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PROCEEDINGS OF THE
AUSTRALIAN PHYSIOLOGICAL SOCIETY

ISSN 0067-2084

Volume 45

2014

CONTENTS

AuPS 2013 Geelong Meeting

Symposium: Physiological roles of noncoding RNA in muscle
MicroRNAs differentially regulated in cardiac and skeletal muscle in health and disease: Potential drug targets?
C.E. Winbanks, J.Y.Y. Ooi, S.S. Nguyen, J.R. McMullen & B.C. Bernardo 1
Science Communication in Physiology Education
I said, “Do you speak my language?” Using media variety to communicate science beyond academia
C.L. Jasoni1P
SURJ: Developing science students’ writing skills through UREs
S.L. Rowland & Z. Pross2P
The development of undergraduate science students’ scientific argument skills in oral presentations
A. Bugarcic, K.L. Colthorpe, K. Zimbardi, H.W. Su & K. Jackson3P
Developing research communication skills in 3rd year Biomedical Science students
Y. Hodgson & J.K. Choate4P
A strategy for student engagement in peer student presentations- assessing critical thinking skills
D.A. Saint5P
Welcome and AuPS Invited Lecture
Getting to the heart of ectopic beats
J.I. Vandenberg6P
Symposium: Genetics influences on skeletal muscle physiology and athletic performance
Genomic markers for athletic performance and trainability: What little we know
N. Eynon7P
A gene for speed: ACTN3, athletes, evolution and impact on human health
K.N. North8P
The POWERGENE consortium: Identifying the genetics of sprint/power performance in elite athletes
P.J. Houweling, F.C. Garton, POWERGENE Consortium, N. Eynon & K.N. North9P
The use of “omics” to individualize exercise training
Y.P. Pitsiladis10P
Symposium: Teaching and learning within undergraduate research experiences in physiology
Exploring connections between teaching, research and learning at Monash University
N.A. Samarawickrema, J.O. Macaulay, B. Diug & R. Benson11P
Providing authentic research experiences: Comparison of two research programs
Y. Hodgson & J.K. Choate12P
Authentic, large-scale undergraduate research experiences (ALUREs) in physiology – development, implementation, evaluation and dissemination
K. Zimbardi, K.L. Colthorpe, A. Bugarcic, L.J. Lluka, P. Chunduri, J. Kibedi, S.L. Rowland, G. Lawrie, J.T.H. Wang, P. Myatt & P. Worthy13P
Learning research skills in undergraduate exercise physiology
G.D. Wadley, K.F. Howlett, A.P. Russell & R.J. Snow14P
Using guided-inquiry lectures to enhance student engagement and understanding
J.K. Choate & Y. Hodgson15P
Symposium: Exocytosis
Lipid regulation of exocytosis
J.R. Coorssen16P
Calpains cleave dysferlin to release a synaptotagmin-like module for the calcium-dependent exocytosis of membrane repair
G.M.I. Redpath, N. Woolger, A. Lek, A.K. Piper, F.A. Lemckert, P.A. Greer, K.N. North & S.T. Cooper17P
Molecular regulation of insulin secretion
W. Han18P
The C-terminal membrane anchor of Syntaxin4 affects Munc18c-supported SNARE assembly in vitro
J.L. Martin, A. Rehman, Z. Tminov, M.P. Christie, A.E. Whitten, G.J. King, R.J. Jarrott, S. Norwood, D.E. James, K. Alexandrov & B.M. Collins19P
Symposium: Ion channels and pathophysiological changes in ionic regulation
Voltage gated proton channels - past, present and future
D. Morgan & T.E. DeCoursey20P
Determination of the junctional space [Ca2+] set by ryanodine receptor Ca2+ leak in fast- and slow-twitch muscle fibres
T.R. Cully & B.S. Launikonis21P
Mechanosensitivity of TRPC6 ion channels
Y.A. Nikolaev, P.R. Rohde, C.D. Cox, D.R. Laver & B. Martinac22P
ORAI channels in lactation and in breast cancer
G.R. Monteith23P
Symposium: Interaction of metabolic balance and growth hormone
Growth hormone action on adipose tissue and liver
M.J. Waters, C.N. Nelson, M.T.N. Ieremia & L. Constantin24P
Sex steroids and the growth hormone system in metabolic regulation
K.K.Y. Ho25P
The production and release of growth hormone during periods of metabolic stress – How and why?
F.J. Steyn26P
Caloric balance and insulin action
S. Schenk27P
Posters
Comparison of contractile responses of single motor units in the toe extensors during unloaded and loaded isotonic and isometric conditions
M. Leitch & V.G. Macefield28P
Antioxidant supplementation inhibits exercise-induced skeletal muscle signaling but did not alter markers of muscle adaptations
K. Yada, T. Mizokami, Y.L. Hung & K. Suzuki29P
The anti-inflammatory effects of stress hormones on lipopolysaccharide-stimulated macrophages
Y.L. Hung & K. Suzuki30P
Impact of in vitro culture and embryo transfer on cardiac metabolism in early postnatal life
M. Padhee, I.C. McMillen, S. Zhang, S.M. MacLaughlin, D.O. Kleemann, S.K. Walker, J. Kelly, S. Rudiger & J.L. Morrison31P
Salbutamol decreases potassium concentration during heavy rowing exercise but not immediately following recovery
T. Atanasovska, A.C. Petersen, R. Smith, A. Tobin & M.J. McKenna32P
Heat stress acutely stimulates insulin-independent glucose transport and 5′ adenosine monophosphate-activated protein kinase in rat skeletal muscle
A. Goto, I. Sakon, R. Oshima, T. Egawa, Y. Serizawa, S. Tsuda & T. Hayashi33P
Responses of circulating microRNAs to unloading-associated atrophy and reloading-induced regrowth of mouse hindlimb skeletal muscle
M. Suzuki, T. Egawa, A. Ikuta, A. Goto, S. Yokoyama, Y. Ohno, T. Sugiura, Y. Ohira, T. Yoshioka & K. Goto34P
ACTN3 R577X genotype influences 100 and 200 m Olympic sprinting performance in seven cohorts of elite sprinters
I.D. Papadimitriou, A. Lucia, V.P. Pushkarev, D.A. Dyatlov, E.F. Orekhov, G.G. Artioli, J.F.L. Guilherme, A.H. Lancha Jr, V. Ginevičienė, P. Cieszczyk, A.M. Karlowska, M. Sawczuk, C.A. Muniesa, A. Kouvatsi, M. Massidda, C.M. Calò, D.J. Bishop, K.N. North & N. Eynon35P
α-actinin-3 deficiency does not affect the unloaded shortening biomechanics of single isolated fast-twitch FDB fibres from Actn3 KO mice
S. Wagner, O. Friedrich, S. Chan, P.J. Houweling, K.R. Quinlan, R.M. Murphy, K.N. North & S.I. Head37P
Novel role for Selenoprotein S in regulating skeletal muscle contractile function in fast twitch mouse muscles
A. Addinsall, C.-H. Weng, N.L. McRae, C. Wright, S. Andrikopoulos, N. Wong & N. Stupka38P
Changes in heart rate variability and ECG in a murine model of hypertrophic cardiomyopathy
W.W. Lim, M. Baumert, M. Neo, P. Kuklik, A. Ganesan, D.H. Lau, T. Tsoutsman, C. Semsarian, D.A. Saint & P. Sanders39P
Detection of microvascular flowmotion within skeletal muscle in vivo
S. Blackwood, E.A. Bradley, S.M. Richards, M.A. Keske, R.M. Dwyer & S. Rattigan40P
A comparative transcriptomic analysis of the regenerating neonatal mouse heart
G.A. Quaife-Ryan, Z.B. Ma, S. Uchida, W.G. Thomas, J.E. Hudson & E.R. Porrello41P
Inter-individual differences in blood pressure responses to stressors: mental versus physical tasks
K. El Sayed, C.E. Taylor, M.J. Joyner & V.G. Macefield42P
The effects of CaMKII inhibition on cardiac muscle contractility in the zucker diabetic fatty rat
L. Daniels, R. Wallace, R. Lamberts & J. Erickson43P
Amitriptyline improves left ventricular recovery in rat hearts subjected to cardiac ischaemic-reperfusion injury
S.M. Lee, D.A. Saint & M. Hutchinson44P
A novel startle mutation of the α1 glycine receptor subunit reveals the role of W170 in receptor function
M.J. Windley, M. Drwal, A.M. Finch & T.M. Lewis45P
Effect of changing the [Mg2+] on ryanodine receptor leak activity in rat skeletal muscle
R.H. Choi & B.S. Launikonis46P
Mutation of cysteines on the α interacting domain of the long NT isoform of the Cav1.2 channel protein alters the biophysical properties of the channel
P. Muralidharan, H. Cserne Szappanos, E. Ingley & L. Hool47P
Discovery and characterization of potent biphasic α5GABAA receptor modulators
M.S. Soh, R.P. McGeary & J.W. Lynch48P
Is it the magnesium or is it the sulphate? Neuroprotective benefit of antenatal magnesium sulphate therapy for preterm infants
P.A. Dawson, F.G. Bowling & E. Hurrion49P
Paternal transmission of metabolic dysfunction to offspring born to a growth restricted father
M.E. Wlodek, E.L. McArthur, T.N. Hosseini, J.N. Cheong, A.J. Jefferies & K.M. Moritz50P
Expression of aldehyde dehydrogenase family 1, member A3 in glycogen trophoblast cells of the murine placenta
J.E. Outhwaite & D.G. Simmons51P
Maternal hypomagnesaemia causes placental abnormalities that may contribute to fetal and postnatal mortality
R.N. Schlegel, J.S.M. Cuffe, K.M. Moritz & T.M. Paravicini52P
The effects of ethanol on trophoblast cell differentiation in culture
J.I. Kalisch-Smith, S.E. Steane, M. Pantaleon, K.M. Moritz & D.G. Simmons53P
Behavioural Correlates of Periconceptional Ethanol Exposure in Aged Offspring
D. Zanfirache, C. Cullen & K.M. Moritz54P
Alterations in key elements of the hexosamine signalling pathway in mouse placenta in response to maternal stress: implications for fetal programming of adult disease
K. McMahon, J.S.M. Cuffe, K.M. Moritz & M. Pantaleon55P
Mature surfactant protein-B expression by immunohistochemistry as a marker for surfactant system development in the fetal sheep lung
E.V. McGillick, M. Lock, S. Orgeig, S. Zhang, I.C. McMillen & J.L. Morrison56P
The impact of intestinal lymph exposure on adipocyte function and insulin resistance
E. Cao, M.J. Watt, L. Hu, C.J.H. Porter & N.L. Trevaskis57P
Hypoxia-induced growth restriction leads to sexually dimorphic changes to the renal and cardiovascular systems in adult mouse offspring
S.L. Walton, R.R. Singh, T.M. Paravicini, M.H. Little & K.M. Moritz58P
TMEM16A may regulate pH in the pancreatic acinar lumen
Y. Han & P. Thorn59P
Small molecules demonstrate that dynamin is a bi-directional modulator of the exocytosis fusion pore
J. Jackson, A. Papadopulos, A. McCluskey, F.A. Meunier, P.J. Robinson & D.J. Keating60P
Species difference in α-conotoxin RegIIA inhibition of neuronal nicotinic acetylcholine receptors: molecular basis for differential sensitivity
D.J. Adams, S.N. Kompella, H. Cuny, A. Hung & R.J. Clark61P
Extensive heterogeneous dye-coupling among cells derived from human induced-pluripotent-stem cells
R. Kanjhan, P.R. Fortuna, M.C. Bellingham & E.J. Wolvetang62P
Michael Roberts Lecture
From active learning to self-regulated learning
K.L. Colthorpe63P
Symposium: Cardiac metabolic stressors and sensors
Protein O-GlcNAcylation: A novel regulator of cardiomyocyte stress response
J.C. Chatham64P
O-linked β-N-acetylglucosamine (O-Glc-NAc) signalling and the hexosamine pathway in diabetic cardiomyopathy
R.H. Ritchie65P
Hexose sugars and cardiomyocyte pathophysiology
K.M. Mellor66P
A novel family of functional cardiac G protein-coupled receptors with potential roles in nutrient sensing and contractility
W.G. Thomas67P
Symposium: Placental development and function: effects of maternal perturbations during pregnancy
Asthma, smoking and the placenta
N.A. Hodyl68P
Developing molecularly targeted therapeutics for severe preeclampsia
S. Tong69P
The spiny mouse: a novel species for studying fetal and placental development and improving obstetric outcomes
H. Dickinson, K.M. Moritz, P.J. Mark & D.W. Walker70P
Heart defects in Ly6e mutant mice are likely a secondary consequence of impaired placental development
D.G. Simmons, M.B. Langford & D.R. Natale71P
Free Communications: Exercise Physiology
The effects of an oral glucose load on plasma K+ and electrolyte homeostasis at rest, during high intensity intermittent exercise and recovery and on skeletal muscle Na+,K+-ATPase isoform abundance
C.H. Steward, R. Smith, N.K. Stepto, M. Brown, I. Ng & M.J. McKenna72P
Cortical activity and motor unit recruitment during a high intensity endurance exercise protocol in normothermic and heated environments
N. Vargas & F. Marino73P
Effects of high-intensity interval exercise, under either induced metabolic acidosis or alkalosis, on the regulation of genes associated with the acid-base regulation in human skeletal muscle
R.S.F. Oliveira, C. McGinley, C. Granata, H. Pilegaard & D.J. Bishop74P
An interaction of morphology in the modulation of evaporative heat loss during exercise
S.R. Notley, J. Park, K. Tagami, N. Ohnishi, G.P. Kenny & N.A.S. Taylor75P
Post-exercise cold-water immersion activates acute PHF20 and p53 signalling in human skeletal muscle
J.R. Broatch, A.C. Petersen & D.J. Bishop76P
Exercise-induced changes in cerebral oxygenation and cognition in the human prefrontal cortex
J. Yamauchi & K.E. Kobayashi77P
ACTN3 R577X genotype affects training-induced changes in mitochondrial respiration in humans
X. Yan, N. Eynon, I.D. Papadimitriou, J. Kuang, O. Tirosh, L. O’Keefe, M. Anderson, K.N. North & D.J. Bishop78P
Invited Lecture
Calmodulin and CaMKII signaling in the heart
D.M. Bers80P
Free Communications: Skeletal Muscle Physiology
Sarcoplasmic reticulum Ca2+ leak is increased in type I muscle fibres of old human subjects
C.R. Lamboley, V.L. Wyckelsma, R.M. Murphy, M.J. McKenna & G.D. Lamb81P
Effect of doublet stimulation on tetanic Ca2+ responses measured in isolated fast interosseous fibres of the mouse
A.J. Bakker, T.R. Cully & B.S. Launikonis82P
Genetic reduction of an extracellular matrix gene improves contractile function in dystrophic mdx mice
D.R. McCulloch, N.L. McRae, R. Kelly, L. Forgan & N. Stupka83P
Induction of heat shock protein 72 improves the cardiomyopathy and reduces fibrosis in severely dystrophic dko mice
T. Kennedy, K. Swiderski, K.T. Murphy, R. Koopman, S.M. Gehrig, M.A. Febbraio & G.S. Lynch84P
Assessment of RyR leak and t-system Ca2+ uptake in dystrophic skeletal muscle
T.R. Cully & B.S. Launikonis85P
The sarcomeric α-actinins perform a dynamic balancing act at the muscle Z-line
F.C. Garton, M.W. Hogarth, P.J. Houweling, X.F. Zheng, K.G. Quinlan, N. Yang, T. Tukiainen, D.G. MacArthur, P. Gregorevic & K.N. North86P
Free Communications: Reproduction
Renal dysfunction is transmitted to third generation offspring born to a growth restricted mother or father
M.E. Wlodek, S.T. Kharal, A.J. Jefferies, J.N. Cheong & K.M. Moritz87P
The developmental programming effects of vitamin D on renal nephron endowment and gene expression of the renin angiotensin system in weanling male rats
K.I. Burkitt, A.C. Boyce, F.C. Britton & K.J. Gibson88P
Prenatal corticosterone exposure induces dysregulation of the renal renin angiotensin system in male offspring
J.S.M. Cuffe, D.J. Burgess & K.M. Moritz89P
Prolactin as a key regulator of Growth Hormone pulsatility in lactation, acting via somatostatin
S. Gounden, C. Chen & F.J. Steyn90P
Periconceptional alcohol alters adult renal and cardiac function in a sex dependent manner
E.S. Dorey, E.M. Gardebjer, F. Campbell, T.M. Paravicini, K.A. Weir, M.E. Wlodek & K.M. Moritz91P
Maternal stress during pregnancy in growth restricted females programs sex-specific metabolic outcomes in second generation male and female rats
J.N. Cheong, A.J. Jefferies, K.M. Moritz & M.E. Wlodek92P
Free Communications: Channels and Nervous System
Control of muscle sympathetic nerve activity to contracting muscle in humans: contributions of central command and peripheral feedback
D. Boulton, C.E. Taylor, V.G. Macefield & S. Green94P
Inhibitory effect of dantrolene on cardiac RyR2 in the presence of calmodulin
Y.W. Oo, D.F. van Helden, M.S. Imtiaz, B.C. Knollmann & D.R. Laver95P
The effects of obesity on hippocampal function in the rat
H.A. Coleman, S. Lye & H.C. Parkington96P
Controlling contractions in human myometrium; an eye on channels
H.C. Parkington, M.A. Tonta, P.J. Sheehan, J. Stevenson, S.P. Brennecke, H.A. Coleman, J. Paul & R. Smith97P
Calcium signalling in epithelial-mesenchymal transition induced by hypoxia in breast cancer cells
I. Azimi, F.M. Davis, P.A. Kenny, E.W. Thompson, S.J. Roberts-Thomson & G.R. Monteith98P
Symposium: Can we age well?
Can we age well?
D.G. Le Couteur99P
The Ageing Liver
V.C. Cogger100P
Ageing muscles: biomarkers and exercise
M.D. Grounds, Z. Soffe, C. McMahon, A.A. Sayer & T. Shavlakadze101P
Sleep well, age well
N.L. Rogers102P
Free Communications: Endocrinology, Diabetes and Cancer
Mechanisms directing blood-lymph transfer of nano-sized therapeutics
N.L. Trevaskis, L.M. Kaminskas, P. Yadav, A.P.R. Johnston & C.J.H. Porter103P
Perilipin 5 regulates hepatic lipid metabolism and systemic glucose tolerance in mice
S.N. Keenan, J. Lo, R.C.R. Meex & M.J. Watt104P
RCAN1 is critical for β-cell mitochondrial function and is overexpressed in human Type 2 diabetes
H. Peiris, M. Duffield, C.F. Jessup, V. Kashmir, J. Fadista, A. Genders, S. McGee, M. Ryan, D.R. Laybutt, P.T. Coates, M.A. Pritchard, L. Groop & D.J. Keating105P
Chronic high fat feeding increases megalin expression and causes albuminuria and proteinuria in rats
J.F. Briffa, K.A. Jenkin, E. Grinfeld, A.J. McAinch, M.L. Mathai & D.H. Hryciw106P
Progression of type 2 diabetes in Leprdb mice: from the animal to the granular levels
O.H. Do & P. Thorn107P
Adipose-secreted factors from peri-prostatic fat stimulate prostate cancer cell tumourigenecity
R.A. Taylor, N. Ascui, J. Lo, M. Papargiris, G.P. Risbridger, M. Frydenberg & M.J. Watt108P
Dysfunction of the dystrophin-glycoprotein complex (DGC) in cancer cachexia
K. Swiderski, K.T. Murphy, N.A. Williamson, C.J. Brock, D.M. Baum, A. Chee, T. Naim & G.S. Lynch109P
Pulsatile luteinizing hormone (LH) secretion in female mice across pubertal development
Y. Wan, F.J. Steyn, J.D. Veldhuis & C. Chen110P
Symposium: Frontiers of molecular mechanisms of ligand recognition and activation of receptor channels
Signal transduction at the subunit interfaces of the human glycine receptor
T.M. Lewis, M. Drwal, D. Tam, L.S. Walton & M.J. Windley111P
Ligand selectivity in pentameric ligand-gated ion channels
H.S. Tae, J.R. Lawson, S. Petrou & B.A. Cromer112P
Mechanism of ATP-dependent gating in CFTR channels
Y. Sohma113P
Signal transmission within the P2X2 trimeric receptor and the voltage dependent structural rearrangements
Y. Kubo & B. Keceli114P
Symposium: Early life environment as an indicator of health; outcomes and prevention
Early life environment as an indicator of health; outcomes and prevention
J.L. Morrison115P
Maternal nutrition and skeletal muscle development in the offspring: long-term impact on health
S.A. Bayol116P
Altered renal signalling in rat offspring born small
D.H. Hryciw, J.F. Briffa, A.J. Jeffries & M.E. Wlodek117P
Mum's the word: Understanding the role of maternal obesity and inflammation during pregnancy in elevating the risk of offspring neuroendocrine disorders
C.L. Jasoni, D.W. Kim, T.R. Sanders & K.A. Glendining118P
Free Communications: Skeletal Muscle Signalling
Glucocorticoid treatment regulates versican pericellular matrix remodelling during myoblast fusion: implications for muscular dystrophy therapies
N.L. McRae, L. Forgan, A. Addinsall, C. Van Der Poel, D.R. McCulloch & N. Stupka119P
Thymosin β4 improves the dystrophic pathology in young mdx mice
J. Pittas, V. El-Khoury, S.J. McDonald, J.E. Church & C. van der Poel120P
Thymosin beta 4 enhances myogenesis in vitro but does not confer regenerative advantage on skeletal muscle in vivo following myotoxic injury
B.L. Cleeland, V. El-Khoury, S.J. McDonald, C. van der Poel & J.E. Church121P
Glycine supplementation during calorie restriction accelerates fat loss and protects against further muscle loss in obese mice
M.K. Caldow, D.J. Ham, D.P. Godeassi, A. Chee, G.S. Lynch & R. Koopman122P
Regulating muscle protein synthesis in human myotubes from young and old subjects with microRNAs
E. Zacharewicz, S. Lamon, P. Della Gatta & A.P. Russell123P
Despecification of myogenic C2C12 cells via metabolic reprogramming
C.H. Ly, G.S. Lynch & J.G. Ryall124P
Exploring new targets within the TGFβ signaling network as interventions for cachexia
P. Gregorevic125P
Invited Lecture
Caveolae as mechanoprotective and signaling organelles
R.G. Parton126P
Symposium: Cardiomyocyte Ca2+ and Na+ signalling - new mechanistic insights
Compartmentalisation and localization - important signaling considerations for cardiomyocytes
D.M. Bers127P
Differential arrhythmogenic actions of cardiac CaMKII
J.R. Bell & L.M.D. Delbridge128P
CaMKII inhibition as a novel target for flavonol cardioprotection
L.S. Silva, J.R. Bell, N.R. Lim, Y.Y. Yeap, C.J. Thomas, O.L. Woodman, L.M.D. Delbridge, C.N. May, S.J. Williams & D.C.H. Ng129P
Oxidative regulation of Na/K-ATPase in the cardiovascular system
G.A. Figtree, C.C. Liu, H.H. Rasmussen, Y.B. Liu, E. Aristarkhova, R. Cohen, C. Bursill, K.M. Sweadner & K. Karimi-Galoughi130P
Symposium: New insights into exercise and insulin sensitivity
Exercise effects on insulin sensitivity
E.A. Richter131P
AMP-activated protein kinase in diabetes
J.F.P. Wojtaszewski132P
Exercise, nitric oxide and glucose metabolism
G.K. McConell133P
Exercise, GLUT4 and insulin action
M. Hargreaves134P
Symposium: Mechanisms and treatments for muscle wasting
Molecular mechanisms of muscle atrophy
M. Sandri135P
The role of the TGF-β superfamily cytokine MIC-1/GDF-15 in anorexia/cachexia of cancer and other diseases
S.N. Breit136P
Novel therapies for reducing muscle wasting in cancer
K.T. Murphy137P
Inhibition of TWEAK/Fn14 signaling prevents cachexia in cancer
A. Johnston, K.T. Murphy, L. Jenkinson, G.S. Lynch, N. Hoogenraad & J. Silke138P
Free Communications: Cardiac Physiology
Atrial remodeling in a murine model of hypertrophic cardiomyopathy: implications for atrial fibrillation
W.W. Lim, M. Neo, P. Kuklik, A. Ganesan, D.H. Lau, M. Baumert, T. Tsoutsman, C. Semsarian, D.A. Saint & P. Sanders139P
Streptozotocin-induced type I diabetes mediates structural and electrophysiological changes in the rat atria: A substrate for atrial fibrillation
M. Neo, W.W. Lim, D.H. Lau, P. Sanders & D.A. Saint140P
Augmented CaMKIIδ activation enhances stress resilience in Ca2+ loaded female aromatase-deficient mouse cardiomyocytes
G.B. Bernasochi, J.R. Bell, A.C. Wollermann, A.J.A. Raaijmakers, E.R. Simpson, C.L. Curl, K.M. Mellor & L.M.D. Delbridge141P
The C-26 tumour-bearing mouse model of cancer cachexia exhibits cardiac atrophy, systolic and diastolic dysfunction
C.J. Brock, K. Swiderski, K.T. Murphy, C.L. Curl, T. Kennedy, C. Chandramouli, L.M.D. Delbridge & G.S. Lynch142P
Scaffolding domains in cardiac aging: Does caveolin-3 govern age-dependent stress-intolerance?
M.E. Reichelt, C.J. Kiessling, M.W. Kidd, I. Niesman, B.P. Head, J.N. Peart, W.G. Thomas, D.M. Roth, K.J. Ashton, J.P. Headrick & H.H. Patel143P
Dynamic changes in the cardiac methylome during post-natal development
C.B. Sim, M. Ziemann, A. Kaspi, KN. Harikrishnan, J. Ooi, I. Khurana, L. Chang, J.E. Hudson, A. El-Osta & E.R. Porrello144P
Free Communications: Exercise and Muscle Signalling
Thioredoxin-interacting protein inhibits glycolysis and proliferation of myogenic cells
J.G. Ryall, M. Phung, C.H. Ly, R. Koopman & G.S. Lynch145P
Effects of endurance exercise intensity on acute signalling responses to subsequent resistance exercise in human skeletal muscle
J.J. Fyfe, D.J. Bishop & N.K. Stepto146P
Phosphoproteomics reveals the complexity of the human muscle exercise-regulated signalling network and a novel role for AKAP1 in regulating mitochondrial respiration via AMPK
N.J. Hoffman, B.L. Parker, R. Chaudhuri, K.H. Fisher-Wellman, M. Kleinert, P. Yang, S.J. Humphrey, S. Trefely, D.J. Fazakerley, R. Jothi, E.A. Richter & D.E. James147P
Training intensity-dependent regulation of mitochondrial respiration in human skeletal muscle: an effect modulated by the transcription factors PGC-1α, p53 and PHF20
C. Granata, R.S.F. Oliveira, K. Renner, J.P. Little & D.J. Bishop148P
High intensity interval and moderate intensity continuous training improves whole body insulin sensitivity and lowers muscle ceramide content in obese individuals
C.S. Shaw, S.O. Shepherd, M. Cocks, N.A. Mellett, P.J. Meikle & A.J.M. Wagenmakers149P
Role of pre-exercise alkalosis on the expression of sarcolemmal proteins involved in muscle pH regulation following a single bout of high-intensity exercise
D.J. Bishop, C. McGinley, R.S.F. Oliveira, R. Delfour-Peyrethon, C. Hanon, K. Lambert, N. Molinari & C. Thomas150P

Index

Author index
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