|
PROCEEDINGS OF THE
AUSTRALIAN PHYSIOLOGICAL SOCIETY |
ISSN 0067-2084 |
Volume 47 |
2016 |
|
CONTENTS |
|
AuPS/ASB 2016 Adelaide Meeting |
|
| AuPS Invited Lecture - Prof Lea Delbridge | |
| Cardiac adventures in autophagy L.M.D. Delbridge | 182P |
| Roberts Lecture | |
| Enhancing students’ university experiences by engaging them with their course and equipping them for life-long learning J.K. Choate | 184P |
| Free Communications - Skeletal Muscle | |
| Role of the extracellular matrix protease ADAMTS5 in diet induced insulin resistance K.F. Howlett, B. Tepper, T. Connor, S. Bond, C. Swinton, C.S. Shaw & S.L. McGee | 1P |
| Dysregulation of miRNA biogenesis machinery, miRNA/RNA ratio and miRNA normalizing targets in skeletal muscle of ALS mice S. Lamon, S. Ngo, J. Yerbury, R. Chung & A.P. Russell | 2P |
| Characteristics of MMP-2 protein in rat skeletal muscle X. Ren, G.D. Lamb & R.M. Murphy | 3P |
| Real time imaging of trans-sarcolemma Ca2+-fluxes in mammalian skeletal muscle X. Koenig, R.H. Choi & B.S. Launikonis | 4P |
| Effect of curcumin exposure on skeletal muscle contractile function J. Lam, G.J. Pinniger & A.J. Bakker | 5P |
| The influence of low carbohydrate and ketogenic diets on longevity and skeletal muscle maintenance with ageing M.A. Wallace, M.H. Hall, J.A. López-Domínguez, G.R. Marcotte, N.W. Aguirre, A.M. Marshall, G. Perez, D. Tran, E. Gutiérrez-Casado, Z. Zhou, K. Kim, T.A. Knotts, A.A. Tomilov, K. Hagopian, K. Baar, G.A. Cortopassi & J.J. Ramsey | 6P |
| Anthracycline-induced skeletal muscle weakness: a role for chronic oxidative stress and disrupted calcium homeostasis? N.A. Beard, M. Obst, A. Blackburn, H. Willemse & A.F. Dulhunty | 8P |
| Symposium: Transforming the classroom and helping others to adopt teaching innovations | |
| Transforming the classroom and helping others to adopt teaching innovations M.K. Smith | 9P |
| “Hands-on” practical class activities to engage students in basic principles of cell physiology A.J. Moorhouse, R.M. Vickery, C. Garvey & P.H. Barry | 10P |
| Strategies for overcoming students’ misconceptions in large class settings T.D. Mulhern, A. Espinosa, J.M. Lodge & H. Verkade | 11P |
| Creating and supporting transformation in physiology teaching P. Poronnik | 12P |
| Symposium: Thinking small: Seeing biological processes with nanotechnology and photonics | |
| Whispering gallery mode lasers for biosensing applications A. François, N. Riesen, T. Reynolds, J.M.M. Hall & T.M. Monro | 13P |
| Reversible sensing with a flip of the switch S. Heng & A.D. Abell | 14P |
| Nanoscale Biophotonics - using light to measure the previously unmeasurable within the central nervous system M.R. Hutchinson | 15P |
| Visualising N-glycosylation patterns in cancer and non-cancer cells N. Packer & A. Everest-Dass | 16P |
| Symposium: Latest advances in fluorescence and applications to physiological problems | |
| Nanoscope odyssey into the presynapse A.T. Bademosi, R. Kasula, M. Joensuu, A. Papadopulos, E. Lauwers, P. Padmanabhan, A. Papadopulos, G.J. Goodhill, P. Verstreken, B. van Swinderen & F.A. Meunier | 21P |
| On and off again: Tools and models for single molecule fluorescence imaging of actin and tropomyosin A.C.F. Coster, M. Janco & T. Böcking | 22P |
| Probing and perturbing receptor signalling with microscopy, nanotechnology and microfluidics A.H.A. Clayton | 23P |
| Profilin membrane dynamics in live cells R.J. Davey, E. Gratton, M.A. Digman, N.M. Andronicos & P.D.J. Moens | 24P |
| Free Communications - Education | |
| Inspiring student learning through the introduction of The Reading Game F.C. Britton, T.M. Lewis, S. Mobbs & R.L. Parker | 25P |
| Online simulations to support the teaching of physiology wet lab practicals R.A. Taylor, S. Ellem, S. Clarke & M. del Mar Quiroga | 26P |
| Assessing critical evaluation skills of undergraduate science students K. Colthorpe, H. Mehari Abraha, K. Zimbardi & L. Ainscough | 27P |
| Learning hindrances and strategies reported by undergraduate physiology students: What makes a student resilient? L. Ainscough, E. Stewart, K. Colthorpe & K. Zimbardi | 28P |
| Online adaptive tutorials that support learning in data interpretation and scientific reasoning T.M. Lewis | 30P |
| Symposium: Enteric neural functional circuits of intestinal motility | |
| Neuromechanical factors of intestinal motility M. Costa | 31P |
| High-resolution analysis of human gastrointestinal motor patterns and the clinical applications G. O'Grady | 32P |
| Synaptic transmission in enteric circuits J.C. Bornstein | 36P |
| High resolution neuronal imaging reveals a novel enteric neural firing pattern that underlies colonic motor patterns in the mouse colon N.J. Spencer, L. Travis, T.J. Hibberd, J. Sorensen, M. Costa, S.J.H. Brookes, P.G. Dinning & L. Wiklendt | 37P |
| Free Communications - Membrane Transport | |
| Molecular basis for substrate and inhibitor interactions with the glycine transporter, GlyT2 R.J. Vandenberg, J.E. Carland, M. Thomas, A. Edington, M.L. O'Mara & R.M. Ryan | 39P |
| Heads and tails: lipid inhibitors of glycine transport S. Mostyn, J.E. Carland, T. Rawling, R.M. Ryan & R.J. Vandenberg | 40P |
| A possible Achilles heel of ion pumps A. Garcia, Q. Jiang, P.R. Pratap, C. Lüpfert, H.-J. Apell, F. Cornelius, D. Jacquemin & R.J. Clarke | 41P |
| Developing novel inhibitors of the glutamine transporter ASCT2 to treat cancer N.J. Freidman, T. Rawling, R.J. Vandenberg & R.M. Ryan | 42P |
| The effect of ageing and hypertension on the proton-coupled transporters PEPT1 and PEPT2 in the renal proximal tubule O. Alghamdi, N. King, N.M. Andronicos, B. Chami, G.L. Jones, P. Witting & P.D.J. Moens | 43P |
| Tuning the ion selectivity of glutamate transporter associated uncoupled conductances R.J. Cater, J. Font, R.J. Vandenberg & R.M. Ryan | 44P |
| Investigating the elevator mechanism in a human nucleoside transporter (hCNT3) Q. Wu, R.J. Vandenberg & R.M. Ryan | 45P |
| Effects of cholesterol depletion on the partial reactions of the Na+, K+-ATPase A. Garcia, F. Cornelius & R.J. Clarke | 46P |
| Free Communications - Cardiac muscle and vessels | |
| Novel fluorescent techniques for investigating calcium handling properties of the cardiac sarcoplasmic reticulum (SR) and calsequestrin in the presence and absence of dantrolene C.M. Loescher & L.M. Gibson | 47P |
| Cavin-1 deficiency modifies cardiac and coronary responses to stretch and ischemia by augmenting NOS activity M.E. Reichelt, M. Kaakinen, W.G. Thomas, J.P. Headrick & R.G. Parton | 48P |
| Further consideration of FKBP12 association with RyR1 and RyR2 and regulation of RyR channel activity A.F. Dulhunty, C. Thekkedam, S.J. Richardson & N.A. Beard | 49P |
| Characterising the measurement of diastolic function in the intact rat cardiomyocyte A.J.A. Raaijmakers, J.V. Janssens, J.R. Bell, C.L. Curl & L.M.D. Delbridge | 51P |
| Serelaxin treatment reverses vascular dysfunction and cardiomyocyte hypertrophy in the streptozotocin-induced mouse model of Type 1 diabetes H.H. Ng, C.H. Leo, D. Prakoso, C.X. Qin, R.H. Ritchie & L.J. Parry | 52P |
| Shear force responsiveness of arteries depends on an interdependent activity of the epithelial Na+ channel and the endothelial glycocalyx Z. Ashley, F. Knöpp, D. Barth, S. Mugloo, J.P. Baldin, M.J. Jennings & M. Fronius | 53P |
| The effect of intrauterine growth restriction on Ca2+-activated force in β-escin skinned mesenteric arteries of 6-month old male Wistar-Kyoto rats M. Christie, T. Romano, R.M. Murphy & G.S. Posterino | 54P |
| Short term serelaxin treatment reduces prostanoid-mediated endothelium-derived vasoconstriction and restores endothelial vasodilator function without concomitant changes to cardiac remodelling in spontaneously hypertensive rats C.H. Leo, S.A. Marshall, H.H. Ng, M. Jelinic, T. Rupasinghe, C.X. Qin, U. Roessner, R.H. Ritchie, M. Tare & L.J. Parry | 55P |
| Symposium: Recent advances in the understanding adipose tissue development and function | |
| Understanding how we get fat: Dietary regulation of adipogenesis M. Rodeheffer | 56P |
| Adipose tissue distribution and thermogenesis: relationships with metabolic disease M.M. Swarbrick | 57P |
| Macrophages and tissue remodelling following acute nutritional modulation in humans L.K. Heilbronn | 58P |
| Exercise training and the molecular regulation of lipid metabolism M.J. Watt, T. Tsiloulis & A. Raajendiran | 59P |
| Free Communications - GI nutrition and digestions | |
| The impact of intestinal lymph extravasation on adipose tissue function and whole body insulin resistance E. Cao, G. Gracia, H. Chu, L. Hu, C.J.H. Porter, M.J. Watt & N.L. Trevaskis | 60P |
| Metformin directly triggers GLP-1 and PYY secretion in human colon and ileum E.W.L. Sun, A.P. Liou, M.L. Jackson, D. DeFontgalland, P. Rabbitt, P. Hollington, L. Sposato, S.L. Due, D.A. Wattchow, R.L. Young & D.J. Keating | 61P |
| The nutrient sensing capacity of mouse enterochromaffin cells is dictated by gastrointestinal location A.M. Martin, A.L. Lumsden, C.F. Jessup, N.J. Spencer & D.J. Keating | 62P |
| Characterisation of glucose-induced serotonin secretion from primary cultured human enterochromaffin cells in health and disease A.L. Lumsden, R.L. Young, A.M. Martin, E.W.L. Sun, A. Liou, V.M. Jackson & D.J. Keating | 63P |
| Symposium: Mechanisms of pumps, channels and transporters | |
| Mechanisms of sodium selectivity in membrane ion transport T.W. Allen | 64P |
| Dynamics and mechanism of amino acid transport C. Grewer | 65P |
| Mechanoelectrical transduction at the membrane-matrix interface K. Poole, M.R. Servin Vences, M. Moroni & G.R. Lewin | 66P |
| Functional characterisation of P-type ATPases using solid-supported membrane based electrophysiology F. Tadini-Buoninsegni | 67P |
| Plenary Lecture | |
| Caveolae membrane domains connect G protein – mediated calcium signals with mechanical deformation S.F. Scarlata | 68P |
| Symposium: The many pathways of gut control of metabolism | |
| L-cell physiology and glucagon-like peptide-1 (GLP-1) secretion F. Reimann | 69P |
| Augmented capacity for intestinal serotonin release in obese subjects A.L. Lumsden, A.M. Martin, N. Pezos, E.W.L. Sun, N.J. Isaacs, N. Cvijanovic, A.P. Liou, V.M. Jackson, D.J. Keating & R.L. Young | 70P |
| Satiety signals from the gastrointestinal tract in health and obesity A.J. Page | 71P |
| Use of a novel Down syndrome genetic screen identifies a regulator of pancreatic β-cell function linked to type 2 diabetes D.J. Keating | 72P |
| Symposium: Stem cells and tissue engineering: New tools for experimental physiology and regenerative medicine | |
| Engineered heart muscle for modelling human cardiac disease M. Tiburcy | 73P |
| Manipulation of mechano-responsive miRNAs to drive mesenchymal stem cell fate in biomaterial composites J.E. Frith | 74P |
| Bioengineering skeletal muscle: how to build an intact human motor
unit R.J. Mills | 75P |
| Obstacles and challenges for tissue engineering and regenerative medicine M.D. Grounds | 76P |
| Symposium: Alternative approaches to the use of animals in physiology and biophysics | |
| Modelling for understanding and prediction of epileptic seizures as a viable replacement for animal models A.D.H. Peterson & M.J. Cook | 77P |
| Using induced pluripotent stem cell derived cardiomyocytes to screen for multichannel pharmacology and proarrhythmic risk in acquired long QT syndrome A.P. Hill, M.D. Perry, W. Lee & J.I. Vandenberg | 78P |
| The Sydney Heart Bank: An international resource to help understand human heart failure while minimising the use of animals S.P. Lal | 79P |
| Droplet-hydrogel lipid bilayers as an alternative model for studying mechanosensation K.R. Rosholm, M.A.B. Baker, P. Ridone, Y. Nakayama, N. Bavi, P.R. Rohde, L.G. Cuello, L.K. Lee & B. Martinac | 80P |
| Allosteric modulation of gating by agonists and antagonists studied in prokaryotic, voltage-gated sodium channels R.J. French, R.K. Finol-Urdaneta, J.R. McArthur, M. Goldschein-Ohm, R. Gaudet, D.B. Tikhonov & B.S. Zhorov | 185P |
| Symposium: Skeletal muscle physiology in health, disease and ageing | |
| Role of ClC-1 Cl− ion channels for skeletal muscle function in health and disease T.H. Pedersen | 81P |
| Using energetics to understand the basis of diverse muscle function C.J. Barclay | 82P |
| Sarcoplasmic reticulum function in human skeletal muscle during ageing and inactivity C.R. Lamboley, R.M. Murphy, M.J. McKenna & G.D. Lamb | 83P |
| Altered Ca2+-handling in human skeletal muscle to alleviate Ca2+-induced damage in the days associated with delayed onset muscle soreness T.R. Cully, R.M. Murphy, L. Roberts, T. Raastad, R.G. Fassett, J.S. Coombes, I.D. Jayasinghe & B.S. Launikonis | 84P |
| Symposium: Developmental origins of health and disease: metabolism and exercise | |
| Developmental origins of health and disease – can exercise improve adult outcomes? K.L. Gatford & G.K. McConell | 85P |
| Exercise before conception – dads matter too M. Lane & N.O. McPherson | 86P |
| Investigating the impact of exercise during pregnancy M.J. Morris | 87P |
| Developmental origins of health and disease: can exercise early in postnatal life improve adult outcomes? G.K. McConell | 88P |
| Free Communications - Cell signalling | |
| Phenotyping the differential innervation of the peripherin knockout mouse cochlea C. Perera, G. von Jonquieres, J.L. Pinyon, K.W. Parley, J.M.E. Cederholm, J.-P. Julien, A.F. Ryan & G.D. Housley | 7P |
| Blocking fatty acid uptake reduces prostate cancer progression R.A. Taylor, A.K. Clarke, S.J. Whitby, P.R. Wijayaratne, R. Rebello, L. Furic & M.J. Watt | 89P |
| Simulating biologically relevant membranes: tackling lipid diversity in bacterial membranes D. Poger, B. Caron & A.E. Mark | 90P |
| Akt translocation under increasing insulin stimulation C.W. Gray | 91P |
| Barrier function and ion transport in an oleic acid-induced model of lung injury H. Ren, N.P. Birch & V. Suresh | 92P |
| Vitamin D and sex affect metabolic function and the development of NAFLD R.M. Dwyer, R.J. Giblin, E.J. Bennett & G.R. Zosky | 93P |
| Golgi calcium pump secretory pathway Ca2+ ATPase 1 (SPCA1) in breast cancer cells A.A. Peters, J.M.H. Lee, D. Marcial, P. Kenny, W. Hu, I. Kineav, S.J. Roberts-Thomson & G.R. Monteith | 94P |
| Regulation of Ca2+ release activated Ca2+ channels by intracellular pH D. Gavriliouk, N.R. Scrimgeour, S. Grigoryev, L. Ma, F.H. Zhou, G.J. Barritt & G.Y. Rychkov | 95P |
| Free Comminications - Membrane and protein biophysics | |
| Nano-domain equilibria in biomimetic membranes I.Y. Hasan & A. Mechler | 96P |
| How the morphology of lipid bilayers is altered by pH C.G. Cranfield, T. Berry, S.A. Holt, K.R. Hossain, A.P. Le Brun, S.M. Valenzuela, H. Coster & B. Cornell | 97P |
| Tethered bilayer lipid membranes to study membrane proteins I. Köper | 98P |
| A model of the outer membrane of Gram-negative bacteria J. Andersson, S.A. Holt & I. Köper | 99P |
| Analysis of profilin dynamics at the cell membrane by image pair correlation and number and brightness analysis R.J. Davey, M.A. Digman, E. Gratton, N.M. Andronicos & P.D.J. Moens | 101P |
| Exploring the binding of photoacids to the surface of insulin amyloid fibril by docking and all-atom simulations M.H. Rashid, N. Amdursky, M.M. Stevens & I. Yarovsky | 102P |
| Huntingtin inclusions trigger cellular quiescence, deactivate apoptosis and lead to delayed necrosis D.M. Hatters | 103P |
| Investigating the role of the N-terminal domain unique to eukaryotic class III Biotin Protein Ligases L.M. Sternicki, T.L. Pukala, N.R. Pendini, M.C. Wilce, G.W. Booker, K.L. Wegener & S.W. Polyak | 104P |
| Posters | |
| Structure and membrane topology of the pore-forming peptide maculatin 1.1 depends on lipid composition M.-A. Sani, S. Overall & F. Separovic | 18P |
| Impairment of an endothelial NAD+-H2S signaling network is a reversible cause of vascular aging A. Das, G.X. Huang, A. Longchamp, L. Kim, C. Li, B. Osborne, S. Joshi, M. Kang, T. Hung, B. Lee, E.O. Williams, M. Igarashi, J.R. Mitchell, L.E. Wu, N. Turner, Z. Arany, L. Guarente & D.A. Sinclair | 105P |
| A general discretization method for connecting free-energy landscape models of biomolecular motors to motor behaviour P.T.T. Nguyen, K.J. Challis & M.W. Jack | 106P |
| Structural dynamics and physical properties of single-chain Fv antibodies against (4-hydroxy-3-nitrophenyl)acetyl M. Oda, Y. Sato, Y. Tanaka, S. Inaba, H. Sekiguchi, Y.C. Sasaki & T. Azuma | 107P |
| A HEK293 bioreporter cell line demonstrates temporally differentiated effects on impedance and ryanodine receptor modulation by venom fractions from the Australian scorpion Liocheles waigiensis D.M. Housley, J.L. Pinyon, M. Smout, M.J. Liddell, E.A. Jennings & G.D. Housley | 108P |
| Thumbs up for PcTx1 – mechanistic insight into the binding of the venom peptide PcTx1 to the acid sensing ion channel 1a from free energy calculations E. Deplazes, M. Stroet, G.F. King & A.E. Mark | 109P |
| Delayed post-prandial insulin secretion in individuals with low diabetes risk and its reversibility with exercise training D. Kloosterman, S. Hamley, G. Morales-Scholz, G.M. Kowalski, K.F. Howlett, C.R. Bruce & C.S. Shaw | 110P |
| Age related changes in mass contractile properties and eccentric contraction damage of fast- and slow-twitch mouse muscles L. Kiriaev, S. Kueh, J. Morley & S.I. Head | 111P |
| Serotonin distribution in the colon: insights from computational biology H. Dockrell, P.G. Dinning, D.J. Keating & L. Wiklendt | 112P |
| Structural dynamics of c-Myb DNA-binding domain revealed by variable temperature and pH studies S. Inaba & M. Oda | 113P |
| Simulations of ion selectivity in the acid-sensing ion channel ASIC1a E. Flood, C. Boiteux, T. Lynagh, S. Pless & T.W. Allen | 114P |
| Computational study of aggregation mechanism in lysozyme [D67H] D. Patel & S. Kuyucak | 115P |
| Development of biomarkers for the protein restriction using Slc6a19 knock out mice K. Javed, Q. Cheng & S. Broer | 116P |
| Identification of novel inhibitors of the amino acid transporter B0AT1 (SLC6A19), a potential target to induce protein restriction and to treat type 2 diabetes Q. Cheng, N. Shah, A. Broer, S. Fairweather, Y. Jiang, D. Schmoll, B. Corry & S. Broer | 117P |
| The cardiac troponin complex is modified by advanced glycation end-products in vivo and in vitro J.V. Janssens, J.R. Bell, K.M. Mellor & L.M.D. Delbridge | 118P |
| Integral role of Mg2+ in observing the inhibitory effect of dantrolene R.H. Choi, X. Koenig, T.R. Cully & B.S. Launikonis | 119P |
| Effects of novel urea analogues of NS1643 on potassium and calcium fluxes in cardiac muscle cells S. Al Rawi, J.T. Heppell, J. Al Rawi & L.M. Gibson | 120P |
| Thymosin beta 4 and its bioactive fragments as preconditioning agents for skeletal myoblasts L.A. Wilsdon, J.E. Church & C.J. Taylor | 121P |
| Mobilities of methanesulfonate, needed for liquid junction potential corrections, and of two related anions, and a mystery solved P.H. Barry, T.M. Lewis & A.J. Moorhouse | 122P |
| The role of TRPM2 channels in the liver ischemia-reperfusion injury F.H. Zhou, J. De Haas, J. Hua, G.J. Barritt & G.Y. Rychkov | 123P |
| Autophagy modulation in the liver and skeletal muscle of high-fat fed mice G. Morales-Scholz, K.F. Howlett, R.M. Murphy, G.M. Kowalski, C.R. Bruce & C.S. Shaw | 124P |
| Cyclic neural motor patterns in the full isolated intact intestine of the mouse L.J. Keightley, L. Wiklendt, J.W. Arkwright, T.J. Hibberd, P.G. Dinning, S.J.H. Brookes, N.J. Spencer & M. Costa | 125P |
| Ca2+ release-activated Ca2+ channels are regulated by Calpain M.K. Adams, L. Ma, F.H. Zhou, G.J. Barritt & G.Y. Rychkov | 127P |
| Human Piezo1 membrane localization and gating kinetics are modulated by cholesterol levels P. Ridone, E. Pandzic, M. Vassalli, C. Cox, P. Gottlieb & B. Martinac | 128P |
| Assessment of gas and liquid bolus movement using impedance manometry in rabbit colon R. Mohd Rosli, R. Leibbrandt, T. Omari, M. Costa, N.J. Spencer, L. Wiklendt & P.G. Dinning | 129P |
| A study of the effects of tethering chemistry on the properties of tethered membranes T. Berry, J. Andersson, I. Köper, P. Duckworth, B. Cornell & C. Cranfield | 130P |
| Molecular, architectural and functional adaptations of skeletal muscle to power resistance exercise H.K. Smith, Y. Zhang, R.G. Paul & M. Zügel | 131P |
| Overexpression of KCC2 reduces neuronal hyperexcitability C.S. Goulton, D.L. Cheung, A. Khoshaba, T.M. Lewis & A.J. Moorhouse | 132P |
| Hypoxic preconditioning of myoblasts implanted in a tissue engineering chamber significantly increases local angiogenesis via regulation of angiogenic growth factors and miRNA C.J. Taylor, J.E. Church, M.D. Williams, Y-W. Gerrand, E. Keramidaris, J.A. Palmer, L.A. Galea, A.J. Pennington, W.A. Morrison & G.M. Mitchell | 133P |
| Serum miRNAs are unsuitable for use as biomarkers for assessing skeletal muscle regeneration in a commonly used mouse model of myotoxic injury C.J. Taylor, C. van der Poel & J.E. Church | 134P |
| A breath of fresh air for cystic fibrosis- using nanotechnology to increase efficacy of gene therapy M.A. Fuller, I. Köper, H. Padmanabhan & D. Parsons | 135P |
| High frequency doublet stimulation enhances the rate of force development in fast-twitch skeletal muscle by increasing early binding of Ca2+ to the second binding site of troponin C A.J. Bakker, C.J. Barclay, T.R. Cully, C.D. Wingate & B.S. Launikonis | 136P |
| (+)-naloxone and (+)-naltrexone limits nuclear factor Κ β translocation in LPS stimulated H9C2s S.M. Lee, D. Saint & M.R. Hutchinson | 137P |
| Inhibition of the extracellular matrix protease ADAMTS5 improves strength in fast-twitch hindlimb muscles from young, dystrophic mdx mice L.G. Forgan, R. Kelly, N.L. McRae, A. Addinsall, B. McNeill, D.R. McCulloch & N. Stupka | 138P |
| The consequences of the genetic reduction of the extracellular protein versican on hindlimb muscle function and structure depend on muscle fibre type and age in dystrophic mdx mice N.L. McRae, L.G. Forgan, A. Addinsall, D.R. McCulloch & N. Stupka | 139P |
| Symposium: New paradigms in myocardial metabolism and pathogenesis | |
| Cofilin: a cardiac amyloid precursor implicated in dilated cardiomyopathy K. Subramanian, D. Gianni, C. Balla, G.E. Assenza, M. Joshi, M.J. Semigran, T.E. Macgillivray, J.E. Van Eyk, G. Agnetti, N. Paolocci, J.R. Bamburg, P.B. Agrawal & F. del Monte | 140P |
| Adipose-derived amyloid protein exerts cardiometabolic effect S.L. McGee, J. Czeczor, A.J. Genders, K.A. De Jong, T. Connor, K. Venardos, K. Aston-Mourney, C. Swinton, S.E. Hussey, M. Hargreaves, K.R. Walder & R. Cappai | 141P |
| Cardiac adipose, aromatase and arrhythmia vulnerability J.R. Bell | 142P |
| HDAC signalling through post-translational modification exerts hypertrophic action K.L. Weeks | 143P |
| Symposium: A placenta for life | |
| Crosstalk between the mother, placenta and fetus in health and disease C.T. Roberts | 144P |
| Hypoxic inducible miRNAs in placental pathologies C. Whitehead, T.J. Kaitu'u-Lino, N.K. Binder, S. Beard, S. Tong & N.J. Hannan | 145P |
| Maternal glucocorticoids impair placental development, induce cellular stress and program fetal outcomes in a sex specific manner J.S.M. Cuffe | 146P |
| The placenta for life: detecting childhood susceptibility to allergy V.L. Clifton | 147P |
| Free Comminications - Channel biophysics | |
| Novel human EAG1 channel antagonists from spider venoms L. Ma, Y.K. Chin, Z. Dekan, M. Ikonomopoulou, V. Herzig, C.Y. Chow, P. Alewood & G.F. King | 148P |
| Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel NaV1.7 A.J. Agwa, N. Lawrence, E. Deplazes, O. Cheneval, R. Chen, D.J. Craik, C.I. Schroeder & S.T. Henriques | 149P |
| Role of GABAa/c receptor N-terminal regions in assembly, trafficking and function L.W. Wong, H.S. Tae & B.A. Cromer | 150P |
| Perturbation of bilayer surface tension differentially modulates mechanosensitive ion channels N. Bavi, C.D. Cox, O. Bavi & B. Martinac | 151P |
| Force sensitivity of TRPC6 ion channel Y.A. Nikolaev, P.R. Rohde, O. Friedrich, D.R. Laver & B. Martinac | 152P |
| Fundamentals of the interaction between BiNSAID chemopreventive agents and cell membrane mimics T. Brown, S. Piantavigna, P. Andrews, S.A. Holt & C.T. Dillon | 153P |
| Pharmacological activation of defective hERG potassium channels in the treatment of long QT type 2 syndrome A.D. Hines, J.I. Vandenberg & M.D. Perry | 154P |
| Fireworks of salt stress: The role of H+/OH− channels in saline pathology of Chara australis M. Absolonova, M.J. Beilby, I. Foissner & A. Sommer | 155P |
| Symposium: Transporters and channels as drug targets in cancer | |
| A systems biology approach to predict amino acid homeostasis in cancer cells S. Broer & A. Broer | 156P |
| Targeting glutamine transport in triple-negative breast cancer M. van Geldermalsen, Q. Wang & J. Holst | 157P |
| Calcium permeable ion channel remodelling in breast cancer G.R. Monteith | 158P |
| Blocking cancer cell migration with novel drugs for aquaporin water and ion channels A.J. Yool | 159P |
| Free Communications - Fetal Physiology | |
| Maternal stress during pregnancy alters placental development and glucose transporter expression M.E. Wlodek, S.S. Hosseini, K.M. Moritz, J.F. Briffa, D. Mahizir, K. Anevska & J.S.M. Cuffe | 160P |
| Sex specific effect of preterm birth on mRNA expression of drug transporters in guinea pig liver J. Soo, M. Berry, R. Dyson, C. Gray & J.L. Morrison | 161P |
| Metabolic and cardiorenal adaptations to pregnancy in females born small on a high fat diet and the benefits of endurance exercise training D. Mahizir, K. Anevska, A.J. Jefferies, G.D. Wadley, K.M. Moritz & M.E. Wlodek | 162P |
| Sex dependant cardiac effects of a postnatal Western diet: exacerbated by low birth weight? J.R. Darby, T.R.H. Regnault & J.L. Morrison | 163P |
| The impact of exercise and high-fat feeding in growth restricted females on the placental IGF-system and nephron number in male fetuses Y.T.M. Mangwiro, D. Mahizir, K. Anevska, J.F. Briffa, A.J. Jefferies, S.S. Hosseini, V.F. Richter, J.S.M. Cuffe, D.H. Hryciw, T. Romano, K.M. Moritz & M.E. Wlodek | 164P |
| Cardiac miRNA expression in the fetus and six month old sheep in response to myocardial infarction M. Lock, J.Y. Soo, J. Darby, D. Brooks, E. Porrello, R. Tellam & J.L. Morrison | 165P |
| Males rats born small have elevated resting metabolic rate despite being less active and do not have exacerbated insulin resistance on a high fat diet J.F. Briffa, A.J. Jefferies, K.A. Anevska, G.D. Wadley, K.M. Moritz & M.E. Wlodek | 166P |
| Sustained expression of KV7 channels during labour is associated with a highly negative uterine muscle resting membrane potential and dysfunctional labour in women D.R. Sekali, M.A. Tonta, J. Stevenson, C. Goundar, P.M. Sheehan, S.P. Brennecke, M. Tare, H.A. Coleman & H.C. Parkington | 167P |
| Symposium: Cardiomyocyte mechano- and myofilament dysfunction in heart failure progression | |
| Role of hexose-sugar-induced post-translational modifications in contractile myofilament dysregulation K.M. Mellor | 168P |
| Myofilament mutations alter calcium channel and mitochondrial functional communication H. Viola, V. Johnstone, H. Cserne Szappanos, T. Richman, T. Tsoutsman, A. Filipovska, C. Semsarian, J. Seidman, C. Seidman & L. Hool | 169P |
| Creatine kinase, myofilament stiffness and cardiomyocyte mechanics E. White | 170P |
| Role of truncating titin mutations in dilated cardiomyopathy D. Fatkin | 183P |
| Free Communications - Exercise physiology | |
| Using a triple glucose tracer technique to quantify postprandial glucose flux after acute exercise and exercise training D.J. Morrison, C.R. Bruce, G.M. Kowalski, A.P. Russell & G.D. Wadley | 171P |
| Effects of chronic inactivity on physiological and biochemical characteristics of rat skeletal muscle H. Xu, G.D. Lamb & R.M. Murphy | 172P |
| The contractile characteristics of a novel dystrophin-negative mouse strain with enhanced voluntary exercise capability C.D. Wingate, G.J. Pinniger, P.G. Arthur, A.J. Bakker & K.J. Nowak | 173P |
| Physiological changes in pH alter markers of mitochondrial biogenesis after a single bout of high-intensity exercise in rats A.J. Genders, J. Kuang, E. Marin, X. Yan, J. Broatch, N. Saner & D.J. Bishop | 174P |
| A single bout of high intensity interval training reduces the autophagosome content in type I and type II muscle fibres C.S. Shaw, E. Zacharewicz, S.G. Wette, A.J. Trewin, L. Parker, A. Garnham, N.K. Stepto & R.M. Murphy | 175P |
| ACTN3 R577X genotype is associated with bone formation markers in humans N. Eynon, X. Yan, I. Papadimitriou, F. Munson, E. Byrnes, T.C. Brennan-Speranza, D.J. Bishop & I. Levinger | 176P |
| Symposium: Imaging cardiovascular disease and promoting repair | |
| Imaging in the clinic: Advances in tissue characterisation and oxygenation assessment J.B. Selvanayagam | 177P |
| Imaging cardiac function and response to infarct in the fetus J.L. Morrison | 178P |
| Fighting cardiovascular disease with knowledge gained from pregnancy L.J. Parry, C.H. Leo, S.A. Marshall, H.H. Ng, M. Jelinic & M. Tare | 179P |
| Desmoglein-2: getting to the heart of adhesion C.S. Bonder, L.M. Ebert, L.Y. Tan, M.Z. Johan, K.K. Myo Min, M.P. Cockshell, K.A. Parham, B.W. Ebert, C. Mintoff, N.L. Harvey, A.C. Zannettino, S. Gronthos, S. Koblar, A. Ruszkiewicz & M. Shackleton | 180P |
| ASB Award Lectures | |
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