.S. Lynch: Mechanisms of SR Ca2+ ATPase dysfunction in muscle wasting disorders159P
13:00 M.J. McKenna: The effects of inactivity and age on Na+,K+-ATPase abundance in skeletal muscle in humans160P
Free communications: Exercise adaptation
Chairs: Victoria Wyckelsma & Aaron Petersen
11:30 B.P. Frankish: Effects of altered carbohydrate availability on glycogen related proteins within skeletal muscle161P
11:45 V.L. Wyckelsma: Plasma K+ dynamics during incremental exercise and recovery in older adults before and after 12 weeks of high-intensity interval training163P
12:00 C. McGinley: Influence of training intensity on adaptations in acid/base transport protein abundance and non-bicarbonate muscle buffer capacity in active men164P
12:15 J. Yamauchi: Acute physiological responses during walking under low oxygen exposure of 4000m altitude environment165P
12:30 S. Green: Effect of acute hypoxia on dynamic response characteristics of ventilation in males and females166P
12:45 A.K. May: Blood flow restriction training induces systemic muscle strength adaptations167P
13:00 A.C. Petersen: Cold water immersion attenuates performance increases and promotes fat loss following resistance training168P
13:15 A.J. Trewin: Skeletal muscle mitochondrial ROS emission and antioxidant genes are elevated 3 h after exercise independent of exercise intensity169P
13:30 Lunch
14:00 Student Prizes and AGM
Chair: Graham Lamb

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