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PROCEEDINGS OF THE
AUSTRALIAN PHYSIOLOGICAL SOCIETY
ISSN 0067-2084

Volume 48

2017

CONTENTS

AuPS 2017 Melbourne Meeting

AuPS Invited Lecture
An earful of physiology
G.D. Housley
1P
Symposium: Strategies for large-scale and authentic assessment of undergraduates
Development and assessment of problem-solving skills
P.J. White, E. Yuriev, J.L. Short, J.E. McLaughlin, S. Naidu & I. Larson
9P
Student Peer Assessment: An efficient assessment method to enhance critical evaluation?
R.M. Vickery, C.S-Y. Lin & A.J. Moorhouse
10P
Academic and student perceptions of assessment
Y. Hodgson & L. Garvey
11P
Professional identity in allied health students: How it affects authentic assessment
H. Gray, K. Colthorpe, H. Ernst & L. Ainscough
13P
Free communications: Muscle wasting
The contractile properties of slow and fast skeletal muscle from dysferlin deficient mice
E.M. Lloyd, M.D. Grounds & G.J. Pinniger
2P
One week of hospital admission following elective hip surgery induces substantial muscle atrophy in older patients
I.W.K. Kouw, B.B.L. Groen, J.S.J. Smeets, J. van Kranenburg, M. Poeze, J.A. Geurts, R.H.M. ten Broeke, L.B. Verdijk & L.J.C. van Loon
3P
Modulating bone morphogenic protein signalling in cancer cachexia
A. Hagg, R. Sartori, C.A. Harrison, M. Sandri & P. Gregorevic
4P
Ingestion of 40 g protein prior to sleep stimulates overnight myofibrillar protein synthesis in healthy older men
I.W.K. Kouw, A.M. Holwerda, J. Trommelen, I.F. Kramer, J. Bastiaanse, S.L. Halson, W.K.W.H. Wodzig, L.B. Verdijk & L.J.C. van Loon
5P
Mitochondrial oxidative capacity and oxidative stress in chronically inactive elderly patients
J. Mikovic, E.J. Artenson-Lantz, D. Paddon-Jones & S. Lamon
6P
Muscle specific kinase protects mdx mouse muscles against eccentric contraction-induced loss of strength
J. Ban, S. Trajanovska & W.D. Phillips
7P
Phosphorylation of dystrophin S3059 protects against skeletal muscle wasting
K. Swiderski, C.J. Brock, S.S. Thakur, J. Trieu, A. Chee, T. Naim, K.T. Murphy & G.S. Lynch
8P
Free communicartions: Cardiac
Dissecting the molecular pathways of glucose mishandling and glycogen disturbance in the diabetic heart
K.M. Mellor, U. Varma, C.L. Curl & L.M.D. Delbridge
14P
Metabolic mechanism for cardiomyocyte cell cycle arrest
R.J. Mills, E.R. Porrello & J.E. Hudson
15P
Inhibitory effect of phenytoin on cardiac RYR2
A. Ashna, D.F. van Helden & D.R. Laver
16P
Therapeutic methods for physiological cardiac hypertrophy: The role of MicroRNAs
G. Mazzarino, S. Lamon & G.D. Wadley
17P
Differential effect of electrical stimulation and β-adrenergic stimulation on neonatal rat ventricular myocyte monolayer conduction properties
S.P. Wells, H.M.M. Waddell, L.M.D. Delbridge & J.R. Bell
18P
Arrhythmia: an ‘off-target’ effect of cancer cardiotoxicity
A.D. Chakraborty, L.A. Gonano, J .C. McLay, A.F. Dulhunty & P.P. Jones
19P
Free communications: Physiology education
Open-note examinations as opportunities for meaningful learning and assessment
E. Yuriev, M. Lazarus & D.T. Malone
24P
Implementation and evaluation of a video feedback model
G.D. Wadley & S. Macfarlane
25P
Transformation of a traditionally delivered exercise physiology theory curriculum into a contemporary model of blended learning that better supports student learning
L.A. Lexis & B.L. Julien
26P
Enhancing students' acquisition and application of the conventions of scientific writing
J. Kibedi, K. Colthorpe, J.D. Mi, J. Hardy & S. Rowland
27P
Numeracy performance in sports and exercise science students at an Australian university
S. Green, S. McGlynn, D.M. Stuart, P. Fahey, J. Pettigrew & P. Clothier
28P
How do students deal with difficult physiological concepts?
K. Colthorpe, H. Abe & L. Ainscough
29P
Using an online simulation to prepare students for an enquiry-based laboratory class
M. Quiroga & J. Choate
30P
Encouraging students’ self-regulated learning skills through the use of discussion boards
R. Leung, L. Ainscough, K. Colthorpe & T. Langfield
31P
Symposium: AuPS/Physiological Society of Japan Joint Symposium: Skeletal muscle physiology and function
The genetics of vertebrate skeletal muscle assembly
J. Berger & P.D. Currie
20P
The role of phospholipid flippase in myotube formation
H.Y. Hara, T.M. Tsuchiya, I.K. Itoh, O.M. Okuda, N.R. Nishioka & U.M. Umeda
21P
Molecular mechanism of type 1 ryanodine receptor-linked muscle diseases: toward diagnosis and therapy
T. Murayama
22P
Calcium handling by human skeletal muscle fibres with ryanodine receptor variants
R.H. Choi & B.S. Launikonis
23P
Free communications: Pharmacology and treatment
Diverse changes to GABAA receptor function by mutations that cause severe childhood epilepsies
N.L. Absalom, V. Liao, P.K. Ahring, M. Bowen, I. McGregor & M. Chebib
32P
Volatile vs injectable anaesthetics: considerations for electrophysiological studies in the rat
B.M. Wild, R. Arnold & R. Morris
33P
Targeting the intestinal lymphatic system using an oral triglyceride mimetic prodrug enhances immunosuppressant activity in vivo
R. Kochappan, S. Han, L. Hu, T. Quach, D. Senyschyn, E. Cao, G. Lee, F. Lim, J.S. Simpson, J. Mintern, N.L. Trevaskis & C.J.H. Porter
34P
High density lipoprotein promotes targeted delivery into lymph and lymph nodes: A viable carrier for immunotherapies and vaccines
G. Gracia, A. Johnston, C.J.H. Porter & N.L. Trevaskis
35P
Is high-density lipoprotein-based therapy an option for the treatment of muscle damage in Facioscapulohumeral muscular dystrophy?
A.P. Denny & A.K. Heather
36P
Maternal selenium deficiency in mice alters placental function, reduces fetal glucose concentrations and impairs fetal growth
P. Hofstee, L. Bartho, D.R. McKeating, O.J. Holland, J.J. Vanderlelie, A.V. Perkins & J.S.M. Cuffe
138P
Posters
Maternal obesity results in impaired brain function in the offspring by mechanisms involving electrical hyperactivity
A.A. Abdulwahid, H.A. Coleman & H.C. Parkington
37P
The role of linoleic acid in placental inflammatory response and fatty acid metabolism
N. Shrestha, J.S.M. Cuffe, O.J. Holland, A.V. Perkins, A.J. McAinch & D.H. Hryciw
38P
Mitochondrial profiling of immortalised myoblasts from a Duchenne Muscular Dystrophy patient
C.A. Timpani, J. White, K. Mamchaoui, G. Butler-Browne, A. Hayes & E. Rybalka
39P
Adenylosuccinic acid therapy for the treatment of Duchenne muscular dystrophy: a pre-clinical evaluation of safety and efficacy
E. Rybalka, C.A. Timpani & A. Hayes
40P
Glucocorticoids dysregulate cellular viability, mitochondrial membrane potential and cellular respiration differently in normal compared to high glucose environments
J.S.M. Cuffe, I. Bray-Narai, J.J. Fisher, O.J. Holland & A.V. Perkins
41P
Glucocorticoid suppression of uncarboxylated osteocalcin impairs basal and post-exercise insulin sensitivity and osteocalcin signalling in humans
L. Parker, A.P. Garnham, G.K. McConell, N.K. Stepto, D. Hare, E. Byrnes, P. Ebeling, E. Seeman, T. Brennan-Speranza & I. Levinger
42P
High fat diet induced lymphatic changes may play a role in promoting fatty liver disease
A.D. Lam, E. Cao, M. Montgomery, P. Yadav, H. Chu, G. Gracia, M.J. Watt & N.L. Trevaskis
44P
Oral administration of L-arginine improves gastrointestinal function in dystrophic mdx mice
K. Swiderski, R. Bindon, J. Trieu, T. Naim, E.L. Hill-Yardin, R. Koopman, J.C. Bornstein & G.S. Lynch
45P
Effects of substituting carbohydrates and fat for whey-protein or adding them to whey protein on energy intake and underlying gastrointestinal-mechanisms in healthy older men
C. Giezenaar, T. Hausken, K.L. Jones, M. Horowitz, I. Chapman & S. Soenen
46P
Investigating the impact of liposome properties on lymphatic distribution following intraperitoneal delivery
I.E. Inocencio, G. Lee, A. Phillips, J. Windsor, C.J.H. Porter & N.L. Trevaskis
47P
A novel cervical lymph cannulation method in rats to evaluate clearance from the brain into the lymphatics
T.A. Hoang, J.A. Nicolazzo & N.L. Trevaskis
48P
Distribution of therapeutic proteins into thoracic lymph after intravenous administration is protein size-dependent and primarily occurs within the liver and mesentery
P. Yadav, V.M. McLeod, A.P.R. Johnston, L.M. Kaminskas & N.L. Trevaskis
49P
Control of glycine receptor activation by a glycine transporter co-expressed in Xenopus oocytes
D. Sheipouri, R.J. Vandenberg & R.M. Ryan
50P
Sodium nitrate treatment escalates doxorubicin-induced cachexia in mice
D.G. Campelj, B.M. Butcher, D.A. Debruin, C.A. Timpani, A. Hayes & E. Rybalka
51P
An essential role for mitochondrial phosphatidylethanolamine synthesis in regulating skeletal muscle and mitochondrial structure
A. Selathurai, G.M. Kowalski & C.R. Bruce
52P
The epigenetic basis of variable responses to exercise training - a novel study design
M. Jacques, S. Voisin, X. Yan & N. Eynon
53P
Hepatic autophagy dysfunction in mice following high fat feeding
G.M. Morales-Scholz, K.F. Howlett, R.M. Murphy, G.M. Kowalski, C.R. Bruce & C.S. Shaw
54P
The investigation of dantrolene sodium analogues on SR calcium loading and release, and calsequestrin Ca2+ binding properties in cardiac muscle
C.M. Loescher, J. Al-Rawi & L.M. Gibson
55P
Cardiac in vivo haemodynamic function is modified by myocardial membrane DHA incorporation attributable to fish oil doses achievable in the human diet
M.J. Macartney, G.E. Peoples & P.L. McLennan
56P
The link between in vivo diastolic function and mechanical stiffness in intact rat cardiomyocytes
A.J.A. Raaijmakers, J.V. Janssens, J.R. Bell, C.L. Curl & L.M.D. Delbridge
57P
Testing a methodology for comparative stiffness measurement in isolated loaded intact cardiomyocytes
J.V. Janssens, A.J.A. Raaijmakers, J.R. Bell, K.M. Mellor, C.L. Curl & L.M.D. Delbridge
58P
Establishing reference conditions for electrophysiological recordings of spontaneously beating neonatal rat cardiomyocytes on a multi-electrode array
H.M.M. Waddell, S.P. Wells, L.M.D. Delbridge & J.R. Bell
59P
The effects of vitamin D supplementation and exercise enrichment on in vivo analysis of physical activity behaviour, exercise capacity and metabolism
D.A. Debruin, E. Rybalka, C. Goodman & A. Hayes
60P
The effect of IPC on central and peripheral fatiguing mechanisms following sustained maximal isometric exercise
S.L. Halley, J. Siegler & P. Marshall
61P
A common morphological variation in the knee insertion of the extensor digitorum longus muscle reduces maximal force production but does not affect other contractile properties
L. Kiriaev, P. Houweling, S. Kueh, J.W. Morley, K. North & S.I. Head
62P
Concurrent training further enhances markers of skeletal muscle ribosome biogenesis, but not associated signalling responses, versus single-mode resistance training
J.J. Fyfe, D.J. Bishop, J.D. Bartlett, E.D. Hanson, M.J. Anderson, A.P. Garnham & N.K. Stepto
63P
Phenotypic variability in response to high-intensity interval training in the Gene SMART study
S. Voisin, X. Yan, M. Jacques, F. Munson, I.D. Papadimitriou, N. Dvir, J. Kuang, O. Tirosh, L. O'Keefe, A.P. Garnham, D.J. Bishop & N. Eynon
64P
Effect of high-intensity intermittent exercise on the contractile properties of human type I and type II skeletal muscle fibres
C.R. Lamboley, D.M. Rouffet, T.L. Dutka, R.M. Murphy, M.J. McKenna & G.D. Lamb
66P
Increasing nuclear NAD+ biosynthesis induces muscle remodelling without alterations in myofibrillar Ca2+ sensitivity
O. Friedrich, N. Turner, B. Osborne, A. Samsudeen, M. Haug, B. Reischl, L. Kiriaev & S.I. Head
67P
Heat shock protein 70 (Hsp70) overexpression drives myoblast fusion during C2C12 cell differentiation
S.S. Thakur, V.L. Chhen, K. Swiderski, J.G. Ryall & G.S. Lynch
68P
Differential oxidation of ryanodine receptors in male and female calsequestrin knock-out mice
L. Pearce & B.S. Launikonis
69P
The role of Fn14 in mouse skeletal muscle recovery post Notexin injury: Effects on myogenic regulatory factors, catabolic markers, and structural proteins
A. Pascoe, A.J. Johnston, L. Jenkinson, C. van der Poel & R.M. Murphy
70P
The effect of novel ryanodine receptor modulators on Ca2+ leak in skeletal muscle fibres
D.P. Singh, R.T. Rebbeck, R.L. Cornea & B.S. Launikonis
71P
Michael Roberts Lecture
Enhancing the commencing student learning experience with innovative learning and teaching approaches and peer support systems
K. Tangalakis
72P
Free communicatons: Skeletal muscle
Muscle stem cell self-renewal is regulated via innate cell metabolism and the extracellular environment
J.G. Ryall, C.H. Ly & G.S. Lynch
74P
Implantation of muscle precursor cells grown as 3D structures improves muscle regeneration after myotoxic injury
C.J. Taylor, C.J. Brooks, C. van der Poel & J.E. Church
75P
E3 ligase substrate receptor ASB2 is a negative regulator of skeletal muscle size
J.R. Davey, B. Parker, L. Sylow, H. Qian, D.E. James & P. Gregorevic
76P
Identifying novel miRNAs targeting NDRG2 regulation in skeletal muscle
B.A. Mir, M. Kalanon, A.P. Russell & V. Foletta
77P
Characterisation of SERCA, phospholamban and sarcolipin proteins in human skeletal muscle
B.P. Frankish, R.M. Murphy & G.D. Lamb
78P
Osmotic compression improves force production in skinned muscle fibres of the rat and human
D. Watanabe, T.L. Dutka, C.R. Lamboley & G.D. Lamb
79P
Symposium: New directions in ischemia cardioprotection
Role of nano-particles in ischemia-reperfusion therapies
L.C. Hool
80P
Impact of reactive oxygen species production on calcium release during ischemia-reperfusion injury
P.P. Jones
81P
Remote ischaemic conditioning for cardioprotection: Bench to bedside in action!
D.J. Hausenloy
82P
Using cardiac stem cells to rescue the ischemic heart
S.Y. Lim
83P
Symposium: Emerging leaders in placental physiology
Intrauterine environment and cardiovascular disease risk in later life
P.H. Andraweera
88P
Maternal glucose metabolism and the gut and placental microbiota
M. Dekker Nitert
89P
The impact of lifestyle and pharmacological interventions on the placenta in complicated pregnancies
J.F. Briffa
90P
Mitochondrial adaptations and dynamics in the human placenta
O.J. Holland, A. Alvsaker, G. McEnroe, K.K. Cheung & A.V. Perkins
91P
Symposium: Assessing and counteracting frailty during ageing
Assessing frailty in older individuals
A.B. Maier
92P
Protein absorption and satiety in older individuals
S. Soenen
93P
Anabolic resistance with aging
L.J.C. van Loon
94P
Novel nutritional interventions to counteract frailty and wasting
R. Koopman
95P
Symposium: Problems in labour: Mother Nature versus Father Time
Is hypoxia good for labour?
S. Wray
96P
Preventing premature birth by exploiting anti-inflammatory actions of progesterone
S.A. Mesiano
97P
Prevention of preterm birth: Novel targets of inflammation in the myometrium
M. Lappas
98P
Mechanisms contributing to Failure-to-Progress in human labour
H.C. Parkington, P.M. Sheehan, H.A. Coleman & S.P. Brennecke
99P
Meet the Editor - Prof Susan Wray
AuPS Plenary Lecture
Downs and ups of calcium in the heart
D.A. Eisner
100P
Free communications: Metabolism and signalling
Measurement of postprandial glucose fluxes in response to 5 and 28 days of overfeeding in healthy humans
D.J. Morrison, G.M. Kowalski, C.R. Bruce & G.D. Wadley
101P
High fat diet remodels the intestinal lymphatic vasculature to promote obesity and glucose intolerance
E. Cao, M.J. Watt, C. Nowell, G. Gracia, H. Chu, L. Hu, C.J.H. Porter & N.L. Trevaskis
102P
Medium chain fatty acids are metabolised by the hypothalamus and regulate energy balance in healthy mice
V.R. Haynes, M. Top, F.W. Zaho, D. De Souza, D. Spanswick & M.J. Watt
103P
Ascorbic acid supplementation improves skeletal muscle oxidative stress and insulin sensitivity in people with type 2 diabetes: findings of a randomized controlled study
S.A. Mason, P.A. Della Gatta, R.J. Snow, A.P. Russell & G.D. Wadley
104P
Liver-muscle crosstalk in sarcopenic obesity?
J.G. Okun, J. Schumacher, A. Zota, M. Blüher, M. Heikenwalder & A.J. Rose
105P
Skeletal muscle interstitial glucose concentration becomes limiting to glucose uptake during insulin exposure after exercise in humans
G.K. McConell, K.A. Sjøberg, F. Ceutz, L. Gliemann, M. Nyberg, Y. Hellsten, C. Frøsig, B. Kiens, J.F.P. Wojtaszewski & E.A. Richter
106P
Dynamic proteome profiling of individual proteins in human skeletal muscle after a high-fat diet and resistance exercise
D.M. Camera, J.G. Burniston, W.J. Smiles & J.A. Hawley
107P
Load-dependent effects of whey-protein supplements on energy intake, gastric emptying and gut hormone concentrations in men and women
C. Giezenaar, N.D. Luscombe-Marsh, A.T. Hutchison, M. Horowitz, I. Chapman & S. Soenen
108P
Symposium: Cellular mechanisms of failure and arrhythmia in the diseased heart
Sodium pump and intracellular sodium in healthy and failing hearts
D. Pavlovic
109P
Cellular mechanisms of failure and arrhythmia in the diseased heart
N.A. Beard, A. Denniss, K. Walweel, D.R. Laver, P. Molenaar & A.F. Dulhunty
110P
Novel therapeutic targets in heart failure and atrial fibrillation
J.R. McMullen, YK. Tham, B.C. Bernardo, J.Y.Y. Ooi & P.J. Meikle
111P
Changes in atrial structure and function in diabetes and obesity
D.A. Saint & W.W. Lim
112P
Free communications: Fetal physiology
Characterising hydrogen sulfide production and degradation pathways in murine kidney: effects of pregnancy and high fat diet
B.A. McNeill, C.J. Bushell & L.G. Forgan
119P
Effects of IUGR on contractile protein expression and Ca2+-activated force in β-escin permeabilised mesenteric arteries of adult (6-month old) and aged (1-year old) WKY rats
M. Christie, T. Romano, R.M. Murphy & G.S. Posterino
120P
Cardiorenal pregnancy adaptations in females born small on a high fat diet and benefits of endurance exercise training
D. Mahizir, K. Anevska, G.D. Wadley, K.M. Moritz & M.E. Wlodek
121P
Mitochondrial function in cell lineages of the placenta: does function alter between gestational disorders?
J.J. Fisher, O.J. Holland, D.R. McKeating, J.S.M. Cuffe, J.J. Vanderlelie & A.V. Perkins
122P
Sex-specific placental IGF-system adaptations to maternal exercise in growth restricted mothers
Y.T.M. Mangwiro, J.S.M. Cuffe, J.F. Briffa, D. Mahizir, K. Anevska, T. Romano, K.M. Moritz & M.E. Wlodek
123P
Expression of immune markers in the fetus and six month old sheep heart in response to myocardial infarction
M.C. Lock, M. Ragless, J.Y. Soo, J.R.T. Darby, D.A. Brooks, L. Nield, A. Atkinson & J.L. Morrison
124P
Human amnion epithelial cells alter lung development and inflammation in 7-day-old preterm lambs exposed to inflammation before birth
P.C. Papagianis, J.J. Pillow, S. Ahmadi-Noorbakhsh, P.B. Noble & T.J. Moss
125P
The sheep as a model of studying pregnant uterine smooth muscle activity
E.R. Siriwardhana, H.A. Coleman & H.C. Parkington
126P
Free communications: Exercise physiology
Regulation of exercise performance and contractile function by the endoplasmic reticulum resident antioxidant Selenoprotein S (SEPS1)
A.B. Addinsall, T.L. Kotsiakos, S. Andrikopolous, C. van der Poel & N. Stupka
113P
Thoraco-pulmonary mechanical perturbations accompanying thoracic loading
L. Hingley, J.N. Caldwell, N.A.S. Taylor & G.E. Peoples
114P
The ACE I/D gene variant predicts ACE enzyme activity in the blood but not the expression of ACE protein in skeletal muscle in the Gene SMART study
X. Yan, N. Dvir, L. Cavalcante, M. Jacques, I.D. Papadimitriou, F. Munson, A.P. Garnham, L. O'Keefe, O. Tirosh, D.J. Bishop, S. Voisin & N. Eynon
115P
Muscle adaptations and protein expression following blood flow restriction and heavy-load resistance training methods
A.K. May, A.P. Russell, P.A. Della Gatta & S.A. Warmington
116P
The allometric scaling of aerobic power in adult humans, across the physiological range
H.M. Bowes, C.A. Burdon & N.A.S. Taylor
117P
Cellular localisation of NaK-ATPase isoforms in human skeletal muscle is muscle fibre-type specific
C.H. Steward & M.J. McKenna
118P
Symposium: How do calcium oscillations regulate biological rhythm?
Clock systems, coupled node signaling and pacemaker function: experimental and computational perspective
Y. Yaniv, S. Segal & J. Behar
127P
Synchronising pacemakers
D.F. van Helden, M.S. Imtiaz & D.R. Laver
128P
Understanding calcium-activated chloride channels in health and disease
F.C. Britton & W.J. Hatton
129P
Oxygen dependent regulation of TRP channel function
G. Rychkov
130P
Symposium: The preterm baby
There is no such thing as a normal preterm baby
T.J. Moss
133P
Supporting preterm cardiovascular function
B.E. Lingwood
134P
Improving brain development in preterm infants with hypoxic-ischaemic encephalopathy
R. Galinsky, L. Bennet & A.J. Gunn
135P
Big data for small babies; the impact of gestational age on health and educational outcomes in New Zealand
M.J. Berry, T. Foster, K. Rowe, B. Robson & N. Pierse
137P
Symposium: Mitochondrial dynamics and function
The machinery involved in mitochondrial dynamics
M.T. Ryan
131P
Effects of exercise training on mitochondrial content and dynamics
R.M. Murphy
132P

Index

Author index
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