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PROCEEDINGS OF THE
AUSTRALIAN PHYSIOLOGICAL SOCIETY

ISSN 0067-2084

Volume 46

2015

CONTENTS

AuPS 2015 Hobart Meeting

Education workshop: Designing assessments in physiology
Using MCQs to assess causal reasoning
J.A. Michael1P
Using EMQs and MCQs to assess higher order thinking and knowledge in physiology
C.P. Sevigny2P
Should students be allowed to “play to their strengths” with flexible assessment?
A. Edwards3P
Student perceptions of a differentiated assessment model in large enrolment undergraduate science cohorts
G.M. Rayner4P
Progressive development of scientific literacy through assessment
K. Colthorpe, K. Zimbardi, A. Bugarcic & A. Smith5P
Opening ceremony - AuPS Invited Lecture
Amino acid transport - Translating basic discovery into improving health
S. Bröer6P
Free communications: Muscle wasting disease
Genetic reduction of the extracellular matrix protein versican modulates the pathology and function of dystrophic mdx mouse hindlimb muscles
N.L. McRae, L. Forgan, A. Addinsall, C. Van Der Poel, B. McNeill, D.R. McCulloch & N. Stupka7P
Fast-twitch muscle from old dystrophic mice contain complex branched fibres which are susceptible to contractile damage while slow-twitch are protected
L. Kiriaev, S. Chan, S. Kueh, J. Morley & S.I. Head8P
Effects of vitamin D supplementation on dystrophic (mdx) muscles during damage and repair
A. Hayes, N. Andreacchio, C.A. Timpani, E.D. Hanson & E. Rybalka9P
Microdystrophin and follistatin combinatorial gene delivery to treat a severe mouse model of Duchenne muscular dystrophy
T.D. Colgan, K.T. Murphy, T. Kennedy, D. Ham, T. Naim, A. Chee, M.N. Nguyen, H. Qian, J.S. Chamberlain, G.S. Lynch & P. Gregorevic10P
Taurine homeostasis in Duchenne Muscular Dystrophy and the use of the amino acid as a therapeutic intervention
J.R. Terrill, G.J. Pinniger, M.D. Grounds & P.G. Arthur11P
Dysfunction of the dystrophin-glycoprotein complex in cancer cachexia
K. Swiderski, K.T. Murphy, C.J. Brock, N.A. Williamson, J. Trieu, A. Chee, D.M. Baum, T. Naim & G.S. Lynch12P
Development of novel TGF-β-targeted therapeutics to treat cachexia
J.L. Chen, K.L. Walton, A. Hagg, E.K. Kelly, H. Qian, C.A. Harrison & P. Gregorevic13P
Integrated expression analysis of follistatin treatment identifies a novel E3 ubiquitin ligase in the regulation of muscle hypertrophy and sarcopenia
J.R. Davey, K.I. Watt, B.L. Parker, R. Chaudhuri, J.G. Ryall, V. Sartorelli, M. Sandri, J.S. Chamberlain, D.E. James & P. Gregorevic14P
Free communications: Muscle and vascular
The effects of diabetic metabolic derangement on left ventricular structure and function
I. Heinonen, O. Sorop, M. van Kranenburg, V.J. de Beer, Y. Octavia, R.W.B. van Duin, R.J. van Geuns, A.H. van den Meiracker, A.H. Danser, J. van der Velden, D. Merkus & D.J. Duncker15P
The Alzheimer’s disease protein Aβ42 is released from adipose tissue and alters cardiac glucose metabolism and function
J. Czeczor, A.J. Genders, K.A. De Jong, T. Connor, K. Venardos, K. Aston-Mourney, C. Swinton, S.E. Hussey, M. Hargreaves, K.R. Walder, R. Cappai & S.L. McGee16P
Aromatase expression in human/rat myocardium and pericardial adipose – a potential mechanistic link between obesity and myocardial disease onset?
J.R. Bell, G.B. Bernasochi, W.T.K. Ip, W.C. Boon, S. Pepe, S.B. Harrap & L.M.D. Delbridge17P
Nicotinamide mononucleotide, an NAD+ precursor, reverses age-associated decline in exercise capacity by increasing skeletal muscle capillary density in a Sirt1-dependent manner
A. Das, G.X. Huang, L. Kim, C. Li, B. Osborne, S. Joshi, E.O. Williams, L.E. Wu, M. Igarashi, L.P. Guarente, N. Turner, Z.P. Arany & D.A. Sinclair18P
Nitroxyl-mediated relaxation is preserved in the diabetic mesenteric artery despite endothelial dysfunction and increased axial stiffness
N. Kahlberg, J. Anthonisz, R.H. Ritchie, E. Jap, L.J. Parry, B.K. Kemp-Harper, C.H. Qin & C.H. Leo20P
Local infusion of a nitric oxide synthase inhibitor reverses increases in leg insulin sensitivity after acute exercise in humans
G.K. McConell, K.A. Sjøberg, C. Frøsig, A.C. Betik, L. Sylow, R. Kjøbsted, M. Kleinert, B. Kiens, S. Rattigan, J.F.P. Wojtaszewski & E.A. Richter21P
Restricted microvascular blood flow in skeletal muscle after an oral glucose challenge in healthy humans
R.D. Russell, T.M. Greenaway, J.E. Sharman, D. Hu, D. Premilovac, S.M. Richards, S. Rattigan & M.A. Keske22P
Forearm blood flow distribution in healthy controls and T2D: Effect of exercise training
S.J. Blackwood, R.D. Russell, R.M. Dwyer, M.A. Keske & S. Rattigan23P
Symposium: Education symposium: What do we want our physiology graduates to know and be able to do?
The core concepts of physiology: What are they and how do we know if our students understand them?
J.A. Michael24P
Online resources to support the teaching of physiology content and practicals
S. Clarke, M. del Mar Quiroga & R. Rajan25P
Teaching the core concept of gradient flow: application of Mathbench modules
D.J. Watters, M.W. Weible II & Y.M. Hodgson26P
Milestones that evidence student progression from novice to an expert understanding of the nature of scientific knowledge
K. Zimbardi & K. Colthorpe27P
Using a course wide professional development program to enhance undergraduate career development and employability
J. Choate, J. Green, S. Cran, J. Macaulay & M. Etheve58P
Symposium: Sex-specific effects of programming: how your gender plays a role in determining your disease risk
Sex, drugs and developmental programming of renal, cardiovascular and metabolic dysfunction
K.M. Moritz & J.S.M. Cuffe28P
Sex-specific effects of programming: how your gender plays a role in determining your disease risk
B.S. Muhlhausler29P
Fetal sex specific differences in the maternal renin-angiotensin system: implications for pregnancy outcome
K.G. Pringle30P
Sex differences in the effects of early life Vitamin D deficiency on vascular regulation
M. Tare, K.J. Bubb, H.A. Coleman & H.C. Parkington31P
Symposium: Stem cells & regenerative medicine
Molecular regulation of stem cell quiescence
T.H. Cheung32P
A functional genomics pipeline for mammalian heart regeneration
E.R. Porrello33P
Metabolic reprogramming in skeletal muscle stem cells
J.G. Ryall, A. Webster, C.H. Ly & G.S. Lynch34P
Determination of the mechanism of disease in myopathies utilizing zebrafish
R.J. Bryson-Richardson35P
Free communications: Drugs and channels
Docking the B0AT: Identification of novel amino acid transport inhibitors
N. Shah, Q. Cheng, A. Bröer, B. Corry & S. Bröer36P
Screening of chemical compounds to identify specific inhibitors of the nutrient transporter B0AT1, a potential drug target to treat type 2 diabetes
Q. Cheng, N. Shah, A. Bröer, B. Corry & S. Bröer37P
Investigating the importance of temperature dependent hERG channel block in proarrhythmic risk assessment
M.J. Windley, S.A. Mann, J.I. Vandenberg & A.P. Hill38P
Quantifying expression defects of LQT2 associated hERG mutations
C.A. Ng, M.D. Perry, M.J. Hunter & J.I. Vandenberg39P
Heat sensation of temperature sensitive TRPV1 channel supported by the transmembrane core domain
L. Ma, F. Yang, Y. Cui, X. Cao, K. Wang & J. Zheng40P
Curcumin and chlorpromazine are novel inhibitors of TRPM2 channel
E. Kheradpezhouh, G.J. Barritt & G. Rychkov41P
Different location same story: Identification of a common binding site for membrane-anchored ancillary proteins in the SLC6 family of neural and epithelial transporters
S.J. Fairweather, A. Bröer, N. Subramanian, E. Tumer, Q. Cheng, D. Schmoll, M. O'Mara & S. Bröer42P
A biomimetic glyceride prodrug approach to promote drug delivery to the lymphatics, associated immune cells and tissues
G. Gracia, S. Han, T. Quach, L. Hu, J.S. Simpson, C.J.H. Porter & N.L. Trevaskis43P
Roberts Lecture
Communicating science: how do we teach undergraduates to become scientists?
D.H. Hryciw44P
Free communications: Disease and signalling/muscle
Differential expression of heat shock proteins in proliferating and differentiating skeletal muscle cells
S.S. Thakur, N.J. Cranna, K. Swiderski, J.G. Ryall & G.S. Lynch45P
Anabolic metabolism and pro-survival signaling are engaged to rescue the phenotype of electron transport chain dysfunction in a cybrid cell model
J.A. Barbour, I.A. Trounce, K.L. Hoehn & N. Turner46P
A physiological drop in pH decreases mitochondrial respiration, and AMPK and Akt signalling, in L6 myotubes
A.J. Genders, S.D. Martin, S.L. McGee & D.J. Bishop47P
Mechanisms of insulin resistance in Type I and Type II muscle fibres from Type 2 diabetics
N.T. Frankenberg, S.A. Mason, G.D. Wadley & R.M. Murphy48P
The relationship between sarcopenic obesity, functional strength and bone mineral density
L.B. McMillan, A. Hayes, C.A. Goodman & D. Scott49P
Cell polarity defines three distinct domains in pancreatic beta cells and is disrupted in type 2 diabetes
W.J. Gan, M. Zavortink, A. Shewan & P. Thorn50P
Single cell transcriptome profiling of prostate epithelial cell types: monitoring androgen responsiveness
R. Taylor, A. Clarke, N. Lister, M. Lawrence, H. Nim & G. Risbridger51P
Free communications: Exercise Physiology/Metabolism
ACTN3 R577X variant influences mitochondrial-related gene expression following a bout of exercise
I.D. Ppadimitriou, X. Yan, J. Kuang, A. Garnham, K.N. North, D.J. Bishop & N. Eynon52P
Acute high-intensity exercise-induced redox signalling is associated with enhanced insulin sensitivity in obese middle-aged men
L. Parker, N.K. Stepto, C.S. Shaw, F. Serpiello, M. Anderson, D. Hare & I. Levinger53P
The scaling of human basal metabolic rate in adult males
H.M. Bowes, C.A. Burdon & N.A.S. Taylor54P
Fit mum, fat dad: Can mum exercising during pregnancy overcome the detrimental effects on insulin sensitivity in offspring of a high fat eating dad?
F. Falcão-Tebas, C.R. Arceri, J.P. Kerris, E.C. Marin & G.K. McConell55P
Long-term cardiac programming by short-term juvenile exercise training
Y. Asif, M.E. Wlodek, M.J. Black, A.P. Russell, P. Soeding & G.D. Wadley56P
Can variations in body morphology explain gender-related differences in heat loss?
S.R. Notley, J. Park, K. Tagami, N. Ohnishi & N.A.S. Taylor57P
Rac1 and AMPK account for the major part of exercise-stimulated muscle glucose uptake
L. Sylow, I.L. Nielsen, L.L.V. Møller, G. Steinberg, T.E. Jensen & E.A. Richter170P
Posters
Endothelial BKCa, but not TRPV4 activity is altered in focal cerebral ischemic stroke
S.L. Sandow, N.M. Jones, H.L. Ngyuen, D.C. Ellinsworth, T.H. Grayson, R. Grimley, A. Dettrick & T.V. Murphy59P
α1-,α2-Na,K-ATPase and Kir 2.1 expression and their implications for cerebral artery function and migraine etiology in a mouse model of Familial Hemiplegic Migraine type 2
S.L. Sandow, V. Hinkley, K. Lykke-Hartmann, L. Hangaard, C.A. Staehr, C. Aalkjaer & V.V. Matchkov60P
Altered arterial mechanics and vasodilator function in an in vitro model of vascular insulin resistance
T.V. Murphy, S.L. Sandow, S. Senadheera & G. Ivanov61P
The effect of intrauterine growth restriction on the Ca2+-sensitivity and maximum Ca2+-activated force of β-escin skinned mesenteric arteries of 5-week old male Wistar-Kyoto rats
M.J. Christie & G.S. Posterino62P
Exaggerated blood pressure responses to mental stress are associated with increases in muscle sympathetic nerve activity
K. El Sayed, V.G. Macefield, S.L. Hissen, M.J. Joyner & C.E. Taylor63P
Individual contributions of isoflurane anaesthesia and surgical incision to haemodynamic regulation in Zucker Diabetic Fatty rats in vivo
C.T. Bussey & R.R. Lamberts64P
The effect of high glucose concentration and oxidative stress on transient receptor potential vanilloid 4 ion channel-mediated relaxation in rat carotid artery
K. Tadros, W. Darby, S.J. Potocnik, P. McIntyre & O.L. Woodman65P
(+)-naloxone and (+)-naltrexone transiently block cardioprotection in ischemic-preconditioned mouse hearts
S.M. Lee, D.A. Saint, M. Hutchinson, W. Thomas & M. Reichelt66P
Increased heart glucose uptake in Slc6a19 (-/-) mice appears to be independent of GLP-1 action
T.H. Goh, Y. Jiang & S. Bröer67P
Intramyocardial delivery of miR-29a improves cardiac function and prevents pathological remodeling following myocardial infarction
Z.B. Ma, G.A. Quaife-Ryan, J.J. Cooper-White, J.E. Hudson & E.R. Porrello68P
Characteristics of MMP-9 protein in rat skeletal muscle
X. Ren, G.D. Lamb & R.M. Murphy69P
MiR-499 reduces muscle protein synthesis in human primary myotubes
E. Zacharewicz, P. Della Gatta, L. Ghobrial, A.P. Russell & S. Lamon70P
Visualisation of intramuscular lipid droplet and perilipin 2 association in isolated human muscle fibres
C.S. Shaw, T. Erftemeyer, A. Aldous, R.M. Murphy & K.F. Howlett71P
Contractile properties of type I and type II skeletal muscle fibres are altered in aged men undergoing androgen deprivation therapy
C.R. Lamboley, T.L. Dutka, E.D. Hanson, A. Hayes, J. Violet & G.D. Lamb72P
MicroRNA expression patterns in post-natal mouse skeletal muscle development
S. Lamon, E. Zacharewicz, L. Orellana, L.C. Butchart, M.D. Grounds & A.P. Russell73P
Gestational age at time of in utero lipopolysaccharide exposure influences the severity of inflammation-induced diaphragm dysfunction in lambs
G.J. Pinniger, K. Karisnan, A.J. Bakker, Y. Song, P.B. Noble & J.J. Pillow74P
Examining the access to and handling of calcium by the t-tubular system in skinned rat fibres
X. Koenig & B.S. Launikonis75P
Complex regulation of ryanodine receptors by calsequestrin in cardiac muscle: the effect of doxorubicin
N.A. Beard, A.D. Hanna, M. Janzcura, C. Thekkedam, H. Willemse & A.F. Dulhunty76P
Adenylosuccinic acid therapy attenuates skeletal muscle histopathology in the dystrophin-deficient mdx mouse
C.A. Timpani, J. Clark, J. Mier, A. Hayes & E. Rybalka77P
The effect of age and taurine supplementation on glycogen associated protein abundance in mdx mice: A comparison between 28 and 70 d mdx mice, a model of Duchenne muscular dystrophy
R.G. Barker, B.P. Frankish, D. Horvath & R.M. Murphy78P
A reduction in Selenoprotein S (SEPS1) amplifies the inflammatory profile of fast twitch skeletal muscle in the mdx dystrophic mouse
G. Keefe, A. Addinsall, S. Andrikopoulos, N. Stupka & C. Wright79P
The effects of normobaric hypoxia on mitochondrial function in humans
J. Kuang, A. Ferri, X. Yan, C. Granata, R.S.F. Oliveira, C.P. Hedges, K. Hill, A.E. Lima-Silva, F. Billaut & D.J. Bishop80P
Single fibre responses of MARPs to an acute bout of resistance exercise in untrained individuals
S.G. Wette, H.K. Smith, G.D. Lamb & R.M. Murphy81P
Diffusibility and glycogen association of AMPK in rat skeletal muscle with and without in vitro stimulation
H. Xu, G.D. Lamb, N.T. Frankenberg, P.R. Gooley, D.I. Stapleton & R.M. Murphy82P
The role of mitochondrial derived phosphatidylethanolamine in regulating skeletal muscle structure and function
A. Selathurai, G.M. Kowalski, M.L. Burch, S.L. McGee & C.R. Bruce83P
Inorganic nitrate supplementation enhances skeletal muscle insulin sensitivity in nNOS null mice
M. Zhang, J.P. Kerris, F. Falcão-Tebas, E.C. Marin, S. Andrikopoulos & G.K. McConell84P
Tocotrienols and Whey Protein Increase Exercise Capacity in Diet -Induced Obese Male Sprague-Dawley Rats
A.C. Betik, J. Aguila, G.K. McConell, A.J. McAinch & M.L. Mathai85P
Agonism of GPR120 regulates markers of skeletal muscle metabolism
A.J. McAinch, L.M. Cornall, M.L. Mathai & D.H. Hryciw86P
Role of insulin receptor substrate-2 serine phosphorylation in the regulation of liver metabolism
K.F. Howlett, C. Swinton, B.J. van Denderen, K. Sakamoto & S.L. McGee87P
Inflammation is not a driving factor in the development of insulin resistance in diet induced obesity in rats
A.A. Brown, M.A. Keske, S. Rattigan & S.M. Richards88P
Mice lacking amino acid transporter B0AT1 (Slc6a19) have improved glycaemic control
Y. Jiang, A. Bröer & S. Bröer89P
Idebenone therapy protects against Oxaliplatin-induced gastrointestinal dysfunction
R.M. McQuade, J. Sorensen, C.A. Timpani, K. Nurgali & E. Rybalka90P
Platinum accumulation and changes in mitochondrial function of the longitudinal muscle & myenteric plexus following oxaliplatin administration
V. Stojanovska, R.M. McQuade, M. Stewart, C.A. Timpani, J. Sorensen, J. Orbell, E. Rybalka & K. Nurgali91P
Flippases and scramblases regulate phospholipid distribution in the plasma membrane during platelet activation and apoptosis
W. Jing, M. Yabas, A. Bröer, L. Coupland, A. Enders & S. Bröer92P
GHB, THIP and NCS-382 activate a subset of GABAARs expressed in Xenopus oocytes
N.L. Absalom, P. van Nieuwenhuijzen, H-J. Lee, G. Hunt, I. McGregor & M. Chebib93P
Impact of ability-weighted team-based learning on performance in introductory physiology laboratory classes in year 2 tertiary education
N.Y. Marden, L.G. Ulman, G.M. Velan & G.D. Housley94P
Fibre-type specific changes to skeletal muscle Na+-K+-ATPase and FXYD1 following post-exercise cold-water immersion in humans
D. Christiansen, J.R. Broatch, D.J. Bishop & R.M. Murphy171P
Plenary Lecture
The impact of exercise on insulin resistance and type 2 diabetes
B.H. Goodpaster95P
Symposium: Cardiovascular metabolo-pathology
MG53 and diabetic cardiomyopathy
X. Hu96P
Myocardial energy mis-appropriation in metabolic stress
L.M.D. Delbridge97P
An alternative approach to protecting the heart under ischaemic stress
C.X. Qin98P
Dietary fuels and metabolic consequences are context specific
G.M. Kowalski99P
Symposium: Novel mechanisms that regulate the physiological attributes of muscle
Circadian rhythms, molecular clock and musculoskeletal health
K.A. Esser100P
Exercise regulated phosphoproteome reveals new AMPK substrates and signaling pathways
N.J. Hoffman, B.L. Parker, R. Chaudhuri, K. Fisher-Wellman, M. Kleinert, S.J. Humphrey, P. Yang, S. Trefely, D.J. Fazakerley, J. Stöckli, R. Jothi, B. Kiens, J.F.P. Wojtaszewski, E.A. Richter & D.E. James101P
A powerful mouse resource for mapping genetic traits, identifying modifying genes and unravelling gene networks
K.J. Nowak, A. Messineo, J.K. Boutilier, E. McNamara, C. Wingate, H. Goullee, J. Ma, R. Ong, M. Faigenbaum, A.J. Bakker, G.J. Pinniger, G. Manship, A. Wallace, C. Murray, R. Chidambaram, M. Mehta, Q. Nguyen, R. Ram, N.G. Laing & G. Morahan102P
Bioengineering human cardiac tissue
J.E. Hudson103P
Free communications: Signal transduction/skeletal muscle
The tubular (t-) system is a dynamic Ca2+-buffer in human skeletal muscle fibres
T.R. Cully, L. Roberts, R. Fassett, T. Raastad, J. Sax, J.S. Coombes & B.S. Launikonis104P
Inhibitory effect of dantrolene on skeletal muscle RYR in the presence of calmodulin
Y.W. Oo, D.F. van Helden, M.S. Imtiaz & D.R. Laver105P
The effect of nitrate supplementation on sarcoplasmic reticulum Ca2+ handling in dystrophic skeletal muscle fibres
R. Blazev, C.A. Timpani, G.K. McConell, A. Hayes & E. Rybalka106P
The effect of intracellular [Mg2+] on Ca2+ handling by the sarcoplasmic reticulum
R.H. Choi & B.S. Launikonis107P
Cardiac-specific FKBP12 deficiency alters RyR2 calcium release and causes severe dilated cardiomyopathy in male and female mice
A.D. Hanna, J.M. Oakes, C. Hsu, L. Wong, M.E. Dickinson & S.L. Hamilton108P
Role for selenoprotein S (SEPS1) in regulating skeletal muscle contractile function in fast twitch muscles
A. Addinsall, N.L. McRae, C. Wright, S. Andrikopoulos & N. Stupka109P
The stress-responsive NDRG2 protein alters the redox state in C2C12 myoblasts and is protective against hydrogen peroxide-induced oxidative stress
V.C. Foletta, K.J. Anderson & A.P. Russell110P
Cochlear type II spiral ganglion afferent fibres are essential for medial olivocochlear reflex – mediated otoprotection from noise – induced hearing loss
K.E. Froud, J.M.E. Cederholm, M. Klugmann, J.-P. Julien, A.F. Ryan & G.D. Housley111P
Symposium: Physiological mechanisms controlling microvascular flow and muscle metabolism
Perivascular adipose tissue in control of organ perfusion and glucose metabolism
E.C. Eringa112P
Regulation of muscle microvascular flow and metabolism: an overview
M.A. Keske & S. Rattigan113P
The effects of GLP-1 on microvascular recruitment in human and rat muscle
K.A. Sjøberg, J.J. Holst, S. Rattigan, E.A. Richter & B. Kiens114P
Beneficial effects of exercise on regulation of microvascular flow
R.M. Dwyer115P
Symposium: The sarcoplasmic reticulum of skeletal muscle
The role of ryanodine receptor Ca2+ leak in t-system Ca2+ handling in skeletal muscle fibres
T.R. Cully, R.H. Choi, T.R. Shannon & B.S. Launikonis116P
α-actinin-3 and sarcoplasmic reticulum function
S.I. Head117P
Functional interactions within the skeletal ryanodine receptor calcium release complex
A.F. Dulhunty, N.A. Beard, M.G. Casarotto, L. Wei, E. Wium, L. Li, R.T. Rebbeck, S.J. Richardson & G.A. Steele118P
Exercise-dependent formation of new SR-TT junctions containing STIM1 and Orai1
S. Boncompagni, A. Michelucci, L. Pietrangelo, R.T. Dirksen & F. Protasi119P
Pregnancy and fetal physiology
Maternal nutrient restriction alters Ca2+ handling properties and contractile function of isolated left ventricle bundles in male but not female rats
T.J. Harvey, R.M. Murphy, J.L. Morrison & G.S. Posterino121P
IKCa-IP3R myoendothelial microdomains in the uterine radial arteriole are present in normal, and absent in gestational and pre-eclamptic hypertensive pregnancies: Targets for therapy?
S.L. Sandow, V. Hinkley, L. Leader, T.H. Grayson & T.V. Murphy122P
F2 fetal nephron number and weight benefits of endurance exercise training for females born small on high fat diet
D.H. Hryciw, V.F.I. Richter, D. Mahizir, K. Anevska, A.J. Jeffries, G.D. Wadley, K.M. Moritz & M.E. Wlodek123P
Periconceptional alcohol exposure alters the mesolimbic reward pathway and behaviour in offspring
E.S. Dorey, C.L. Cullen, K.M. Mah, D. Zanfirache, B.S. Muhlhausler & K.M. Moritz124P
Maternal corticosterone exposure in the mouse programs dysregulation of plasma corticosterone levels and adrenal size in offspring in an age and sex specific manner
J.S.M. Cuffe, E.L. Turton, D.J. Burgess, L.K. Akison, L. O'Sullivan & K.M. Moritz125P
Complex interacting mechanisms regulating contraction and inter-contraction relaxation in labouring human myometrium
H.C. Parkington, M. Jigau, C. Goundar, M.A. Tonta, J. Stevenson, P.J. Sheehan, S.P. Brennecke, M. Tare & H.A. Coleman126P
Differential effect of early versus late onset chronic hypoxemia on molecular mechanisms regulating lung maturation in the late gestation fetus
E.V. McGillick, S. Orgeig, B.J. Allison, K.L. Brain, Y. Niu, N. Itani, K.L. Skeffington, A.D. Kane, E.A. Herrera, D.A. Giussani & J.L. Morrison127P
The mechanism(s) of vitamin D deficiency induced alterations in lung structure and function
G.R. Zosky, E. Bennett, N. Nuñez & L. Chen128P
Symposium: Controlling the excitable heart
Cyclic nucleotide coupled phosphodiesterase signalling in cardiac sympathetic neurons in heart disease: novel therapeutic targets
D.J. Paterson129P
Calmodulin regulation of ryanodine receptors (RYR2) differs in failing and non-faling human hearts due to differences in RYR2 phosphorylation
K. Walweel, Y.W. Oo, D.F. van Helden, C. dos Remedios, P. Molenaar & D.R. Laver130P
Regulation of the cardiac ryanodine (RyR2) receptor by RyR2 associated proteins
P.P. Jones, J.Z. Zhang, J.C. McLay, H.M.M. Waddell & E. Wu131P
Insights into adrenergic stimulation of calcium channels
L.C. Hool132P
Symposium: New insights into exercise-induced mitochondrial adaptations
Factors influencing exercise-induced mitochondrial biogenesis
D.J. Bishop133P
Autophagy and exercise-induced mitochondrial adaptions
Z. Yan134P
Does antioxidant supplementation reduce skeletal muscle mitochondrial biogenesis?
G.D. Wadley135P
NRF-2 and mitochondrial biogenesis
J.S. Coombes, A.R. Mallard & C.A. Houghton136P
Free communications: Muscle growth/development
Assessing postprandial glucose using the triple tracer technique
D.J. Morrison, C.R. Bruce, G.M. Kowalski, A.P. Russell & G.D. Wadley137P
The NAD+ precursors, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), regulate exercise capacity in aged mice in a SIRT1-dependent manner
S. Joshi, B. Osborne, A. Das, C. Fiveash, L. Kim, C. Li, H. Toop, L.E. Wu, J. Morris, D.A. Sinclair & N. Turner138P
The evolution of ACTN3: Why has α-actinin-3 deficiency become so common and why do we care?
P.J. Houweling, A.E.G. Traill, C.F.H. Tiong, K.N. Roeszler, K.C. Thomas, J.T. Seto, F. Zheng, K.G.R. Quinlan, S.I. Head & K.N. North139P
Global phosphoproteomics reveals the skeletal muscle contraction signalling repertoire and novel regulation of sarcoplasmic reticulum calcium sensing machinery via AMPK
N.J. Hoffman, B.L. Parker, R. Chaudhuri, T. Naim, J.G. Burchfield, J. Stöckli, G.S. Lynch & D.E. James140P
The long and short of non-coding RNAs during post-natal growth of skeletal muscles in mice: a focus on lncRNA and miRNAs
L.C. Butchart, T. Shavlakadze & M.D. Grounds141P
Idebenone protects against chemotherapy-induced skeletal muscle wasting and mitochondrial dysfunction in mice
J. Sorensen, C.A. Timpani, D. Campelj, A.C. Petersen, A. Hayes & E. Rybalka142P
Non-invasive characterisation of early disease progression in mouse models of Duchenne muscular dystrophy
T.D. Colgan, M. Sashindranath, M. Daglas, M.N. Nguyen, R.L. Medcalf, K.T. Murphy, G.S. Lynch & P. Gregorevic143P
Insights into the role and regulation of the Translationally Controlled Tumor Protein in skeletal muscle
C.A. Goodman, A.M. Coenen & T.A. Hornberger144P
Symposium: Lipid metabolism in health & disease - novel techniques to assess lipids
What has lipidomics done for me lately: insights, advances and limitations in the application of lipidomics to the study of lipid metabolism in health and disease
T.W. Mitchell146P
Phospholipids and skeletal muscle function
C.R. Bruce147P
Mass spectrometric imaging, a novel way of visualising lipid distribution in tissue
P.J. Trim & M.F. Snel148P
Fatty acids and prostate cancer: a journey from the lab to the clinic
A.J. Hoy172P
Symposium: Linking mitochondria with health and disease
Understanding the landscape of inherited mitochondrial diseases
D.R. Thorburn149P
Mitochondrial redox in aging skeletal muscle
D.J. Marcinek, M. Campbell, Y.A. Chiao, P.S. Rabinovitch & H.H. Szeto150P
Mitochondrial dysfunction in Parkinson’s disease
A.A. Cooper151P
Distinct metabolic effects of elevated NAD biosynthesis in the nuclear or mitochondrial compartments
N. Turner, N. Bentley, B. Osborne, S. Joshi, A. Das, C. Fiveash, L.E. Wu, P. Polly, T. Araki, D.A. Sinclair & M. Montgomery152P
Symposium: Age, sex and cardiovascular protection strategies
Different cardioprotection strategies in ageing
S.E. Howlett153P
GPER pharmacotherapy in ischemic stroke
C.G. Sobey154P
Manipulating the innate immune system as a cardioprotective strategy
D.A. Saint, M. Hutchinson & S.M. Lee155P
Nitroxyl (HNO) as a vasoprotective signalling molecule
B.K. Kemp-Harper156P
Symposium: SERCA and NaK properties and regulation in skeletal muscle
Furthering our insights into the ATPases in muscle
R.M. Murphy, B.P. Frankish, D. Christiansen & G.D. Lamb157P
The diverse roles of phospholamban and sarcolipin in skeletal muscle: From adaptive thermogenesis to muscle myopathy
A.R. Tupling158P
Mechanisms of SR Ca2+ ATPase dysfunction in muscle wasting disorders
S.M. Gehrig, K.T. Murphy, M.I. Hossain, T. Rupasinghe, S.J. Dayalan, M.J. McConville, D.I. Stapleton, B.R. Roberts, J.G. Ryall & G.S. Lynch159P
The effects of inactivity and age on Na+,K+-ATPase abundance in skeletal muscle in humans
M.J. McKenna, V.L. Wyckelsma, B.D. Perry & R.M. Murphy160P
Free communications: Exercise adaptation
Effects of altered carbohydrate availability on glycogen related proteins within skeletal muscle
B.P. Frankish, S.C. Lane, J.L. Areta, D.I. Stapleton, J.A. Hawley & R.M. Murphy161P
Plasma K+ dynamics during incremental exercise and recovery in older adults before and after 12 weeks of high-intensity interval training
V.L. Wyckelsma, I. Levinger, A.C. Petersen & M.J. McKenna163P
Influence of training intensity on adaptations in acid/base transport protein abundance and non-bicarbonate muscle buffer capacity in active men
C. McGinley & D.J. Bishop164P
Acute physiological responses during walking under low oxygen exposure of 4000m altitude environment
J. Yamauchi, H. Koike & N. Morita165P
Effect of acute hypoxia on dynamic response characteristics of ventilation in males and females
S. Green, L. Rispen & D. Marks166P
Blood flow restriction training induces systemic muscle strength adaptations
A.K. May, A.P. Russell & S.A. Warmington167P
Cold water immersion attenuates performance increases and promotes fat loss following resistance training
A.C. Petersen, J.R. Broatch, C. Argus, R. Polman, S. Halson, E.D. Hanson & D.J. Bishop168P
Skeletal muscle mitochondrial ROS emission and antioxidant genes are elevated 3 h after exercise independent of exercise intensity
A.J. Trewin, L. Parker, C.S. Shaw, A. Garnham, D.S. Hiam, I. Levinger, G.K. McConell & N.K. Stepto169P

Index

Author index
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