|
PROCEEDINGS OF THE
AUSTRALIAN PHYSIOLOGICAL SOCIETY |
ISSN 0067-2084 |
Volume 46 |
2015 |
|
CONTENTS |
|
AuPS 2015 Hobart Meeting |
|
| Education workshop: Designing assessments in physiology | |
| Using MCQs to assess causal reasoning J.A. Michael | 1P |
| Using EMQs and MCQs to assess higher order thinking and knowledge in physiology C.P. Sevigny | 2P |
| Should students be allowed to “play to their strengths” with flexible assessment? A. Edwards | 3P |
| Student perceptions of a differentiated assessment model in large enrolment undergraduate science cohorts G.M. Rayner | 4P |
| Progressive development of scientific literacy through assessment K. Colthorpe, K. Zimbardi, A. Bugarcic & A. Smith | 5P |
| Opening ceremony - AuPS Invited Lecture | |
| Amino acid transport - Translating basic discovery into improving health S. Bröer | 6P |
| Free communications: Muscle wasting disease | |
| Genetic reduction of the extracellular matrix protein versican modulates the pathology and function of dystrophic mdx mouse hindlimb muscles N.L. McRae, L. Forgan, A. Addinsall, C. Van Der Poel, B. McNeill, D.R. McCulloch & N. Stupka | 7P |
| Fast-twitch muscle from old dystrophic mice contain complex branched fibres which are susceptible to contractile damage while slow-twitch are protected L. Kiriaev, S. Chan, S. Kueh, J. Morley & S.I. Head | 8P |
| Effects of vitamin D supplementation on dystrophic (mdx) muscles during damage and repair A. Hayes, N. Andreacchio, C.A. Timpani, E.D. Hanson & E. Rybalka | 9P |
| Microdystrophin and follistatin combinatorial gene delivery to treat a severe mouse model of Duchenne muscular dystrophy T.D. Colgan, K.T. Murphy, T. Kennedy, D. Ham, T. Naim, A. Chee, M.N. Nguyen, H. Qian, J.S. Chamberlain, G.S. Lynch & P. Gregorevic | 10P |
| Taurine homeostasis in Duchenne Muscular Dystrophy and the use of the amino acid as a therapeutic intervention J.R. Terrill, G.J. Pinniger, M.D. Grounds & P.G. Arthur | 11P |
| Dysfunction of the dystrophin-glycoprotein complex in cancer cachexia K. Swiderski, K.T. Murphy, C.J. Brock, N.A. Williamson, J. Trieu, A. Chee, D.M. Baum, T. Naim & G.S. Lynch | 12P |
| Development of novel TGF-β-targeted therapeutics to treat cachexia J.L. Chen, K.L. Walton, A. Hagg, E.K. Kelly, H. Qian, C.A. Harrison & P. Gregorevic | 13P |
| Integrated expression analysis of follistatin treatment identifies a novel E3 ubiquitin ligase in the regulation of muscle hypertrophy and sarcopenia J.R. Davey, K.I. Watt, B.L. Parker, R. Chaudhuri, J.G. Ryall, V. Sartorelli, M. Sandri, J.S. Chamberlain, D.E. James & P. Gregorevic | 14P |
| Free communications: Muscle and vascular | |
| The effects of diabetic metabolic derangement on left ventricular structure and function I. Heinonen, O. Sorop, M. van Kranenburg, V.J. de Beer, Y. Octavia, R.W.B. van Duin, R.J. van Geuns, A.H. van den Meiracker, A.H. Danser, J. van der Velden, D. Merkus & D.J. Duncker | 15P |
| The Alzheimer’s disease protein Aβ42 is released from adipose tissue and alters cardiac glucose metabolism and function J. Czeczor, A.J. Genders, K.A. De Jong, T. Connor, K. Venardos, K. Aston-Mourney, C. Swinton, S.E. Hussey, M. Hargreaves, K.R. Walder, R. Cappai & S.L. McGee | 16P |
| Aromatase expression in human/rat myocardium and pericardial adipose – a potential mechanistic link between obesity and myocardial disease onset? J.R. Bell, G.B. Bernasochi, W.T.K. Ip, W.C. Boon, S. Pepe, S.B. Harrap & L.M.D. Delbridge | 17P |
| Nicotinamide mononucleotide, an NAD+ precursor, reverses age-associated decline in exercise capacity by increasing skeletal muscle capillary density in a Sirt1-dependent manner A. Das, G.X. Huang, L. Kim, C. Li, B. Osborne, S. Joshi, E.O. Williams, L.E. Wu, M. Igarashi, L.P. Guarente, N. Turner, Z.P. Arany & D.A. Sinclair | 18P |
| Nitroxyl-mediated relaxation is preserved in the diabetic mesenteric artery despite endothelial dysfunction and increased axial stiffness N. Kahlberg, J. Anthonisz, R.H. Ritchie, E. Jap, L.J. Parry, B.K. Kemp-Harper, C.H. Qin & C.H. Leo | 20P |
| Local infusion of a nitric oxide synthase inhibitor reverses increases in leg insulin sensitivity after acute exercise in humans G.K. McConell, K.A. Sjøberg, C. Frøsig, A.C. Betik, L. Sylow, R. Kjøbsted, M. Kleinert, B. Kiens, S. Rattigan, J.F.P. Wojtaszewski & E.A. Richter | 21P |
| Restricted microvascular blood flow in skeletal muscle after an oral glucose challenge in healthy humans R.D. Russell, T.M. Greenaway, J.E. Sharman, D. Hu, D. Premilovac, S.M. Richards, S. Rattigan & M.A. Keske | 22P |
| Forearm blood flow distribution in healthy controls and T2D: Effect of exercise training S.J. Blackwood, R.D. Russell, R.M. Dwyer, M.A. Keske & S. Rattigan | 23P |
| Symposium: Education symposium: What do we want our physiology graduates to know and be able to do? | |
| The core concepts of physiology: What are they and how do we know if our students understand them? J.A. Michael | 24P |
| Online resources to support the teaching of physiology content and practicals S. Clarke, M. del Mar Quiroga & R. Rajan | 25P |
| Teaching the core concept of gradient flow: application of Mathbench modules D.J. Watters, M.W. Weible II & Y.M. Hodgson | 26P |
| Milestones that evidence student progression from novice to an expert understanding of the nature of scientific knowledge K. Zimbardi & K. Colthorpe | 27P |
| Using a course wide professional development program to enhance undergraduate career development and employability J. Choate, J. Green, S. Cran, J. Macaulay & M. Etheve | 58P |
| Symposium: Sex-specific effects of programming: how your gender plays a role in determining your disease risk | |
| Sex, drugs and developmental programming of renal, cardiovascular and metabolic dysfunction K.M. Moritz & J.S.M. Cuffe | 28P |
| Sex-specific effects of programming: how your gender plays a role in determining your disease risk B.S. Muhlhausler | 29P |
| Fetal sex specific differences in the maternal renin-angiotensin system: implications for pregnancy outcome K.G. Pringle | 30P |
| Sex differences in the effects of early life Vitamin D deficiency on vascular regulation M. Tare, K.J. Bubb, H.A. Coleman & H.C. Parkington | 31P |
| Symposium: Stem cells & regenerative medicine | |
| Molecular regulation of stem cell quiescence T.H. Cheung | 32P |
| A functional genomics pipeline for mammalian heart regeneration E.R. Porrello | 33P |
| Metabolic reprogramming in skeletal muscle stem cells J.G. Ryall, A. Webster, C.H. Ly & G.S. Lynch | 34P |
| Determination of the mechanism of disease in myopathies utilizing zebrafish R.J. Bryson-Richardson | 35P |
| Free communications: Drugs and channels | |
| Docking the B0AT: Identification of novel amino acid transport inhibitors N. Shah, Q. Cheng, A. Bröer, B. Corry & S. Bröer | 36P |
| Screening of chemical compounds to identify specific inhibitors of the nutrient transporter B0AT1, a potential drug target to treat type 2 diabetes Q. Cheng, N. Shah, A. Bröer, B. Corry & S. Bröer | 37P |
| Investigating the importance of temperature dependent hERG channel block in proarrhythmic risk assessment M.J. Windley, S.A. Mann, J.I. Vandenberg & A.P. Hill | 38P |
| Quantifying expression defects of LQT2 associated hERG mutations C.A. Ng, M.D. Perry, M.J. Hunter & J.I. Vandenberg | 39P |
| Heat sensation of temperature sensitive TRPV1 channel supported by the transmembrane core domain L. Ma, F. Yang, Y. Cui, X. Cao, K. Wang & J. Zheng | 40P |
| Curcumin and chlorpromazine are novel inhibitors of TRPM2 channel E. Kheradpezhouh, G.J. Barritt & G. Rychkov | 41P |
| Different location same story: Identification of a common binding site for membrane-anchored ancillary proteins in the SLC6 family of neural and epithelial transporters S.J. Fairweather, A. Bröer, N. Subramanian, E. Tumer, Q. Cheng, D. Schmoll, M. O'Mara & S. Bröer | 42P |
| A biomimetic glyceride prodrug approach to promote drug delivery to the lymphatics, associated immune cells and tissues G. Gracia, S. Han, T. Quach, L. Hu, J.S. Simpson, C.J.H. Porter & N.L. Trevaskis | 43P |
| Roberts Lecture | |
| Communicating science: how do we teach undergraduates to become scientists? D.H. Hryciw | 44P |
| Free communications: Disease and signalling/muscle | |
| Differential expression of heat shock proteins in proliferating and differentiating skeletal muscle cells S.S. Thakur, N.J. Cranna, K. Swiderski, J.G. Ryall & G.S. Lynch | 45P |
| Anabolic metabolism and pro-survival signaling are engaged to rescue the phenotype of electron transport chain dysfunction in a cybrid cell model J.A. Barbour, I.A. Trounce, K.L. Hoehn & N. Turner | 46P |
| A physiological drop in pH decreases mitochondrial respiration, and AMPK and Akt signalling, in L6 myotubes A.J. Genders, S.D. Martin, S.L. McGee & D.J. Bishop | 47P |
| Mechanisms of insulin resistance in Type I and Type II muscle fibres from Type 2 diabetics N.T. Frankenberg, S.A. Mason, G.D. Wadley & R.M. Murphy | 48P |
| The relationship between sarcopenic obesity, functional strength and bone mineral density L.B. McMillan, A. Hayes, C.A. Goodman & D. Scott | 49P |
| Cell polarity defines three distinct domains in pancreatic beta cells and is disrupted in type 2 diabetes W.J. Gan, M. Zavortink, A. Shewan & P. Thorn | 50P |
| Single cell transcriptome profiling of prostate epithelial cell types: monitoring androgen responsiveness R. Taylor, A. Clarke, N. Lister, M. Lawrence, H. Nim & G. Risbridger | 51P |
| Free communications: Exercise Physiology/Metabolism | |
| ACTN3 R577X variant influences mitochondrial-related gene expression following a bout of exercise I.D. Ppadimitriou, X. Yan, J. Kuang, A. Garnham, K.N. North, D.J. Bishop & N. Eynon | 52P |
| Acute high-intensity exercise-induced redox signalling is associated with enhanced insulin sensitivity in obese middle-aged men L. Parker, N.K. Stepto, C.S. Shaw, F. Serpiello, M. Anderson, D. Hare & I. Levinger | 53P |
| The scaling of human basal metabolic rate in adult males H.M. Bowes, C.A. Burdon & N.A.S. Taylor | 54P |
| Fit mum, fat dad: Can mum exercising during pregnancy overcome the detrimental
effects on insulin sensitivity in offspring of a high fat eating dad? F. Falcão-Tebas, C.R. Arceri, J.P. Kerris, E.C. Marin & G.K. McConell | 55P |
| Long-term cardiac programming by short-term juvenile exercise training Y. Asif, M.E. Wlodek, M.J. Black, A.P. Russell, P. Soeding & G.D. Wadley | 56P |
| Can variations in body morphology explain gender-related differences in heat loss? S.R. Notley, J. Park, K. Tagami, N. Ohnishi & N.A.S. Taylor | 57P |
| Rac1 and AMPK account for the major part of exercise-stimulated muscle glucose uptake L. Sylow, I.L. Nielsen, L.L.V. Møller, G. Steinberg, T.E. Jensen & E.A. Richter | 170P |
| Posters | |
| Endothelial BKCa, but not TRPV4 activity is altered in focal cerebral ischemic stroke S.L. Sandow, N.M. Jones, H.L. Ngyuen, D.C. Ellinsworth, T.H. Grayson, R. Grimley, A. Dettrick & T.V. Murphy | 59P |
| α1-,α2-Na,K-ATPase and Kir 2.1 expression and their implications for cerebral artery function and migraine etiology in a mouse model of Familial Hemiplegic Migraine type 2 S.L. Sandow, V. Hinkley, K. Lykke-Hartmann, L. Hangaard, C.A. Staehr, C. Aalkjaer & V.V. Matchkov | 60P |
| Altered arterial mechanics and vasodilator function in an in vitro model of vascular insulin resistance T.V. Murphy, S.L. Sandow, S. Senadheera & G. Ivanov | 61P |
| The effect of intrauterine growth restriction on the Ca2+-sensitivity and maximum Ca2+-activated force of β-escin skinned mesenteric arteries of 5-week old male Wistar-Kyoto rats M.J. Christie & G.S. Posterino | 62P |
| Exaggerated blood pressure responses to mental stress are associated with increases in muscle sympathetic nerve activity K. El Sayed, V.G. Macefield, S.L. Hissen, M.J. Joyner & C.E. Taylor | 63P |
| Individual contributions of isoflurane anaesthesia and surgical incision to haemodynamic regulation in Zucker Diabetic Fatty rats in vivo C.T. Bussey & R.R. Lamberts | 64P |
| The effect of high glucose concentration and oxidative stress on transient receptor potential vanilloid 4 ion channel-mediated relaxation in rat carotid artery K. Tadros, W. Darby, S.J. Potocnik, P. McIntyre & O.L. Woodman | 65P |
| (+)-naloxone and (+)-naltrexone transiently block cardioprotection in ischemic-preconditioned mouse hearts S.M. Lee, D.A. Saint, M. Hutchinson, W. Thomas & M. Reichelt | 66P |
| Increased heart glucose uptake in Slc6a19 (-/-) mice appears to be independent of GLP-1 action T.H. Goh, Y. Jiang & S. Bröer | 67P |
| Intramyocardial delivery of miR-29a improves cardiac function and prevents pathological remodeling following myocardial infarction Z.B. Ma, G.A. Quaife-Ryan, J.J. Cooper-White, J.E. Hudson & E.R. Porrello | 68P |
| Characteristics of MMP-9 protein in rat skeletal muscle X. Ren, G.D. Lamb & R.M. Murphy | 69P |
| MiR-499 reduces muscle protein synthesis in human primary myotubes E. Zacharewicz, P. Della Gatta, L. Ghobrial, A.P. Russell & S. Lamon | 70P |
| Visualisation of intramuscular lipid droplet and perilipin 2 association in isolated human muscle fibres C.S. Shaw, T. Erftemeyer, A. Aldous, R.M. Murphy & K.F. Howlett | 71P |
| Contractile properties of type I and type II skeletal muscle fibres are altered in aged men undergoing androgen deprivation therapy C.R. Lamboley, T.L. Dutka, E.D. Hanson, A. Hayes, J. Violet & G.D. Lamb | 72P |
| MicroRNA expression patterns in post-natal mouse skeletal muscle development S. Lamon, E. Zacharewicz, L. Orellana, L.C. Butchart, M.D. Grounds & A.P. Russell | 73P |
| Gestational age at time of in utero lipopolysaccharide exposure influences the severity of inflammation-induced diaphragm dysfunction in lambs G.J. Pinniger, K. Karisnan, A.J. Bakker, Y. Song, P.B. Noble & J.J. Pillow | 74P |
| Examining the access to and handling of calcium by the t-tubular system in skinned rat fibres X. Koenig & B.S. Launikonis | 75P |
| Complex regulation of ryanodine receptors by calsequestrin in cardiac muscle: the effect of doxorubicin N.A. Beard, A.D. Hanna, M. Janzcura, C. Thekkedam, H. Willemse & A.F. Dulhunty | 76P |
| Adenylosuccinic acid therapy attenuates skeletal muscle histopathology in the dystrophin-deficient mdx mouse C.A. Timpani, J. Clark, J. Mier, A. Hayes & E. Rybalka | 77P |
| The effect of age and taurine supplementation on glycogen associated protein abundance in mdx mice: A comparison between 28 and 70 d mdx mice, a model of Duchenne muscular dystrophy R.G. Barker, B.P. Frankish, D. Horvath & R.M. Murphy | 78P |
| A reduction in Selenoprotein S (SEPS1) amplifies the inflammatory profile of fast twitch skeletal muscle in the mdx dystrophic mouse G. Keefe, A. Addinsall, S. Andrikopoulos, N. Stupka & C. Wright | 79P |
| The effects of normobaric hypoxia on mitochondrial function in humans J. Kuang, A. Ferri, X. Yan, C. Granata, R.S.F. Oliveira, C.P. Hedges, K. Hill, A.E. Lima-Silva, F. Billaut & D.J. Bishop | 80P |
| Single fibre responses of MARPs to an acute bout of resistance exercise in untrained individuals S.G. Wette, H.K. Smith, G.D. Lamb & R.M. Murphy | 81P |
| Diffusibility and glycogen association of AMPK in rat skeletal muscle with and without in vitro stimulation H. Xu, G.D. Lamb, N.T. Frankenberg, P.R. Gooley, D.I. Stapleton & R.M. Murphy | 82P |
| The role of mitochondrial derived phosphatidylethanolamine in regulating skeletal muscle structure and function A. Selathurai, G.M. Kowalski, M.L. Burch, S.L. McGee & C.R. Bruce | 83P |
| Inorganic nitrate supplementation enhances skeletal muscle insulin sensitivity in nNOS null mice M. Zhang, J.P. Kerris, F. Falcão-Tebas, E.C. Marin, S. Andrikopoulos & G.K. McConell | 84P |
| Tocotrienols and Whey Protein Increase Exercise Capacity in Diet -Induced Obese Male Sprague-Dawley Rats A.C. Betik, J. Aguila, G.K. McConell, A.J. McAinch & M.L. Mathai | 85P |
| Agonism of GPR120 regulates markers of skeletal muscle metabolism A.J. McAinch, L.M. Cornall, M.L. Mathai & D.H. Hryciw | 86P |
| Role of insulin receptor substrate-2 serine phosphorylation in the regulation of liver metabolism K.F. Howlett, C. Swinton, B.J. van Denderen, K. Sakamoto & S.L. McGee | 87P |
| Inflammation is not a driving factor in the development of insulin resistance in diet induced obesity in rats A.A. Brown, M.A. Keske, S. Rattigan & S.M. Richards | 88P |
| Mice lacking amino acid transporter B0AT1 (Slc6a19) have improved glycaemic control Y. Jiang, A. Bröer & S. Bröer | 89P |
| Idebenone therapy protects against Oxaliplatin-induced gastrointestinal dysfunction R.M. McQuade, J. Sorensen, C.A. Timpani, K. Nurgali & E. Rybalka | 90P |
| Platinum accumulation and changes in mitochondrial function of the longitudinal muscle & myenteric plexus following oxaliplatin administration V. Stojanovska, R.M. McQuade, M. Stewart, C.A. Timpani, J. Sorensen, J. Orbell, E. Rybalka & K. Nurgali | 91P |
| Flippases and scramblases regulate phospholipid distribution in the plasma membrane during platelet activation and apoptosis W. Jing, M. Yabas, A. Bröer, L. Coupland, A. Enders & S. Bröer | 92P |
| GHB, THIP and NCS-382 activate a subset of GABAARs expressed in Xenopus oocytes N.L. Absalom, P. van Nieuwenhuijzen, H-J. Lee, G. Hunt, I. McGregor & M. Chebib | 93P |
| Impact of ability-weighted team-based learning on performance in introductory physiology laboratory classes in year 2 tertiary education N.Y. Marden, L.G. Ulman, G.M. Velan & G.D. Housley | 94P |
| Fibre-type specific changes to skeletal muscle Na+-K+-ATPase and FXYD1 following post-exercise cold-water immersion in humans D. Christiansen, J.R. Broatch, D.J. Bishop & R.M. Murphy | 171P |
| Plenary Lecture | |
| The impact of exercise on insulin resistance and type 2 diabetes B.H. Goodpaster | 95P |
| Symposium: Cardiovascular metabolo-pathology | |
| MG53 and diabetic cardiomyopathy X. Hu | 96P |
| Myocardial energy mis-appropriation in metabolic stress L.M.D. Delbridge | 97P |
| An alternative approach to protecting the heart under ischaemic stress C.X. Qin | 98P |
| Dietary fuels and metabolic consequences are context specific G.M. Kowalski | 99P |
| Symposium: Novel mechanisms that regulate the physiological attributes of muscle | |
| Circadian rhythms, molecular clock and musculoskeletal health K.A. Esser | 100P |
| Exercise regulated phosphoproteome reveals new AMPK substrates and signaling pathways N.J. Hoffman, B.L. Parker, R. Chaudhuri, K. Fisher-Wellman, M. Kleinert, S.J. Humphrey, P. Yang, S. Trefely, D.J. Fazakerley, J. Stöckli, R. Jothi, B. Kiens, J.F.P. Wojtaszewski, E.A. Richter & D.E. James | 101P |
| A powerful mouse resource for mapping genetic traits, identifying modifying genes and unravelling gene networks K.J. Nowak, A. Messineo, J.K. Boutilier, E. McNamara, C. Wingate, H. Goullee, J. Ma, R. Ong, M. Faigenbaum, A.J. Bakker, G.J. Pinniger, G. Manship, A. Wallace, C. Murray, R. Chidambaram, M. Mehta, Q. Nguyen, R. Ram, N.G. Laing & G. Morahan | 102P |
| Bioengineering human cardiac tissue J.E. Hudson | 103P |
| Free communications: Signal transduction/skeletal muscle | |
| The tubular (t-) system is a dynamic Ca2+-buffer in human skeletal muscle fibres T.R. Cully, L. Roberts, R. Fassett, T. Raastad, J. Sax, J.S. Coombes & B.S. Launikonis | 104P |
| Inhibitory effect of dantrolene on skeletal muscle RYR in the presence of calmodulin Y.W. Oo, D.F. van Helden, M.S. Imtiaz & D.R. Laver | 105P |
| The effect of nitrate supplementation on sarcoplasmic reticulum Ca2+ handling in dystrophic skeletal muscle fibres R. Blazev, C.A. Timpani, G.K. McConell, A. Hayes & E. Rybalka | 106P |
| The effect of intracellular [Mg2+] on Ca2+ handling by the sarcoplasmic reticulum R.H. Choi & B.S. Launikonis | 107P |
| Cardiac-specific FKBP12 deficiency alters RyR2 calcium release and causes severe dilated cardiomyopathy in male and female mice A.D. Hanna, J.M. Oakes, C. Hsu, L. Wong, M.E. Dickinson & S.L. Hamilton | 108P |
| Role for selenoprotein S (SEPS1) in regulating skeletal muscle contractile function in fast twitch muscles A. Addinsall, N.L. McRae, C. Wright, S. Andrikopoulos & N. Stupka | 109P |
| The stress-responsive NDRG2 protein alters the redox state in C2C12 myoblasts and is protective against hydrogen peroxide-induced oxidative stress V.C. Foletta, K.J. Anderson & A.P. Russell | 110P |
| Cochlear type II spiral ganglion afferent fibres are essential for medial olivocochlear reflex – mediated otoprotection from noise – induced hearing loss K.E. Froud, J.M.E. Cederholm, M. Klugmann, J.-P. Julien, A.F. Ryan & G.D. Housley | 111P |
| Symposium: Physiological mechanisms controlling microvascular flow and muscle metabolism | |
| Perivascular adipose tissue in control of organ perfusion and glucose metabolism E.C. Eringa | 112P |
| Regulation of muscle microvascular flow and metabolism: an overview M.A. Keske & S. Rattigan | 113P |
| The effects of GLP-1 on microvascular recruitment in human and rat muscle K.A. Sjøberg, J.J. Holst, S. Rattigan, E.A. Richter & B. Kiens | 114P |
| Beneficial effects of exercise on regulation of microvascular flow R.M. Dwyer | 115P |
| Symposium: The sarcoplasmic reticulum of skeletal muscle | |
| The role of ryanodine receptor Ca2+ leak in t-system Ca2+ handling in skeletal muscle fibres T.R. Cully, R.H. Choi, T.R. Shannon & B.S. Launikonis | 116P |
| α-actinin-3 and sarcoplasmic reticulum function S.I. Head | 117P |
| Functional interactions within the skeletal ryanodine receptor calcium release complex A.F. Dulhunty, N.A. Beard, M.G. Casarotto, L. Wei, E. Wium, L. Li, R.T. Rebbeck, S.J. Richardson & G.A. Steele | 118P |
| Exercise-dependent formation of new SR-TT junctions containing STIM1 and Orai1 S. Boncompagni, A. Michelucci, L. Pietrangelo, R.T. Dirksen & F. Protasi | 119P |
| Pregnancy and fetal physiology | |
| Maternal nutrient restriction alters Ca2+ handling properties and contractile function of isolated left ventricle bundles in male but not female rats T.J. Harvey, R.M. Murphy, J.L. Morrison & G.S. Posterino | 121P |
| IKCa-IP3R myoendothelial microdomains in the uterine radial arteriole are present in normal, and absent in gestational and pre-eclamptic hypertensive pregnancies: Targets for therapy? S.L. Sandow, V. Hinkley, L. Leader, T.H. Grayson & T.V. Murphy | 122P |
| F2 fetal nephron number and weight benefits of endurance exercise training for females born small on high fat diet D.H. Hryciw, V.F.I. Richter, D. Mahizir, K. Anevska, A.J. Jeffries, G.D. Wadley, K.M. Moritz & M.E. Wlodek | 123P |
| Periconceptional alcohol exposure alters the mesolimbic reward pathway and behaviour in offspring E.S. Dorey, C.L. Cullen, K.M. Mah, D. Zanfirache, B.S. Muhlhausler & K.M. Moritz | 124P |
| Maternal corticosterone exposure in the mouse programs dysregulation of plasma corticosterone levels and adrenal size in offspring in an age and sex specific manner J.S.M. Cuffe, E.L. Turton, D.J. Burgess, L.K. Akison, L. O'Sullivan & K.M. Moritz | 125P |
| Complex interacting mechanisms regulating contraction and inter-contraction relaxation in labouring human myometrium H.C. Parkington, M. Jigau, C. Goundar, M.A. Tonta, J. Stevenson, P.J. Sheehan, S.P. Brennecke, M. Tare & H.A. Coleman | 126P |
| Differential effect of early versus late onset chronic hypoxemia on molecular mechanisms regulating lung maturation in the late gestation fetus E.V. McGillick, S. Orgeig, B.J. Allison, K.L. Brain, Y. Niu, N. Itani, K.L. Skeffington, A.D. Kane, E.A. Herrera, D.A. Giussani & J.L. Morrison | 127P |
| The mechanism(s) of vitamin D deficiency induced alterations in lung structure and function G.R. Zosky, E. Bennett, N. Nuñez & L. Chen | 128P |
| Symposium: Controlling the excitable heart | |
| Cyclic nucleotide coupled phosphodiesterase signalling in cardiac sympathetic neurons in heart disease: novel therapeutic targets D.J. Paterson | 129P |
| Calmodulin regulation of ryanodine receptors (RYR2) differs in failing and non-faling human hearts due to differences in RYR2 phosphorylation K. Walweel, Y.W. Oo, D.F. van Helden, C. dos Remedios, P. Molenaar & D.R. Laver | 130P |
| Regulation of the cardiac ryanodine (RyR2) receptor by RyR2 associated proteins P.P. Jones, J.Z. Zhang, J.C. McLay, H.M.M. Waddell & E. Wu | 131P |
| Insights into adrenergic stimulation of calcium channels L.C. Hool | 132P |
| Symposium: New insights into exercise-induced mitochondrial adaptations | |
| Factors influencing exercise-induced mitochondrial biogenesis D.J. Bishop | 133P |
| Autophagy and exercise-induced mitochondrial adaptions Z. Yan | 134P |
| Does antioxidant supplementation reduce skeletal muscle mitochondrial biogenesis? G.D. Wadley | 135P |
| NRF-2 and mitochondrial biogenesis J.S. Coombes, A.R. Mallard & C.A. Houghton | 136P |
| Free communications: Muscle growth/development | |
| Assessing postprandial glucose using the triple tracer technique D.J. Morrison, C.R. Bruce, G.M. Kowalski, A.P. Russell & G.D. Wadley | 137P |
| The NAD+ precursors, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), regulate exercise capacity in aged mice in a SIRT1-dependent manner S. Joshi, B. Osborne, A. Das, C. Fiveash, L. Kim, C. Li, H. Toop, L.E. Wu, J. Morris, D.A. Sinclair & N. Turner | 138P |
| The evolution of ACTN3: Why has α-actinin-3 deficiency become so common and why do we care? P.J. Houweling, A.E.G. Traill, C.F.H. Tiong, K.N. Roeszler, K.C. Thomas, J.T. Seto, F. Zheng, K.G.R. Quinlan, S.I. Head & K.N. North | 139P |
| Global phosphoproteomics reveals the skeletal muscle contraction signalling repertoire and novel regulation of sarcoplasmic reticulum calcium sensing machinery via AMPK N.J. Hoffman, B.L. Parker, R. Chaudhuri, T. Naim, J.G. Burchfield, J. Stöckli, G.S. Lynch & D.E. James | 140P |
| The long and short of non-coding RNAs during post-natal growth of skeletal muscles in mice: a focus on lncRNA and miRNAs L.C. Butchart, T. Shavlakadze & M.D. Grounds | 141P |
| Idebenone protects against chemotherapy-induced skeletal muscle wasting and mitochondrial dysfunction in mice J. Sorensen, C.A. Timpani, D. Campelj, A.C. Petersen, A. Hayes & E. Rybalka | 142P |
| Non-invasive characterisation of early disease progression in mouse models of Duchenne muscular dystrophy T.D. Colgan, M. Sashindranath, M. Daglas, M.N. Nguyen, R.L. Medcalf, K.T. Murphy, G.S. Lynch & P. Gregorevic | 143P |
| Insights into the role and regulation of the Translationally Controlled Tumor Protein in skeletal muscle C.A. Goodman, A.M. Coenen & T.A. Hornberger | 144P |
| Symposium: Lipid metabolism in health & disease - novel techniques to assess lipids | |
| What has lipidomics done for me lately: insights, advances and limitations in the application of lipidomics to the study of lipid metabolism in health and disease T.W. Mitchell | 146P |
| Phospholipids and skeletal muscle function C.R. Bruce | 147P |
| Mass spectrometric imaging, a novel way of visualising lipid distribution in tissue P.J. Trim & M.F. Snel | 148P |
| Fatty acids and prostate cancer: a journey from the lab to the clinic A.J. Hoy | 172P |
| Symposium: Linking mitochondria with health and disease | |
| Understanding the landscape of inherited mitochondrial diseases D.R. Thorburn | 149P |
| Mitochondrial redox in aging skeletal muscle D.J. Marcinek, M. Campbell, Y.A. Chiao, P.S. Rabinovitch & H.H. Szeto | 150P |
| Mitochondrial dysfunction in Parkinson’s disease A.A. Cooper | 151P |
| Distinct metabolic effects of elevated NAD biosynthesis in the nuclear or mitochondrial compartments N. Turner, N. Bentley, B. Osborne, S. Joshi, A. Das, C. Fiveash, L.E. Wu, P. Polly, T. Araki, D.A. Sinclair & M. Montgomery | 152P |
| Symposium: Age, sex and cardiovascular protection strategies | |
| Different cardioprotection strategies in ageing S.E. Howlett | 153P |
| GPER pharmacotherapy in ischemic stroke C.G. Sobey | 154P |
| Manipulating the innate immune system as a cardioprotective strategy D.A. Saint, M. Hutchinson & S.M. Lee | 155P |
| Nitroxyl (HNO) as a vasoprotective signalling molecule B.K. Kemp-Harper | 156P |
| Symposium: SERCA and NaK properties and regulation in skeletal muscle | |
| Furthering our insights into the ATPases in muscle R.M. Murphy, B.P. Frankish, D. Christiansen & G.D. Lamb | 157P |
| The diverse roles of phospholamban and sarcolipin in skeletal muscle: From adaptive thermogenesis to muscle myopathy A.R. Tupling | 158P |
| Mechanisms of SR Ca2+ ATPase dysfunction in muscle wasting disorders S.M. Gehrig, K.T. Murphy, M.I. Hossain, T. Rupasinghe, S.J. Dayalan, M.J. McConville, D.I. Stapleton, B.R. Roberts, J.G. Ryall & G.S. Lynch | 159P |
| The effects of inactivity and age on Na+,K+-ATPase abundance in skeletal muscle in humans M.J. McKenna, V.L. Wyckelsma, B.D. Perry & R.M. Murphy | 160P |
| Free communications: Exercise adaptation | |
| Effects of altered carbohydrate availability on glycogen related proteins within skeletal muscle B.P. Frankish, S.C. Lane, J.L. Areta, D.I. Stapleton, J.A. Hawley & R.M. Murphy | 161P |
| Plasma K+ dynamics during incremental exercise and recovery in older adults before and after 12 weeks of high-intensity interval training V.L. Wyckelsma, I. Levinger, A.C. Petersen & M.J. McKenna | 163P |
| Influence of training intensity on adaptations in acid/base transport protein abundance and non-bicarbonate muscle buffer capacity in active men C. McGinley & D.J. Bishop | 164P |
| Acute physiological responses during walking under low oxygen exposure of 4000m altitude environment J. Yamauchi, H. Koike & N. Morita | 165P |
| Effect of acute hypoxia on dynamic response characteristics of ventilation in males and females S. Green, L. Rispen & D. Marks | 166P |
| Blood flow restriction training induces systemic muscle strength adaptations A.K. May, A.P. Russell & S.A. Warmington | 167P |
| Cold water immersion attenuates performance increases and promotes fat loss following resistance training A.C. Petersen, J.R. Broatch, C. Argus, R. Polman, S. Halson, E.D. Hanson & D.J. Bishop | 168P |
| Skeletal muscle mitochondrial ROS emission and antioxidant genes are elevated 3 h after exercise independent of exercise intensity A.J. Trewin, L. Parker, C.S. Shaw, A. Garnham, D.S. Hiam, I. Levinger, G.K. McConell & N.K. Stepto | 169P |
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