AuPS/ASB/PSNZ Sydney 2012 Programme

Author index

Sunday 2nd December 2012
Mathews AMathews BMathews CMathews D
17:30 Opening Ceremony
Location: Mathews A
AuPS Invited Lecture - Prof Joe Lynch
Location: Mathews A
17:45 J.W. Lynch: The glycine receptor – a new therapeutic target for chronic inflammatory pain1P
Welcome reception
Location: Pavillion


Monday 3rd December 2012
Mathews AMathews BMathews CMathews D
08:30 Symposium: New insights into cardiac Ca2+ handling and excitability
Chairs: Yue-kun Ju & David Allen
08:30 M. Lei: P21 activated kinase-1 as a key regulator of cardiac automaticity and excitability2P
09:10 D.G. Allen: Involvement of calcium in pacemaker firing3P
09:30 M.S. Imtiaz: Role of intracellular Ca2+ in sinoatrial node pacemaking4P
09:50 J.N. Edwards: Effects of redox environment on calcium alternans in isolated rabbit cardiomyocytes5P
10:10 L.C. Hool: Plasma membrane Ca2+ channel handling and arrhythmogenesis6P
Symposium: Assessment in physiology - Changing philosophy and practice
Chairs: Lesley Ulman & Phil Poronnik
08:30 D. Boud: Changing assessment: shifting the emphasis to learning and use7P
09:10 Y.M. Hodgson: Students assessing each other - why and how?8P
09:30 D.A. Saint: Assessment - What, why and how?9P
09:50 P. Poronnik: Developing assessment as a collaborative endeavour10P
Symposium: Advances in methods for intestinal motility
Chair: Marcello Costa
08:30 M. Costa: Introduction
08:34 G. O'Grady: Mapping and modelling human gastric slow wave activation in health and disease11P
09:03 P.G. Dinning: Multimodal recordings of intestinal motor activity12P
09:32 J.C. Bornstein: Computational modelling of enteric motor patterns13P
10:01 M. Costa: Spatio-temporal maps of intestinal motor patterns14P
10:30 End of session
Free Communications - Exercise Physiology
Location: Mathews D
Chairs: Glenn Wadley & Simon Green
08:30 G.D. Lamb: Calcium-dependent proteolysis of junctophilin-1 and junctophilin-2 in skeletal and cardiac muscle15P
08:45 S.C. Gandevia: Interpolated twitches decline progressively during a tetanic contraction of human adductor pollicis16P
09:00 S.G. Wette: Effects of high intensity power resistance exercise and feeding on mechanosensing and stress-related gene expression in human skeletal muscle17P
09:15 S. Green: Functional sympatholysis is a time- and intensity-dependent process in the contracting human calf muscle18P
09:30 C.R. Brandner: Acute cardiac responses to blood flow restriction strength exercise19P
09:45 C.E. Taylor: Neural control of blood flow to a contracting muscle: roles of central command and metaboreceptors20P
10:00 J. Yamauchi: The effects of exercise duration on cerebral oxygenation in the human prefrontal cortex at moderate exercise intensity21P
10:15 G.D. Wadley: Team Based Learning to undergraduates at Deakin University22P
10:30 Morning tea
11:00 Symposium: Molecular insight via advanced fluorescence microscopy
Chair: Till Böcking
11:00 D.M. Hatters: New flow cytometry tricks to view protein conformations in cells and their subcellular localization23P
12:00 N. Plachta: Imaging transcription factors in the living mouse embryo25P
12:30 D.M. Owen: Evidence for, and function of, sub-resolution ordered membrane domains26P
Symposium: Cystic fibrosis: Today and tomorrow
Chair: Kirk Hamilton
11:00 R.A. Frizzell: Fluorogen activating proteins report corrector-mediated restoration of mutant CFTR trafficking to the cell surface and its regulated peripheral recycling27P
11:45 P.T.P. Bye: Hypertonic saline nebulisation for pulmonary disease in people with cystic fibrosis28P
12:10 C.E. Wainwright: Early lung disease in cystic fibrosis29P
12:35 D. Parsons: Developing a gene therapy for cystic fibrosis airway disease30P
Symposium: Bridging the gap between molecular reductionism and physiology- the usefulness of ‘omics’
Chair: Matthew Watt
11:00 T.R. Koves: Using targeted mass spectrometry-based metabolomics to dissect metabolic flux in health and disease31P
11:35 M.J. Watt: Identification of factors secreted from the fatty liver: impact on metabolic function in other tissues32P
12:00 M.A. Febbraio: Muscle secretory factors - where are we at a decade later?33P
12:30 K. Walder: A gene expression signature for insulin resistance34P
Free Communications - General Physiology
Chair: Andrew Moorhouse
11:00 E. Kheradpezhouh: The role of TRPM2 channels in paracetamol overdose-induced Ca2+ entry in hepatocytes35P
11:15 K. Karisnan: Gestational age at time of the initial exposure to lipopolysaccharide determines the severity of diaphragmatic contractile dysfunction in preterm lambs36P
11:30 A.D. Hanna: Anthracycline-induced dysfunction of cardiac SR Ca2+ handling: a potential pathway to anthracycline-induced cardiotoxicity37P
11:45 I.Y. Kuo: Calcium binding to the EF hand motif regulates polycystin 2 function38P
12:00 K.W. Stewart: The role of a newly discovered pancreatic islet peptide in the control of insulin secretion39P
12:15 D.J. Keating: Huntingtin-associated protein 1 (HAP1) regulates exocytosis, vesicle localization and interacts with multiple vesicle proteins40P
13:00 Posters and Lunch
Location: Pavillion
Presenting authors of posters on odd numbered boards in attendance.
1 41PV. Zaitsev: Anabolic effect of formoterol administration on skeletal muscle is not impaired by co-treatment with the β1-adrenoceptor antagonist CGP-20712A
2 42PC.R. Lamboley: Endogenous and maximal sarcoplasmic reticulum calcium content in human vastus lateralis muscle fibres is decreased with ageing
3 43PH. Willemse: Human aging and expression of proteins interacting with the ryanodine receptor in skeletal muscle
4 44PC. van der Poel: The pathogenesis of inflammation in knee osteoarthritis and its effect on muscle function
5 45PJ.P. Mollica: Calpastatin and m-calpain have different cellular localizations in rat skeletal muscle: implications for function
6 46PN.Y. Marden: Online feedback assessments in introductory physiology courses: effects on students’ learning experience and outcomes
7 47PR.G. Barker: Taurine improves tibialis anterior force production and muscle architecture in the 28 day old mdx mouse model of Duchenne muscular dystrophy
8 48PS. Chan: SR pump function and fatigue characteristics of fast fibres from α-actinin-3-deficient speed gene knockout mice
9 49PE.J. Stephenson: The oxidative profile of white adipose tissue is not related to intrinsic exercise capacity or whole-body metabolic health
10 50PC.A. Lucas: Contraction induces a cyclic promoter hypomethylation in mouse skeletal muscle
11 51PH. Xu: The effect of amylase treatment on the detection of glycogenin, glycogen debranching enzyme and glycogen phosphorylase proteins in rat fast-twitch skeletal muscle
12 52PV. Nylander: The role of epigenetic modifications in the long term memory of cancer treatment
13 53PC.R. Brandner: Acute neural responses to blood flow restriction strength exercise
14 54PA.J. Craig: A photothrombosis-induced ischaemic infarct model for study of hind brain stroke
15 55PS. El-Ajouz: Understanding the molecular gates of KirBac3.1
16 56PT. Guo: Influence of cell morphology in computational models of on and off retinal ganglion cells
17 57PM.H. Rashid: Binding site of Scorpion toxin HsTx1 to the potassium channel Kv1.1 and Kv1.3 from Molecular Dynamics simulations
18 58PS. Talwar: Identification and characterization of novel synthetic variabilin analogues targeting the glycine receptor Cl channels
19 59PS. Mahdavi: Computational investigation of μ-conotoxin binding to voltage gated sodium channels
20 60PD. Robertson: Olivocochlear reflex strength and the auditory attentional filter
21 61PP.H. Barry: Further measurements of liquid junction potentials, and their implications, using a refined freshly-cut 3M KCl reference salt-bridge methodology
22 62PA. Bhaskaracharya: Probenecid, a gout treatment, blocks the human P2X7 receptor
23 63PJ.R. Lawson: Agonist selectivity of neuronal glycine receptors
24 64PK.A. Jenkin: Cannabinoid receptor 2 expression in proximal tubule cells exposed to elevated glucose and albumin
25 65PH. Cuny: Identifying key amino acid residues for α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors
26 66PH.J. Lee: Pharmacological characterization of individual subtypes of α4β3δ GABAA receptor, include the novel description of β3δ GABAA receptor subtype
27 67PT.K.H. Nguyen: Melittin-membrane interaction follows lipid-specific multi-step mechanism
28 68PC.L. Dixon: Using artificial synapses to investigate GABAA receptor kinetics
29 69PH.-S. Tae: A salt-bridge network determines agonist size selectivity in ρ1 GABAC receptor
30 70PT.M. Lewis: Mixed antagonistic effects of the ginkgolides at recombinant human ρ1 GABAC receptors
31 71PL.W. Wong: Are the putative N-terminal α-helix and preceding residues important in GABAA/C receptor function?
32 72PK.L. Hamilton: Membrane trafficking and localization, residence time and degradation of KCa3.1 in a polarized epithelium
33 74PJ.E. Hare: Structural insight into the CLIC1 integral membrane structure by fluorescence resonance energy transfer and electron microscopy
34 75PA. Bode: Effects of new human startle disease mutations on glycine receptor function and structure
35 76PT. Stockner: The ATP-bound state of P-glycoprotein is closed towards the cell exterior
36 77PY. Kim: TRPC3c (high activity) transient receptor potential channel expression in the mouse brain
37 78PE.L. Daniel: Determining a link between XLID and missense mutations in Chloride Intracellular Ion Channel Protein 2 (CLIC2): a biophysical approach
38 79PL. Han: Differential movement of M4 transmembrane segments during activation of α1 and α3 glycine receptors
39 80PC. Boiteux: Insights into voltage gated sodium channel NavAb function from multi-microsecond molecular dynamics simulations
40 81PL.J. Munro: Modulation of GlyT2 by endogenous lipid based compounds occurs through interactions with EL3
41 82PG. Heinzelmann: Molecular Dynamics simulations on a bacterial homolog of the human glutamate transporters
42 83PA.P. Tosolini: Characterization of the muscle-motor neuron topography of the mouse forelimb
43 84PN. Subramanian: The binding of morphine and nicardipine to the multidrug transporter P-glycoprotein
44 85PR. Mohan: Characterization of the muscle-motor neuron topography of the mouse hindlimb
45 86PD. Robertson: Timecourse of development of hyperactivity in the auditory midbrain after cochlear trauma
46 87PJ.L. Pinyon: Evaluation of auditory nerve fibre recruitment by eABR via cochlear implant stimulation in the guinea-pig model
47 88PA. Al Abed: Electrical restitution properties of rabbit atrial tissue
48 89PG. Ivanov: Acute effects of insulin on the endothelium-dependent dilation of rat cremaster muscle arteries
49 90PM.S. Imtiaz: Three-dimensional modeling of Ca2+ dynamics in single cardiac cells
50 91PJ.M. Power: Calcium waves alter dendritic spine morphology in basolateral amygdala projection neurons
51 92PS.A. Mann: The importance of cardiac ion channels on the electrocardiogram - partial least squares regression as a new tool in computational biology
52 93PX.H. Chan: Atorvastatin-induced changes in micro-vascular smooth muscle function
14:30 Symposium: Spectral imaging in physiology – a highlight of techniques
Chair: Robyn Murphy
14:30 V.G. Macefield: Combining microelectrode recordings from human peripheral nerves with functional magnetic resonance imaging of the brain94P
14:55 P.R. Gooley: AMP-activated protein kinase β subunit requires internal motion for optimal carbohydrate binding95P
15:20 D. Stapleton: The how and why of glycogen ultrastructure - implications for physiology and disease96P
15:45 R.M. Murphy: Single muscle fibre analysis reveals differential fibre type, localization and stimulation responses of enzymes important for glycogen metabolism: insights into muscle glycogen structure and function97P
Free communications - Channels: Molecular Interactions
Chair: Boris Martinac
14:30 A. Mechler: Salt concentration effects on the viscoelasticity of supported bilayers98P
14:45 E. Deplazes: Combining experiment and simulations to characterize the interactions of a sea-anemone toxin with the analgesic target acid-sensing ion channel 399P
15:00 M.D. Perry: The S4 domain is directly involved in determining the voltage sensitivity of Kv11.1 channel inactivation100P
15:15 B.A. Cromer: Molecular mechanisms for agonist selectivity in inhibitory Cys-loop ligand-gated ion channels101P
15:30 T. Nomura: Orientation of the bacterial mechanosensitive channel MscS in liposomal membranes102P
15:45 B. Martinac: Ion selectivity of the mechanosensitive channel MscS is determined by charged residues within the cytoplasmic vestibulum103P
Free communications - Cardiac Physiology
Chair: Lea Delbridge
14:30 T.F. Reardon: Mechanisms contributing to angiotensin II induced increases in nerve-evoked contractions of mouse tail artery104P
14:45 D.A. Saint: Asian immigrants to Australia show a lower sympathetic component to the baro-reflex than resident caucasians, as measured by heart rate variability analysis105P
15:00 A.W. Quail: Propofol selectively modifies the arterial chemoreflex during severe hypoxia in the rabbit106P
15:15 D.O. Schwenke: The serotonin pathway – a therapeutic target for pulmonary hypertension? Assessing vascular function using synchrotron radiation microangiography107P
15:30 J.R. Bell: An augmented CaMKII response in the post-ischemic female heart is not proarrhythmic – towards understanding the sex-specificity of CaMKII pathophysiology108P
15:45 A. Li: A cardiac troponin I mutation that causes familial dilated cardiomyopathy109P
Free Communcations - Neuro-signalling
Location: Mathews D
Chair: John Power
14:30 K.E. Froud: Modulation of cochlear amplifier performance by contralateral suppression110P
14:45 R. Raghupathi: Enterochromaffin cells release 5-HT with synaptic kinetics111P
15:00 J.M.E. Cederholm: Transcriptional responses to noise stress in mice112P
15:15 A.E. Harasta: Septal glucagon-like peptide 1 receptors (GLP-1Rs) mediate the behavioural effects of cocaine113P
15:30 L.G.T. van den Heuij: Human amniotic epithelial cell therapy for preterm perinatal asphyxia114P
15:45 C.J. Schwiening: Pre-synaptic pH changes and vesicle fusion at the Drosophila neuromuscular junction115P
16:00 Afternoon tea
16:30 Symposium: Perinatal asphyxia: adaptation and consequences
Chair: Alistair Jan Gunn
16:30 A.J. Gunn: Making birth safer116P
16:40 S.B. Hooper: Resuscitating the asphyxic infant at birth117P
17:05 G.R. Polglase: Brain inflammation and injury resulting from chorioamnionitis is exacerbated by resuscitation in preterm lambs118P
17:30 S.L. Miller: New strategies to protect the newborn brain119P
17:55 L. Bennet: Maternal glucocorticoids: timing is everything for the fetal brain120P
Symposium: A vignette of TRP ion channel physiology
Chair: Gary Housley
16:30 L. Birnbaumer: TRPC channels: An overview121P
16:50 G.J. Barritt: Multiple roles for transient receptor potential (TRP) non-selective cation channels in liver function125P
17:15 G.Y. Rychkov: TRPM2 channels in oxidative stress-induced cell death126P
17:40 N.W. Bunnett: Proteolytic regulation of TRP channels: implications for pain and neurogenic inflammation127P
18:05 S.L. Sandow: Myoendothelial microdomains and TRPC3: anatomical links to function129P
Free Communications: ASB Young Investigator & Spectroscopy
Location: Mathews C
Chairs: Jamie Vandenberg & Frances Separovic
16:30 D.R. Whelan: Quantification and detection of DNA in eukaryotic cells using Fourier transform infrared spectroscopy130P
16:45 T.D.M. Bell: Super-resolution imaging of cells using a home built dSTORM microscope costing less than A$100k131P
17:00 T. Holm: dSTORM super-resolution made cheap and easy132P
17:15 M.-A. Sani: Antimicrobial peptide activity in a competitive lipid environment133P
17:30 C.G. Cranfield: Tethered Bilayer Lipid Membranes (tBLMs) to measure pore formation by antimicrobial peptide (AMP) insertion134P
17:45 P.S. Tan: Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels135P
18:00 T.A. Hilder: Characterizing various inward rectifier potassium channels136P
18:15 R.J. Clarke: Kinetic comparisons of heart and kidney Na+,K+-ATPases137P
Free Communications - Muscle Metabolism/Signalling
Chair: Matthew Watt
16:30 A.J. Hoy: Regulation of plasma ceramide levels with fatty acid oversupply - evidence that the liver detects and secretes de novo synthesized ceramide138P
16:45 S. Lamon: Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis139P
17:00 J.G. Ryall: A switch in metabolism underlies the initiation of MyoD transcription in satellite cells140P
17:15 R. Koopman: Glycine, a pharmaco-nutrient that protects muscle cells from cachectic stimuli in vitro and in vivo141P
17:30 V.C. Foletta: Suppression of NDRG2, a novel PGC-1α and PGC-1β target gene, contributes to the metabolic profile and protein synthesis rates of skeletal muscle cells142P
17:45 D.J. Ham: Citrulline protects muscle cells from cachectic stimuli and preserves protein metabolism in vitro143P
18:00 S. Trajanovska: Role of glycogen depletion in muscle fatigue144P
18:15 C.W. Gray: Local sensitivity analysis of GLUT4 translocation in response to insulin145P
19:30 Student Member Function - BBQ in the Whitehouse


Tuesday 4th December 2012
Mathews AMathews BMathews CMathews D
08:30 AuPS Plenary Lecture - Scandinavian Exchange Lecturer - Prof Håkan Westerblad
08:30 H. Westerblad: Muscle fatigue146P
09:30 Morning tea
10:00 Symposium: Calcium signalling in microdomains essential to normal cell function
Chair: Bradley Launikonis
10:00 I.F. Smith: Imaging the motility of inositol trisphosphate receptors in intact mammalian cells using single particle tracking photoactivated localization microscopy (sptPALM)147P
10:30 I.D. Jayasinghe: Three-dimensional analysis of the tubular networks in mammalian and amphibian skeletal muscle fibres148P
11:00 B.S. Launikonis: Specialization of the skeletal muscle junctional membranes allow rapid activation of store-operated calcium entry, tightly controlled by [Ca2+]SR149P
11:30 P. Thorn: Focal secretion of insulin within intact islets of langerhans150P
Symposium: Science at the high performance computing frontier
Chair: Adam Hill
10:00 E. Afgan: Genomics Virtual Laboratory151P
10:30 B. Corry: Long time scale molecular simulations for understanding ion channel function153P
11:00 P.M.F. Nielsen: Sharing physiological models154P
11:30 A. Sadrieh: Massive parallelization of cardiac simulations using unconventional processing architectures155P
Free communications - Transporters
Chair: Tim Murphy
10:00 R.J. Cater: Mapping the chloride permeation pathway of a human glutamate transporter156P
10:15 A.J. Scopelliti: Molecular determinants for functional differences between the neutral amino acid transporter ASCT1 and acidic amino acid transporters of the EAAT family157P
10:30 N.L. Absalom: γ hydroxybutyrate activates specific GABAA receptor subtypes158P
10:45 J.E. Carland: Oleoyl L-carnitine inhibits glycine transport by GLYT2159P
11:00 R.M. Ryan: Using N-modified aspartate analogues to probe the ‘open-to-inside’ structure of the bacterial aspartate transporter, GltPh160P
11:15 B.C. McIlwain: Conformational dynamics of an archaeal aspartate transporter are determined by the lipid bilayer161P
11:30 K.E. Polglaze: Benzamil, but not triamterene, reduces mechanosensitive 5-HT release from EC cells of guinea pig intestine162P
11:45 S. Senadheera: Enhanced T-type calcium channel function, but not L-type or TRPC3 channels, augments uteroplacental arterial vascular tone in late pregnancy163P
12:00 Posters and Lunch - ASB AGM (Mathews 312) - PSNZ AGM (Mathews 125)
Presenting authors of posters on even numbered boards in attendance.
13:30 Symposium: Muscular adaptations to exercise: mechanisms at play
Chair: David Simar
13:30 R. Barres: Adaptations to exercise: the role of epigenetic changes164P
14:00 B.E. Kemp: AMPK signaling and exercise165P
14:30 J.A. Hawley: Sending the message: Training-nutrient interactions to stimulate mitochondrial biogenesis166P
15:00 J.E. Sharman: Exercise central haemodynamics: mechanisms and relation to end organ damage167P
Symposium: Integrative physiology of the heart
Chairs: Bruce Smaill & Jamie Vandenberg
13:30 D.S. Loiselle: Multi-scale cardiac energetics168P
13:50 L.M.D. Delbridge: Cardiac ischemia - different contexts and different consequences169P
14:10 M.L. Trew: Cardiomyocyte group architecture and electrical activation pathways in the heart170P
14:30 A.P. Hill: Computational analysis of the contribution of ionic conductances to ECG parameters171P
Free communications - Molecular Dynamics
Chair: Toby Allen
13:30 S. Kuyucak: Rational drug design from toxins - how rational can one get?172P
13:45 R. Chen: Binding of scorpion toxins to the voltage sensors of Na+ channels: molecular dynamics studies173P
14:00 D. Gordon: Brownian dynamics simulation of ion channel block by polypeptide toxins174P
14:15 M. Thomas: Biological channel mimics for use as desalination membranes175P
14:30 H. Yu: Catalysis in silico176P
14:45 M.L. O'Mara: The effect of ATP binding on the conformation of P-glycoprotein177P
15:00 Z. Jia: The effect of environment on the recognition and binding of vancomycin to native and resistance forms of lipid II178P
15:15 T.W. Allen: Long molecular dynamics simulations to explore ion channel function179P
15:30 Afternoon tea
16:00 Free communications - Gene for Speed
Chair: Peter Houweling
16:00 N. Eynon: Overcoming the barrier of sample size: The ACTN3 R577X polymorphism across three groups of elite European athletes180P
16:15 F. Garton: Deficiency of a fast twitch muscle fibre protein alters muscle adaptation in response to denervation and immobilization181P
16:30 M.W. Hogarth: α-Actinin-3: a novel genetic modifier of Duchenne muscular dystrophy182P
16:45 S.I. Head: Alterations in Ca2+ transients and SR function in isolated fast fibres from α-actinin-3-deficient speed gene knockout mice183P
17:00 P.J. Houweling: Metabolic consequences of α-actinin-3 deficiency – more than a structural muscle protein!184P
17:15 M. Kreissl: Mutations in the α-tropomyosin-slow gene (TPM3) cause sarcomeric dysfunction in slow muscle fibres185P
Free Communications - Cardiac Physiology
Chair: Nicole Beard
16:00 A.F. Dulhunty: Functional analyses of a cluster of CCD mutations reveals a gating module within TM6 of RyR1186P
16:15 K. Walweel: Regulation of human RYR2 by intracellular Ca2+ and Mg2+187P
16:30 J. Li: Adrenergic stimulation increases RYR2 activity via intracellular Ca2+ and Mg2+ regulation188P
16:45 D. Mehra: Role of cardiac Na+ channel blockers and Mg2+ in inhibiting the cardiac calcium release channel189P
17:00 J. Liu: Store-operated calcium entry activity revealed by confocal live cell calcium imaging in isolated mouse pacemaker cells190P
17:15 A. Gogoi: Autonomic functions and serum leptin levels in normal and obese, a comparative study191P
PSNZ - John Hubbard and Mary Bullivant Student Prize Competition
16:00 Peter Hunter: John Hubbard Prize
16:05 J.-C. Han: Does the heart really operate at 'isoefficiency'?192P
16:30 Kirk Hamilton: Mary Bullivant Prizes
16:35 H.P.A. Thaung: Sympathetic modulation of cardiac function in diabetes - in vivo and ex vivo study193P
17:00 S. Fan: Inflammation of the proximal colon of IL10−/− mice induced by Helicobacter typhlonius infection reduces anion secretion and expression of the NaHCO3 cotransporter, NBCe1194P
18:00 Conference Dinner and Awards


Wednesday 5th December 2012
Mathews AMathews BMathews CMathews D
09:00 Invited Lecture - Prof Lutz Birnbaumer
09:00 L. Birnbaumer: TRPC channels: on-going discovery of molecular physiological function in relation to store operated Ca2+ entry and Orai proteins195P
10:00 Morning tea
10:30 Symposium: Brain dysfunction and translational neurophysiology
Chairs: Andrew Moorhouse & Arun Krishnan
10:35 A. Yamanaka: Optogenetical approach to reveal the regulatory mechanism of instinctive behaviors by the hypothalamic neurons196P
10:55 J. Nabekura: Glia and neuron interactions: their role in synapse remodeling in vivo197P
11:15 A.J. Moorhouse: Membrane transporters regulating inhibitory neurotransmitter signaling in health and disease198P
11:30 R. Rajan: Traumatic brain injury and sensory cortex: using barrel cortex to understand functional changes in the injured brain199P
11:45 D. Burke: Excitability and action potential in human axons200P
12:05 M.C. Kiernan: Central assessment of motor dysfunction using transcranial magnetic stimulation201P
Symposium: Autonomic physiology - nutrient sensing in the GI tract
Chair: Paul Bertrand
10:30 H.E. Raybould: Nutrient-sensing in the GI tract: fat, the gut microbiota and obesity202P
11:15 R.L. Young: Dysregulation of intestinal glucose sensing and transport in critical illness203P
11:40 P.P. Bertrand: Iron sensing by the intestine: A new model for iron-induced changes to GI motility204P
12:05 C. Feinle-Bisset: Nutrient sensing in the human gastrointestinal lumen - role in appetite regulation and implications for obesity205P
Symposium: Skeletal muscle in health and disease
Chair: Gordon Lynch
10:30 H. Westerblad: Mitochondrial myopathies206P
11:00 E. Hardeman: Insights into and therapies for nemaline myopathy207P
11:30 K.T. Murphy: Tackling muscle wasting in cancer208P
12:00 G. Ravenscroft: Uncovering the genetics of neuromuscular foetal akinesias using next generation sequencing209P
12:30 Lunch - AuPS AGM
14:00 Symposium: Developments in auditory and vestibular physiology
Chair: Ramesh Rajan
14:00 A.W. Gummer: Nanomechanical mechanisms of cochlear amplification210P
14:20 G.D. Housley: Neurohumoral mechanisms for regulating sound transduction211P
14:40 R.B. Patuzzi: Spreadsheet analysis of ion transport in epithelia212P
14:55 P. J. Blamey: Factors affecting clinical outcomes in adult patients with cochlear implants213P
15:15 A.M. Brichta: The other part of the ear – a ‘balanced’ view214P
15:35 I.S. Curthoys: The sensitive response of irregular otolithic vestibular afferents to bone conducted vibration and air conducted sound underpins fast, simple, safe clinical testing of otolithic function215P
Symposium: Ion Channels as drug targets
Chairs: Trevor Lewis & Joe Lynch
14:00 D. Julius: Exploiting toxins to probe pain pathways216P
14:40 G.F. King: Spider-venom peptides that target the human Nav1.7 channel: potential analgesics for the treatment of chronic pain217P
15:00 R.S. Norton: Conotoxins targeting voltage-gated sodium channels: harnessing nature’s analgesics218P
15:20 M. Chebib: Modulation of Cys-loop receptors to address CNS disorders219P
15:40 A. Keramidas: Correlating functional models of channel activation with subunit specific GABAA receptors220P
Free Communications - Muscle Diseases
Chair: Stewart Head
14:00 J.L. Chen: Targeting activin to counteract muscle wasting and cachexia221P
14:15 B.P. Frankish: Calpain-3 deficiency results in the perturbation of specific Ca2+-handling proteins in skeletal muscle of mice222P
14:30 T.R. Cully: Adeno-associated virus directed expression of Orai1 to examine store operated calcium entry in wild-type and dystrophic skeletal muscle223P
14:45 T.D. Colgan: Combinatorial gene therapy using AAV technology to treat Duchenne muscular dystrophy224P
15:00 T. Kennedy: Altered expression of heat shock proteins in Duchenne muscular dystrophy225P
15:15 A. Cheng: Time-course of decline in the size of neuromuscular synaptic contacts with sedentary aging in mice226P
15:30 P.W. Sheard: A new view of fibre type transformations in elderly skeletal muscles227P
15:45 M. Morsch: Patient autoantibodies reveal the role of muscle specific kinase in maintaining the mature neuromuscular junction228P
16:00 K. Swiderski: Endogenous phosphorylation of the dystrophin protein modulates protein function229P
16:30 Afternoon tea and Drinks - Closing Reception and Awards

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