2022 Conference Proceedings

A joint meeting of AuPS and ASB, hosted by the University of Tasmania, Hobart

Hobart 2022

Compiled book of abstracts

VOLUME 52 - Hobart 2022
Seeing the baby grow: MRI to measure placental and cardiac function in the fetusProf Janna Morrison1I
Acetylation of myofilament proteins modulate diastolic function Kathleen Woulfe
University of Colorado
Cardiac protein phosphatases: more than an 'off' switch for protein kinases Kate Weeks
University of Melbourne
Adiponectin signalling as a therapeutic target for diabetic cardiomyopathy and heart failure Miles De Blasio
Monash University
Physiological Society NZ, New & Emerging Researcher Award - 2022 Winner:
Reinstating heart rate variability restores cardiac function in chronic heart failure sheep
Julia Shanks
University of Auckland
The role of pericytes in the regulation of brain blood flow and their dysfunction in dementia Brad Sutherland,
University of Tasmania
Transcriptomic profiling of the mouse aorta to identify novel cellular drivers of aortic stiffening in hypertension Maria Jelinic,
La Trobe University
Harnessing non-invasive ultrasound to understand brain blood flow regulation following stroke Dino Premilovac
University of Tasmania
Muscle microvascular flow regulation in health and disease Michelle Keske
Deakin University
The gut/liver axis: a novel therapeutic approach to treat NASH Michael Karin
Using single Nucleus RNA sequencing of pre-malignant liver to predict NASH driven liver cancer Nina Tirnitz-Parker
Curtin University
Identification of a blood biomarker to predict NASH driven liver cancer Benoit Smeuninx
Monash University
Mouse strain-dependent variation in the NASH lipidome - Novel therapeutic avenues for NAFLD Magda Montgomery
University of Melbourne
Interrogating the biological roles of dystrophin and utrophin in dystrophic muscle adaptations to exercise Justin Hardee 15O
The effect of gestational stress on behavioral and physiological phenotypes in the dystrophin-deficient mdx mouse Saba gharibi 16O
Muscle stem cell function is maintained in mouse models of type 1 diabetes Jin Chung 17O
Fibre type-specific abundance of dysferlin in rodent skeletal muscle Stefan Wette 18O
Isolated Extensor Digitorum Longus muscles from old mdx dystrophic mice show little force recovery 120 minutes after eccentric damage Leonit Kiriaev 19O
Phosphorylation of C18ORF25 regulates skeletal muscle function Ronnie Blazev 20O
Biomechanical properties of dysferlin-deficient skeletal muscle and the impact of muscle type and age Erin Lloyd 21O
MicroRNA-205: a novel epicardial regulator of cell cycle and cardiac growth in the perinatal heart Patrick Burgon 22O
Bitter Taste Receptors (T2Rs) in the Heart - a New Cardiovascular Physiology? Walter Thomas 23O
Inactivation of the local cardiac renin angiotensin system improves cardiac performance after myocardial infarction Zunha Lu 24O
AAV-directed expression of Neuregulin 1-b1 drives cardiac enlargement in neonatal mice - a critical role for Neuregulin 1-b1 and ErbB4 in postnatal cardiomyocyte survival Hui Yi Khoo 25O
MiR-558 inhibitor induces cardiac proliferation after myocardial infarction Catherine Dimasi 26O
Post-weaning early life dietary macronutrient balance variably affects biometric and metabolic outcomes in adulthood Adam Rose 27O
The designer cytokine IC7Fc promotes weight loss by decreasing digestive efficiency in obese mice Gideon Kang 28O
Pericyte characterisation in healthy and type 2 diabetic skeletal muscle microvasculature Emily Attrill 29O
Ceramide metabolism in skeletal muscle - questioning previous models Sarah Turpin-Nolan 30O
Loss of Acyl-CoA dehydrogenase family member (ACAD10) does not alter whole-body metabolism or metformin action Darren Henstridge 31O
Control of metabolism by proglucagon-derived hormones from the gut Damien Keating
Flinders University
The role of a bile acid-GLP1 axis in the regulation of glucose metabolism Tongzhi Wu
The University of Adelaide
Integration of glucose and amino acid metabolism by glucagon Clinton Bruce
Deakin University
Hepatic glucagon action in obesity and type 2 diabetes: insights from mouse models Yuqin WU
Monash University
Why retractions are growing so fast - and why there still aren't enough Ivan Oransky
Retraction Watch
Research Quality: you should be worried! Simon Gandevia
Freezer Study: An Investigation of the Stability of Skeletal Muscle Proteins after prolong freezer storage Noni Frankenberg
La Trobe University
Technical considerations when assessing gene expression in human skeletal muscle using quantitative real-time PCR Jujiao Kuang
Victoria University
2020 Prize Winner:
Empowering student ownership through flexibility, authenticity, and co-creation
Dr Charles Sevigny
University of Melbourne
2021 Prize Winner:
The school of hard knocks: what did not work when introducing technology-enhanced learning to physiology lectures, labs and workshops.
A/Prof Christian Moro
Bond University
Characterising brain inflammation during pregnancy in a new mouse model of metabolic syndrome Abdiweli Warsame 42O
Thyroglobulin antibody positivity induces maternal hyperglycaemia and increases placental weight in a Lewis rat model Nykola Kent 43O
The Effects of Maternal Hyperglycaemia During Pregnancy on One-Carbon Metabolism Dayna Zimmerman 44O
Metabolic syndrome in pregnancy causes fetal growth restriction and attenuates placental leukocyte populations Maral Baghaei 45O
Transthyretin binds to soluble endoglin: a possible role for transthyretin in the prevention of preeclampsia? Melanie Young 46O
The abundance of cell-free mitochondria are increased in human blood following an acute bout of endurance exercise Glenn Wadley 47O
Preliminary results from an investigation of exercise timing to mitigate postprandial hyperglycaemia and vascular dysfunction in healthy adults Laura Smith 48O
C18ORF25 is a novel exercise-regulated AMPK substrate regulating skeletal muscle function Kit Ng 49O
Metabolomic analysis of mouse skeletal muscle and liver responses to acute exercise and disruption of AMPK-glycogen binding Mehdi Belhaj 50O
The role of testosterone in skeletal muscle adaptation to resistance training in pre-menopausal females Sarah Alexander 51O
Obesity and the brain- how disrupting neural networks causes diabetes Garron Dodd 53S
Obesity and cancer- metabolic reprogramming and cancer progression Renea Taylor
Monash University
Obesity and reproduction- oocyte quality and fertility Rebecca Robker
University of Adelaide
Novel primary afferent auditory and vestibular neuron phenotypes in the mouse inner ear resolved using peripherin promoter-driven transgene reporters and subtype-selective immunofluorescence Lily Pearson 57O
Maintenance of hearing sensitivity in an ultraquiet environment requires olivocochlear efferent feedback Jennie Cederholm 58O
Impaired neuromuscular signalling is a feature of Motor Neuron Disease Peter Noakes 59O
Single point mutation of miRNA-873 and the synaptic protein neurexin induce autism-like behavioural changes and hippocampal dysfunction in a mouse model. Helena Parkington 60O
Epileptic Encephalopathies associated with gain-of-function GABAA receptor variants are more severe than loss Nathan Absalom 61O
Microglia Associate with the Vasculature and Pericytes in the Healthy and Inflamed Brain Catherine Foster 62O
Ablation of pericytes impedes motor function, induces blood-brain barrier leakage, and stimulates glial cell activation Jake Cashion 63O
Insulin infusion increases brain blood flow in healthy Sprague Dawley rats Nicole Sumargo 64O
Characterisation of placental-specific cytochrome P450 enzyme activity in response to fetal growth restriction Ashley Meakin
University of South Australia
Placental one carbon metabolism and complications of pregnancy James Cuffe
University of Queensland
Oxidative stress and the placental renin-angiotensin system Sarah Delforce
University of Newcastle
The Placenta: A Window into Maternal Disease Rebecca Simmons
University of Pennsylvania
Transciptome analysis of the effects of polarized photobiomodulation on human dermal fibroblasts Nicholas Tripodi 69O
Identification and characterization of a novel SNAT2 (SLC38A2) inhibitor reveals synergy with glucose transport inhibition in cancer cells Stefan Broer 70O
Sulforaphane attenuates cancer-induced muscle wasting in C2C12 myotubes Wenlan Li 71O
A combination screen finds inhibition of GCN2 sensitises growth of MDA-MB-231 and HPAFII cancer cell lines to CDK inhibitors Gregory Gauthier-Coles 72O
Treatment of non-alcoholic steatohepatitis with the designer cytokine IC7Fc Jingjing Zhao 73O
Urinary bladder contractions and the influence of extracellular calcium Charlotte Phelps 74O
Novel role for protein kinase D in cardiac extracellular matrix signalling Mark Renton 75O
Liver-derived small extracellular vesicles regulate glycemic control through increased insulin secretion and enhanced glucose effectiveness Paula Miotto 76O
Strange species-specific sugar metabolic adaptations yield cardiac pathophysiology insights Dunja Aksentijevic
Queen Mary University of London
The atypical Alpha Kinase 3 regulates sarcomeric protein metabolism in cardiomyopathy James McNamara
Murdoch Children's Research Institute
Lipid dysregulation and cardio - vascular implications Anna Calkin
Baker Heart & Diabetes Institute
Reinstating heart rate variability improves cardiac output in heart failure - novel metabolic insights from proteomics David Crossman
University of Auckland
Optogenetic approaches for the modulation of membrane excitability and synaptic plasticity John Lin
University of Tasmania
Neuromodulation of striatal neurons and the encoding of goal-directed learning Chelsea Goulton
UNSW Sydney
Remapping neural circuits to mediate cross modal plasticity between seeing and feeling Hiroaki Wake
Nagoya, Japan
Neural circuits that mediate drinking Bowen Dempsey
Macquarie University
Mechanotransduction in Neutrophils Sara Baratchi 85O
Structural mechanisms of human Aquaporin-1 ion channel gating and block by divalent cations, analysed by histidine scanning mutagenesis. Andrea Yool 86O
Development of a multiplexed biophysical method of analysis for quantification of DNA repair factor dynamics. Shikun (Tony) Ma 87O
A novel triglyceride tethered bilayer lipid membrane (tBLM) architecture Upeksha Shashikala (Randunu) Mirissa Lankage 88O
Hyper-phosphorylation induces structural alterations and exacerbates the cytotoxicity of alpha-synuclein in Parkinson's Disease pathogenicity Minal Chaturvedi 89O
A molecular mechanism for the lupus causing mutation in the RNA receptor TLR7 Ben Corry 90O
Using Tethered Bilayer Lipid Membranes to test Phospholipase A2 Activity as a Biomarker for IBD Flare Events Harry Clarke 91O
Nanotechnology and biopharmaceutics: molecular engineering of self-assembling therapeutic peptides for intrinsic nano-formulation Celine Valery 92O
The synergy of a Lactoferrin-derived peptide with the antifungal drug Amphotericin B is lipid-mediated Lissy Maike Hartmann 93O
Perfringolysin O pore formation dynamics: monomeric interactions, membrane tracking and membrane composition effects Conall Mc Guinness 94O
Spatiotemporally Mapping Thermal Dynamics of Lysosomes and Mitochondria using Cascade Organelle-Targeting Upconversion Nanoparticles Qian (Peter) Su 95O
A fluorescently-tagged peptide toxin, Cy5-HsTX1[R14A], as a tool for KV1.3 visualisation Dorothy Wai 96O
3D super-resolution imaging of whole nuclear lamina Ashley Rozario 97O
Investigating biological noise: building a tuneable model system with DNA nanotechnology and droplet hydrogel bilayers Alexander Mason 98O
From Superbugs to tBLMs: increasing the complexity in model membrane systems. Ingo Koeper 99O
Effect of membrane composition on lipid packing and solute permeability. Lauren Lowe 100O
Rational design of potent ultrashort antimicrobial peptides with programmable assembly into nanostructured hydrogels Priscila Cardoso 101O
Single-molecule genotyping of thousands of variants Lisanne Spenkelink 102O
Deep eutectic solvents for cryopreservation Saffron Bryant 103O
Brightness cross correlation spectroscopy quantifies protein dynamics as a function of stoichiometry within live cells. Ashleigh Solano 104O
Ultra-resolution in the cell nucleus with single molecule expansion microscopy Toby Bell 105O
Behavior of citrate-capped ultrasmall gold nanoparticles on a supported lipid bilayer interface at atomic resolution Rashad Kariuki 106O
Tracking the nuclear wide dynamics of live cell nucleosome proximity by fluorescence Elizabeth Hinde 107O
How Do Steroids Impact Batten's Disease? Trang Do Le 108O
Interrogating the biophysics of protein cage nanoreactors Yu Heng Lau 109O
Behaviour of citrate-capped gold nanoparticles at biomembranes - atomic insight at supported lipid bilayer and liposome interfaces. Aaron Elbourne 110O
A multi-scale kinetic and spatial model of yeast replication and prion transmission Damien Hall 111O
How an acid trip saves malaria: a proton-transfer mechanism for the malaria lactate-proton transporter PfFNT Ciara Wallis 112O
Computational modelling of metabolism within the ageing heart Michael Pan 113O
Utilising Enhanced Sampling to Resolve a Conducting Conformation of the CFTR Ion Channel Miro Astore 114O
Australia wide concensus on Core Concepts in Physiology Kathy Tangalakis115E
Re-creating an introductory physiology unit in the Core Concepts form Sarah Etherington 116E
Incorporating planetary health concepts into physiology. Christian Moro 117E
Clinical and Translational Physiology: Student perception of processed based learning to create an Authentic learning experience Yossi Rathner 118E
Alumni graduate career pathways as a learning tool to assist career planning Caroline Taylor 119E
A journey to BSEEN: bringing career pathways to the Biomedical Science experience Judit Kibedi 120E
Redesigning a subject: What do students think of pre-recorded videos and high-stake team projects? Angelina Fong 121E
The use of online resources to explain difficult physiological concepts by medical students at a Middle Eastern university - shouldn't we do something about this? Sean Holroyd 122E
Curating student learning in virtual galleries Craig Campbell 123E
Predicting Physiology Student Performance from LMS Data in the Post-COVID Era Ari Pinar 124E
To Quitch or not to Quitch: Using a gamified mobile app to increase student performance and engagment Iris Lim 125E
Can an anatomy and physiology bridging program impact first year University science engagement? Puspha Sinnayah 126E
The pleasures and perils of virtual undergraduate biomedical industry placements Julia Choate
Monash University
Building career awareness and skills throughout the Health Sciences Degree Brianna Julien and
Louise Lexis
La Trobe University
Enriching a WIL experience by fostering habits of head, heart and hand Dr Chris Adams
University of Tasmania
Employability for Science Degrees: foundations, challenges and options Liz Johnson
Deakin University
How equipped are first year undergraduate students in navigating common teamwork challenges? Nilushi Karunaratne 131E
Evaluating students' awareness of their group work capabilities in physiology laboratory classes Kay Colthorpe 132E
Students designing for students - using a "deteriorating patient" to teach second year physiology Melissa Cameron 133E
Comparing student and academic grading of assessment tasks in an introductory neuroscience course Jennie Cederholm 134E
Too many is not enough: exploring effective motivation strategies in nursing and midwifery students Luli Faber 135E
Introducing learning workshops into the biosciences: A student-staff partnership Louise Ainscough 136E
Developing C-reactive protein modulators as new treatments for inflammation Karen S Cheung 137O
A multiscale model of calcium release reveals a novel mechanism for calcium wave initiation Derek Laver 138P
The relationship between muscle mass and function with bone remodelling markers in older adults: effects of acute aerobic and resistance exercise Cassandra Smith 139P
LncRNA Tug1 regulates expression of the mitochondrial calcium uniporter complex in myotubes and cardiomyocytes. Adam Trewin 140P
Subtype-specific block of glioblastoma motility through dual inhibition of water and ion flux Alanah Varricchio 141P
Learning from skeletal muscle to treat metastatic cancer Alastair Saunders 142P
New insights into assessment of mitochondrial dysfunction and oxidative stress in preclinical models of diabetic cardiomyopathy Alex Parker 143P
Differential responses in muscle atrogene expression in a mouse model of critical illness Amy Bongetti 144P
Effects of sex on skeletal muscle phenotype in heart failure patients Annabel Critchlow 145P
The role of N-acetylcysteine (NAC) in reducing pathological skeletal muscle fibre branching in an mdx mouse model of human Duchenne Muscular Dystrophy Asma Redwan 146P
Is near-infrared spectroscopy a valid method for measuring skeletal muscle microvascular blood flow? Emily Wordie-Thompson 147P
Response of circulating miRNAs to acute exercise: A systematic Review and Meta-Analysis Danielle Hiam 148P
Establishing a platform mediated avoidance paradigm in female rats Elise Cleary 149P
The cardiovascular effects of mechanical ventilation Ella Smalley 150P
Establishing a platform mediated avoidance paradigm in male rats Fergus Scott 151P
Sex differences in cardiovascular risk factor responses to resistance and endurance training in a primary prevention cohort Hannah Thomas 152P
What to do when Westerns go wild Heidy Latchman 153P
Can an old dog learn new tricks? Novel applications of Microdialysis for detecting skeletal muscle reactive oxygen species and assessing microvascular endothelial function in hypertensive populations Hollie Speer 154P
Integrative transcriptomic and proteomic analysis show circulating osteoprogenitors to have a mixed immune and mesenchymal progenitor function in humans Jack Feehan 155P
Calcium release-activated channel activity in the uterus - CRAC-ing labour contractions Jawaher Alfaidi 156P
A single session of high intensity interval exercise in hypoxia modulates changes in mitochondrial biogenesis related gene and protein in human skeletal muscle Jia Li 157P
Metabolic regulation of skeletal muscle regeneration after injury John Nguyen 158P
High-glucose ingestion and acute exercise elicit dynamic and individualised responses in systemic markers of redox homeostasis. Lewan Parker 159P
Characterising the opposing impact of obesity and exercise training on the cardiac phenotype in mice Nimna Perera 160P
Thyroglobulin antibodies impair fertility and litter parameters and impact fetal survival in a rodent model of Autoimmune Thyroiditis Rebecca Brady 161P
Hematopoietic Prostaglandin D Synthase Inhibitor PK007 Decreases Muscle Necrosis in DMD mdx Model Mice Sai Yarlagadda 162P
Regeneration of mouse skeletal muscle after myotoxic injury is impacted by fucoidan supplementation Samantha Kucewicz 163P
Utilizing a "four core genotypes" rat model to investigate sex differences in human disease Shanie Landen 164P
Regular insulin administration increases muscle mass and exercise performance in otherwise healthy Sprague Dawley rats Sophie Mayne 165P
Vascular RAGE and AGE binding protein expression and function in gestational diabetes. Timothy Murphy 166P
Autophagy Flux in Human Peripheral Blood Mononuclear Cells in the 24 h Fasted and Fed State Vicky Kuriel 167P
The urothelium and lamina propria as an alternative target for clinical antimuscarinics Vineesha Veer 168P
What makes a good B0AT1 (SLC6A19) inhibitor? Yashan Jiang 169P
Machine learning approaches for the discovery and optimization of oxazolidinones with therapeutic potential McKenna Buckley 170P
The mechanism and structural basis of ion conduction in an inward rectifier potassium channel Ruitao Jin 171P
Investigating molecular dynamics and sequence dependency of invading DNA strand in Homologous recombination double strand break repair Cheree Fitzgibbon 172P
Cardiac forces regulate zebrafish heart valve delamination by modulating Nfat signaling Wei-Yan Chow 173P
Elucidating mitochondrial dynamics and localisation upon T cell activation through advanced microscopy Sofia Alfonso 174P
Benchmarking biophysical readouts of nanoscale chromatin compaction in live cells. Kedi Wang 175P
Super-Resolution Analysis of Bisphenol A Effects on Meiotic Recombination in spermatocytes Lynette Mirembe 176P
Application of super resolution microscopy to visualise immune activated interactions between lipid droplets and STAT proteins Abbey Milligan 177P
Imaging changes to the membranes of live fungal cells caused by exposure to gold nanoparticles Rowan Penman 178P
Identifying Lipid Mixtures for Optimal Tethered Bilayer Lipid Membrane Sensing of Lipase Activity Samara Bridge 179P
Structure-function insight into the two-component DNA repair system of Mycobacterium tuberculosis Joydeep Baral 180P
IP3R activity increases propensity of RyR-mediated Ca2+ sparks by elevating dyadic [Ca2+] Joshua Chung 181P
Simulating the effects of delipidation on the mechanosensitive channel of small conductance MscS Yiechang Lin 182P
Image correlation spectroscopy of DNA double strand break repair foci structure Niall Karunaratne 183P
Structure-activity relationship of a-conotoxin Mr1.1 at the human a9a10 nicotinic acetylcholine receptor Han-Shen Tae 184P
Involvement of Alpha-Subunit N-Termini in the Mechanism and Regulation of the Na+,K+-ATPase Milna Chennath 185P
A hybrid approach to membrane disruption based intracellular delivery William Hansen 186P
Single-molecule genotyping of thousands of variants Stefan Mueller 187P
Disparate sodium channel inhibitors bind promiscuously inside the pore Elaine Tao 188P
How the world lost one of its most effective anti-malarials to mutations in a Malarial multi-drug resistance protein: a molecular perspective John Tanner 189P
Controllable liposome binding interactions using PEG-mediated DNA nanostructures James Gaston 190P
Susceptibility of leukemia cells to synergistic treatment with vitamin C and select flavonoids Suganeya Soundararajana 191P
Isoform specificity of Na+, K+-ATPase regulation by protein kinase C Emma-Lucille Blayney 192P