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PROCEEDINGS OF THE
AUSTRALIAN PHYSIOLOGICAL SOCIETY
ISSN 0067-2084

Volume 45

2014

CONTENTS

AuPS 2013 Geelong Meeting

Symposium: Physiological roles of noncoding RNA in muscle
MicroRNAs differentially regulated in cardiac and skeletal muscle in health and disease: Potential drug targets?
C.E. Winbanks, J.Y.Y. Ooi, S.S. Nguyen, J.R. McMullen & B.C. Bernardo 1

AuPS 2014 Brisbane Meeting

Science Communication in Physiology Education
I said, “Do you speak my language?” Using media variety to communicate science beyond academia
C.L. Jasoni
1P
SURJ: Developing science students’ writing skills through UREs
S.L. Rowland & Z. Pross
2P
The development of undergraduate science students’ scientific argument skills in oral presentations
A. Bugarcic, K.L. Colthorpe, K. Zimbardi, H.W. Su & K. Jackson
3P
Developing research communication skills in 3rd year Biomedical Science students
Y. Hodgson & J.K. Choate
4P
A strategy for student engagement in peer student presentations- assessing critical thinking skills
D.A. Saint
5P
Welcome and AuPS Invited Lecture
Getting to the heart of ectopic beats
J.I. Vandenberg
6P
Symposium: Genetics influences on skeletal muscle physiology and athletic performance
Genomic markers for athletic performance and trainability: What little we know
N. Eynon
7P
A gene for speed: ACTN3, athletes, evolution and impact on human health
K.N. North
8P
The POWERGENE consortium: Identifying the genetics of sprint/power performance in elite athletes
P.J. Houweling, F.C. Garton, POWERGENE Consortium, N. Eynon & K.N. North
9P
The use of “omics” to individualize exercise training
Y.P. Pitsiladis
10P
Symposium: Teaching and learning within undergraduate research experiences in physiology
Exploring connections between teaching, research and learning at Monash University
N.A. Samarawickrema, J.O. Macaulay, B. Diug & R. Benson
11P
Providing authentic research experiences: Comparison of two research programs
Y. Hodgson & J.K. Choate
12P
Authentic, large-scale undergraduate research experiences (ALUREs) in physiology – development, implementation, evaluation and dissemination
K. Zimbardi, K.L. Colthorpe, A. Bugarcic, L.J. Lluka, P. Chunduri, J. Kibedi, S.L. Rowland, G. Lawrie, J.T.H. Wang, P. Myatt & P. Worthy
13P
Learning research skills in undergraduate exercise physiology
G.D. Wadley, K.F. Howlett, A.P. Russell & R.J. Snow
14P
Using guided-inquiry lectures to enhance student engagement and understanding
J.K. Choate & Y. Hodgson
15P
Symposium: Exocytosis
Lipid regulation of exocytosis
J.R. Coorssen
16P
Calpains cleave dysferlin to release a synaptotagmin-like module for the calcium-dependent exocytosis of membrane repair
G.M.I. Redpath, N. Woolger, A. Lek, A.K. Piper, F.A. Lemckert, P.A. Greer, K.N. North & S.T. Cooper
17P
Molecular regulation of insulin secretion
W. Han
18P
The C-terminal membrane anchor of Syntaxin4 affects Munc18c-supported SNARE assembly in vitro
J.L. Martin, A. Rehman, Z. Tminov, M.P. Christie, A.E. Whitten, G.J. King, R.J. Jarrott, S. Norwood, D.E. James, K. Alexandrov & B.M. Collins
19P
Symposium: Ion channels and pathophysiological changes in ionic regulation
Voltage gated proton channels - past, present and future
D. Morgan & T.E. DeCoursey
20P
Determination of the junctional space [Ca2+] set by ryanodine receptor Ca2+ leak in fast- and slow-twitch muscle fibres
T.R. Cully & B.S. Launikonis
21P
Mechanosensitivity of TRPC6 ion channels
Y.A. Nikolaev, P.R. Rohde, C.D. Cox, D.R. Laver & B. Martinac
22P
ORAI channels in lactation and in breast cancer
G.R. Monteith
23P
Symposium: Interaction of metabolic balance and growth hormone
Growth hormone action on adipose tissue and liver
M.J. Waters, C.N. Nelson, M.T.N. Ieremia & L. Constantin
24P
Sex steroids and the growth hormone system in metabolic regulation
K.K.Y. Ho
25P
The production and release of growth hormone during periods of metabolic stress – How and why?
F.J. Steyn
26P
Caloric balance and insulin action
S. Schenk
27P
Posters
Comparison of contractile responses of single motor units in the toe extensors during unloaded and loaded isotonic and isometric conditions
M. Leitch & V.G. Macefield
28P
Antioxidant supplementation inhibits exercise-induced skeletal muscle signaling but did not alter markers of muscle adaptations
K. Yada, T. Mizokami, Y.L. Hung & K. Suzuki
29P
The anti-inflammatory effects of stress hormones on lipopolysaccharide-stimulated macrophages
Y.L. Hung & K. Suzuki
30P
Impact of in vitro culture and embryo transfer on cardiac metabolism in early postnatal life
M. Padhee, I.C. McMillen, S. Zhang, S.M. MacLaughlin, D.O. Kleemann, S.K. Walker, J. Kelly, S. Rudiger & J.L. Morrison
31P
Salbutamol decreases potassium concentration during heavy rowing exercise but not immediately following recovery
T. Atanasovska, A.C. Petersen, R. Smith, A. Tobin & M.J. McKenna
32P
Heat stress acutely stimulates insulin-independent glucose transport and 5′ adenosine monophosphate-activated protein kinase in rat skeletal muscle
A. Goto, I. Sakon, R. Oshima, T. Egawa, Y. Serizawa, S. Tsuda & T. Hayashi
33P
Responses of circulating microRNAs to unloading-associated atrophy and reloading-induced regrowth of mouse hindlimb skeletal muscle
M. Suzuki, T. Egawa, A. Ikuta, A. Goto, S. Yokoyama, Y. Ohno, T. Sugiura, Y. Ohira, T. Yoshioka & K. Goto
34P
ACTN3 R577X genotype influences 100 and 200 m Olympic sprinting performance in seven cohorts of elite sprinters
I.D. Papadimitriou, A. Lucia, V.P. Pushkarev, D.A. Dyatlov, E.F. Orekhov, G.G. Artioli, J.F.L. Guilherme, A.H. Lancha Jr, V. Ginevičienė, P. Cieszczyk, A.M. Karlowska, M. Sawczuk, C.A. Muniesa, A. Kouvatsi, M. Massidda, C.M. Calò, D.J. Bishop, K.N. North & N. Eynon
35P
α-actinin-3 deficiency does not affect the unloaded shortening biomechanics of single isolated fast-twitch FDB fibres from Actn3 KO mice
S. Wagner, O. Friedrich, S. Chan, P.J. Houweling, K.R. Quinlan, R.M. Murphy, K.N. North & S.I. Head
37P
Novel role for Selenoprotein S in regulating skeletal muscle contractile function in fast twitch mouse muscles
A. Addinsall, C.-H. Weng, N.L. McRae, C. Wright, S. Andrikopoulos, N. Wong & N. Stupka
38P
Changes in heart rate variability and ECG in a murine model of hypertrophic cardiomyopathy
W.W. Lim, M. Baumert, M. Neo, P. Kuklik, A. Ganesan, D.H. Lau, T. Tsoutsman, C. Semsarian, D.A. Saint & P. Sanders
39P
Detection of microvascular flowmotion within skeletal muscle in vivo
S. Blackwood, E.A. Bradley, S.M. Richards, M.A. Keske, R.M. Dwyer & S. Rattigan
40P
A comparative transcriptomic analysis of the regenerating neonatal mouse heart
G.A. Quaife-Ryan, Z.B. Ma, S. Uchida, W.G. Thomas, J.E. Hudson & E.R. Porrello
41P
Inter-individual differences in blood pressure responses to stressors: mental versus physical tasks
K. El Sayed, C.E. Taylor, M.J. Joyner & V.G. Macefield
42P
The effects of CaMKII inhibition on cardiac muscle contractility in the zucker diabetic fatty rat
L. Daniels, R. Wallace, R. Lamberts & J. Erickson
43P
Amitriptyline improves left ventricular recovery in rat hearts subjected to cardiac ischaemic-reperfusion injury
S.M. Lee, D.A. Saint & M. Hutchinson
44P
A novel startle mutation of the α1 glycine receptor subunit reveals the role of W170 in receptor function
M.J. Windley, M. Drwal, A.M. Finch & T.M. Lewis
45P
Effect of changing the [Mg2+] on ryanodine receptor leak activity in rat skeletal muscle
R.H. Choi & B.S. Launikonis
46P
Mutation of cysteines on the α interacting domain of the long NT isoform of the Cav1.2 channel protein alters the biophysical properties of the channel
P. Muralidharan, H. Cserne Szappanos, E. Ingley & L. Hool
47P
Discovery and characterization of potent biphasic α5GABAA receptor modulators
M.S. Soh, R.P. McGeary & J.W. Lynch
48P
Is it the magnesium or is it the sulphate? Neuroprotective benefit of antenatal magnesium sulphate therapy for preterm infants
P.A. Dawson, F.G. Bowling & E. Hurrion
49P
Paternal transmission of metabolic dysfunction to offspring born to a growth restricted father
M.E. Wlodek, E.L. McArthur, T.N. Hosseini, J.N. Cheong, A.J. Jefferies & K.M. Moritz
50P
Expression of aldehyde dehydrogenase family 1, member A3 in glycogen trophoblast cells of the murine placenta
J.E. Outhwaite & D.G. Simmons
51P
Maternal hypomagnesaemia causes placental abnormalities that may contribute to fetal and postnatal mortality
R.N. Schlegel, J.S.M. Cuffe, K.M. Moritz & T.M. Paravicini
52P
The effects of ethanol on trophoblast cell differentiation in culture
J.I. Kalisch-Smith, S.E. Steane, M. Pantaleon, K.M. Moritz & D.G. Simmons
53P
Behavioural Correlates of Periconceptional Ethanol Exposure in Aged Offspring
D. Zanfirache, C. Cullen & K.M. Moritz
54P
Alterations in key elements of the hexosamine signalling pathway in mouse placenta in response to maternal stress: implications for fetal programming of adult disease
K. McMahon, J.S.M. Cuffe, K.M. Moritz & M. Pantaleon
55P
Mature surfactant protein-B expression by immunohistochemistry as a marker for surfactant system development in the fetal sheep lung
E.V. McGillick, M. Lock, S. Orgeig, S. Zhang, I.C. McMillen & J.L. Morrison
56P
The impact of intestinal lymph exposure on adipocyte function and insulin resistance
E. Cao, M.J. Watt, L. Hu, C.J.H. Porter & N.L. Trevaskis
57P
Hypoxia-induced growth restriction leads to sexually dimorphic changes to the renal and cardiovascular systems in adult mouse offspring
S.L. Walton, R.R. Singh, T.M. Paravicini, M.H. Little & K.M. Moritz
58P
TMEM16A may regulate pH in the pancreatic acinar lumen
Y. Han & P. Thorn
59P
Small molecules demonstrate that dynamin is a bi-directional modulator of the exocytosis fusion pore
J. Jackson, A. Papadopulos, A. McCluskey, F.A. Meunier, P.J. Robinson & D.J. Keating
60P
Species difference in α-conotoxin RegIIA inhibition of neuronal nicotinic acetylcholine receptors: molecular basis for differential sensitivity
D.J. Adams, S.N. Kompella, H. Cuny, A. Hung & R.J. Clark
61P
Extensive heterogeneous dye-coupling among cells derived from human induced-pluripotent-stem cells
R. Kanjhan, P.R. Fortuna, M.C. Bellingham & E.J. Wolvetang
62P
Michael Roberts Lecture
From active learning to self-regulated learning
K.L. Colthorpe
63P
Symposium: Cardiac metabolic stressors and sensors
Protein O-GlcNAcylation: A novel regulator of cardiomyocyte stress response
J.C. Chatham
64P
O-linked β-N-acetylglucosamine (O-Glc-NAc) signalling and the hexosamine pathway in diabetic cardiomyopathy
R.H. Ritchie
65P
Hexose sugars and cardiomyocyte pathophysiology
K.M. Mellor
66P
A novel family of functional cardiac G protein-coupled receptors with potential roles in nutrient sensing and contractility
W.G. Thomas
67P
Symposium: Placental development and function: effects of maternal perturbations during pregnancy
Asthma, smoking and the placenta
N.A. Hodyl
68P
Developing molecularly targeted therapeutics for severe preeclampsia
S. Tong
69P
The spiny mouse: a novel species for studying fetal and placental development and improving obstetric outcomes
H. Dickinson, K.M. Moritz, P.J. Mark & D.W. Walker
70P
Heart defects in Ly6e mutant mice are likely a secondary consequence of impaired placental development
D.G. Simmons, M.B. Langford & D.R. Natale
71P
Free Communications: Exercise Physiology
The effects of an oral glucose load on plasma K+ and electrolyte homeostasis at rest, during high intensity intermittent exercise and recovery and on skeletal muscle Na+,K+-ATPase isoform abundance
C.H. Steward, R. Smith, N.K. Stepto, M. Brown, I. Ng & M.J. McKenna
72P
Cortical activity and motor unit recruitment during a high intensity endurance exercise protocol in normothermic and heated environments
N. Vargas & F. Marino
73P
Effects of high-intensity interval exercise, under either induced metabolic acidosis or alkalosis, on the regulation of genes associated with the acid-base regulation in human skeletal muscle
R.S.F. Oliveira, C. McGinley, C. Granata, H. Pilegaard & D.J. Bishop
74P
An interaction of morphology in the modulation of evaporative heat loss during exercise
S.R. Notley, J. Park, K. Tagami, N. Ohnishi, G.P. Kenny & N.A.S. Taylor
75P
Post-exercise cold-water immersion activates acute PHF20 and p53 signalling in human skeletal muscle
J.R. Broatch, A.C. Petersen & D.J. Bishop
76P
Exercise-induced changes in cerebral oxygenation and cognition in the human prefrontal cortex
J. Yamauchi & K.E. Kobayashi
77P
ACTN3 R577X genotype affects training-induced changes in mitochondrial respiration in humans
X. Yan, N. Eynon, I.D. Papadimitriou, J. Kuang, O. Tirosh, L. O’Keefe, M. Anderson, K.N. North & D.J. Bishop
78P
Invited Lecture
Calmodulin and CaMKII signaling in the heart
D.M. Bers
80P
Free Communications: Skeletal Muscle Physiology
Sarcoplasmic reticulum Ca2+ leak is increased in type I muscle fibres of old human subjects
C.R. Lamboley, V.L. Wyckelsma, R.M. Murphy, M.J. McKenna & G.D. Lamb
81P
Effect of doublet stimulation on tetanic Ca2+ responses measured in isolated fast interosseous fibres of the mouse
A.J. Bakker, T.R. Cully & B.S. Launikonis
82P
Genetic reduction of an extracellular matrix gene improves contractile function in dystrophic mdx mice
D.R. McCulloch, N.L. McRae, R. Kelly, L. Forgan & N. Stupka
83P
Induction of heat shock protein 72 improves the cardiomyopathy and reduces fibrosis in severely dystrophic dko mice
T. Kennedy, K. Swiderski, K.T. Murphy, R. Koopman, S.M. Gehrig, M.A. Febbraio & G.S. Lynch
84P
Assessment of RyR leak and t-system Ca2+ uptake in dystrophic skeletal muscle
T.R. Cully & B.S. Launikonis
85P
The sarcomeric α-actinins perform a dynamic balancing act at the muscle Z-line
F.C. Garton, M.W. Hogarth, P.J. Houweling, X.F. Zheng, K.G. Quinlan, N. Yang, T. Tukiainen, D.G. MacArthur, P. Gregorevic & K.N. North
86P
Free Communications: Reproduction
Renal dysfunction is transmitted to third generation offspring born to a growth restricted mother or father
M.E. Wlodek, S.T. Kharal, A.J. Jefferies, J.N. Cheong & K.M. Moritz
87P
The developmental programming effects of vitamin D on renal nephron endowment and gene expression of the renin angiotensin system in weanling male rats
K.I. Burkitt, A.C. Boyce, F.C. Britton & K.J. Gibson
88P
Prenatal corticosterone exposure induces dysregulation of the renal renin angiotensin system in male offspring
J.S.M. Cuffe, D.J. Burgess & K.M. Moritz
89P
Prolactin as a key regulator of Growth Hormone pulsatility in lactation, acting via somatostatin
S. Gounden, C. Chen & F.J. Steyn
90P
Periconceptional alcohol alters adult renal and cardiac function in a sex dependent manner
E.S. Dorey, E.M. Gardebjer, F. Campbell, T.M. Paravicini, K.A. Weir, M.E. Wlodek & K.M. Moritz
91P
Maternal stress during pregnancy in growth restricted females programs sex-specific metabolic outcomes in second generation male and female rats
J.N. Cheong, A.J. Jefferies, K.M. Moritz & M.E. Wlodek
92P
Free Communications: Channels and Nervous System
Control of muscle sympathetic nerve activity to contracting muscle in humans: contributions of central command and peripheral feedback
D. Boulton, C.E. Taylor, V.G. Macefield & S. Green
94P
Inhibitory effect of dantrolene on cardiac RyR2 in the presence of calmodulin
Y.W. Oo, D.F. van Helden, M.S. Imtiaz, B.C. Knollmann & D.R. Laver
95P
The effects of obesity on hippocampal function in the rat
H.A. Coleman, S. Lye & H.C. Parkington
96P
Controlling contractions in human myometrium; an eye on channels
H.C. Parkington, M.A. Tonta, P.J. Sheehan, J. Stevenson, S.P. Brennecke, H.A. Coleman, J. Paul & R. Smith
97P
Calcium signalling in epithelial-mesenchymal transition induced by hypoxia in breast cancer cells
I. Azimi, F.M. Davis, P.A. Kenny, E.W. Thompson, S.J. Roberts-Thomson & G.R. Monteith
98P
Symposium: Can we age well?
Can we age well?
D.G. Le Couteur
99P
The Ageing Liver
V.C. Cogger
100P
Ageing muscles: biomarkers and exercise
M.D. Grounds, Z. Soffe, C. McMahon, A.A. Sayer & T. Shavlakadze
101P
Sleep well, age well
N.L. Rogers
102P
Free Communications: Endocrinology, Diabetes and Cancer
Mechanisms directing blood-lymph transfer of nano-sized therapeutics
N.L. Trevaskis, L.M. Kaminskas, P. Yadav, A.P.R. Johnston & C.J.H. Porter
103P
Perilipin 5 regulates hepatic lipid metabolism and systemic glucose tolerance in mice
S.N. Keenan, J. Lo, R.C.R. Meex & M.J. Watt
104P
RCAN1 is critical for β-cell mitochondrial function and is overexpressed in human Type 2 diabetes
H. Peiris, M. Duffield, C.F. Jessup, V. Kashmir, J. Fadista, A. Genders, S. McGee, M. Ryan, D.R. Laybutt, P.T. Coates, M.A. Pritchard, L. Groop & D.J. Keating
105P
Chronic high fat feeding increases megalin expression and causes albuminuria and proteinuria in rats
J.F. Briffa, K.A. Jenkin, E. Grinfeld, A.J. McAinch, M.L. Mathai & D.H. Hryciw
106P
Progression of type 2 diabetes in Leprdb mice: from the animal to the granular levels
O.H. Do & P. Thorn
107P
Adipose-secreted factors from peri-prostatic fat stimulate prostate cancer cell tumourigenecity
R.A. Taylor, N. Ascui, J. Lo, M. Papargiris, G.P. Risbridger, M. Frydenberg & M.J. Watt
108P
Dysfunction of the dystrophin-glycoprotein complex (DGC) in cancer cachexia
K. Swiderski, K.T. Murphy, N.A. Williamson, C.J. Brock, D.M. Baum, A. Chee, T. Naim & G.S. Lynch
109P
Pulsatile luteinizing hormone (LH) secretion in female mice across pubertal development
Y. Wan, F.J. Steyn, J.D. Veldhuis & C. Chen
110P
Symposium: Frontiers of molecular mechanisms of ligand recognition and activation of receptor channels
Signal transduction at the subunit interfaces of the human glycine receptor
T.M. Lewis, M. Drwal, D. Tam, L.S. Walton & M.J. Windley
111P
Ligand selectivity in pentameric ligand-gated ion channels
H.S. Tae, J.R. Lawson, S. Petrou & B.A. Cromer
112P
Mechanism of ATP-dependent gating in CFTR channels
Y. Sohma
113P
Signal transmission within the P2X2 trimeric receptor and the voltage dependent structural rearrangements
Y. Kubo & B. Keceli
114P
Symposium: Early life environment as an indicator of health; outcomes and prevention
Early life environment as an indicator of health; outcomes and prevention
J.L. Morrison
115P
Maternal nutrition and skeletal muscle development in the offspring: long-term impact on health
S.A. Bayol
116P
Altered renal signalling in rat offspring born small
D.H. Hryciw, J.F. Briffa, A.J. Jeffries & M.E. Wlodek
117P
Mum's the word: Understanding the role of maternal obesity and inflammation during pregnancy in elevating the risk of offspring neuroendocrine disorders
C.L. Jasoni, D.W. Kim, T.R. Sanders & K.A. Glendining
118P
Free Communications: Skeletal Muscle Signalling
Glucocorticoid treatment regulates versican pericellular matrix remodelling during myoblast fusion: implications for muscular dystrophy therapies
N.L. McRae, L. Forgan, A. Addinsall, C. Van Der Poel, D.R. McCulloch & N. Stupka
119P
Thymosin β4 improves the dystrophic pathology in young mdx mice
J. Pittas, V. El-Khoury, S.J. McDonald, J.E. Church & C. van der Poel
120P
Thymosin beta 4 enhances myogenesis in vitro but does not confer regenerative advantage on skeletal muscle in vivo following myotoxic injury
B.L. Cleeland, V. El-Khoury, S.J. McDonald, C. van der Poel & J.E. Church
121P
Glycine supplementation during calorie restriction accelerates fat loss and protects against further muscle loss in obese mice
M.K. Caldow, D.J. Ham, D.P. Godeassi, A. Chee, G.S. Lynch & R. Koopman
122P
Regulating muscle protein synthesis in human myotubes from young and old subjects with microRNAs
E. Zacharewicz, S. Lamon, P. Della Gatta & A.P. Russell
123P
Despecification of myogenic C2C12 cells via metabolic reprogramming
C.H. Ly, G.S. Lynch & J.G. Ryall
124P
Exploring new targets within the TGFβ signaling network as interventions for cachexia
P. Gregorevic
125P
Invited Lecture
Caveolae as mechanoprotective and signaling organelles
R.G. Parton
126P
Symposium: Cardiomyocyte Ca2+ and Na+ signalling - new mechanistic insights
Compartmentalisation and localization - important signaling considerations for cardiomyocytes
D.M. Bers
127P
Differential arrhythmogenic actions of cardiac CaMKII
J.R. Bell & L.M.D. Delbridge
128P
CaMKII inhibition as a novel target for flavonol cardioprotection
L.S. Silva, J.R. Bell, N.R. Lim, Y.Y. Yeap, C.J. Thomas, O.L. Woodman, L.M.D. Delbridge, C.N. May, S.J. Williams & D.C.H. Ng
129P
Oxidative regulation of Na/K-ATPase in the cardiovascular system
G.A. Figtree, C.C. Liu, H.H. Rasmussen, Y.B. Liu, E. Aristarkhova, R. Cohen, C. Bursill, K.M. Sweadner & K. Karimi-Galoughi
130P
Symposium: New insights into exercise and insulin sensitivity
Exercise effects on insulin sensitivity
E.A. Richter
131P
AMP-activated protein kinase in diabetes
J.F.P. Wojtaszewski
132P
Exercise, nitric oxide and glucose metabolism
G.K. McConell
133P
Exercise, GLUT4 and insulin action
M. Hargreaves
134P
Symposium: Mechanisms and treatments for muscle wasting
Molecular mechanisms of muscle atrophy
M. Sandri
135P
The role of the TGF-β superfamily cytokine MIC-1/GDF-15 in anorexia/cachexia of cancer and other diseases
S.N. Breit
136P
Novel therapies for reducing muscle wasting in cancer
K.T. Murphy
137P
Inhibition of TWEAK/Fn14 signaling prevents cachexia in cancer
A. Johnston, K.T. Murphy, L. Jenkinson, G.S. Lynch, N. Hoogenraad & J. Silke
138P
Free Communications: Cardiac Physiology
Atrial remodeling in a murine model of hypertrophic cardiomyopathy: implications for atrial fibrillation
W.W. Lim, M. Neo, P. Kuklik, A. Ganesan, D.H. Lau, M. Baumert, T. Tsoutsman, C. Semsarian, D.A. Saint & P. Sanders
139P
Streptozotocin-induced type I diabetes mediates structural and electrophysiological changes in the rat atria: A substrate for atrial fibrillation
M. Neo, W.W. Lim, D.H. Lau, P. Sanders & D.A. Saint
140P
Augmented CaMKIIδ activation enhances stress resilience in Ca2+ loaded female aromatase-deficient mouse cardiomyocytes
G.B. Bernasochi, J.R. Bell, A.C. Wollermann, A.J.A. Raaijmakers, E.R. Simpson, C.L. Curl, K.M. Mellor & L.M.D. Delbridge
141P
The C-26 tumour-bearing mouse model of cancer cachexia exhibits cardiac atrophy, systolic and diastolic dysfunction
C.J. Brock, K. Swiderski, K.T. Murphy, C.L. Curl, T. Kennedy, C. Chandramouli, L.M.D. Delbridge & G.S. Lynch
142P
Scaffolding domains in cardiac aging: Does caveolin-3 govern age-dependent stress-intolerance?
M.E. Reichelt, C.J. Kiessling, M.W. Kidd, I. Niesman, B.P. Head, J.N. Peart, W.G. Thomas, D.M. Roth, K.J. Ashton, J.P. Headrick & H.H. Patel
143P
Dynamic changes in the cardiac methylome during post-natal development
C.B. Sim, M. Ziemann, A. Kaspi, KN. Harikrishnan, J. Ooi, I. Khurana, L. Chang, J.E. Hudson, A. El-Osta & E.R. Porrello
144P
Free Communications: Exercise and Muscle Signalling
Thioredoxin-interacting protein inhibits glycolysis and proliferation of myogenic cells
J.G. Ryall, M. Phung, C.H. Ly, R. Koopman & G.S. Lynch
145P
Effects of endurance exercise intensity on acute signalling responses to subsequent resistance exercise in human skeletal muscle
J.J. Fyfe, D.J. Bishop & N.K. Stepto
146P
Phosphoproteomics reveals the complexity of the human muscle exercise-regulated signalling network and a novel role for AKAP1 in regulating mitochondrial respiration via AMPK
N.J. Hoffman, B.L. Parker, R. Chaudhuri, K.H. Fisher-Wellman, M. Kleinert, P. Yang, S.J. Humphrey, S. Trefely, D.J. Fazakerley, R. Jothi, E.A. Richter & D.E. James
147P
Training intensity-dependent regulation of mitochondrial respiration in human skeletal muscle: an effect modulated by the transcription factors PGC-1α, p53 and PHF20
C. Granata, R.S.F. Oliveira, K. Renner, J.P. Little & D.J. Bishop
148P
High intensity interval and moderate intensity continuous training improves whole body insulin sensitivity and lowers muscle ceramide content in obese individuals
C.S. Shaw, S.O. Shepherd, M. Cocks, N.A. Mellett, P.J. Meikle & A.J.M. Wagenmakers
149P
Role of pre-exercise alkalosis on the expression of sarcolemmal proteins involved in muscle pH regulation following a single bout of high-intensity exercise
D.J. Bishop, C. McGinley, R.S.F. Oliveira, R. Delfour-Peyrethon, C. Hanon, K. Lambert, N. Molinari & C. Thomas
150P

Index

Author index
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