AuPS 2017 Melbourne Programme

Author index

Sunday 19th November 2017
Sissons LT1Sissons LT2Sissons LT3Scott CLS
17:00 AuPS Invited Lecture
Chair: Graham Lamb
17:00 G.D. Housley: An earful of physiology1P
18:00 Welcome Reception
Location: Cossar Hall


Monday 20th November 2017
Sissons LT1Sissons LT2Sissons LT3Scott CLS
08:30 Symposium: Strategies for large-scale and authentic assessment of undergraduates
Chair: Julia Choate
08:30 P.J. White: Development and assessment of problem-solving skills9P
09:00 R.M. Vickery: Student Peer Assessment: An efficient assessment method to enhance critical evaluation?10P
09:30 Y. Hodgson: Academic and student perceptions of assessment11P
10:00 H. Gray: Professional identity in allied health students: How it affects authentic assessment13P
Free communications: Muscle wasting
Chair: Victoria Foletta
08:30 E.M. Lloyd: The contractile properties of slow and fast skeletal muscle from dysferlin deficient mice2P
08:45 I.W.K. Kouw: One week of hospital admission following elective hip surgery induces substantial muscle atrophy in older patients3P
09:00 A. Hagg: Modulating bone morphogenic protein signalling in cancer cachexia4P
09:15 I.W.K. Kouw: Ingestion of 40 g protein prior to sleep stimulates overnight myofibrillar protein synthesis in healthy older men5P
09:30 J. Mikovic: Mitochondrial oxidative capacity and oxidative stress in chronically inactive elderly patients6P
09:45 W.D. Phillips: Muscle specific kinase protects mdx mouse muscles against eccentric contraction-induced loss of strength7P
10:00 K. Swiderski: Phosphorylation of dystrophin S3059 protects against skeletal muscle wasting8P
Free communicartions: Cardiac
Chair: Nicole Beard
08:30 K.M. Mellor: Dissecting the molecular pathways of glucose mishandling and glycogen disturbance in the diabetic heart14P
08:45 R.J. Mills: Metabolic mechanism for cardiomyocyte cell cycle arrest15P
09:00 A. Ashna: Inhibitory effect of phenytoin on cardiac RYR216P
09:15 G. Mazzarino: Therapeutic methods for physiological cardiac hypertrophy: The role of MicroRNAs17P
09:30 S.P. Wells: Differential effect of electrical stimulation and β-adrenergic stimulation on neonatal rat ventricular myocyte monolayer conduction properties18P
09:45 A.D. Chakraborty: Arrhythmia: an ‘off-target’ effect of cancer cardiotoxicity19P
10:30 Morning Tea
11:00 Free communications: Physiology education
Chair: Kathy Tangalakis
11:00 E. Yuriev: Open-note examinations as opportunities for meaningful learning and assessment24P
11:15 G.D. Wadley: Implementation and evaluation of a video feedback model25P
11:30 L.A. Lexis: Transformation of a traditionally delivered exercise physiology theory curriculum into a contemporary model of blended learning that better supports student learning26P
11:45 J. Kibedi: Enhancing students' acquisition and application of the conventions of scientific writing27P
12:00 S. Green: Numeracy performance in sports and exercise science students at an Australian university28P
12:15 K. Colthorpe: How do students deal with difficult physiological concepts?29P
12:30 M. Quiroga: Using an online simulation to prepare students for an enquiry-based laboratory class30P
12:45 L. Ainscough: Encouraging students’ self-regulated learning skills through the use of discussion boards31P
Symposium: AuPS/Physiological Society of Japan Joint Symposium: Skeletal muscle physiology and function
Chair: Graham Lamb
11:00 P.D. Currie: The genetics of vertebrate skeletal muscle assembly20P
11:30 H.Y. Hara: The role of phospholipid flippase in myotube formation21P
12:00 T. Murayama: Molecular mechanism of type 1 ryanodine receptor-linked muscle diseases: toward diagnosis and therapy22P
12:30 B.S. Launikonis: Calcium handling by human skeletal muscle fibres with ryanodine receptor variants23P
Free communications: Pharmacology and treatment
Chair: Daniel Poole
11:00 N.L. Absalom: Diverse changes to GABAA receptor function by mutations that cause severe childhood epilepsies32P
11:15 B.M. Wild: Volatile vs injectable anaesthetics: considerations for electrophysiological studies in the rat33P
11:30 R. Kochappan: Targeting the intestinal lymphatic system using an oral triglyceride mimetic prodrug enhances immunosuppressant activity in vivo34P
11:45 G. Gracia: High density lipoprotein promotes targeted delivery into lymph and lymph nodes: A viable carrier for immunotherapies and vaccines35P
12:00 A.P. Denny: Is high-density lipoprotein-based therapy an option for the treatment of muscle damage in Facioscapulohumeral muscular dystrophy?36P
12:15 P. Hofstee: Maternal selenium deficiency in mice alters placental function, reduces fetal glucose concentrations and impairs fetal growth138P
13:00 Lunch and Posters
Presenting authors of odd boards present on Monday; even boards on Tuesday.
1 37PA.A. Abdulwahid: Maternal obesity results in impaired brain function in the offspring by mechanisms involving electrical hyperactivity
2 38PN. Shrestha: The role of linoleic acid in placental inflammatory response and fatty acid metabolism
3 39PA. Hayes: Mitochondrial profiling of immortalised myoblasts from a Duchenne Muscular Dystrophy patient
4 40PA. Hayes: Adenylosuccinic acid therapy for the treatment of Duchenne muscular dystrophy: a pre-clinical evaluation of safety and efficacy
5 41PJ.S.M. Cuffe: Glucocorticoids dysregulate cellular viability, mitochondrial membrane potential and cellular respiration differently in normal compared to high glucose environments
6 42PL. Parker: Glucocorticoid suppression of uncarboxylated osteocalcin impairs basal and post-exercise insulin sensitivity and osteocalcin signalling in humans
7 44PA.D. Lam: High fat diet induced lymphatic changes may play a role in promoting fatty liver disease
8 45PK. Swiderski: Oral administration of L-arginine improves gastrointestinal function in dystrophic mdx mice
9 46PC. Giezenaar: Effects of substituting carbohydrates and fat for whey-protein or adding them to whey protein on energy intake and underlying gastrointestinal-mechanisms in healthy older men
10 47PI.E. Inocencio: Investigating the impact of liposome properties on lymphatic distribution following intraperitoneal delivery
11 48PT.A. Hoang: A novel cervical lymph cannulation method in rats to evaluate clearance from the brain into the lymphatics
12 49PP. Yadav: Distribution of therapeutic proteins into thoracic lymph after intravenous administration is protein size-dependent and primarily occurs within the liver and mesentery
13 50PD. Sheipouri: Control of glycine receptor activation by a glycine transporter co-expressed in Xenopus oocytes
14 51PD.G. Campelj: Sodium nitrate treatment escalates doxorubicin-induced cachexia in mice
15 52PA. Selathurai: An essential role for mitochondrial phosphatidylethanolamine synthesis in regulating skeletal muscle and mitochondrial structure
16 53PM. Jacques: The epigenetic basis of variable responses to exercise training - a novel study design
17 54PG.M. Morales-Scholz: Hepatic autophagy dysfunction in mice following high fat feeding
18 55PC.M. Loescher: The investigation of dantrolene sodium analogues on SR calcium loading and release, and calsequestrin Ca2+ binding properties in cardiac muscle
19 56PM.J. Macartney: Cardiac in vivo haemodynamic function is modified by myocardial membrane DHA incorporation attributable to fish oil doses achievable in the human diet
20 57PA.J.A. Raaijmakers: The link between in vivo diastolic function and mechanical stiffness in intact rat cardiomyocytes
21 58PJ.V. Janssens: Testing a methodology for comparative stiffness measurement in isolated loaded intact cardiomyocytes
22 59PH.M.M. Waddell: Establishing reference conditions for electrophysiological recordings of spontaneously beating neonatal rat cardiomyocytes on a multi-electrode array
23 60PD.A. Debruin: The effects of vitamin D supplementation and exercise enrichment on in vivo analysis of physical activity behaviour, exercise capacity and metabolism
24 61PS.L. Halley: The effect of IPC on central and peripheral fatiguing mechanisms following sustained maximal isometric exercise
25 62PL. Kiriaev: A common morphological variation in the knee insertion of the extensor digitorum longus muscle reduces maximal force production but does not affect other contractile properties
26 63PJ.J. Fyfe: Concurrent training further enhances markers of skeletal muscle ribosome biogenesis, but not associated signalling responses, versus single-mode resistance training
27 64PS. Voisin: Phenotypic variability in response to high-intensity interval training in the Gene SMART study
28 66PC.R. Lamboley: Effect of high-intensity intermittent exercise on the contractile properties of human type I and type II skeletal muscle fibres
29 67PS.I. Head: Increasing nuclear NAD+ biosynthesis induces muscle remodelling without alterations in myofibrillar Ca2+ sensitivity
30 68PS.S. Thakur: Heat shock protein 70 (Hsp70) overexpression drives myoblast fusion during C2C12 cell differentiation
31 69PL. Pearce: Differential oxidation of ryanodine receptors in male and female calsequestrin knock-out mice
32 70PA. Pascoe: The role of Fn14 in mouse skeletal muscle recovery post Notexin injury: Effects on myogenic regulatory factors, catabolic markers, and structural proteins
33 71PD.P. Singh: The effect of novel ryanodine receptor modulators on Ca2+ leak in skeletal muscle fibres
14:30 Michael Roberts Lecture
Chair: Deanne Skelly
14:30 K. Tangalakis: Enhancing the commencing student learning experience with innovative learning and teaching approaches and peer support systems72P
15:00 Afternoon tea
15:30 Free communicatons: Skeletal muscle
Chair: Cedric Lamboley
15:30 J.G. Ryall: Muscle stem cell self-renewal is regulated via innate cell metabolism and the extracellular environment74P
15:45 C.J. Taylor: Implantation of muscle precursor cells grown as 3D structures improves muscle regeneration after myotoxic injury75P
16:00 J.R. Davey: E3 ligase substrate receptor ASB2 is a negative regulator of skeletal muscle size76P
16:15 B.A. Mir: Identifying novel miRNAs targeting NDRG2 regulation in skeletal muscle77P
16:30 B.P. Frankish: Characterisation of SERCA, phospholamban and sarcolipin proteins in human skeletal muscle78P
16:45 D. Watanabe: Osmotic compression improves force production in skinned muscle fibres of the rat and human79P
Symposium: New directions in ischemia cardioprotection
Chair: Lea Delbridge
15:30 L.C. Hool: Role of nano-particles in ischemia-reperfusion therapies80P
16:00 P.P. Jones: Impact of reactive oxygen species production on calcium release during ischemia-reperfusion injury81P
16:30 D.J. Hausenloy: Remote ischaemic conditioning for cardioprotection: Bench to bedside in action!82P
17:00 S.Y. Lim: Using cardiac stem cells to rescue the ischemic heart83P
Education Workshop
17:30 ECR Workshop
Location: Scott Building Collaborative Learning Spaces
Location: Scott Building Collaborative Learning Spaces
19:00 Student and ECR Mixer
Location: The Captain Melville


Tuesday 21st November 2017
Sissons LT1Sissons LT2Sissons LT3Scott CLS
08:30 Symposium: Molecular mechanisms regulating skeletal muscle attributes in health and disease
Chair: Paul Gregorevic
08:30 A.R. Judge: Investigating cellular processes that drive skeletal muscle wasting84P
09:00 K.T. Murphy: Novel mechanisms associated with cachexia during chemotherapy85P
09:30 N. Turner: Increasing nuclear NAD+ biosynthesis alters skeletal muscle size and metabolism86P
10:00 N.G. Laing: Functional genomics in disease gene discovery and diagnosis of Mendelian disorders87P
Symposium: Emerging leaders in placental physiology
Chair: James Cuffe
08:30 P.H. Andraweera: Intrauterine environment and cardiovascular disease risk in later life88P
09:00 M. Dekker Nitert: Maternal glucose metabolism and the gut and placental microbiota89P
09:30 J.F. Briffa: The impact of lifestyle and pharmacological interventions on the placenta in complicated pregnancies90P
10:00 O.J. Holland: Mitochondrial adaptations and dynamics in the human placenta91P
10:30 Morning Tea
11:00 Symposium: Assessing and counteracting frailty during ageing
Chair: René Koopman
11:00 A.B. Maier: Assessing frailty in older individuals92P
11:30 S. Soenen: Protein absorption and satiety in older individuals93P
12:00 I.W.K. Kouw - Anabolic resistance with aging
12:30 R. Koopman: Novel nutritional interventions to counteract frailty and wasting95P
Symposium: Problems in labour: Mother Nature versus Father Time
Chair: Helena Parkington
11:00 S. Wray: Is hypoxia good for labour?96P
11:30 S.A. Mesiano: Preventing premature birth by exploiting anti-inflammatory actions of progesterone97P
12:00 M. Lappas: Prevention of preterm birth: Novel targets of inflammation in the myometrium98P
12:30 H.C. Parkington: Mechanisms contributing to Failure-to-Progress in human labour99P
13:00 Lunch and Posters
Presenting authors of odd boards present on Monday; even boards on Tuesday.
14:30 Meet the Editor - Prof Susan Wray
Editor-in-Chief of Physiological Reprots
15:00 AGM
Afternoon tea
16:00 AuPS Plenary Lecture
Chair: Graham Lamb
16:00 D.A. Eisner: Downs and ups of calcium in the heart100P
18:30 Conference Dinner
Location: Melbourne Museum Foyer


Wednesday 22nd November 2017
Sissons LT1Sissons LT2Sissons LT3Scott CLS
08:30 Free communications: Metabolism and signalling
Chair: Sean Yan
08:30 D.J. Morrison: Measurement of postprandial glucose fluxes in response to 5 and 28 days of overfeeding in healthy humans101P
08:45 E. Cao: High fat diet remodels the intestinal lymphatic vasculature to promote obesity and glucose intolerance102P
09:00 V.R. Haynes: Medium chain fatty acids are metabolised by the hypothalamus and regulate energy balance in healthy mice103P
09:15 S.A. Mason: Ascorbic acid supplementation improves skeletal muscle oxidative stress and insulin sensitivity in people with type 2 diabetes: findings of a randomized controlled study104P
09:30 A.J. Rose: Liver-muscle crosstalk in sarcopenic obesity?105P
09:45 G.K. McConell: Skeletal muscle interstitial glucose concentration becomes limiting to glucose uptake during insulin exposure after exercise in humans106P
10:00 D.M. Camera: Dynamic proteome profiling of individual proteins in human skeletal muscle after a high-fat diet and resistance exercise107P
10:15 C. Giezenaar: Load-dependent effects of whey-protein supplements on energy intake, gastric emptying and gut hormone concentrations in men and women108P
Symposium: Cellular mechanisms of failure and arrhythmia in the diseased heart
Chair: James Bell
08:30 D. Pavlovic: Sodium pump and intracellular sodium in healthy and failing hearts109P
09:00 N.A. Beard: Cellular mechanisms of failure and arrhythmia in the diseased heart110P
09:30 J.R. McMullen: Novel therapeutic targets in heart failure and atrial fibrillation111P
10:00 D.A. Saint: Changes in atrial structure and function in diabetes and obesity112P
10:30 Morning Tea
11:00 Free communications: Fetal physiology
Chair: Sarah Marshall
11:00 B.A. McNeill: Characterising hydrogen sulfide production and degradation pathways in murine kidney: effects of pregnancy and high fat diet119P
11:15 M. Christie: Effects of IUGR on contractile protein expression and Ca2+-activated force in β-escin permeabilised mesenteric arteries of adult (6-month old) and aged (1-year old) WKY rats120P
11:30 D. Mahizir: Cardiorenal pregnancy adaptations in females born small on a high fat diet and benefits of endurance exercise training121P
11:45 J.J. Fisher: Mitochondrial function in cell lineages of the placenta: does function alter between gestational disorders?122P
12:00 Y.T.M. Mangwiro: Sex-specific placental IGF-system adaptations to maternal exercise in growth restricted mothers123P
12:15 M.C. Lock: Expression of immune markers in the fetus and six month old sheep heart in response to myocardial infarction124P
12:30 P.C. Papagianis: Human amnion epithelial cells alter lung development and inflammation in 7-day-old preterm lambs exposed to inflammation before birth125P
12:45 E.R. Siriwardhana: The sheep as a model of studying pregnant uterine smooth muscle activity126P
Free communications: Exercise physiology
Chairs: Donny Camera & Nir Eyon
11:00 A.B. Addinsall: Regulation of exercise performance and contractile function by the endoplasmic reticulum resident antioxidant Selenoprotein S (SEPS1)113P
11:15 L. Hingley: Thoraco-pulmonary mechanical perturbations accompanying thoracic loading114P
11:30 N. Eynon: The ACE I/D gene variant predicts ACE enzyme activity in the blood but not the expression of ACE protein in skeletal muscle in the Gene SMART study115P
11:45 A.K. May: Muscle adaptations and protein expression following blood flow restriction and heavy-load resistance training methods116P
12:00 H.M. Bowes: The allometric scaling of aerobic power in adult humans, across the physiological range117P
12:15 C.H. Steward: Cellular localisation of NaK-ATPase isoforms in human skeletal muscle is muscle fibre-type specific118P
Symposium: How do calcium oscillations regulate biological rhythm?
Chair: Livia Hool
11:00 D.F. van Helden: Synchronising pacemakers128P
11:40 F.C. Britton: Understanding calcium-activated chloride channels in health and disease129P
12:20 G. Rychkov: Oxygen dependent regulation of TRP channel function130P
13:00 Lunch
13:30 Symposium: The preterm baby
Chair: Janna Morrison
13:30 T.J. Moss: There is no such thing as a normal preterm baby133P
14:00 B.E. Lingwood: Supporting preterm cardiovascular function134P
14:30 R. Galinsky: Improving brain development in preterm infants with hypoxic-ischaemic encephalopathy135P
15:00 M.J. Berry: Big data for small babies; the impact of gestational age on health and educational outcomes in New Zealand137P
Symposium: Mitochondrial dynamics and function
Chair: David Bishop
13:30 M.T. Ryan: The machinery involved in mitochondrial dynamics131P
14:00 M. Lazarou: The role and regulation of PINK1/Parkin mitophagy in maintaining mitochondrial health139P
14:30 R.M. Murphy: Effects of exercise training on mitochondrial content and dynamics132P
15:00 D.J. Bishop: Exercise prescription and mitochondrial content and function140P
15:30 Student prize announcements

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