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PROCEEDINGS OF THE
AUSTRALIAN PHYSIOLOGICAL SOCIETY

ISSN 0067-2084

Volume 47

2016

CONTENTS

AuPS 2016 Adelaide Meeting

AuPS Invited Lecture - Prof Lea Delbridge
Cardiac adventures in autophagy
L.M.D. Delbridge182P
Roberts Lecture
Enhancing students’ university experiences by engaging them with their course and equipping them for life-long learning
J.K. Choate184P
Free Communications - Skeletal Muscle
Role of the extracellular matrix protease ADAMTS5 in diet induced insulin resistance
K.F. Howlett, B. Tepper, T. Connor, S. Bond, C. Swinton, C.S. Shaw & S.L. McGee1P
Dysregulation of miRNA biogenesis machinery, miRNA/RNA ratio and miRNA normalizing targets in skeletal muscle of ALS mice
S. Lamon, S. Ngo, J. Yerbury, R. Chung & A.P. Russell2P
Characteristics of MMP-2 protein in rat skeletal muscle
X. Ren, G.D. Lamb & R.M. Murphy3P
Real time imaging of trans-sarcolemma Ca2+-fluxes in mammalian skeletal muscle
X. Koenig, R.H. Choi & B.S. Launikonis4P
Effect of curcumin exposure on skeletal muscle contractile function
J. Lam, G.J. Pinniger & A.J. Bakker5P
The influence of low carbohydrate and ketogenic diets on longevity and skeletal muscle maintenance with ageing
M.A. Wallace, M.H. Hall, J.A. López-Domínguez, G.R. Marcotte, N.W. Aguirre, A.M. Marshall, G. Perez, D. Tran, E. Gutiérrez-Casado, Z. Zhou, K. Kim, T.A. Knotts, A.A. Tomilov, K. Hagopian, K. Baar, G.A. Cortopassi & J.J. Ramsey6P
Anthracycline-induced skeletal muscle weakness: a role for chronic oxidative stress and disrupted calcium homeostasis?
N.A. Beard, M. Obst, A. Blackburn, H. Willemse & A.F. Dulhunty8P
Symposium: Transforming the classroom and helping others to adopt teaching innovations
Transforming the classroom and helping others to adopt teaching innovations
M.K. Smith9P
“Hands-on” practical class activities to engage students in basic principles of cell physiology
A.J. Moorhouse, R.M. Vickery, C. Garvey & P.H. Barry10P
Strategies for overcoming students’ misconceptions in large class settings
T.D. Mulhern, A. Espinosa, J.M. Lodge & H. Verkade11P
Creating and supporting transformation in physiology teaching
P. Poronnik12P
Symposium: Thinking small: Seeing biological processes with nanotechnology and photonics
Whispering gallery mode lasers for biosensing applications
A. François, N. Riesen, T. Reynolds, J.M.M. Hall & T.M. Monro13P
Reversible sensing with a flip of the switch
S. Heng & A.D. Abell14P
Nanoscale Biophotonics - using light to measure the previously unmeasurable within the central nervous system
M.R. Hutchinson15P
Visualising N-glycosylation patterns in cancer and non-cancer cells
N. Packer & A. Everest-Dass16P
Symposium: Latest advances in fluorescence and applications to physiological problems
Nanoscope odyssey into the presynapse
A.T. Bademosi, R. Kasula, M. Joensuu, A. Papadopulos, E. Lauwers, P. Padmanabhan, A. Papadopulos, G.J. Goodhill, P. Verstreken, B. van Swinderen & F.A. Meunier21P
On and off again: Tools and models for single molecule fluorescence imaging of actin and tropomyosin
A.C.F. Coster, M. Janco & T. Böcking22P
Probing and perturbing receptor signalling with microscopy, nanotechnology and microfluidics
A.H.A. Clayton23P
Profilin membrane dynamics in live cells
R.J. Davey, E. Gratton, M.A. Digman, N.M. Andronicos & P.D.J. Moens24P
Free Communications - Education
Inspiring student learning through the introduction of The Reading Game
F.C. Britton, T.M. Lewis, S. Mobbs & R.L. Parker25P
Online simulations to support the teaching of physiology wet lab practicals
R.A. Taylor, S. Ellem, S. Clarke & M. del Mar Quiroga26P
Assessing critical evaluation skills of undergraduate science students
K. Colthorpe, H. Mehari Abraha, K. Zimbardi & L. Ainscough27P
Learning hindrances and strategies reported by undergraduate physiology students: What makes a student resilient?
L. Ainscough, E. Stewart, K. Colthorpe & K. Zimbardi28P
Online adaptive tutorials that support learning in data interpretation and scientific reasoning
T.M. Lewis30P
Symposium: Enteric neural functional circuits of intestinal motility
Neuromechanical factors of intestinal motility
M. Costa31P
High-resolution analysis of human gastrointestinal motor patterns and the clinical applications
G. O'Grady32P
Synaptic transmission in enteric circuits
J.C. Bornstein36P
High resolution neuronal imaging reveals a novel enteric neural firing pattern that underlies colonic motor patterns in the mouse colon
N.J. Spencer, L. Travis, T.J. Hibberd, J. Sorensen, M. Costa, S.J.H. Brookes, P.G. Dinning & L. Wiklendt37P
Free Communications - Membrane Transport
Molecular basis for substrate and inhibitor interactions with the glycine transporter, GlyT2
R.J. Vandenberg, J.E. Carland, M. Thomas, A. Edington, M.L. O'Mara & R.M. Ryan39P
Heads and tails: lipid inhibitors of glycine transport
S. Mostyn, J.E. Carland, T. Rawling, R.M. Ryan & R.J. Vandenberg40P
A possible Achilles heel of ion pumps
A. Garcia, Q. Jiang, P.R. Pratap, C. Lüpfert, H.-J. Apell, F. Cornelius, D. Jacquemin & R.J. Clarke41P
Developing novel inhibitors of the glutamine transporter ASCT2 to treat cancer
N.J. Freidman, T. Rawling, R.J. Vandenberg & R.M. Ryan42P
The effect of ageing and hypertension on the proton-coupled transporters PEPT1 and PEPT2 in the renal proximal tubule
O. Alghamdi, N. King, N.M. Andronicos, B. Chami, G.L. Jones, P. Witting & P.D.J. Moens43P
Tuning the ion selectivity of glutamate transporter associated uncoupled conductances
R.J. Cater, J. Font, R.J. Vandenberg & R.M. Ryan44P
Investigating the elevator mechanism in a human nucleoside transporter (hCNT3)
Q. Wu, R.J. Vandenberg & R.M. Ryan45P
Effects of cholesterol depletion on the partial reactions of the Na+, K+-ATPase
A. Garcia, F. Cornelius & R.J. Clarke46P
Free Communications - Cardiac muscle and vessels
Novel fluorescent techniques for investigating calcium handling properties of the cardiac sarcoplasmic reticulum (SR) and calsequestrin in the presence and absence of dantrolene
C.M. Loescher & L.M. Gibson47P
Cavin-1 deficiency modifies cardiac and coronary responses to stretch and ischemia by augmenting NOS activity
M.E. Reichelt, M. Kaakinen, W.G. Thomas, J.P. Headrick & R.G. Parton48P
Further consideration of FKBP12 association with RyR1 and RyR2 and regulation of RyR channel activity
A.F. Dulhunty, C. Thekkedam, S.J. Richardson & N.A. Beard49P
Characterising the measurement of diastolic function in the intact rat cardiomyocyte
A.J.A. Raaijmakers, J.V. Janssens, J.R. Bell, C.L. Curl & L.M.D. Delbridge51P
Serelaxin treatment reverses vascular dysfunction and cardiomyocyte hypertrophy in the streptozotocin-induced mouse model of Type 1 diabetes
H.H. Ng, C.H. Leo, D. Prakoso, C.X. Qin, R.H. Ritchie & L.J. Parry52P
Shear force responsiveness of arteries depends on an interdependent activity of the epithelial Na+ channel and the endothelial glycocalyx
Z. Ashley, F. Knöpp, D. Barth, S. Mugloo, J.P. Baldin, M.J. Jennings & M. Fronius53P
The effect of intrauterine growth restriction on Ca2+-activated force in β-escin skinned mesenteric arteries of 6-month old male Wistar-Kyoto rats
M. Christie, T. Romano, R.M. Murphy & G.S. Posterino54P
Short term serelaxin treatment reduces prostanoid-mediated endothelium-derived vasoconstriction and restores endothelial vasodilator function without concomitant changes to cardiac remodelling in spontaneously hypertensive rats
C.H. Leo, S.A. Marshall, H.H. Ng, M. Jelinic, T. Rupasinghe, C.X. Qin, U. Roessner, R.H. Ritchie, M. Tare & L.J. Parry55P
Symposium: Recent advances in the understanding adipose tissue development and function
Understanding how we get fat: Dietary regulation of adipogenesis
M. Rodeheffer56P
Adipose tissue distribution and thermogenesis: relationships with metabolic disease
M.M. Swarbrick57P
Macrophages and tissue remodelling following acute nutritional modulation in humans
L.K. Heilbronn58P
Exercise training and the molecular regulation of lipid metabolism
M.J. Watt, T. Tsiloulis & A. Raajendiran59P
Free Communications - GI nutrition and digestions
The impact of intestinal lymph extravasation on adipose tissue function and whole body insulin resistance
E. Cao, G. Gracia, H. Chu, L. Hu, C.J.H. Porter, M.J. Watt & N.L. Trevaskis60P
Metformin directly triggers GLP-1 and PYY secretion in human colon and ileum
E.W.L. Sun, A.P. Liou, M.L. Jackson, D. DeFontgalland, P. Rabbitt, P. Hollington, L. Sposato, S.L. Due, D.A. Wattchow, R.L. Young & D.J. Keating61P
The nutrient sensing capacity of mouse enterochromaffin cells is dictated by gastrointestinal location
A.M. Martin, A.L. Lumsden, C.F. Jessup, N.J. Spencer & D.J. Keating62P
Characterisation of glucose-induced serotonin secretion from primary cultured human enterochromaffin cells in health and disease
A.L. Lumsden, R.L. Young, A.M. Martin, E.W.L. Sun, A. Liou, V.M. Jackson & D.J. Keating63P
Symposium: Mechanisms of pumps, channels and transporters
Mechanisms of sodium selectivity in membrane ion transport
T.W. Allen64P
Dynamics and mechanism of amino acid transport
C. Grewer65P
Mechanoelectrical transduction at the membrane-matrix interface
K. Poole, M.R. Servin Vences, M. Moroni & G.R. Lewin66P
Functional characterisation of P-type ATPases using solid-supported membrane based electrophysiology
F. Tadini-Buoninsegni67P
Plenary Lecture
Caveolae membrane domains connect G protein – mediated calcium signals with mechanical deformation
S.F. Scarlata68P
Symposium: The many pathways of gut control of metabolism
L-cell physiology and glucagon-like peptide-1 (GLP-1) secretion
F. Reimann69P
Augmented capacity for intestinal serotonin release in obese subjects
A.L. Lumsden, A.M. Martin, N. Pezos, E.W.L. Sun, N.J. Isaacs, N. Cvijanovic, A.P. Liou, V.M. Jackson, D.J. Keating & R.L. Young70P
Satiety signals from the gastrointestinal tract in health and obesity
A.J. Page71P
Use of a novel Down syndrome genetic screen identifies a regulator of pancreatic β-cell function linked to type 2 diabetes
D.J. Keating72P
Symposium: Stem cells and tissue engineering: New tools for experimental physiology and regenerative medicine
Engineered heart muscle for modelling human cardiac disease
M. Tiburcy73P
Manipulation of mechano-responsive miRNAs to drive mesenchymal stem cell fate in biomaterial composites
J.E. Frith74P
Bioengineering skeletal muscle: how to build an intact human motor unit
R.J. Mills75P
Obstacles and challenges for tissue engineering and regenerative medicine
M.D. Grounds76P
Symposium: Alternative approaches to the use of animals in physiology and biophysics
Modelling for understanding and prediction of epileptic seizures as a viable replacement for animal models
A.D.H. Peterson & M.J. Cook77P
Using induced pluripotent stem cell derived cardiomyocytes to screen for multichannel pharmacology and proarrhythmic risk in acquired long QT syndrome
A.P. Hill, M.D. Perry, W. Lee & J.I. Vandenberg78P
The Sydney Heart Bank: An international resource to help understand human heart failure while minimising the use of animals
S.P. Lal79P
Droplet-hydrogel lipid bilayers as an alternative model for studying mechanosensation
K.R. Rosholm, M.A.B. Baker, P. Ridone, Y. Nakayama, N. Bavi, P.R. Rohde, L.G. Cuello, L.K. Lee & B. Martinac80P
Allosteric modulation of gating by agonists and antagonists studied in prokaryotic, voltage-gated sodium channels
R.J. French, R.K. Finol-Urdaneta, J.R. McArthur, M. Goldschein-Ohm, R. Gaudet, D.B. Tikhonov & B.S. Zhorov185P
Symposium: Skeletal muscle physiology in health, disease and ageing
Role of ClC-1 Cl ion channels for skeletal muscle function in health and disease
T.H. Pedersen81P
Using energetics to understand the basis of diverse muscle function
C.J. Barclay82P
Sarcoplasmic reticulum function in human skeletal muscle during ageing and inactivity
C.R. Lamboley, R.M. Murphy, M.J. McKenna & G.D. Lamb83P
Altered Ca2+-handling in human skeletal muscle to alleviate Ca2+-induced damage in the days associated with delayed onset muscle soreness
T.R. Cully, R.M. Murphy, L. Roberts, T. Raastad, R.G. Fassett, J.S. Coombes, I.D. Jayasinghe & B.S. Launikonis84P
Symposium: Developmental origins of health and disease: metabolism and exercise
Developmental origins of health and disease – can exercise improve adult outcomes?
K.L. Gatford & G.K. McConell85P
Exercise before conception – dads matter too
M. Lane & N.O. McPherson86P
Investigating the impact of exercise during pregnancy
M.J. Morris87P
Developmental origins of health and disease: can exercise early in postnatal life improve adult outcomes?
G.K. McConell88P
Free Communications - Cell signalling
Phenotyping the differential innervation of the peripherin knockout mouse cochlea
C. Perera, G. von Jonquieres, J.L. Pinyon, K.W. Parley, J.M.E. Cederholm, J.-P. Julien, A.F. Ryan & G.D. Housley7P
Blocking fatty acid uptake reduces prostate cancer progression
R.A. Taylor, A.K. Clarke, S.J. Whitby, P.R. Wijayaratne, R. Rebello, L. Furic & M.J. Watt89P
Simulating biologically relevant membranes: tackling lipid diversity in bacterial membranes
D. Poger, B. Caron & A.E. Mark90P
Akt translocation under increasing insulin stimulation
C.W. Gray91P
Barrier function and ion transport in an oleic acid-induced model of lung injury
H. Ren, N.P. Birch & V. Suresh92P
Vitamin D and sex affect metabolic function and the development of NAFLD
R.M. Dwyer, R.J. Giblin, E.J. Bennett & G.R. Zosky93P
Golgi calcium pump secretory pathway Ca2+ ATPase 1 (SPCA1) in breast cancer cells
A.A. Peters, J.M.H. Lee, D. Marcial, P. Kenny, W. Hu, I. Kineav, S.J. Roberts-Thomson & G.R. Monteith94P
Regulation of Ca2+ release activated Ca2+ channels by intracellular pH
D. Gavriliouk, N.R. Scrimgeour, S. Grigoryev, L. Ma, F.H. Zhou, G.J. Barritt & G.Y. Rychkov95P
Free Comminications - Membrane and protein biophysics
Nano-domain equilibria in biomimetic membranes
I.Y. Hasan & A. Mechler96P
How the morphology of lipid bilayers is altered by pH
C.G. Cranfield, T. Berry, S.A. Holt, K.R. Hossain, A.P. Le Brun, S.M. Valenzuela, H. Coster & B. Cornell97P
Tethered bilayer lipid membranes to study membrane proteins
I. Köper98P
A model of the outer membrane of Gram-negative bacteria
J. Andersson, S.A. Holt & I. Köper99P
Analysis of profilin dynamics at the cell membrane by image pair correlation and number and brightness analysis
R.J. Davey, M.A. Digman, E. Gratton, N.M. Andronicos & P.D.J. Moens101P
Exploring the binding of photoacids to the surface of insulin amyloid fibril by docking and all-atom simulations
M.H. Rashid, N. Amdursky, M.M. Stevens & I. Yarovsky102P
Huntingtin inclusions trigger cellular quiescence, deactivate apoptosis and lead to delayed necrosis
D.M. Hatters103P
Investigating the role of the N-terminal domain unique to eukaryotic class III Biotin Protein Ligases
L.M. Sternicki, T.L. Pukala, N.R. Pendini, M.C. Wilce, G.W. Booker, K.L. Wegener & S.W. Polyak104P
Posters
Structure and membrane topology of the pore-forming peptide maculatin 1.1 depends on lipid composition
M.-A. Sani, S. Overall & F. Separovic18P
Impairment of an endothelial NAD+-H2S signaling network is a reversible cause of vascular aging
A. Das, G.X. Huang, A. Longchamp, L. Kim, C. Li, B. Osborne, S. Joshi, M. Kang, T. Hung, B. Lee, E.O. Williams, M. Igarashi, J.R. Mitchell, L.E. Wu, N. Turner, Z. Arany, L. Guarente & D.A. Sinclair105P
A general discretization method for connecting free-energy landscape models of biomolecular motors to motor behaviour
P.T.T. Nguyen, K.J. Challis & M.W. Jack106P
Structural dynamics and physical properties of single-chain Fv antibodies against (4-hydroxy-3-nitrophenyl)acetyl
M. Oda, Y. Sato, Y. Tanaka, S. Inaba, H. Sekiguchi, Y.C. Sasaki & T. Azuma107P
A HEK293 bioreporter cell line demonstrates temporally differentiated effects on impedance and ryanodine receptor modulation by venom fractions from the Australian scorpion Liocheles waigiensis
D.M. Housley, J.L. Pinyon, M. Smout, M.J. Liddell, E.A. Jennings & G.D. Housley108P
Thumbs up for PcTx1 – mechanistic insight into the binding of the venom peptide PcTx1 to the acid sensing ion channel 1a from free energy calculations
E. Deplazes, M. Stroet, G.F. King & A.E. Mark109P
Delayed post-prandial insulin secretion in individuals with low diabetes risk and its reversibility with exercise training
D. Kloosterman, S. Hamley, G. Morales-Scholz, G.M. Kowalski, K.F. Howlett, C.R. Bruce & C.S. Shaw110P
Age related changes in mass contractile properties and eccentric contraction damage of fast- and slow-twitch mouse muscles
L. Kiriaev, S. Kueh, J. Morley & S.I. Head111P
Serotonin distribution in the colon: insights from computational biology
H. Dockrell, P.G. Dinning, D.J. Keating & L. Wiklendt112P
Structural dynamics of c-Myb DNA-binding domain revealed by variable temperature and pH studies
S. Inaba & M. Oda113P
Simulations of ion selectivity in the acid-sensing ion channel ASIC1a
E. Flood, C. Boiteux, T. Lynagh, S. Pless & T.W. Allen114P
Computational study of aggregation mechanism in lysozyme [D67H]
D. Patel & S. Kuyucak115P
Development of biomarkers for the protein restriction using Slc6a19 knock out mice
K. Javed, Q. Cheng & S. Broer116P
Identification of novel inhibitors of the amino acid transporter B0AT1 (SLC6A19), a potential target to induce protein restriction and to treat type 2 diabetes
Q. Cheng, N. Shah, A. Broer, S. Fairweather, Y. Jiang, D. Schmoll, B. Corry & S. Broer117P
The cardiac troponin complex is modified by advanced glycation end-products in vivo and in vitro
J.V. Janssens, J.R. Bell, K.M. Mellor & L.M.D. Delbridge118P
Integral role of Mg2+ in observing the inhibitory effect of dantrolene
R.H. Choi, X. Koenig, T.R. Cully & B.S. Launikonis119P
Effects of novel urea analogues of NS1643 on potassium and calcium fluxes in cardiac muscle cells
S. Al Rawi, J.T. Heppell, J. Al Rawi & L.M. Gibson120P
Thymosin beta 4 and its bioactive fragments as preconditioning agents for skeletal myoblasts
L.A. Wilsdon, J.E. Church & C.J. Taylor121P
Mobilities of methanesulfonate, needed for liquid junction potential corrections, and of two related anions, and a mystery solved
P.H. Barry, T.M. Lewis & A.J. Moorhouse122P
The role of TRPM2 channels in the liver ischemia-reperfusion injury
F.H. Zhou, J. De Haas, J. Hua, G.J. Barritt & G.Y. Rychkov123P
Autophagy modulation in the liver and skeletal muscle of high-fat fed mice
G. Morales-Scholz, K.F. Howlett, R.M. Murphy, G.M. Kowalski, C.R. Bruce & C.S. Shaw124P
Cyclic neural motor patterns in the full isolated intact intestine of the mouse
L.J. Keightley, L. Wiklendt, J.W. Arkwright, T.J. Hibberd, P.G. Dinning, S.J.H. Brookes, N.J. Spencer & M. Costa125P
Ca2+ release-activated Ca2+ channels are regulated by Calpain
M.K. Adams, L. Ma, F.H. Zhou, G.J. Barritt & G.Y. Rychkov127P
Human Piezo1 membrane localization and gating kinetics are modulated by cholesterol levels
P. Ridone, E. Pandzic, M. Vassalli, C. Cox, P. Gottlieb & B. Martinac128P
Assessment of gas and liquid bolus movement using impedance manometry in rabbit colon
R. Mohd Rosli, R. Leibbrandt, T. Omari, M. Costa, N.J. Spencer, L. Wiklendt & P.G. Dinning129P
A study of the effects of tethering chemistry on the properties of tethered membranes
T. Berry, J. Andersson, I. Köper, P. Duckworth, B. Cornell & C. Cranfield130P
Molecular, architectural and functional adaptations of skeletal muscle to power resistance exercise
H.K. Smith, Y. Zhang, R.G. Paul & M. Zügel131P
Overexpression of KCC2 reduces neuronal hyperexcitability
C.S. Goulton, D.L. Cheung, A. Khoshaba, T.M. Lewis & A.J. Moorhouse132P
Hypoxic preconditioning of myoblasts implanted in a tissue engineering chamber significantly increases local angiogenesis via regulation of angiogenic growth factors and miRNA
C.J. Taylor, J.E. Church, M.D. Williams, Y-W. Gerrand, E. Keramidaris, J.A. Palmer, L.A. Galea, A.J. Pennington, W.A. Morrison & G.M. Mitchell133P
Serum miRNAs are unsuitable for use as biomarkers for assessing skeletal muscle regeneration in a commonly used mouse model of myotoxic injury
C.J. Taylor, C. van der Poel & J.E. Church134P
A breath of fresh air for cystic fibrosis- using nanotechnology to increase efficacy of gene therapy
M.A. Fuller, I. Köper, H. Padmanabhan & D. Parsons135P
High frequency doublet stimulation enhances the rate of force development in fast-twitch skeletal muscle by increasing early binding of Ca2+ to the second binding site of troponin C
A.J. Bakker, C.J. Barclay, T.R. Cully, C.D. Wingate & B.S. Launikonis136P
(+)-naloxone and (+)-naltrexone limits nuclear factor Κ β translocation in LPS stimulated H9C2s
S.M. Lee, D. Saint & M.R. Hutchinson137P
Inhibition of the extracellular matrix protease ADAMTS5 improves strength in fast-twitch hindlimb muscles from young, dystrophic mdx mice
L.G. Forgan, R. Kelly, N.L. McRae, A. Addinsall, B. McNeill, D.R. McCulloch & N. Stupka138P
The consequences of the genetic reduction of the extracellular protein versican on hindlimb muscle function and structure depend on muscle fibre type and age in dystrophic mdx mice
N.L. McRae, L.G. Forgan, A. Addinsall, D.R. McCulloch & N. Stupka139P
Symposium: New paradigms in myocardial metabolism and pathogenesis
Cofilin: a cardiac amyloid precursor implicated in dilated cardiomyopathy
K. Subramanian, D. Gianni, C. Balla, G.E. Assenza, M. Joshi, M.J. Semigran, T.E. Macgillivray, J.E. Van Eyk, G. Agnetti, N. Paolocci, J.R. Bamburg, P.B. Agrawal & F. del Monte140P
Adipose-derived amyloid protein exerts cardiometabolic effect
S.L. McGee, J. Czeczor, A.J. Genders, K.A. De Jong, T. Connor, K. Venardos, K. Aston-Mourney, C. Swinton, S.E. Hussey, M. Hargreaves, K.R. Walder & R. Cappai141P
Cardiac adipose, aromatase and arrhythmia vulnerability
J.R. Bell142P
HDAC signalling through post-translational modification exerts hypertrophic action
K.L. Weeks143P
Symposium: A placenta for life
Crosstalk between the mother, placenta and fetus in health and disease
C.T. Roberts144P
Hypoxic inducible miRNAs in placental pathologies
C. Whitehead, T.J. Kaitu'u-Lino, N.K. Binder, S. Beard, S. Tong & N.J. Hannan145P
Maternal glucocorticoids impair placental development, induce cellular stress and program fetal outcomes in a sex specific manner
J.S.M. Cuffe146P
The placenta for life: detecting childhood susceptibility to allergy
V.L. Clifton147P
Free Comminications - Channel biophysics
Novel human EAG1 channel antagonists from spider venoms
L. Ma, Y.K. Chin, Z. Dekan, M. Ikonomopoulou, V. Herzig, C.Y. Chow, P. Alewood & G.F. King148P
Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel NaV1.7
A.J. Agwa, N. Lawrence, E. Deplazes, O. Cheneval, R. Chen, D.J. Craik, C.I. Schroeder & S.T. Henriques149P
Role of GABAa/c receptor N-terminal regions in assembly, trafficking and function
L.W. Wong, H.S. Tae & B.A. Cromer150P
Perturbation of bilayer surface tension differentially modulates mechanosensitive ion channels
N. Bavi, C.D. Cox, O. Bavi & B. Martinac151P
Force sensitivity of TRPC6 ion channel
Y.A. Nikolaev, P.R. Rohde, O. Friedrich, D.R. Laver & B. Martinac152P
Fundamentals of the interaction between BiNSAID chemopreventive agents and cell membrane mimics
T. Brown, S. Piantavigna, P. Andrews, S.A. Holt & C.T. Dillon153P
Pharmacological activation of defective hERG potassium channels in the treatment of long QT type 2 syndrome
A.D. Hines, J.I. Vandenberg & M.D. Perry154P
Fireworks of salt stress: The role of H+/OH channels in saline pathology of Chara australis
M. Absolonova, M.J. Beilby, I. Foissner & A. Sommer155P
Symposium: Transporters and channels as drug targets in cancer
A systems biology approach to predict amino acid homeostasis in cancer cells
S. Broer & A. Broer156P
Targeting glutamine transport in triple-negative breast cancer
M. van Geldermalsen, Q. Wang & J. Holst157P
Calcium permeable ion channel remodelling in breast cancer
G.R. Monteith158P
Blocking cancer cell migration with novel drugs for aquaporin water and ion channels
A.J. Yool159P
Free Communications - Fetal Physiology
Maternal stress during pregnancy alters placental development and glucose transporter expression
M.E. Wlodek, S.S. Hosseini, K.M. Moritz, J.F. Briffa, D. Mahizir, K. Anevska & J.S.M. Cuffe160P
Sex specific effect of preterm birth on mRNA expression of drug transporters in guinea pig liver
J. Soo, M. Berry, R. Dyson, C. Gray & J.L. Morrison161P
Metabolic and cardiorenal adaptations to pregnancy in females born small on a high fat diet and the benefits of endurance exercise training
D. Mahizir, K. Anevska, A.J. Jefferies, G.D. Wadley, K.M. Moritz & M.E. Wlodek162P
Sex dependant cardiac effects of a postnatal Western diet: exacerbated by low birth weight?
J.R. Darby, T.R.H. Regnault & J.L. Morrison163P
The impact of exercise and high-fat feeding in growth restricted females on the placental IGF-system and nephron number in male fetuses
Y.T.M. Mangwiro, D. Mahizir, K. Anevska, J.F. Briffa, A.J. Jefferies, S.S. Hosseini, V.F. Richter, J.S.M. Cuffe, D.H. Hryciw, T. Romano, K.M. Moritz & M.E. Wlodek164P
Cardiac miRNA expression in the fetus and six month old sheep in response to myocardial infarction
M. Lock, J.Y. Soo, J. Darby, D. Brooks, E. Porrello, R. Tellam & J.L. Morrison165P
Males rats born small have elevated resting metabolic rate despite being less active and do not have exacerbated insulin resistance on a high fat diet
J.F. Briffa, A.J. Jefferies, K.A. Anevska, G.D. Wadley, K.M. Moritz & M.E. Wlodek166P
Sustained expression of KV7 channels during labour is associated with a highly negative uterine muscle resting membrane potential and dysfunctional labour in women
D.R. Sekali, M.A. Tonta, J. Stevenson, C. Goundar, P.M. Sheehan, S.P. Brennecke, M. Tare, H.A. Coleman & H.C. Parkington167P
Symposium: Cardiomyocyte mechano- and myofilament dysfunction in heart failure progression
Role of hexose-sugar-induced post-translational modifications in contractile myofilament dysregulation
K.M. Mellor168P
Myofilament mutations alter calcium channel and mitochondrial functional communication
H. Viola, V. Johnstone, H. Cserne Szappanos, T. Richman, T. Tsoutsman, A. Filipovska, C. Semsarian, J. Seidman, C. Seidman & L. Hool169P
Creatine kinase, myofilament stiffness and cardiomyocyte mechanics
E. White170P
Role of truncating titin mutations in dilated cardiomyopathy
D. Fatkin183P
Free Communications - Exercise physiology
Using a triple glucose tracer technique to quantify postprandial glucose flux after acute exercise and exercise training
D.J. Morrison, C.R. Bruce, G.M. Kowalski, A.P. Russell & G.D. Wadley171P
Effects of chronic inactivity on physiological and biochemical characteristics of rat skeletal muscle
H. Xu, G.D. Lamb & R.M. Murphy172P
The contractile characteristics of a novel dystrophin-negative mouse strain with enhanced voluntary exercise capability
C.D. Wingate, G.J. Pinniger, P.G. Arthur, A.J. Bakker & K.J. Nowak173P
Physiological changes in pH alter markers of mitochondrial biogenesis after a single bout of high-intensity exercise in rats
A.J. Genders, J. Kuang, E. Marin, X. Yan, J. Broatch, N. Saner & D.J. Bishop174P
A single bout of high intensity interval training reduces the autophagosome content in type I and type II muscle fibres
C.S. Shaw, E. Zacharewicz, S.G. Wette, A.J. Trewin, L. Parker, A. Garnham, N.K. Stepto & R.M. Murphy175P
ACTN3 R577X genotype is associated with bone formation markers in humans
N. Eynon, X. Yan, I. Papadimitriou, F. Munson, E. Byrnes, T.C. Brennan-Speranza, D.J. Bishop & I. Levinger176P
Symposium: Imaging cardiovascular disease and promoting repair
Imaging in the clinic: Advances in tissue characterisation and oxygenation assessment
J.B. Selvanayagam177P
Imaging cardiac function and response to infarct in the fetus
J.L. Morrison178P
Fighting cardiovascular disease with knowledge gained from pregnancy
L.J. Parry, C.H. Leo, S.A. Marshall, H.H. Ng, M. Jelinic & M. Tare179P
Desmoglein-2: getting to the heart of adhesion
C.S. Bonder, L.M. Ebert, L.Y. Tan, M.Z. Johan, K.K. Myo Min, M.P. Cockshell, K.A. Parham, B.W. Ebert, C. Mintoff, N.L. Harvey, A.C. Zannettino, S. Gronthos, S. Koblar, A. Ruszkiewicz & M. Shackleton180P
ASB Award Lectures

Index

Author index
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