Volume 41
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2010
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Whole issue (2 Mbytes)
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CONTENTS
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AuPS/ASB 2010 Adelaide Meeting
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| AuPS Invited Lecture |
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| Calcium signalling, pacing and rhythmic cell activity in the lymphatic system - a physiologist's paradise |
| D.F. van Helden | 1P |
| Symposium: Mechanisms of multidrug resistance - the role of transporters in human disease |
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| Perspectives on multidrug resistance in membrane transporters |
| A.M. George | 2P |
| Molecular determinants of MRP1/ABCC1 expression and transport |
| S.P.C. Cole | 3P |
| Drug translocation by P-glycoprotein: how do topographical changes in transmembrane helices assist? |
| R. Callaghan, R.M. McMahon, E. Crowley, M. O'Mara & I.D. Kerr | 4P |
| The malaria parasite's chloroquine resistance transporter: a multidrug resistance carrier? |
| R.E. Martin, R.L. Summers, M. Nash, R.V. Marchetti, T.J. Dolstra & K. Kirk | 5P |
| Antimicrobial resistance in staphylococci: Molecular architecture of a multidrug binding site |
| M.H. Brown | 6P |
| Free communications: Energy metabolism in exercise |
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| Reduced mitochondrial biogenesis activation during exercise after short-term training |
| N.K. Stepto, G. Wadley, B. Benziane, A.V. Chibalin, B.J. Canny & G.K. McConell | 7P |
| 30 days of normobaric hypoxia increases mitochondrial respiration |
| D.J. Bishop, A. Ferri, I. Rivolta, A. Panariti, A. Zaza & G. Miserocchi | 8P |
| 3-day oral N-acetyl-cysteine supplementation alters metabolism but not performance of high intensity aerobic exercise in trained cyclists |
| A. Trewin, F. Billaut, A. Petersen, B.D. Perry, E. Goff, T. Atanasovska & N.K. Stepto | 9P |
| Actions of the antioxidant N-acetylcysteine on cell signaling response to exercise in human skeletal muscle |
| A.C. Petersen, M.J. McKenna, I. Medved, K.T. Murphy, M.J. Brown, P. Della Gatta & D. Cameron-Smith | 10P |
| Symposium: Physiology education |
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| Rigour or rigor mortis: a challenge for physiology |
| P. Poronnik | 11P |
| Using the Finapres to teach cardiovascular physiology to second year science students |
| Y.M. Hodgson & J. Choate | 12P |
| The KISS approach: How to develop an effective self directed e-learning application |
| R. Guy, H. Pisani, P. Rich, G. Mandarano, C. Leahy, T. Molyneux & R. Davidson | 13P |
| Lecture attendance, learning style and assessment outcome in physiology students |
| D.A. Saint, D.M. Horton & S.D. Wiederman | 14P |
| The Human Physiology Writing Centre: Task-based building of student capacity |
| S. Wiederman, J. Miller & C. Habel | 15P |
| Free communications: Systemic influences in skeletal muscle |
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| Effect of hypoxia on the dynamic response of leg blood flow during exercise |
| S. Green & J. Donnelly | 16P |
| Citrulline supplementation does not prevent atrophy during limb-casting in mice |
| R. Koopman, D. Ham, B.G. Gleeson & G.S. Lynch | 17P |
| Inhibition of the renin-angiotensin system enhances whole body and skeletal muscle function in healthy and tumour-bearing mice |
| K.T. Murphy, A. Chee, A.M. Allen & G.S. Lynch | 18P |
| Symposium: Skeletal muscle: the coupling of excitation to contraction |
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| Voltage-dependent and -independent Ca2+ entry into skeletal muscle during excitation-contraction coupling |
| B.S. Launikonis | 19P |
| Coupling and uncoupling of the DHPRs and Ca2+ release channels in skeletal muscle fibres |
| T.L. Dutka | 20P |
| One is enough: RyR1 allele-specific gene silencing in mouse models of central core disease (CCD) and malignant hyperthermia (MH) |
| R.T. Dirksen, R.E. Loy, J.D. Lueck & M. Mostajo-Radji | 21P |
| Free communications: Imaging and structural analysis of lipids and proteins |
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| Small molecule diffusion in inverse cubic phase lipid systems |
| S. Fraser, R. Mulder, J. Cosgriff, X. Mulet, F. Separovic & A. Polyzos | 22P |
| Detection of proteins in the pathological deposits in Pseudoexfoliation syndrome using Atomic Force Microscopy |
| R. Creasey, C. Gibson, S. Sharma, J.E. Craig, T. Becker, P. Hinterdorfer & N.H. Voelcker | 23P |
| Visualisation of bacterial hydrodynamics |
| J.L. Flewellen | 24P |
| Shedding light on liposomes: Using lipid-mimetic metal complexes for fluorescent labeling |
| A. Mechler, M. S. Huda, E. Doevan & C. Hogan | 25P |
| Shedding light on neurodegeneration: small angle X-ray scattering and misfolded proteins |
| C.C. Curtain | 26P |
| Symposium: Regulation of metabolic balance through co-ordination of central and peripheral signalling |
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| Integrating peripheral and central mechanisms that regulate growth hormone (GH) secretion during periods of altered food consumption |
| F.J. Steyn, J.W. Leong & C. Chen | 27P |
| Control of energy balance by nutrient sensing neurons |
| M.A. Cowley | 28P |
| Regulation of hypothalamic GHRH neuronal activity by ghrelin and obestatin |
| J. Epelbaum | 29P |
| Poster session |
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| Protein interactions |
| Electron microscopic study of the effect of p75NTR extracellular domain on the amyloid β protein assembly |
| J.J. Lu, M. Yang, Y. Lim, J.H. Zhong, Y.J. Wang & X.F. Zhou | 30P |
| Superoxide dismutase 2 in human brain: A marker for mitochondria and mitochondrial dysfunction in Parkinson’s disease and dementia with Lewy bodies |
| O. Barnes & J.H.T. Power | 31P |
| The relationship between fibrillin and Marfan’s syndrome |
| Y. Lu, R. Jeremy, M. Kekic & B.D. Hambly | 32P |
| Fetal physiology and pregnancy |
| Oxytocin depolarizes mitochondrial membrane in freshly isolated myometrial cells |
| F.S. Gravina, P. Jobling, R.B. de Oliveira, K.P. Kerr, H. Parkington & D.F. van Helden | 33P |
| Intrauterine growth restricted fetuses have increased blood flow to the adrenals and decreased blood flow to the heart but no difference in brain blood flow |
| R. Poudel, I.C. McMillen, S. Dunn & J.L. Morrison | 34P |
| Nervous system |
| Nedd4 and Nedd4-2 heterozygosity leads to opposing anxiety behaviour in mice |
| D. Bongiorno, N. Boase, S. Kumar & P. Poronnik | 35P |
| Parvalbumin-immunoreactive neurons in the rat ventral respiratory column receive close appositions from galanin-immunoreactive axons |
| K.L. Jung, D.R. McCrimmon, G.F. Alheid, G.M. Etelvino & I.J. Llewellyn-Smith | 36P |
| Mechanism underlying distension-evoked peristalsis in guinea-pig distal colon: is there a role for enterochromaffin (EC) cells? |
| N.J. Spencer, L. Robinson, S.J. Gregory, M. Kyloh, V. Zagorodnyuk, H. Peiris, S. Brookes & D.J. Keating | 37P |
| Identification of the pacemaker mechanism underlying migrating motor complexes in mouse small intestine |
| L. Beech, S. Gregory, M. Kyloh & N.J. Spencer | 38P |
| The affects of amyloid precursor protein (APP) trafficking, processing and interaction with p75 in the presence of amyloid-β |
| K. Smith, M. Yang & X. Zhou | 39P |
| Thiol-reactivity: A small molecule approach to identifying proteins involved in regulating the calcium sensing steps of native membrane fusion |
| K.L. Furber & J.R. Coorssen | 40P |
| Spinal projections of medium sized sensory neurons that express Calcitonin Gene-Related Peptide but not Substance P in mice |
| G.R. Kestell, R.L. Anderson, J.N. Clarke, R.V. Haberberger & I.L. Gibbins | 41P |
| Metabolism and signalling |
| Activation of CB1 receptor inhibits fasting-induced increase in growth hormone (GH) secretion in mice |
| J.W. Leong, F.J. Steyn, L. Huang & C. Chen | 42P |
| Characterising the impact of lipid-rich diets on the endocrine profile of C57 mice during progressive weight gain resulting in the development of obesity |
| T. Xie, F.J. Steyn, J.W. Leong & C. Chen | 43P |
| Possible role of fatty acid GPCRs in endometrial cancer cell growth in vitro |
| K.W. Lee, F.J. Steyn & C. Chen | 44P |
| The effect of maternal separation stress and high fat diet on tyrosine hydroxylase regulation in the rat adrenal gland |
| L. Bobrovskaya, J. Maniam, L.K. Ong, P.R. Dunkley & M.J. Morris | 45P |
| Fasting increases fat mobilisation and utilisation subsequent to high intensity intermittent exercise in healthy adults |
| M. Attardi, E. Rybalka, A. Hayes & C.G. Stathis | 46P |
| Caffeine ingestion and high intensity intermittent exercise increases post exercise fat mobilisation and glycogenolysis in healthy individuals |
| T. Gerber, E. Rybalka, A. Hayes & C. Stathis | 47P |
| N-acetylcysteine decreases insulin sensitivity after moderate intensity exercise |
| B.D. Perry, I. Levinger, M.J. Brown, M.J. McKenna & N.K. Stepto | 48P |
| Channels |
| Role of phosphorylation in the Ca2+ regulation of Ca2+ release channels in skeletal muscle |
| K. Walweel, D.F. van Helden & D.R. Laver | 49P |
| Ion channels as nanovalves for the controlled release of liposome-encapsulated particulates |
| M.J. Landsberg, A.F.W. Foo, A.R. Battle, B.J. Marsh, B. Hankamer & B. Martinac | 50P |
| The availability of Aquaporin 1 to function as a gated cation channel is regulated by tyrosine kinase signalling |
| E.M. Campbell & A.J. Yool | 51P |
| Conformational changes associated with desensitisation in the ligand binding domain of the glyicne receptor |
| Q. Wang, S.A. Pless & J.W. Lynch | 52P |
| Modelling the response of ion transporters to hyperosmotic shock in cells of salt-sensitive Chara australis and salt-tolerant Lamprothamnium succinctum |
| S. Al Khazaaly & M. Beilby | 53P |
| Ivermectin interacts with an intersubunit transmembrane domain of the glycine receptor |
| T. Lynagh, T.I. Webb & J.W. Lynch | 54P |
| How do mutations in the cytoplasmic PAS domain of hERG affect channel structure? |
| Y. Ke, M. Hunter, CA. Ng, D. Stock & JI. Vandenberg | 55P |
| Charged residues involved in GABAC receptor agonist selectivity |
| H-S. Tae & B.A. Cromer | 56P |
| Characterisation of ASCT-mediated transport at low pH |
| A.J. Scopelliti, R.M. Ryan & R.J. Vandenberg | 57P |
| Rapid down-regulation of the rat glutamine transporter SNAT3 by a caveolin-dependent trafficking mechanism in Xenopus laevis oocytes |
| S. Balkrishna, A. Bröer, A. Kingsland & S. Bröer | 58P |
| Characterization of tolaasin inhibitory factors for the suppression of brown blotch |
| S.W. Park, M.H. Kim & Y.K. Kim | 59P |
| Ophiobolin A is an inhibitor of STIM1/Orai1-mediated current |
| M-S. To, J. Castro, B.P. Hughes, G.J. Barritt & G.Y. Rychkov | 60P |
| Characterization of a novel hERG potassium channel isoform upregulated in schizophrenia patients |
| J. Heide, S.A. Mann & J.I. Vandenberg | 61P |
| Modeling of the open-channel structure of MscL using restrained simulations |
| E. Deplazes, M. Louhivuori, S.J. Marrink & B. Corry | 62P |
| The Tyr-315 to Cys polymorphism in the P2X4 receptor causes loss of function and is associated with increased pulse pressure in humans |
| L. Stokes, K. Scurrah, J. Ellis, B. Cromer, K. Skarratt, S. Harrap & J. Wiley | 63P |
| Brush-border peptidases alter the kinetic properties of neutral amino acid transporters B0AT1 and B0AT3 |
| S. Fairweather, A. Bröer, T. Thavjogarajah & S. Bröer | 64P |
| Inhibitory activity of plant extracts on Plasmodium falciparum aquaporin |
| J. Pei & A.J. Yool | 65P |
| Characterization of microbial nitrate uptake for the treatment of agricultural wastewater |
| Y.B. Yoon & Y.K. Kim | 66P |
| Methodology strategies for the purification and biophysical characterization of bacterial ATP-binding cassette transporters |
| M.P. Ween, V.G. Lewis, J.C. Paton & C.A. McDevitt | 67P |
| Re-examining the role of the voltage sensor in hERG channel inactivation |
| S.C.E. Wong, M.D. Perry & J.I. Vandenberg | 68P |
| Facilitation of tolaasin-induced haemolysis by phospholipid composed of short length fatty acids |
| M.H. Kim & Y.K. Kim | 69P |
| Mapping the importance of 4 factors in creating monovalent ion selectivity in biological molecules |
| M. Thomas, D. Jayatilaka & B. Corry | 70P |
| GABAB receptor gene knockdown impairs inhibition of N-type calcium channels in rat sensory neurons by α-conotoxin Vc1.1 |
| H. Cuny, T. Yasuda, A. de Faoite & D.J. Adams | 71P |
| Biological activity of α-conotoxins on N-type calcium channels in rat sensory neurons |
| B.P. Callaghan, A. De Faoite, N. Daly, D.J. Craik & D.J. Adams | 72P |
| Illuminating the mechanism of hERG channel activators using voltage clamp fluorometry |
| P.S.P. Tan, A.P. Hill & J.I. Vandenberg | 73P |
| A new simple method for the experimental measurement of liquid junction potentials |
| P.H. Barry, T.M. Lewis & A.J. Moorhouse | 74P |
| Identification of Nav1.8 channel domains responsible for µO-conotoxin MrVIB binding and channel biophysical properties |
| O. Knapp, T. Yasuda, N. Lawrence, R. J. Lewis & D.J. Adams | 75P |
| Lipid and lyso-lipid effects on the behavior of liposome co-reconstituted MscS and MscL |
| T. Nomura, A.R. Battle & B. Martinac | 76P |
| Binding of sea anemone toxin Shk to the potassium channel Kv1.3 from molecular dynamics simulations |
| M.H. Rashid & S. Kuyucak | 77P |
| Biophysics |
| Stabilisation of quasi stable states by flash turnover of photosystem II core complexes from higher plants. Back reaction kinetics |
| P.J. Smith, B. Bataituti, Lu. Jin, E. Krausz & R.J. Pace | 78P |
| Rapid characterization of bacterial motility using Dynamic Light Scattering (DLS) |
| R. Nixon-Luke, G. Bryant & J.N. D Goder | 79P |
| Exercise physiology |
| Arterial potassium regulation during a 2000 metre rowing trial |
| T. Atanasovska, F. Billaut, A.C. Petersen, D. Rouffet, C. Steward, A. Trewin, B. Gatt, M. Altarawneh, I. Ng & M.J. McKenna | 80P |
| Interaction of muscle glycogen status and nutrient supplementation on skeletal muscle adaptation following resistance exercise |
| D.M. Camera, A. Garnham, J.A. Hawley & V.G. Coffey | 81P |
| The local dynamics of thermal sweat suppression following a systemic cholinergic blockade |
| C.A. Machado-Moreira, P.L. McLennan, S. Lillioja, W. van Dijk, J.N. Caldwell & N.A.S. Taylor | 82P |
| Do non-cholinergic efferent pathways have a functional relevance during the thermal and non-thermal stimulation of human eccrine sweat glands? |
| C.A. Machado-Moreira, P.L. McLennan, S. Lillioja, W. van Dijk, J.N. Caldwell & N.A.S. Taylor | 83P |
| Vesicular secretion |
| The role of F-actin in vesicular secretion |
| Y. Jang & P. Thorn | 84P |
| The role of dynamin in fusion pore closure and endocytosis in pancreatic acinar cells |
| A. Banerjee & P. Thorn | 85P |
| Heart |
| Multiple effects of anthracyclines on cardiac ryanodine receptors |
| A.D. Hanna, A.F. Dulhunty & N.A. Beard | 86P |
| Ryanodine receptor phosphorylation in human heart failure |
| N.A. Beard, M. Janczura, A.F. Dulhunty, P. Molenaar & D.R. Laver | 87P |
| Inhibition of cardiac Ca2+ release channels as therapy for arrhythmia |
| D. Mehra, D.F. van Helden, H.S. Hwang, B.C. Knollmann & D.R. Laver | 88P |
| How additive effects of small changes in repolarising currents can increase the risk for atrial fibrillation – a modelling study |
| S.A. Mann, J.I. Vandenberg & D. Fatkin | 89P |
| Biomolecular structure and dynamics |
| Measuring receptor motility and filopodia dynamics |
| K. Hendy, Y. DeGraaf, J. Clarke, W.G. Thomas & I.L. Gibbins | 90P |
| Pulmonary surfactant membranes of hibernating ground squirrels possess increased fluidity but are capable of maintaining an ordered membrane structure at low temperatures |
| S. Orgeig, L. Suri, L. McCaig, V. Picardi, R. Veldhuizen, J. Staples, F. Possmayer & J. Perez-Gil | 91P |
| Aggregation state of Aβ peptides in model membranes |
| M.A. Sani, J.D. Gehman & F. Separovic | 92P |
| Boltzmann statistics maximum entropy of solid-state NMR dipolar recoupling and magic angle spinning data |
| J.D. Gehman, M.-A. Sani & A.K. Mehta | 93P |
| Measuring the incorporation of fluorescently labelled lipid analogues into the membrane of giant unilamellar vesicles |
| I.L. Salvemini, J. Reid & P.D.J. Moens | 94P |
| Which residues are important within the N-terminal helix of hERG PAS domain to maintain a functional channel? |
| C.A. Ng, M. Hunter, M.D. Perry, M. Mobli, Y. Ke, D. Stock, P.W. Kuchel, G.F. King & J.I. Vandenberg | 95P |
| Muscle |
| Kinetics of glucose transport across the surface membranes of single fast- and slow-twitch muscle fibres of the rat |
| H.A. Rudayni, G. S. Posterino & D.G. Stephenson | 96P |
| Myotoxin induced regeneration of fast-twitch EDL skeletal muscles from aged mice results in fibre branching and increased susceptibility to dystrophic type eccentric damage |
| S.I. Head, A.S.J. Lee, A.J. Kee, P.W. Gunning & E.C. Hardeman | 97P |
| Identifying the skeletal muscle ryanodine receptor activation domain of triadin |
| E. Wium, A.F. Dulhunty & N.A. Beard | 98P |
| Possible contribution of SPRY2 and ASI regions of RyR1 to interdomain interaction |
| H. Willemse, S. Mirza, E.M. Gallant, H.S. Tae, L. Wei, M.G. Casarotto, R.T. Dirksen & A.F. Dulhunty | 99P |
| In vitro interactions between C-terminal residues of the β1a subunit of DHPR and RyR1 from skeletal muscle |
| R.T. Rebbeck, Y. Karunasekara, E. M Gallant, N.A. Beard, M.G. Casarotto & A.F. Dulhunty | 100P |
| GSTM2-2 C terminus modulates the contractility of cultured rat ventricular cardiomyocytes |
| R.P . Hewawasam, M.G. Casarotto, P.G. Board & A.F. Dulhunty | 101P |
| Effects of membrane cholesterol depletion on excitation-contraction coupling in mammalian skeletal muscle |
| A.J.H. Hewson & B.S. Launikonis | 102P |
| The response of healthy and dystrophic mdx mouse muscle to prolonged elevations of cytoplasmic Ca2+ |
| K.A. Burlinson & B.S. Launikonis | 103P |
| Muscle membrane permeability, damage and atrophy in Zucker obese rats |
| N. Capitanio, E. Rybalka, R. Murphy, H. Latchman, K. Croft & A. Hayes | 104P |
| Stimulating the Notch signalling pathway does not improve muscle regeneration after myotoxic injury in dystrophic mice |
| J.E. Church, J. Trieu, A.P. Russell & G.S. Lynch | 105P |
| Influence of myo-inositol on protein turnover in C2C12 myotubes |
| E. Zacharewicz & A.P. Russell | 106P |
| Does folic acid supplementation during pregnancy reduce skeletal muscle mitochondrial biogenesis and insulin signalling in adult offspring? |
| D.S. Hiam, G.D. Wadley & J.A. Owens | 107P |
| The effect of taurine and β-alanine supplementation on taurine content and contractile properties of skeletal muscle in the mdx mouse |
| D.M. Horvath, A. Hayes & C.A. Goodman | 108P |
| Symposium: New insights into the molecular architecture of the heart and their implications for heart disease |
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| The molecular architecture of the heart's conduction system in health and disease |
| M.R. Boyett & H. Dobrzynski | 109P |
| Distribution and functional role of IP3R receptors in mouse sino-atrial node |
| Y.K. Ju | 110P |
| Proteins in the lumen of the sarcoplasmic reticulum determine cardiac RyR channel activity, cardiac function and the structure of Ca2+ release units |
| A.F. Dulhunty & N.A. Beard | 111P |
| A new twist in cardiac muscle: dislocated and helicoid arrangements of myofibrillar z-disks in mammalian ventricular myocytes |
| M.B. Cannell, I.D. Jayasinghe, D.J. Crossman, D. Baddeley & C. Soeller | 112P |
| Mechanisms of contractile dysfunction in lamin A/C-deficient hearts |
| D. Fatkin | 113P |
| Free communications: Membrane transport |
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| Hot and cold running ion pumps |
| S.L. Myers, F. Cornelius, H.-J. Apell & R.J. Clarke | 114P |
| Mapping the ion translocation pathway in the glutamine transporter SNAT3 |
| S. Bröer, S. Balkrishna, H.-P. Schneider & J.W. Deitmer | 115P |
| Glutamate transporter loss-of-function mutations cause human dicarboxylic aminoaciduria |
| R.M. Ryan, C.G. Bailey, A.D. Thoeng, C. Ng, K. King, J.M. Vanslambrouck, C. Auray-Blias, R.J. Vandenberg, S. Bröer & J.E.J. Rasko | 116P |
| Determining the physiological state of a membrane protein: investigating the P-gycoprotein crystal structure |
| M.L. O'Mara & A.E. Mark | 117P |
| Acquisition and dissemination of multidrug resistance in cancer via microparticles |
| R. Jaiswal, S. Sambasivam, J. Gong, J.M. Mathys, V. Combes, G.E. Grau & M. Bebawy | 118P |
| Microparticles confer multidrug resistance in breast cancer |
| J. Gong, R. Jaiswal, S. Sambasivam, J-M. Mathys, V. Combes, G.E. Grau & M. Bebawy | 119P |
| Symposium: Imaging and dynamic microscopy (imaging of biological and biophysical processes) |
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| Cadherin dynamics and the cytoskeleton |
| M. Smutny, S. Mangold, S. Wu, G. Gomez, E. Kovacs, N.A. Hamilton & A.S. Yap | 120P |
| Detecting stem cell differentiation using fluorescence lifetime microscopy (FLIM) by the phasor approach |
| E. Gratton | 121P |
| Light, x-rays or electrons for imaging malaria parasites? |
| L. Tilley, E. Hanssen, N. Klonis, M. Dixon, P. McMillan, N. Abu-Bakar & C. Whitchurch | 122P |
| Molecular transport in cells by the pair correlation fluctuation method |
| M.A. Digman | 123P |
| In vivo pair correlation analysis of enhanced green fluorescent protein (EGFP) intra nuclear diffusion |
| E. Hinde, F. Cardarelli, M.A. Digman & E. Gratton | 124P |
| Free communications: Calcium signalling in muscle |
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| SPontaneous Oscillatory Contraction (SPOC): Quantifying contractile performance in isolated human cardiomyocytes under partial activation |
| J.E. Robinson, R. Whan, F. Braet, Y. Su, S. Ishiwata, M. Yamane, T. Kagemoto, N. Fukuda, J. Hughes, T. Kraft, J. van der Velden, S.B. Marston, M. Steenman, P.S. Macdonald & C.G. dos Remedios | 125P |
| The effects of membrane potential and cytoplasmic calcium concentration on calcium extrusion across the tubular system in mammalian skeletal muscle |
| J.N. Edwards & B.S. Launikonis | 126P |
| The effect of suramin (a calmodulin antagonist) on caffeine-induced Ca2+-release in mechanically skinned fast-twitch skeletal muscle fibres of the rat |
| D.W. Williams, G.S. Posterino & D.G. Stephenson | 127P |
| Symposium: Calcium signalling |
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| Calcium regulation of apoptosis in pancreatic acinar cells |
| J.V. Gerasimenko, P. Ferdek, A.V. Tepikin, O.H. Petersen & O.V. Gerasimenko | 128P |
| The application of complementary luminescent and fluorescent imaging techniques to visualize nuclear and cytoplasmic Ca2+ signaling during in vivo differentiation of slow muscle cells in zebrafish embryos |
| C.Y. Cheung, S.E. Webb, D.R. Love & A.L. Miller | 129P |
| STIM:Orai stoichiometry and the trapping and activation of store-operated calcium channels |
| P.J. Hoover & R.S. Lewis | 130P |
| Free communications: Neuronal development and pathology |
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| Peroxiredoxin 4 is confined to the endoplasmic reticulum in human brain and associated with Lewy body formation in Parkinson's disease and dementia with Lewy bodies |
| L.J. Turnbull & J.H.T. Power | 131P |
| ProBDNF inhibits neurites outgrowth in neurons of mice by activating RhoA |
| Y. Sun, Y. Lim, J.H. Zhong, M. Yang & X.F. Zhou | 132P |
| Postsynaptic GABAA receptor number and enhanced gaboxadol induced change in holding currents in Purkinje cells of the dystrophin-deficient mdx mouse |
| S.I. Head, S.L. Kueh, J. Dempster & J.W. Morley | 133P |
| Huntingtin associated protein 1 associates with amyloid precursor protein and regulates its trafficking and Aβ levels |
| X.F. Zhou, G.Z. Yang, J.J. Lu, Y. Lim, J.H. Zhong & M. Yang | 134P |
| Huntingtin-associated protein 1 (HAP1) regulates exocytosis via multiple mechanisms |
| K. Mackenzie, X.F. Zhou & D.J. Keating | 135P |
| Symposium: Lipid Metabolism and disease: new insights from the lab to the clinic |
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| Circulating ceramide, inflammation and insulin resistance |
| M.J. Watt, J. Boon, D.C. Henstridge, J.S. Oakhill, B.A. Kingwell & A.J. Hoy | 136P |
| Dual, but opposing, roles for the double stranded RNA-dependent protein kinase in metabolic homeostasis |
| G.I. Lancaster | 137P |
| The emerging role of HDL in glucose metabolism |
| B.A. Kingwell, A.K. Natoli, M. Reddy-Luthmoodoo, A.L. Carey, A.L. Siebel, D. Sviridov & B.G. Drew | 138P |
| Calorie restriction versus exercise: which produces the best health outcomes? |
| L.K. Heilbronn, D. Samocha-Bonet, E. Larsen-Meyer, L. Redman, A. Civitarese, S. Smith & E. Ravussin | 139P |
| Symposium: Ion channel modulation by peptide toxins |
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| Probing the interaction between psalmotoxin 1 and acid sensing ion channel 1a, an analgesic drug target |
| N.J. Saez, M. Mobli, M. Bieri, A.K. Malde, A.E. Mark, P.R. Gooley, L.D. Rash & G.F. King | 140P |
| Conotoxins targeting voltage-gated sodium channels:
Designing new analgesics |
| R.S. Norton, K.K. Khoo, Z. Kuang, B.J. Smith, M.J. Wilson, M-M. Zhang, J.E.F. Rivier, D. Yoshikami, B.M. Olivera & G. Bulaj | 141P |
| Subverting the biological actions of Conus peptides to modulate physiological responses |
| R.J. French | 142P |
| Calcium, Vc1.1 and α9α10 nicotinic acetylcholine receptors |
| M. Chebib, N. Absalom, G. Liang, E. Pera, C. Chu & H-L. Kim | 143P |
| Analgesic conotoxins: modulation of voltage-gated calcium channels in pain pathways |
| D.J. Adams | 144P |
| Free comunications: Smooth muscle |
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| Temporal relationships between intraluminal manometry and actual gut movement in the isolated rabbit small intestine |
| P.G. Dinning, M. Costa, J.W. Arkwtight, S.J. Brookes & N.J. Spencer | 145P |
| Gap junction coupling between smooth muscle cells modulates responses to inhibitory motorneurons and exogenous ATP |
| S.E. Carbone, D.A. Wattchow, N.J. Spencer & S.J.H. Brookes | 146P |
| KV4 and ANO1 / TMEN16A chloride channel expression profiles distinguish between atypical and typical smooth muscle cells in the mouse renal pelvis |
| R.J. Lang, J. Iqbal, M.A. Tonta, H.C. Parkington & H. Hashitani | 147P |
| Controlling uterine contractions: the role of interstitial cells |
| H.C. Parkington, Q. Li, M.A. Tonta, J. Iqbal, M.M. Davies, K.W. Taylor, S.P. Brennecke, H.A. Coleman, R.J. Lang & P.J. Sheehan | 148P |
| Symposium: Emerging leaders in developmental physiology |
|
| Developmental programming following prenatal alcohol exposure: models and mechanisms of disease |
| K.M. Moritz | 149P |
| Intrauterine inflammation: effects on fetal lung development |
| T.J.M. Moss | 150P |
| Early origins of cardiovascular disease: The heart of the matter |
| K. Wang, K.J. Botting, D. A. Brooks, L. Zhang, L. Rattanatray, S. Zhang, J. Duffield, C. Suter, I.C. McMillen & J.L. Morrison | 151P |
| Maternal diets rich in fat programme obesity, hypertension and altered sympathetic nervous system activity in adult offspring |
| J.A. Armitage, L.J. Prior, S.L. Burke & G.A. Head | 152P |
| Early life environments and programming of the vascular phenotype |
| M. Tare | 153P |
| Free communications: Sensory |
|
| Selective loss of visceral pain in the aganglionic rectum of lethal spotted mutant mice |
| V.P. Zagorodnyuk, M. Kyloh, S. Nicholas, S.J.H. Brookes & N.J. Spencer | 154P |
| Purinergic signalling via ATP-gated ion channels mitigates noise-induced hearing loss |
| G.D. Housley, Y. Sivakumaran, T.L. Loh, S.F. Tadros, A.C.Y. Wong, P.R. Thorne, S.M. Vlajkovic & A.F. Ryan | 155P |
| Extracellular recording of viscerofugal neurons in guinea-pig colon |
| T.J. Hibberd, N.J. Spencer & S.J.H. Brookes | 156P |
| Symposium: Stress, disease and Ca2+ management: the cardiovascular challenge. |
|
| Cardiac SR Ca2+ release channels and adrenergic stimulation |
| D.R. Laver, J. Li, N.A. Beard, A.F. Dulhunty & D.F. van Helden | 157P |
| Cardiac ischemic stress: Ca2+ and sex scenarios |
| J.R. Bell & L.M.D. Delbridge | 158P |
| Cardiomyopathies: When is Ca2+ the culprit? |
| M. Ward | 159P |
| Defining the roles of Ca2+ entry in endothelin-1 and thromboxane A2 receptor mediated vascular contractile responses |
| Y.Y. Chan, N. Scrimgeour, G.Y. Rychkov & D.P. Wilson | 160P |
| Free communications: Regulation of skeletal muscle growth and repair |
|
| The role of G-CSF in the growth and development of skeletal muscle cells in vitro |
| C.R. Wright, E.L. Brown, A.C. Ward & A.P. Russell | 161P |
| β2-adrenoceptors are the dominant subtype involved in early muscle regeneration after injury |
| J.E. Church, J. Trieu, P. Moore, P. Gregorevic & G.S. Lynch | 162P |
| Muscle-specific heat shock protein 72 (HSP72) overexpression improves muscle structure and function in dystrophic mdx mice |
| S.M. Gehrig, T.A. Sayer, C. van der Poel, D. Henstridge, J.D. Schertzer, J.E. Church, M.A. Febbraio & G.S. Lynch | 163P |
| Properties and proteolytic activity of m-calpain in rat skeletal muscle |
| J.P. Mollica, R.M. Murphy & G.D. Lamb | 164P |
| Properties of AMP kinase (AMPK) β isoforms and glycogen related proteins in segments of single fibres from rat skeletal muscle |
| R.M. Murphy, H. Latchman, B. Kemp, P. Gooley & D.I. Stapleton | 165P |
| Symposium: Molecular physiology and membrane dynamics |
|
| Pre-, hemi- and postfusion stages of lamellar body (LB) exocytosis in the rat lung: mechanisms of regulation and implications for surfactant release |
| P. Dietl | 166P |
| Targeting membrane lipids to modulate amyloid precursor protein processing |
| B. Garner | 167P |
| The effect of membrane-active peptides on membrane dynamics and molecular order |
| F. Separovic | 168P |
| Mechanisms of mechanosensation: Evolutionary origins of mechanosensitive ion channels |
| B. Martinac | 169P |
| Molecules in motion: imaging peptides, their receptors and diffusion models |
| I.L. Gibbins, S. Goh, Y. DeGraaf, K. Hendy & J. Clarke | 170P |
| ASB MacCauley-Hope Award Lecture |
|
| Pumping ions |
| R. J. Clarke | 216P |
| Symposium: Fatigue mechanisms limiting exercise performance |
|
| Neuromuscular fatigue: interactions between central and peripheral factors |
| M. Amann | 171P |
| Fatigue during intermittent exercise: novel insights and real-world applications |
| D.J. Bishop | 172P |
| Symposium: Fundamentals of Biophysics - development of mathematical and computational methods |
|
| Erythrocyte shape, metabolism and membrane transport – computations |
| P.W. Kuchel | 173P |
| Fast acquisition of multidimensional NMR experiments by maximum entropy reconstruction of non-uniformly sampled data |
| M. Mobli | 174P |
| Toward the virtual heart: graphics processor accelerated interactive simulations of cardiac function |
| D. Szekely, A.P. Hill & J.I. Vandenberg | 175P |
| Vesicle docking and delivery: Life in the TIRF zone |
| A.C.F. Coster | 176P |
| Free communications: Ion channel gating |
|
| Lipid effects on the gating behaviour and reconstitution of MscL and MscS |
| A.R. Battle, T. Nomura & B. Martinac | 177P |
| Mapping the sequence of conformational changes underlying selectivity filter
gating in a potassium channel |
| A.P. Hill, D. Wang, S. Mann, M. Perry, P. Tan & J.I. Vandenberg | 178P |
| Rigid body Brownian dynamics simulations of ion channels and channel blockers |
| D. Gordon & S.H. Chung | 179P |
| Metamorphic chloride intracellular channel proteins: evidence for transmembrane extension and membrane induced oligomerisation of CLIC1 |
| S.C. Goodchild, S.N. Breit, P.M. Curmi & L.J. Brown | 180P |
| pH dependence of the Ca2+ release activated Ca2+ (CRAC) channel |
| N.R. Scrimgeour, D.P. Wilson & G.Y. Rychkov | 181P |
| Plenary |
|
| The congenital Long QT Syndrome: broad lessons from a rare disease |
| R.S. Kass | 182P |
| Plenary |
|
| Molecular mechanism of store-operated calcium entry (SOCE) in skeletal muscle and potential role in fatigue resistance |
| R.T. Dirksen, A.D. Lyfenko & L. Wei | 183P |
| Symposium: Skeletal muscle ROS: the good, the bad and the, well it kinda depends |
|
| Skeletal muscle ROS and glucose uptake during contraction |
| G.K. McConell & T.L. Merry | 184P |
| Effects of S-glutathionylation, S-nitrosylation and oxidation on Ca-sensitivity and force: a balancing act |
| G.D. Lamb, J.P. Mollica, T.L. Dutka, G.S. Posterino & R.M. Murphy | 185P |
| Skeletal Muscle H2O2 and Insulin Sensitivity |
| T. Tiganis | 186P |
| The role of ROS in insulin resistance |
| D.E. James | 187P |
| Free communications: Endocrine signalling |
|
| Periconceptional and early preimplantational undernutrition alters gene expression of metabolic and gluconeogenic regulating factors in the liver |
| S. Lie, J.L. Morrison, O. Wyss, S. Zhang & I.C. McMillen | 188P |
| The effects of chronic moderate prenatal ethanol exposure on cardiovascular and renal artery function in adult rats |
| M. Tjongue, M. Tare, M.E. Probyn, K.M. Moritz & K.M. Denton | 189P |
| Gonadotropin-inhibiting hormone (GnIH) regulates spontaneous action potentials in anorexigenic proopiomelanocortin neurons and orexigenic neuropeptide Y cells |
| J.S. Jacobi, H.A. Coleman, A. Sali, H.C. Parkington, M.A. Cowley & I.J. Clarke | 190P |
| Maternal overnutrition during the periconceptional period and gender influences insulin signalling and glucose handling in lambs after birth |
| L.M. Nicholas, L. Rattanatray, S. McLaughlin, S.E. Ozanne, B.S. Muhlhausler, D. Kleeman, S. Walker, J.L. Morrison & I.C. McMillen | 191P |
| The role of regulator of calcineurin 1 (RCAN1) in the regulation of glucose homeostasis |
| H. Peiris, D. Mohanasundaram, J. Brealey, C. Jessup, T. Coates, M. Pritchard & D. Keating | 192P |
| Free communications: Ion channels |
|
| Agonist interactions and selectivity in GABAA/C receptors |
| B.A. Cromer, H.S. Tae & S. Petrou | 193P |
| Defining GABAA receptor pharmacology and physiologies through the disruption of receptor protein interactions |
| M.L. Tierney, V.A.L. Seymour, J. Curmi, W. Xu & H.C. Chan | 194P |
| Developing activation mechanisms for GABAA receptors |
| A. Keramidas | 195P |
| Understanding the molecular and pharmacological basis of selectivity of nicotinic acetylcholine receptor antagonists using reactive methyllycaconitine analogues |
| N.L. Absalom, G. Quek, J. Ambrus, M.D. McLeod & M. Chebib | 196P |
| Reciprocal regulation of expression of STIM1 and Orai1 proteins |
| L. Ma, D.P. Wilson, G.J. Barritt & G.Y. Rychkov | 197P |
| Free communications: Regulation of protein expression in skeletal muscle |
|
| Atrogin-1 regulation in human and mouse skeletal myotubes |
| R.J. Stefanetti & A.P. Russell | 198P |
| NDRG2, a novel player in the control of skeletal muscle mass? |
| V.C. Foletta & A.P. Russell | 199P |
| Multiple cell types express myokines following intense resistance exercise |
| P.A. Della Gatta, J. Peake, A.P. Garnham & D. Cameron-Smith | 200P |
| PGC-1α and PGC-1β regulate protein synthesis in C2C12 myotubes |
| E.L. Brown, P. Sepulveda, C.R. Wright, R. Snow & A.P. Russell | 201P |
| Properties and amounts of heat shock proteins in skeletal muscle |
| N.T. Larkins, R.M. Murphy & G.D. Lamb | 202P |
| Knockdown of STARS alters protein synthesis and degradation |
| M.A. Wallace & A.P. Russell | 203P |
| Free communications: Calcium signalling |
|
| Expression of STIM and Orai in liver disease |
| C.H. Wilson, G.Y. Rychkov & G.J. Barritt | 204P |
| Molecular mechanisms of paracetamol induced liver damage |
| E. Kheradpezhouh, G.J. Barritt & G.Y. Rychkov | 205P |
| Mitochondria-induced hyperpolarization in mouse locus coeruleus neurons is dependent on Ca2+ entry but not intracellular Ca2+ release |
| R.B. de Oliveira, F.S. Gravina, A.M. Brichta, R.J. Callister & D.F. van Helden | 206P |
| Calcium influx-activating action of P-EPTX-Ar1a: an isolated neurotoxin from the venom of Irian Jayan death adder |
| J. Chaisakul, H.C. Parkington, M.A. Tonta, H.A. Coleman, N. Konstantakopoulos & W.C. Hodgson | 207P |
| Alcohol-induced pancreatic trypsinogen activation depends on calmodulin-sensitive inositol trisphosphate receptors types 2 and 3 |
| J. Gerasimenko | 208P |
| Symposium: Computational studies on biological and synthetic nanotubes |
|
| Selective ion binding and its role in potassium channel selectivity |
| T.W. Allen | 209P |
| The induction and stabilization of transmembrane pores by peptides |
| A.E. Mark | 210P |
| Monitoring the conformational changes involved in MscL channel gating using FRET microscopy and simulation |
| B. Corry | 211P |
| Free energy simulations of Asp/Glu transporter GltPh |
| S. Kuyucak & T. Bastug | 212P |
| Mimicking biological ion channels using nanotubes |
| T.A. Hilder, D. Gordon & S.H. Chung | 213P |
| Plenary |
|
| Multi-drug efflux by P-glycoprotein; why has this protein not been stopped yet? |
| R. Callaghan, R. Ford, M. O'Mara & I.D. Kerr | 214P |
| Plenary |
|
| Metabolic regulation in exercise: mechanisms and experimental models |
| E.A. Richter | 215P |
