AuPS 2014 Brisbane Programme

Author index

Sunday 30th November 2014
Rm 348Rm 358Rm 360
14:00 Science Communication in Physiology Education
Education workshop
Chair: Kay Colthorpe
14:00 Welcome
14:10 C.L. Jasoni: I said, “Do you speak my language?” Using media variety to communicate science beyond academia1P
14:50 S.L. Rowland: SURJ: Developing science students’ writing skills through UREs2P
15:30 A. Bugarcic: The development of undergraduate science students’ scientific argument skills in oral presentations3P
16:00 Y. Hodgson: Developing research communication skills in 3rd year Biomedical Science students4P
16:30 D.A. Saint: A strategy for student engagement in peer student presentations- assessing critical thinking skills5P
17:00 Open discussion
17:30 Close
16:00 Registration
Location: Lecture theatre foyer
Lecture theatre foyer
17:30 Welcome and AuPS Invited Lecture
Chair: Graham Lamb
17:30 Welcome
17:45 J.I. Vandenberg: Getting to the heart of ectopic beats6P
Welcome reception
Location: Advanced Engineering Building Level 6
21:00 Buses to Southbank and Queen St Mall


Monday 1st December 2014
Rm 348Rm 358Rm 360
08:30 Symposium: Genetics influences on skeletal muscle physiology and athletic performance
Chair: David Bishop
08:30 N. Eynon: Genomic markers for athletic performance and trainability: What little we know7P
09:00 K.N. North: A gene for speed: ACTN3, athletes, evolution and impact on human health8P
09:30 P.J. Houweling: The POWERGENE consortium: Identifying the genetics of sprint/power performance in elite athletes9P
10:00 Y.P. Pitsiladis: The use of “omics” to individualize exercise training10P
Symposium: Teaching and learning within undergraduate research experiences in physiology
Chairs: Andrea Bugarcic & Louise Ainscough
08:30 N.A. Samarawickrema: Exploring connections between teaching, research and learning at Monash University11P
08:55 Y. Hodgson: Providing authentic research experiences: Comparison of two research programs12P
09:20 J.K. Choate: Using guided-inquiry lectures to enhance student engagement and understanding15P
09:35 K. Zimbardi: Authentic, large-scale undergraduate research experiences (ALUREs) in physiology – development, implementation, evaluation and dissemination13P
10:00 G.D. Wadley: Learning research skills in undergraduate exercise physiology14P
Symposium: Exocytosis
Chair: Peter Thorn
08:30 J.R. Coorssen: Lipid regulation of exocytosis16P
09:00 S.T. Cooper: Calpains cleave dysferlin to release a synaptotagmin-like module for the calcium-dependent exocytosis of membrane repair17P
09:30 W. Han: Molecular regulation of insulin secretion18P
10:00 J.L. Martin: The C-terminal membrane anchor of Syntaxin4 affects Munc18c-supported SNARE assembly in vitro19P
10:30 Morning Tea
Location: Chemistry Podium
11:00 Symposium: Ion channels and pathophysiological changes in ionic regulation
Chairs: Peter Thorn & Bradley Launikonis
11:00 D. Morgan: Voltage gated proton channels - past, present and future20P
11:30 B.S. Launikonis: Determination of the junctional space [Ca2+] set by ryanodine receptor Ca2+ leak in fast- and slow-twitch muscle fibres21P
12:00 B. Martinac: Mechanosensitivity of TRPC6 ion channels22P
12:30 G.R. Monteith: ORAI channels in lactation and in breast cancer23P
Symposium: Interaction of metabolic balance and growth hormone
Chair: Chen Chen
11:00 M.J. Waters: Growth hormone action on adipose tissue and liver24P
11:30 K.K.Y. Ho: Sex steroids and the growth hormone system in metabolic regulation25P
12:00 F.J. Steyn: The production and release of growth hormone during periods of metabolic stress – How and why?26P
12:30 S. Schenk: Caloric balance and insulin action27P
13:00 Lunch
Location: Chemistry Podium
13:30 Posters
Location: Chemistry Podium
Odd board authors in attendance.
1 28PM. Leitch: Comparison of contractile responses of single motor units in the toe extensors during unloaded and loaded isotonic and isometric conditions
2 29PK. Yada: Antioxidant supplementation inhibits exercise-induced skeletal muscle signaling but did not alter markers of muscle adaptations
3 30PY.L. Hung: The anti-inflammatory effects of stress hormones on lipopolysaccharide-stimulated macrophages
4 31PJ.L. Morrison: Impact of in vitro culture and embryo transfer on cardiac metabolism in early postnatal life
5 32PT. Atanasovska: Salbutamol decreases potassium concentration during heavy rowing exercise but not immediately following recovery
6 33PA. Goto: Heat stress acutely stimulates insulin-independent glucose transport and 5′ adenosine monophosphate-activated protein kinase in rat skeletal muscle
7 34PM. Suzuki: Responses of circulating microRNAs to unloading-associated atrophy and reloading-induced regrowth of mouse hindlimb skeletal muscle
8 35PI.D. Papadimitriou: ACTN3 R577X genotype influences 100 and 200 m Olympic sprinting performance in seven cohorts of elite sprinters
9 37PS.I. Head: α-actinin-3 deficiency does not affect the unloaded shortening biomechanics of single isolated fast-twitch FDB fibres from Actn3 KO mice
10 38PA. Addinsall: Novel role for Selenoprotein S in regulating skeletal muscle contractile function in fast twitch mouse muscles
11 39PW.W. Lim: Changes in heart rate variability and ECG in a murine model of hypertrophic cardiomyopathy
12 40PS. Rattigan: Detection of microvascular flowmotion within skeletal muscle in vivo
13 41PG.A. Quaife-Ryan: A comparative transcriptomic analysis of the regenerating neonatal mouse heart
14 42PK. El Sayed: Inter-individual differences in blood pressure responses to stressors: mental versus physical tasks
15 43PL. Daniels: The effects of CaMKII inhibition on cardiac muscle contractility in the zucker diabetic fatty rat
16 44PS.M. Lee: Amitriptyline improves left ventricular recovery in rat hearts subjected to cardiac ischaemic-reperfusion injury
17 45PM.J. Windley: A novel startle mutation of the α1 glycine receptor subunit reveals the role of W170 in receptor function
18 46PR.H. Choi: Effect of changing the [Mg2+] on ryanodine receptor leak activity in rat skeletal muscle
19 47PP. Muralidharan: Mutation of cysteines on the α interacting domain of the long NT isoform of the Cav1.2 channel protein alters the biophysical properties of the channel
20 48PM.S. Soh: Discovery and characterization of potent biphasic α5GABAA receptor modulators
21 49PP.A. Dawson: Is it the magnesium or is it the sulphate? Neuroprotective benefit of antenatal magnesium sulphate therapy for preterm infants
22 50PM.E. Wlodek: Paternal transmission of metabolic dysfunction to offspring born to a growth restricted father
23 51PJ.E. Outhwaite: Expression of aldehyde dehydrogenase family 1, member A3 in glycogen trophoblast cells of the murine placenta
24 52PR.N. Schlegel: Maternal hypomagnesaemia causes placental abnormalities that may contribute to fetal and postnatal mortality
25 53PJ.I. Kalisch-Smith: The effects of ethanol on trophoblast cell differentiation in culture
26 54PD. Zanfirache: Behavioural Correlates of Periconceptional Ethanol Exposure in Aged Offspring
27 55PM. Pantaleon: Alterations in key elements of the hexosamine signalling pathway in mouse placenta in response to maternal stress: implications for fetal programming of adult disease
28 56PJ.L. Morrison: Mature surfactant protein-B expression by immunohistochemistry as a marker for surfactant system development in the fetal sheep lung
29 57PE. Cao: The impact of intestinal lymph exposure on adipocyte function and insulin resistance
30 58PS.L. Walton: Hypoxia-induced growth restriction leads to sexually dimorphic changes to the renal and cardiovascular systems in adult mouse offspring
31 59PY. Han: TMEM16A may regulate pH in the pancreatic acinar lumen
32 60PD.J. Keating: Small molecules demonstrate that dynamin is a bi-directional modulator of the exocytosis fusion pore
33 61PD.J. Adams: Species difference in α-conotoxin RegIIA inhibition of neuronal nicotinic acetylcholine receptors: molecular basis for differential sensitivity
34 62PR. Kanjhan: Extensive heterogeneous dye-coupling among cells derived from human induced-pluripotent-stem cells
14:30 Michael Roberts Lecture
Chair: David Saint
14:30 K.L. Colthorpe: From active learning to self-regulated learning63P
15:00 Afternoon Tea
Location: Chemistry Podium
15:30 Symposium: Cardiac metabolic stressors and sensors
Chair: Lea Delbridge
15:30 J.C. Chatham: Protein O-GlcNAcylation: A novel regulator of cardiomyocyte stress response64P
16:00 R.H. Ritchie: O-linked β-N-acetylglucosamine (O-Glc-NAc) signalling and the hexosamine pathway in diabetic cardiomyopathy65P
16:30 K.M. Mellor: Hexose sugars and cardiomyocyte pathophysiology66P
17:00 W.G. Thomas: A novel family of functional cardiac G protein-coupled receptors with potential roles in nutrient sensing and contractility67P
Symposium: Placental development and function: effects of maternal perturbations during pregnancy
Chairs: Paul Dawson & Karen Moritz
15:30 N.A. Hodyl: Asthma, smoking and the placenta68P
16:00 S. Tong: Developing molecularly targeted therapeutics for severe preeclampsia69P
16:30 H. Dickinson: The spiny mouse: a novel species for studying fetal and placental development and improving obstetric outcomes70P
17:00 D.G. Simmons: Heart defects in Ly6e mutant mice are likely a secondary consequence of impaired placental development71P
Free Communications: Exercise Physiology
Chairs: Tony Bakker & Mark Hargreaves
15:30 C.H. Steward: The effects of an oral glucose load on plasma K+ and electrolyte homeostasis at rest, during high intensity intermittent exercise and recovery and on skeletal muscle Na+,K+-ATPase isoform abundance72P
15:45 N. Vargas: Cortical activity and motor unit recruitment during a high intensity endurance exercise protocol in normothermic and heated environments73P
16:00 R.S.F. Oliveira: Effects of high-intensity interval exercise, under either induced metabolic acidosis or alkalosis, on the regulation of genes associated with the acid-base regulation in human skeletal muscle74P
16:15 S.R. Notley: An interaction of morphology in the modulation of evaporative heat loss during exercise75P
16:30 J.R. Broatch: Post-exercise cold-water immersion activates acute PHF20 and p53 signalling in human skeletal muscle76P
16:45 J. Yamauchi: Exercise-induced changes in cerebral oxygenation and cognition in the human prefrontal cortex77P
17:00 X. Yan: ACTN3 R577X genotype affects training-induced changes in mitochondrial respiration in humans78P
17:45 & 18:00: 2 Buses to Southbank and Customs House
18:30 18:30-20:30 Student/ECR Mixer
Location: Next Door Kitchen & Bar, Southbank


Tuesday 2nd December 2014
Rm 348Rm 358Rm 360
08:30 Invited Lecture
Chair: David Allen
08:30 D.M. Bers: Calmodulin and CaMKII signaling in the heart80P
09:30 Free Communications: Skeletal Muscle Physiology
Chairs: Enzo Porrello & Tanya Cully
09:30 C.R. Lamboley: Sarcoplasmic reticulum Ca2+ leak is increased in type I muscle fibres of old human subjects81P
09:45 A.J. Bakker: Effect of doublet stimulation on tetanic Ca2+ responses measured in isolated fast interosseous fibres of the mouse82P
10:00 N. Stupka: Genetic reduction of an extracellular matrix gene improves contractile function in dystrophic mdx mice83P
10:15 T. Kennedy: Induction of heat shock protein 72 improves the cardiomyopathy and reduces fibrosis in severely dystrophic dko mice84P
10:30 T.R. Cully: Assessment of RyR leak and t-system Ca2+ uptake in dystrophic skeletal muscle85P
10:45 F.C. Garton: The sarcomeric α-actinins perform a dynamic balancing act at the muscle Z-line86P
Free Communications: Reproduction
Chairs: David Simmons & Karen Gibson
09:30 M.E. Wlodek: Renal dysfunction is transmitted to third generation offspring born to a growth restricted mother or father87P
09:45 K.J. Gibson: The developmental programming effects of vitamin D on renal nephron endowment and gene expression of the renin angiotensin system in weanling male rats88P
10:00 J.S.M. Cuffe: Prenatal corticosterone exposure induces dysregulation of the renal renin angiotensin system in male offspring89P
10:15 S. Gounden: Prolactin as a key regulator of Growth Hormone pulsatility in lactation, acting via somatostatin90P
10:30 E.S. Dorey: Periconceptional alcohol alters adult renal and cardiac function in a sex dependent manner91P
10:45 J.N. Cheong: Maternal stress during pregnancy in growth restricted females programs sex-specific metabolic outcomes in second generation male and female rats92P
Free Communications: Channels and Nervous System
Chairs: David Adams & Helena Parkinson
09:30 D. Boulton: Control of muscle sympathetic nerve activity to contracting muscle in humans: contributions of central command and peripheral feedback94P
09:45 Y.W. Oo: Inhibitory effect of dantrolene on cardiac RyR2 in the presence of calmodulin95P
10:00 H.A. Coleman: The effects of obesity on hippocampal function in the rat96P
10:15 H.C. Parkington: Controlling contractions in human myometrium; an eye on channels97P
10:30 I. Azimi: Calcium signalling in epithelial-mesenchymal transition induced by hypoxia in breast cancer cells98P
11:00 Morning Tea
Location: Chemistry Podium
11:30 Symposium: Can we age well?
Chairs: Robyn Murphy & Peter Houweling
11:30 D.G. Le Couteur: Can we age well?99P
12:00 V.C. Cogger: The Ageing Liver100P
12:30 M.D. Grounds: Ageing muscles: biomarkers and exercise101P
13:00 N.L. Rogers: Sleep well, age well102P
Free Communications: Endocrinology, Diabetes and Cancer
Chairs: Damien Keating & Frederik Steyn
11:30 N.L. Trevaskis: Mechanisms directing blood-lymph transfer of nano-sized therapeutics103P
11:45 M.J. Watt: Perilipin 5 regulates hepatic lipid metabolism and systemic glucose tolerance in mice104P
12:00 D.J. Keating: RCAN1 is critical for β-cell mitochondrial function and is overexpressed in human Type 2 diabetes105P
12:15 J.F. Briffa: Chronic high fat feeding increases megalin expression and causes albuminuria and proteinuria in rats106P
12:30 O.H. Do: Progression of type 2 diabetes in Leprdb mice: from the animal to the granular levels107P
12:45 R.A. Taylor: Adipose-secreted factors from peri-prostatic fat stimulate prostate cancer cell tumourigenecity108P
13:00 K. Swiderski: Dysfunction of the dystrophin-glycoprotein complex (DGC) in cancer cachexia109P
13:15 Y. Wan: Pulsatile luteinizing hormone (LH) secretion in female mice across pubertal development110P
13:30 Lunch
Location: Chemistry Podium
14:00 Posters
See Monday for list. Even board authors in attendance.
14:30 14:30 Student/ECR & Professors Talk
Jamie Vandenberg and Mary Wlodek will co-head the open discussion
15:00 Afternoon Tea
Location: Chemistry Podium
15:30 Symposium: Frontiers of molecular mechanisms of ligand recognition and activation of receptor channels
Chairs: Yoshihiro Kubo & Trevor Lewis
15:30 T.M. Lewis: Signal transduction at the subunit interfaces of the human glycine receptor111P
16:00 B.A. Cromer: Ligand selectivity in pentameric ligand-gated ion channels112P
16:30 Y. Sohma: Mechanism of ATP-dependent gating in CFTR channels113P
17:00 Y. Kubo: Signal transmission within the P2X2 trimeric receptor and the voltage dependent structural rearrangements114P
Symposium: Early life environment as an indicator of health; outcomes and prevention
Chairs: Deanne Hryciw & Glenn Wadley
15:30 J.L. Morrison: Early life environment as an indicator of health; outcomes and prevention115P
16:00 S.A. Bayol: Maternal nutrition and skeletal muscle development in the offspring: long-term impact on health116P
16:30 D.H. Hryciw: Altered renal signalling in rat offspring born small117P
17:00 C.L. Jasoni: Mum's the word: Understanding the role of maternal obesity and inflammation during pregnancy in elevating the risk of offspring neuroendocrine disorders118P
Free Communications: Skeletal Muscle Signalling
Chairs: Nicole Stupka & David Bishop
15:30 N.L. McRae: Glucocorticoid treatment regulates versican pericellular matrix remodelling during myoblast fusion: implications for muscular dystrophy therapies119P
15:45 C. van der Poel: Thymosin β4 improves the dystrophic pathology in young mdx mice120P
16:00 J.E. Church: Thymosin beta 4 enhances myogenesis in vitro but does not confer regenerative advantage on skeletal muscle in vivo following myotoxic injury121P
16:15 M.K. Caldow: Glycine supplementation during calorie restriction accelerates fat loss and protects against further muscle loss in obese mice122P
16:30 E. Zacharewicz: Regulating muscle protein synthesis in human myotubes from young and old subjects with microRNAs123P
16:45 C.H. Ly: Despecification of myogenic C2C12 cells via metabolic reprogramming124P
17:00 P. Gregorevic: Exploring new targets within the TGFβ signaling network as interventions for cachexia125P
17:45 & 18:00: 2 Buses to Southbank and Customs House
19:30 19:30 - midnight - Conference Dinner
Location: Customs House


Wednesday 3rd December 2014
Rm 348Rm 358Rm 360
09:00 Invited Lecture
Chair: David Adams
09:00 R.G. Parton: Caveolae as mechanoprotective and signaling organelles126P
10:00 Morning Tea
Location: Chemistry Podium
10:30 Symposium: Cardiomyocyte Ca2+ and Na+ signalling - new mechanistic insights
Chairs: James Bell & David Saint
10:30 D.M. Bers: Compartmentalisation and localization - important signaling considerations for cardiomyocytes127P
11:00 J.R. Bell: Differential arrhythmogenic actions of cardiac CaMKII128P
11:30 D.C.H. Ng: CaMKII inhibition as a novel target for flavonol cardioprotection129P
12:00 G.A. Figtree: Oxidative regulation of Na/K-ATPase in the cardiovascular system130P
Symposium: New insights into exercise and insulin sensitivity
Chair: Glenn McConnell
10:30 E.A. Richter: Exercise effects on insulin sensitivity131P
11:00 J.F.P. Wojtaszewski: AMP-activated protein kinase in diabetes132P
11:30 G.K. McConell: Exercise, nitric oxide and glucose metabolism133P
12:00 M. Hargreaves: Exercise, GLUT4 and insulin action134P
12:30 Lunch
Location: Chemistry Podium
13:00 13:00 AGM
14:00 Symposium: Mechanisms and treatments for muscle wasting
Chairs: Kate Murphy & Gordon Lynch
14:00 M. Sandri: Molecular mechanisms of muscle atrophy135P
14:30 S.N. Breit: The role of the TGF-β superfamily cytokine MIC-1/GDF-15 in anorexia/cachexia of cancer and other diseases136P
15:00 K.T. Murphy: Novel therapies for reducing muscle wasting in cancer137P
15:30 J. Silke: Inhibition of TWEAK/Fn14 signaling prevents cachexia in cancer138P
Free Communications: Cardiac Physiology
Chairs: David Allen & Melissa Reichelt
14:00 W.W. Lim: Atrial remodeling in a murine model of hypertrophic cardiomyopathy: implications for atrial fibrillation139P
14:15 M. Neo: Streptozotocin-induced type I diabetes mediates structural and electrophysiological changes in the rat atria: A substrate for atrial fibrillation140P
14:30 G.B. Bernasochi: Augmented CaMKIIδ activation enhances stress resilience in Ca2+ loaded female aromatase-deficient mouse cardiomyocytes141P
14:45 C.J. Brock: The C-26 tumour-bearing mouse model of cancer cachexia exhibits cardiac atrophy, systolic and diastolic dysfunction142P
15:00 M.E. Reichelt: Scaffolding domains in cardiac aging: Does caveolin-3 govern age-dependent stress-intolerance?143P
15:15 C.B. Sim: Dynamic changes in the cardiac methylome during post-natal development144P
Free Communications: Exercise and Muscle Signalling
Chairs: Torie Foletta & Robyn Murphy
14:00 J.G. Ryall: Thioredoxin-interacting protein inhibits glycolysis and proliferation of myogenic cells145P
14:15 J.J. Fyfe: Effects of endurance exercise intensity on acute signalling responses to subsequent resistance exercise in human skeletal muscle146P
14:30 N.J. Hoffman: Phosphoproteomics reveals the complexity of the human muscle exercise-regulated signalling network and a novel role for AKAP1 in regulating mitochondrial respiration via AMPK147P
14:45 C. Granata: Training intensity-dependent regulation of mitochondrial respiration in human skeletal muscle: an effect modulated by the transcription factors PGC-1α, p53 and PHF20148P
15:00 C.S. Shaw: High intensity interval and moderate intensity continuous training improves whole body insulin sensitivity and lowers muscle ceramide content in obese individuals149P
15:15 D.J. Bishop: Role of pre-exercise alkalosis on the expression of sarcolemmal proteins involved in muscle pH regulation following a single bout of high-intensity exercise150P

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