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ISSN 0067-2084

Volume 47



AuPS 2016 Adelaide Meeting

AuPS Invited Lecture - Prof Lea Delbridge
Cardiac adventures in autophagy
L.M.D. Delbridge
Roberts Lecture
Enhancing students’ university experiences by engaging them with their course and equipping them for life-long learning
J.K. Choate
Free Communications - Skeletal Muscle
Role of the extracellular matrix protease ADAMTS5 in diet induced insulin resistance
K.F. Howlett, B. Tepper, T. Connor, S. Bond, C. Swinton, C.S. Shaw & S.L. McGee
Dysregulation of miRNA biogenesis machinery, miRNA/RNA ratio and miRNA normalizing targets in skeletal muscle of ALS mice
S. Lamon, S. Ngo, J. Yerbury, R. Chung & A.P. Russell
Characteristics of MMP-2 protein in rat skeletal muscle
X. Ren, G.D. Lamb & R.M. Murphy
Real time imaging of trans-sarcolemma Ca2+-fluxes in mammalian skeletal muscle
X. Koenig, R.H. Choi & B.S. Launikonis
Effect of curcumin exposure on skeletal muscle contractile function
J. Lam, G.J. Pinniger & A.J. Bakker
The influence of low carbohydrate and ketogenic diets on longevity and skeletal muscle maintenance with ageing
M.A. Wallace, M.H. Hall, J.A. López-Domínguez, G.R. Marcotte, N.W. Aguirre, A.M. Marshall, G. Perez, D. Tran, E. Gutiérrez-Casado, Z. Zhou, K. Kim, T.A. Knotts, A.A. Tomilov, K. Hagopian, K. Baar, G.A. Cortopassi & J.J. Ramsey
Anthracycline-induced skeletal muscle weakness: a role for chronic oxidative stress and disrupted calcium homeostasis?
N.A. Beard, M. Obst, A. Blackburn, H. Willemse & A.F. Dulhunty
Symposium: Transforming the classroom and helping others to adopt teaching innovations
Transforming the classroom and helping others to adopt teaching innovations
M.K. Smith
“Hands-on” practical class activities to engage students in basic principles of cell physiology
A.J. Moorhouse, R.M. Vickery, C. Garvey & P.H. Barry
Strategies for overcoming students’ misconceptions in large class settings
T.D. Mulhern, A. Espinosa, J.M. Lodge & H. Verkade
Creating and supporting transformation in physiology teaching
P. Poronnik
Symposium: Thinking small: Seeing biological processes with nanotechnology and photonics
Whispering gallery mode lasers for biosensing applications
A. François, N. Riesen, T. Reynolds, J.M.M. Hall & T.M. Monro
Reversible sensing with a flip of the switch
S. Heng & A.D. Abell
Nanoscale Biophotonics - using light to measure the previously unmeasurable within the central nervous system
M.R. Hutchinson
Visualising N-glycosylation patterns in cancer and non-cancer cells
N. Packer & A. Everest-Dass
Symposium: Latest advances in fluorescence and applications to physiological problems
Nanoscope odyssey into the presynapse
A.T. Bademosi, R. Kasula, M. Joensuu, A. Papadopulos, E. Lauwers, P. Padmanabhan, A. Papadopulos, G.J. Goodhill, P. Verstreken, B. van Swinderen & F.A. Meunier
On and off again: Tools and models for single molecule fluorescence imaging of actin and tropomyosin
A.C.F. Coster, M. Janco & T. Böcking
Probing and perturbing receptor signalling with microscopy, nanotechnology and microfluidics
A.H.A. Clayton
Profilin membrane dynamics in live cells
R.J. Davey, E. Gratton, M.A. Digman, N.M. Andronicos & P.D.J. Moens
Free Communications - Education
Inspiring student learning through the introduction of The Reading Game
F.C. Britton, T.M. Lewis, S. Mobbs & R.L. Parker
Online simulations to support the teaching of physiology wet lab practicals
R.A. Taylor, S. Ellem, S. Clarke & M. del Mar Quiroga
Assessing critical evaluation skills of undergraduate science students
K. Colthorpe, H. Mehari Abraha, K. Zimbardi & L. Ainscough
Learning hindrances and strategies reported by undergraduate physiology students: What makes a student resilient?
L. Ainscough, E. Stewart, K. Colthorpe & K. Zimbardi
Online adaptive tutorials that support learning in data interpretation and scientific reasoning
T.M. Lewis
Symposium: Enteric neural functional circuits of intestinal motility
Neuromechanical factors of intestinal motility
M. Costa
High-resolution analysis of human gastrointestinal motor patterns and the clinical applications
G. O'Grady
Synaptic transmission in enteric circuits
J.C. Bornstein
High resolution neuronal imaging reveals a novel enteric neural firing pattern that underlies colonic motor patterns in the mouse colon
N.J. Spencer, L. Travis, T.J. Hibberd, J. Sorensen, M. Costa, S.J.H. Brookes, P.G. Dinning & L. Wiklendt
Free Communications - Membrane Transport
Molecular basis for substrate and inhibitor interactions with the glycine transporter, GlyT2
R.J. Vandenberg, J.E. Carland, M. Thomas, A. Edington, M.L. O'Mara & R.M. Ryan
Heads and tails: lipid inhibitors of glycine transport
S. Mostyn, J.E. Carland, T. Rawling, R.M. Ryan & R.J. Vandenberg
A possible Achilles heel of ion pumps
A. Garcia, Q. Jiang, P.R. Pratap, C. Lüpfert, H.-J. Apell, F. Cornelius, D. Jacquemin & R.J. Clarke
Developing novel inhibitors of the glutamine transporter ASCT2 to treat cancer
N.J. Freidman, T. Rawling, R.J. Vandenberg & R.M. Ryan
The effect of ageing and hypertension on the proton-coupled transporters PEPT1 and PEPT2 in the renal proximal tubule
O. Alghamdi, N. King, N.M. Andronicos, B. Chami, G.L. Jones, P. Witting & P.D.J. Moens
Tuning the ion selectivity of glutamate transporter associated uncoupled conductances
R.J. Cater, J. Font, R.J. Vandenberg & R.M. Ryan
Investigating the elevator mechanism in a human nucleoside transporter (hCNT3)
Q. Wu, R.J. Vandenberg & R.M. Ryan
Effects of cholesterol depletion on the partial reactions of the Na+, K+-ATPase
A. Garcia, F. Cornelius & R.J. Clarke
Free Communications - Cardiac muscle and vessels
Novel fluorescent techniques for investigating calcium handling properties of the cardiac sarcoplasmic reticulum (SR) and calsequestrin in the presence and absence of dantrolene
C.M. Loescher & L.M. Gibson
Cavin-1 deficiency modifies cardiac and coronary responses to stretch and ischemia by augmenting NOS activity
M.E. Reichelt, M. Kaakinen, W.G. Thomas, J.P. Headrick & R.G. Parton
Further consideration of FKBP12 association with RyR1 and RyR2 and regulation of RyR channel activity
A.F. Dulhunty, C. Thekkedam, S.J. Richardson & N.A. Beard
Characterising the measurement of diastolic function in the intact rat cardiomyocyte
A.J.A. Raaijmakers, J.V. Janssens, J.R. Bell, C.L. Curl & L.M.D. Delbridge
Serelaxin treatment reverses vascular dysfunction and cardiomyocyte hypertrophy in the streptozotocin-induced mouse model of Type 1 diabetes
H.H. Ng, C.H. Leo, D. Prakoso, C.X. Qin, R.H. Ritchie & L.J. Parry
Shear force responsiveness of arteries depends on an interdependent activity of the epithelial Na+ channel and the endothelial glycocalyx
Z. Ashley, F. Knöpp, D. Barth, S. Mugloo, J.P. Baldin, M.J. Jennings & M. Fronius
The effect of intrauterine growth restriction on Ca2+-activated force in β-escin skinned mesenteric arteries of 6-month old male Wistar-Kyoto rats
M. Christie, T. Romano, R.M. Murphy & G.S. Posterino
Short term serelaxin treatment reduces prostanoid-mediated endothelium-derived vasoconstriction and restores endothelial vasodilator function without concomitant changes to cardiac remodelling in spontaneously hypertensive rats
C.H. Leo, S.A. Marshall, H.H. Ng, M. Jelinic, T. Rupasinghe, C.X. Qin, U. Roessner, R.H. Ritchie, M. Tare & L.J. Parry
Symposium: Recent advances in the understanding adipose tissue development and function
Understanding how we get fat: Dietary regulation of adipogenesis
M. Rodeheffer
Adipose tissue distribution and thermogenesis: relationships with metabolic disease
M.M. Swarbrick
Macrophages and tissue remodelling following acute nutritional modulation in humans
L.K. Heilbronn
Exercise training and the molecular regulation of lipid metabolism
M.J. Watt, T. Tsiloulis & A. Raajendiran
Free Communications - GI nutrition and digestions
The impact of intestinal lymph extravasation on adipose tissue function and whole body insulin resistance
E. Cao, G. Gracia, H. Chu, L. Hu, C.J.H. Porter, M.J. Watt & N.L. Trevaskis
Metformin directly triggers GLP-1 and PYY secretion in human colon and ileum
E.W.L. Sun, A.P. Liou, M.L. Jackson, D. DeFontgalland, P. Rabbitt, P. Hollington, L. Sposato, S.L. Due, D.A. Wattchow, R.L. Young & D.J. Keating
The nutrient sensing capacity of mouse enterochromaffin cells is dictated by gastrointestinal location
A.M. Martin, A.L. Lumsden, C.F. Jessup, N.J. Spencer & D.J. Keating
Characterisation of glucose-induced serotonin secretion from primary cultured human enterochromaffin cells in health and disease
A.L. Lumsden, R.L. Young, A.M. Martin, E.W.L. Sun, A. Liou, V.M. Jackson & D.J. Keating
Symposium: Mechanisms of pumps, channels and transporters
Mechanisms of sodium selectivity in membrane ion transport
T.W. Allen
Dynamics and mechanism of amino acid transport
C. Grewer
Mechanoelectrical transduction at the membrane-matrix interface
K. Poole, M.R. Servin Vences, M. Moroni & G.R. Lewin
Functional characterisation of P-type ATPases using solid-supported membrane based electrophysiology
F. Tadini-Buoninsegni
Plenary Lecture
Caveolae membrane domains connect G protein – mediated calcium signals with mechanical deformation
S.F. Scarlata
Symposium: The many pathways of gut control of metabolism
L-cell physiology and glucagon-like peptide-1 (GLP-1) secretion
F. Reimann
Augmented capacity for intestinal serotonin release in obese subjects
A.L. Lumsden, A.M. Martin, N. Pezos, E.W.L. Sun, N.J. Isaacs, N. Cvijanovic, A.P. Liou, V.M. Jackson, D.J. Keating & R.L. Young
Satiety signals from the gastrointestinal tract in health and obesity
A.J. Page
Use of a novel Down syndrome genetic screen identifies a regulator of pancreatic β-cell function linked to type 2 diabetes
D.J. Keating
Symposium: Stem cells and tissue engineering: New tools for experimental physiology and regenerative medicine
Engineered heart muscle for modelling human cardiac disease
M. Tiburcy
Manipulation of mechano-responsive miRNAs to drive mesenchymal stem cell fate in biomaterial composites
J.E. Frith
Bioengineering skeletal muscle: how to build an intact human motor unit
R.J. Mills
Obstacles and challenges for tissue engineering and regenerative medicine
M.D. Grounds
Symposium: Alternative approaches to the use of animals in physiology and biophysics
Modelling for understanding and prediction of epileptic seizures as a viable replacement for animal models
A.D.H. Peterson & M.J. Cook
Using induced pluripotent stem cell derived cardiomyocytes to screen for multichannel pharmacology and proarrhythmic risk in acquired long QT syndrome
A.P. Hill, M.D. Perry, W. Lee & J.I. Vandenberg
The Sydney Heart Bank: An international resource to help understand human heart failure while minimising the use of animals
S.P. Lal
Droplet-hydrogel lipid bilayers as an alternative model for studying mechanosensation
K.R. Rosholm, M.A.B. Baker, P. Ridone, Y. Nakayama, N. Bavi, P.R. Rohde, L.G. Cuello, L.K. Lee & B. Martinac
Allosteric modulation of gating by agonists and antagonists studied in prokaryotic, voltage-gated sodium channels
R.J. French, R.K. Finol-Urdaneta, J.R. McArthur, M. Goldschein-Ohm, R. Gaudet, D.B. Tikhonov & B.S. Zhorov
Symposium: Skeletal muscle physiology in health, disease and ageing
Role of ClC-1 Cl ion channels for skeletal muscle function in health and disease
T.H. Pedersen
Using energetics to understand the basis of diverse muscle function
C.J. Barclay
Sarcoplasmic reticulum function in human skeletal muscle during ageing and inactivity
C.R. Lamboley, R.M. Murphy, M.J. McKenna & G.D. Lamb
Altered Ca2+-handling in human skeletal muscle to alleviate Ca2+-induced damage in the days associated with delayed onset muscle soreness
T.R. Cully, R.M. Murphy, L. Roberts, T. Raastad, R.G. Fassett, J.S. Coombes, I.D. Jayasinghe & B.S. Launikonis
Symposium: Developmental origins of health and disease: metabolism and exercise
Developmental origins of health and disease – can exercise improve adult outcomes?
K.L. Gatford & G.K. McConell
Exercise before conception – dads matter too
M. Lane & N.O. McPherson
Investigating the impact of exercise during pregnancy
M.J. Morris
Developmental origins of health and disease: can exercise early in postnatal life improve adult outcomes?
G.K. McConell
Free Communications - Cell signalling
Phenotyping the differential innervation of the peripherin knockout mouse cochlea
C. Perera, G. von Jonquieres, J.L. Pinyon, K.W. Parley, J.M.E. Cederholm, J.-P. Julien, A.F. Ryan & G.D. Housley
Blocking fatty acid uptake reduces prostate cancer progression
R.A. Taylor, A.K. Clarke, S.J. Whitby, P.R. Wijayaratne, R. Rebello, L. Furic & M.J. Watt
Simulating biologically relevant membranes: tackling lipid diversity in bacterial membranes
D. Poger, B. Caron & A.E. Mark
Akt translocation under increasing insulin stimulation
C.W. Gray
Barrier function and ion transport in an oleic acid-induced model of lung injury
H. Ren, N.P. Birch & V. Suresh
Vitamin D and sex affect metabolic function and the development of NAFLD
R.M. Dwyer, R.J. Giblin, E.J. Bennett & G.R. Zosky
Golgi calcium pump secretory pathway Ca2+ ATPase 1 (SPCA1) in breast cancer cells
A.A. Peters, J.M.H. Lee, D. Marcial, P. Kenny, W. Hu, I. Kineav, S.J. Roberts-Thomson & G.R. Monteith
Regulation of Ca2+ release activated Ca2+ channels by intracellular pH
D. Gavriliouk, N.R. Scrimgeour, S. Grigoryev, L. Ma, F.H. Zhou, G.J. Barritt & G.Y. Rychkov
Free Comminications - Membrane and protein biophysics
Nano-domain equilibria in biomimetic membranes
I.Y. Hasan & A. Mechler
How the morphology of lipid bilayers is altered by pH
C.G. Cranfield, T. Berry, S.A. Holt, K.R. Hossain, A.P. Le Brun, S.M. Valenzuela, H. Coster & B. Cornell
Tethered bilayer lipid membranes to study membrane proteins
I. Köper
A model of the outer membrane of Gram-negative bacteria
J. Andersson, S.A. Holt & I. Köper
Analysis of profilin dynamics at the cell membrane by image pair correlation and number and brightness analysis
R.J. Davey, M.A. Digman, E. Gratton, N.M. Andronicos & P.D.J. Moens
Exploring the binding of photoacids to the surface of insulin amyloid fibril by docking and all-atom simulations
M.H. Rashid, N. Amdursky, M.M. Stevens & I. Yarovsky
Huntingtin inclusions trigger cellular quiescence, deactivate apoptosis and lead to delayed necrosis
D.M. Hatters
Investigating the role of the N-terminal domain unique to eukaryotic class III Biotin Protein Ligases
L.M. Sternicki, T.L. Pukala, N.R. Pendini, M.C. Wilce, G.W. Booker, K.L. Wegener & S.W. Polyak
Structure and membrane topology of the pore-forming peptide maculatin 1.1 depends on lipid composition
M.-A. Sani, S. Overall & F. Separovic
Impairment of an endothelial NAD+-H2S signaling network is a reversible cause of vascular aging
A. Das, G.X. Huang, A. Longchamp, L. Kim, C. Li, B. Osborne, S. Joshi, M. Kang, T. Hung, B. Lee, E.O. Williams, M. Igarashi, J.R. Mitchell, L.E. Wu, N. Turner, Z. Arany, L. Guarente & D.A. Sinclair
A general discretization method for connecting free-energy landscape models of biomolecular motors to motor behaviour
P.T.T. Nguyen, K.J. Challis & M.W. Jack
Structural dynamics and physical properties of single-chain Fv antibodies against (4-hydroxy-3-nitrophenyl)acetyl
M. Oda, Y. Sato, Y. Tanaka, S. Inaba, H. Sekiguchi, Y.C. Sasaki & T. Azuma
A HEK293 bioreporter cell line demonstrates temporally differentiated effects on impedance and ryanodine receptor modulation by venom fractions from the Australian scorpion Liocheles waigiensis
D.M. Housley, J.L. Pinyon, M. Smout, M.J. Liddell, E.A. Jennings & G.D. Housley
Thumbs up for PcTx1 – mechanistic insight into the binding of the venom peptide PcTx1 to the acid sensing ion channel 1a from free energy calculations
E. Deplazes, M. Stroet, G.F. King & A.E. Mark
Delayed post-prandial insulin secretion in individuals with low diabetes risk and its reversibility with exercise training
D. Kloosterman, S. Hamley, G. Morales-Scholz, G.M. Kowalski, K.F. Howlett, C.R. Bruce & C.S. Shaw
Age related changes in mass contractile properties and eccentric contraction damage of fast- and slow-twitch mouse muscles
L. Kiriaev, S. Kueh, J. Morley & S.I. Head
Serotonin distribution in the colon: insights from computational biology
H. Dockrell, P.G. Dinning, D.J. Keating & L. Wiklendt
Structural dynamics of c-Myb DNA-binding domain revealed by variable temperature and pH studies
S. Inaba & M. Oda
Simulations of ion selectivity in the acid-sensing ion channel ASIC1a
E. Flood, C. Boiteux, T. Lynagh, S. Pless & T.W. Allen
Computational study of aggregation mechanism in lysozyme [D67H]
D. Patel & S. Kuyucak
Development of biomarkers for the protein restriction using Slc6a19 knock out mice
K. Javed, Q. Cheng & S. Broer
Identification of novel inhibitors of the amino acid transporter B0AT1 (SLC6A19), a potential target to induce protein restriction and to treat type 2 diabetes
Q. Cheng, N. Shah, A. Broer, S. Fairweather, Y. Jiang, D. Schmoll, B. Corry & S. Broer
The cardiac troponin complex is modified by advanced glycation end-products in vivo and in vitro
J.V. Janssens, J.R. Bell, K.M. Mellor & L.M.D. Delbridge
Integral role of Mg2+ in observing the inhibitory effect of dantrolene
R.H. Choi, X. Koenig, T.R. Cully & B.S. Launikonis
Effects of novel urea analogues of NS1643 on potassium and calcium fluxes in cardiac muscle cells
S. Al Rawi, J.T. Heppell, J. Al Rawi & L.M. Gibson
Thymosin beta 4 and its bioactive fragments as preconditioning agents for skeletal myoblasts
L.A. Wilsdon, J.E. Church & C.J. Taylor
Mobilities of methanesulfonate, needed for liquid junction potential corrections, and of two related anions, and a mystery solved
P.H. Barry, T.M. Lewis & A.J. Moorhouse
The role of TRPM2 channels in the liver ischemia-reperfusion injury
F.H. Zhou, J. De Haas, J. Hua, G.J. Barritt & G.Y. Rychkov
Autophagy modulation in the liver and skeletal muscle of high-fat fed mice
G. Morales-Scholz, K.F. Howlett, R.M. Murphy, G.M. Kowalski, C.R. Bruce & C.S. Shaw
Cyclic neural motor patterns in the full isolated intact intestine of the mouse
L.J. Keightley, L. Wiklendt, J.W. Arkwright, T.J. Hibberd, P.G. Dinning, S.J.H. Brookes, N.J. Spencer & M. Costa
Ca2+ release-activated Ca2+ channels are regulated by Calpain
M.K. Adams, L. Ma, F.H. Zhou, G.J. Barritt & G.Y. Rychkov
Human Piezo1 membrane localization and gating kinetics are modulated by cholesterol levels
P. Ridone, E. Pandzic, M. Vassalli, C. Cox, P. Gottlieb & B. Martinac
Assessment of gas and liquid bolus movement using impedance manometry in rabbit colon
R. Mohd Rosli, R. Leibbrandt, T. Omari, M. Costa, N.J. Spencer, L. Wiklendt & P.G. Dinning
A study of the effects of tethering chemistry on the properties of tethered membranes
T. Berry, J. Andersson, I. Köper, P. Duckworth, B. Cornell & C. Cranfield
Molecular, architectural and functional adaptations of skeletal muscle to power resistance exercise
H.K. Smith, Y. Zhang, R.G. Paul & M. Zügel
Overexpression of KCC2 reduces neuronal hyperexcitability
C.S. Goulton, D.L. Cheung, A. Khoshaba, T.M. Lewis & A.J. Moorhouse
Hypoxic preconditioning of myoblasts implanted in a tissue engineering chamber significantly increases local angiogenesis via regulation of angiogenic growth factors and miRNA
C.J. Taylor, J.E. Church, M.D. Williams, Y-W. Gerrand, E. Keramidaris, J.A. Palmer, L.A. Galea, A.J. Pennington, W.A. Morrison & G.M. Mitchell
Serum miRNAs are unsuitable for use as biomarkers for assessing skeletal muscle regeneration in a commonly used mouse model of myotoxic injury
C.J. Taylor, C. van der Poel & J.E. Church
A breath of fresh air for cystic fibrosis- using nanotechnology to increase efficacy of gene therapy
M.A. Fuller, I. Köper, H. Padmanabhan & D. Parsons
High frequency doublet stimulation enhances the rate of force development in fast-twitch skeletal muscle by increasing early binding of Ca2+ to the second binding site of troponin C
A.J. Bakker, C.J. Barclay, T.R. Cully, C.D. Wingate & B.S. Launikonis
(+)-naloxone and (+)-naltrexone limits nuclear factor Κ β translocation in LPS stimulated H9C2s
S.M. Lee, D. Saint & M.R. Hutchinson
Inhibition of the extracellular matrix protease ADAMTS5 improves strength in fast-twitch hindlimb muscles from young, dystrophic mdx mice
L.G. Forgan, R. Kelly, N.L. McRae, A. Addinsall, B. McNeill, D.R. McCulloch & N. Stupka
The consequences of the genetic reduction of the extracellular protein versican on hindlimb muscle function and structure depend on muscle fibre type and age in dystrophic mdx mice
N.L. McRae, L.G. Forgan, A. Addinsall, D.R. McCulloch & N. Stupka
Symposium: New paradigms in myocardial metabolism and pathogenesis
Cofilin: a cardiac amyloid precursor implicated in dilated cardiomyopathy
K. Subramanian, D. Gianni, C. Balla, G.E. Assenza, M. Joshi, M.J. Semigran, T.E. Macgillivray, J.E. Van Eyk, G. Agnetti, N. Paolocci, J.R. Bamburg, P.B. Agrawal & F. del Monte
Adipose-derived amyloid protein exerts cardiometabolic effect
S.L. McGee, J. Czeczor, A.J. Genders, K.A. De Jong, T. Connor, K. Venardos, K. Aston-Mourney, C. Swinton, S.E. Hussey, M. Hargreaves, K.R. Walder & R. Cappai
Cardiac adipose, aromatase and arrhythmia vulnerability
J.R. Bell
HDAC signalling through post-translational modification exerts hypertrophic action
K.L. Weeks
Symposium: A placenta for life
Crosstalk between the mother, placenta and fetus in health and disease
C.T. Roberts
Hypoxic inducible miRNAs in placental pathologies
C. Whitehead, T.J. Kaitu'u-Lino, N.K. Binder, S. Beard, S. Tong & N.J. Hannan
Maternal glucocorticoids impair placental development, induce cellular stress and program fetal outcomes in a sex specific manner
J.S.M. Cuffe
The placenta for life: detecting childhood susceptibility to allergy
V.L. Clifton
Free Comminications - Channel biophysics
Novel human EAG1 channel antagonists from spider venoms
L. Ma, Y.K. Chin, Z. Dekan, M. Ikonomopoulou, V. Herzig, C.Y. Chow, P. Alewood & G.F. King
Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel NaV1.7
A.J. Agwa, N. Lawrence, E. Deplazes, O. Cheneval, R. Chen, D.J. Craik, C.I. Schroeder & S.T. Henriques
Role of GABAa/c receptor N-terminal regions in assembly, trafficking and function
L.W. Wong, H.S. Tae & B.A. Cromer
Perturbation of bilayer surface tension differentially modulates mechanosensitive ion channels
N. Bavi, C.D. Cox, O. Bavi & B. Martinac
Force sensitivity of TRPC6 ion channel
Y.A. Nikolaev, P.R. Rohde, O. Friedrich, D.R. Laver & B. Martinac
Fundamentals of the interaction between BiNSAID chemopreventive agents and cell membrane mimics
T. Brown, S. Piantavigna, P. Andrews, S.A. Holt & C.T. Dillon
Pharmacological activation of defective hERG potassium channels in the treatment of long QT type 2 syndrome
A.D. Hines, J.I. Vandenberg & M.D. Perry
Fireworks of salt stress: The role of H+/OH channels in saline pathology of Chara australis
M. Absolonova, M.J. Beilby, I. Foissner & A. Sommer
Symposium: Transporters and channels as drug targets in cancer
A systems biology approach to predict amino acid homeostasis in cancer cells
S. Broer & A. Broer
Targeting glutamine transport in triple-negative breast cancer
M. van Geldermalsen, Q. Wang & J. Holst
Calcium permeable ion channel remodelling in breast cancer
G.R. Monteith
Blocking cancer cell migration with novel drugs for aquaporin water and ion channels
A.J. Yool
Free Communications - Fetal Physiology
Maternal stress during pregnancy alters placental development and glucose transporter expression
M.E. Wlodek, S.S. Hosseini, K.M. Moritz, J.F. Briffa, D. Mahizir, K. Anevska & J.S.M. Cuffe
Sex specific effect of preterm birth on mRNA expression of drug transporters in guinea pig liver
J. Soo, M. Berry, R. Dyson, C. Gray & J.L. Morrison
Metabolic and cardiorenal adaptations to pregnancy in females born small on a high fat diet and the benefits of endurance exercise training
D. Mahizir, K. Anevska, A.J. Jefferies, G.D. Wadley, K.M. Moritz & M.E. Wlodek
Sex dependant cardiac effects of a postnatal Western diet: exacerbated by low birth weight?
J.R. Darby, T.R.H. Regnault & J.L. Morrison
The impact of exercise and high-fat feeding in growth restricted females on the placental IGF-system and nephron number in male fetuses
Y.T.M. Mangwiro, D. Mahizir, K. Anevska, J.F. Briffa, A.J. Jefferies, S.S. Hosseini, V.F. Richter, J.S.M. Cuffe, D.H. Hryciw, T. Romano, K.M. Moritz & M.E. Wlodek
Cardiac miRNA expression in the fetus and six month old sheep in response to myocardial infarction
M. Lock, J.Y. Soo, J. Darby, D. Brooks, E. Porrello, R. Tellam & J.L. Morrison
Males rats born small have elevated resting metabolic rate despite being less active and do not have exacerbated insulin resistance on a high fat diet
J.F. Briffa, A.J. Jefferies, K.A. Anevska, G.D. Wadley, K.M. Moritz & M.E. Wlodek
Sustained expression of KV7 channels during labour is associated with a highly negative uterine muscle resting membrane potential and dysfunctional labour in women
D.R. Sekali, M.A. Tonta, J. Stevenson, C. Goundar, P.M. Sheehan, S.P. Brennecke, M. Tare, H.A. Coleman & H.C. Parkington
Symposium: Cardiomyocyte mechano- and myofilament dysfunction in heart failure progression
Role of hexose-sugar-induced post-translational modifications in contractile myofilament dysregulation
K.M. Mellor
Myofilament mutations alter calcium channel and mitochondrial functional communication
H. Viola, V. Johnstone, H. Cserne Szappanos, T. Richman, T. Tsoutsman, A. Filipovska, C. Semsarian, J. Seidman, C. Seidman & L. Hool
Creatine kinase, myofilament stiffness and cardiomyocyte mechanics
E. White
Role of truncating titin mutations in dilated cardiomyopathy
D. Fatkin
Free Communications - Exercise physiology
Using a triple glucose tracer technique to quantify postprandial glucose flux after acute exercise and exercise training
D.J. Morrison, C.R. Bruce, G.M. Kowalski, A.P. Russell & G.D. Wadley
Effects of chronic inactivity on physiological and biochemical characteristics of rat skeletal muscle
H. Xu, G.D. Lamb & R.M. Murphy
The contractile characteristics of a novel dystrophin-negative mouse strain with enhanced voluntary exercise capability
C.D. Wingate, G.J. Pinniger, P.G. Arthur, A.J. Bakker & K.J. Nowak
Physiological changes in pH alter markers of mitochondrial biogenesis after a single bout of high-intensity exercise in rats
A.J. Genders, J. Kuang, E. Marin, X. Yan, J. Broatch, N. Saner & D.J. Bishop
A single bout of high intensity interval training reduces the autophagosome content in type I and type II muscle fibres
C.S. Shaw, E. Zacharewicz, S.G. Wette, A.J. Trewin, L. Parker, A. Garnham, N.K. Stepto & R.M. Murphy
ACTN3 R577X genotype is associated with bone formation markers in humans
N. Eynon, X. Yan, I. Papadimitriou, F. Munson, E. Byrnes, T.C. Brennan-Speranza, D.J. Bishop & I. Levinger
Symposium: Imaging cardiovascular disease and promoting repair
Imaging in the clinic: Advances in tissue characterisation and oxygenation assessment
J.B. Selvanayagam
Imaging cardiac function and response to infarct in the fetus
J.L. Morrison
Fighting cardiovascular disease with knowledge gained from pregnancy
L.J. Parry, C.H. Leo, S.A. Marshall, H.H. Ng, M. Jelinic & M. Tare
Desmoglein-2: getting to the heart of adhesion
C.S. Bonder, L.M. Ebert, L.Y. Tan, M.Z. Johan, K.K. Myo Min, M.P. Cockshell, K.A. Parham, B.W. Ebert, C. Mintoff, N.L. Harvey, A.C. Zannettino, S. Gronthos, S. Koblar, A. Ruszkiewicz & M. Shackleton
ASB Award Lectures


Author index
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