AuPS/ASB/PSNZ | Sydney 2012

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Sunday 2nd December 2012

Mathews A

Mathews B

Mathews C

Mathews D

17:30

Opening Ceremony
Location: Mathews A

AuPS Invited Lecture - Prof Joe Lynch

17:45

J.W. Lynch: The glycine receptor – a new therapeutic target for chronic inflammatory pain

18:00

18:30

Welcome reception
Location: Pavillion

19:00

19:30

20:00

20:30

21:00

21:30

Monday 3rd December 2012

Mathews A

Mathews B

Mathews C

Mathews D

08:30

Symposium: New insights into cardiac Ca²⁺ handling and excitability
Chairs: Yue-kun Ju & David Allen

08:30	M. Lei: P²¹ activated kinase-1 as a key regulator of cardiac automaticity and excitability	2P
09:10	D.G. Allen: Involvement of calcium in pacemaker firing	3P
09:30	M.S. Imtiaz: Role of intracellular Ca²⁺ in sinoatrial node pacemaking	4P
09:50	J.N. Edwards: Effects of redox environment on calcium alternans in isolated rabbit cardiomyocytes	5P
10:10	L.C. Hool: Plasma membrane Ca²⁺ channel handling and arrhythmogenesis	6P

Symposium: Assessment in physiology - Changing philosophy and practice
Chairs: Lesley Ulman & Phil Poronnik

08:30	D. Boud: Changing assessment: shifting the emphasis to learning and use	7P
09:10	Y.M. Hodgson: Students assessing each other - why and how?	8P
09:30	D.A. Saint: Assessment - What, why and how?	9P
09:50	P. Poronnik: Developing assessment as a collaborative endeavour	10P

Symposium: Advances in methods for intestinal motility
Chair: Marcello Costa

08:30	M. Costa: Introduction
08:34	G. O'Grady: Mapping and modelling human gastric slow wave activation in health and disease	11P
09:03	P.G. Dinning: Multimodal recordings of intestinal motor activity	12P
09:32	J.C. Bornstein: Computational modelling of enteric motor patterns	13P
10:01	M. Costa: Spatio-temporal maps of intestinal motor patterns	14P
10:30	End of session

Free Communications - Exercise Physiology
Chairs: Glenn Wadley & Simon Green

08:30	G.D. Lamb: Calcium-dependent proteolysis of junctophilin-1 and junctophilin-2 in skeletal and cardiac muscle	15P
08:45	S.C. Gandevia: Interpolated twitches decline progressively during a tetanic contraction of human adductor pollicis	16P
09:00	S.G. Wette: Effects of high intensity power resistance exercise and feeding on mechanosensing and stress-related gene expression in human skeletal muscle	17P
09:15	S. Green: Functional sympatholysis is a time- and intensity-dependent process in the contracting human calf muscle	18P
09:30	C.R. Brandner: Acute cardiac responses to blood flow restriction strength exercise	19P
09:45	C.E. Taylor: Neural control of blood flow to a contracting muscle: roles of central command and metaboreceptors	20P
10:00	J. Yamauchi: The effects of exercise duration on cerebral oxygenation in the human prefrontal cortex at moderate exercise intensity	21P
10:15	G.D. Wadley: Team Based Learning to undergraduates at Deakin University	22P

09:00

09:30

10:00

10:30

Morning tea

11:00

Symposium: Molecular insight via advanced fluorescence microscopy
Chair: Till Böcking

11:00	D.M. Hatters: New flow cytometry tricks to view protein conformations in cells and their subcellular localization	23P
12:00	N. Plachta: Imaging transcription factors in the living mouse embryo	25P
12:30	D.M. Owen: Evidence for, and function of, sub-resolution ordered membrane domains	26P

Symposium: Cystic fibrosis: Today and tomorrow
Chair: Kirk Hamilton

11:00	R.A. Frizzell: Fluorogen activating proteins report corrector-mediated restoration of mutant CFTR trafficking to the cell surface and its regulated peripheral recycling	27P
11:45	P.T.P. Bye: Hypertonic saline nebulisation for pulmonary disease in people with cystic fibrosis	28P
12:10	C.E. Wainwright: Early lung disease in cystic fibrosis	29P
12:35	D. Parsons: Developing a gene therapy for cystic fibrosis airway disease	30P

Symposium: Bridging the gap between molecular reductionism and physiology- the usefulness of ‘omics’
Chair: Matthew Watt

11:00	T.R. Koves: Using targeted mass spectrometry-based metabolomics to dissect metabolic flux in health and disease	31P
11:35	M.J. Watt: Identification of factors secreted from the fatty liver: impact on metabolic function in other tissues	32P
12:00	M.A. Febbraio: Muscle secretory factors - where are we at a decade later?	33P
12:30	K. Walder: A gene expression signature for insulin resistance	34P

Free Communications - General Physiology
Chair: Andrew Moorhouse

11:00	E. Kheradpezhouh: The role of TRPM2 channels in paracetamol overdose-induced Ca²⁺ entry in hepatocytes	35P
11:15	K. Karisnan: Gestational age at time of the initial exposure to lipopolysaccharide determines the severity of diaphragmatic contractile dysfunction in preterm lambs	36P
11:30	A.D. Hanna: Anthracycline-induced dysfunction of cardiac SR Ca²⁺ handling: a potential pathway to anthracycline-induced cardiotoxicity	37P
11:45	I.Y. Kuo: Calcium binding to the EF hand motif regulates polycystin 2 function	38P
12:00	K.W. Stewart: The role of a newly discovered pancreatic islet peptide in the control of insulin secretion	39P
12:15	D.J. Keating: Huntingtin-associated protein 1 (HAP1) regulates exocytosis, vesicle localization and interacts with multiple vesicle proteins	40P

11:30

12:00

12:30

13:00

Posters and Lunch
Location: Pavillion
Presenting authors of posters on odd numbered boards in attendance.

1	41P	V. Zaitsev: Anabolic effect of formoterol administration on skeletal muscle is not impaired by co-treatment with the β1-adrenoceptor antagonist CGP-20712A
2	42P	C.R. Lamboley: Endogenous and maximal sarcoplasmic reticulum calcium content in human vastus lateralis muscle fibres is decreased with ageing
3	43P	H. Willemse: Human aging and expression of proteins interacting with the ryanodine receptor in skeletal muscle
4	44P	C. van der Poel: The pathogenesis of inflammation in knee osteoarthritis and its effect on muscle function
5	45P	J.P. Mollica: Calpastatin and m-calpain have different cellular localizations in rat skeletal muscle: implications for function
6	46P	N.Y. Marden: Online feedback assessments in introductory physiology courses: effects on students’ learning experience and outcomes
7	47P	R.G. Barker: Taurine improves tibialis anterior force production and muscle architecture in the 28 day old mdx mouse model of Duchenne muscular dystrophy
8	48P	S. Chan: SR pump function and fatigue characteristics of fast fibres from α-actinin-3-deficient speed gene knockout mice
9	49P	E.J. Stephenson: The oxidative profile of white adipose tissue is not related to intrinsic exercise capacity or whole-body metabolic health
10	50P	C.A. Lucas: Contraction induces a cyclic promoter hypomethylation in mouse skeletal muscle
11	51P	H. Xu: The effect of amylase treatment on the detection of glycogenin, glycogen debranching enzyme and glycogen phosphorylase proteins in rat fast-twitch skeletal muscle
12	52P	V. Nylander: The role of epigenetic modifications in the long term memory of cancer treatment
13	53P	C.R. Brandner: Acute neural responses to blood flow restriction strength exercise
14	54P	A.J. Craig: A photothrombosis-induced ischaemic infarct model for study of hind brain stroke
15	55P	S. El-Ajouz: Understanding the molecular gates of KirBac3.1
16	56P	T. Guo: Influence of cell morphology in computational models of on and off retinal ganglion cells
17	57P	M.H. Rashid: Binding site of Scorpion toxin HsTx1 to the potassium channel Kv1.1 and Kv1.3 from Molecular Dynamics simulations
18	58P	S. Talwar: Identification and characterization of novel synthetic variabilin analogues targeting the glycine receptor Cl⁻ channels
19	59P	S. Mahdavi: Computational investigation of μ-conotoxin binding to voltage gated sodium channels
20	60P	D. Robertson: Olivocochlear reflex strength and the auditory attentional filter
21	61P	P.H. Barry: Further measurements of liquid junction potentials, and their implications, using a refined freshly-cut 3M KCl reference salt-bridge methodology
22	62P	A. Bhaskaracharya: Probenecid, a gout treatment, blocks the human P2X7 receptor
23	63P	J.R. Lawson: Agonist selectivity of neuronal glycine receptors
24	64P	K.A. Jenkin: Cannabinoid receptor 2 expression in proximal tubule cells exposed to elevated glucose and albumin
25	65P	H. Cuny: Identifying key amino acid residues for α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors
26	66P	H.J. Lee: Pharmacological characterization of individual subtypes of α4β3δ GABA_A receptor, include the novel description of β3δ GABA_A receptor subtype
27	67P	T.K.H. Nguyen: Melittin-membrane interaction follows lipid-specific multi-step mechanism
28	68P	C.L. Dixon: Using artificial synapses to investigate GABA_A receptor kinetics
29	69P	H.-S. Tae: A salt-bridge network determines agonist size selectivity in ρ1 GABA_C receptor
30	70P	T.M. Lewis: Mixed antagonistic effects of the ginkgolides at recombinant human ρ1 GABA_C receptors
31	71P	L.W. Wong: Are the putative N-terminal α-helix and preceding residues important in GABA_A/C receptor function?
32	72P	K.L. Hamilton: Membrane trafficking and localization, residence time and degradation of KCa3.1 in a polarized epithelium
33	74P	J.E. Hare: Structural insight into the CLIC1 integral membrane structure by fluorescence resonance energy transfer and electron microscopy
34	75P	A. Bode: Effects of new human startle disease mutations on glycine receptor function and structure
35	76P	T. Stockner: The ATP-bound state of P-glycoprotein is closed towards the cell exterior
36	77P	Y. Kim: TRPC3c (high activity) transient receptor potential channel expression in the mouse brain
37	78P	E.L. Daniel: Determining a link between XLID and missense mutations in Chloride Intracellular Ion Channel Protein 2 (CLIC2): a biophysical approach
38	79P	L. Han: Differential movement of M4 transmembrane segments during activation of α1 and α3 glycine receptors
39	80P	C. Boiteux: Insights into voltage gated sodium channel NavAb function from multi-microsecond molecular dynamics simulations
40	81P	L.J. Munro: Modulation of GlyT2 by endogenous lipid based compounds occurs through interactions with EL3
41	82P	G. Heinzelmann: Molecular Dynamics simulations on a bacterial homolog of the human glutamate transporters
42	83P	A.P. Tosolini: Characterization of the muscle-motor neuron topography of the mouse forelimb
43	84P	N. Subramanian: The binding of morphine and nicardipine to the multidrug transporter P-glycoprotein
44	85P	R. Mohan: Characterization of the muscle-motor neuron topography of the mouse hindlimb
45	86P	D. Robertson: Timecourse of development of hyperactivity in the auditory midbrain after cochlear trauma
46	87P	J.L. Pinyon: Evaluation of auditory nerve fibre recruitment by eABR via cochlear implant stimulation in the guinea-pig model
47	88P	A. Al Abed: Electrical restitution properties of rabbit atrial tissue
48	89P	G. Ivanov: Acute effects of insulin on the endothelium-dependent dilation of rat cremaster muscle arteries
49	90P	M.S. Imtiaz: Three-dimensional modeling of Ca²⁺ dynamics in single cardiac cells
50	91P	J.M. Power: Calcium waves alter dendritic spine morphology in basolateral amygdala projection neurons
51	92P	S.A. Mann: The importance of cardiac ion channels on the electrocardiogram - partial least squares regression as a new tool in computational biology
52	93P	X.H. Chan: Atorvastatin-induced changes in micro-vascular smooth muscle function

13:30

14:00

14:30

Symposium: Spectral imaging in physiology – a highlight of techniques
Chair: Robyn Murphy

14:30	V.G. Macefield: Combining microelectrode recordings from human peripheral nerves with functional magnetic resonance imaging of the brain	94P
14:55	P.R. Gooley: AMP-activated protein kinase β subunit requires internal motion for optimal carbohydrate binding	95P
15:20	D. Stapleton: The how and why of glycogen ultrastructure - implications for physiology and disease	96P
15:45	R.M. Murphy: Single muscle fibre analysis reveals differential fibre type, localization and stimulation responses of enzymes important for glycogen metabolism: insights into muscle glycogen structure and function	97P

Free communications - Channels: Molecular Interactions
Chair: Boris Martinac

14:30	A. Mechler: Salt concentration effects on the viscoelasticity of supported bilayers	98P
14:45	E. Deplazes: Combining experiment and simulations to characterize the interactions of a sea-anemone toxin with the analgesic target acid-sensing ion channel 3	99P
15:00	M.D. Perry: The S4 domain is directly involved in determining the voltage sensitivity of Kv11.1 channel inactivation	100P
15:15	B.A. Cromer: Molecular mechanisms for agonist selectivity in inhibitory Cys-loop ligand-gated ion channels	101P
15:30	T. Nomura: Orientation of the bacterial mechanosensitive channel MscS in liposomal membranes	102P
15:45	B. Martinac: Ion selectivity of the mechanosensitive channel MscS is determined by charged residues within the cytoplasmic vestibulum	103P

Free communications - Cardiac Physiology
Chair: Lea Delbridge

14:30	T.F. Reardon: Mechanisms contributing to angiotensin II induced increases in nerve-evoked contractions of mouse tail artery	104P
14:45	D.A. Saint: Asian immigrants to Australia show a lower sympathetic component to the baro-reflex than resident caucasians, as measured by heart rate variability analysis	105P
15:00	A.W. Quail: Propofol selectively modifies the arterial chemoreflex during severe hypoxia in the rabbit	106P
15:15	D.O. Schwenke: The serotonin pathway – a therapeutic target for pulmonary hypertension? Assessing vascular function using synchrotron radiation microangiography	107P
15:30	J.R. Bell: An augmented CaMKII response in the post-ischemic female heart is not proarrhythmic – towards understanding the sex-specificity of CaMKII pathophysiology	108P
15:45	A. Li: A cardiac troponin I mutation that causes familial dilated cardiomyopathy	109P

Free Communcations - Neuro-signalling
Chair: John Power

14:30	K.E. Froud: Modulation of cochlear amplifier performance by contralateral suppression	110P
14:45	R. Raghupathi: Enterochromaffin cells release 5-HT with synaptic kinetics	111P
15:00	J.M.E. Cederholm: Transcriptional responses to noise stress in mice	112P
15:15	A.E. Harasta: Septal glucagon-like peptide 1 receptors (GLP-1Rs) mediate the behavioural effects of cocaine	113P
15:30	L.G.T. van den Heuij: Human amniotic epithelial cell therapy for preterm perinatal asphyxia	114P
15:45	C.J. Schwiening: Pre-synaptic pH changes and vesicle fusion at the Drosophila neuromuscular junction	115P

15:00

15:30

16:00

Afternoon tea

16:30

Symposium: Perinatal asphyxia: adaptation and consequences
Chair: Alistair Jan Gunn

16:30	A.J. Gunn: Making birth safer	116P
16:40	S.B. Hooper: Resuscitating the asphyxic infant at birth	117P
17:05	G.R. Polglase: Brain inflammation and injury resulting from chorioamnionitis is exacerbated by resuscitation in preterm lambs	118P
17:30	S.L. Miller: New strategies to protect the newborn brain	119P
17:55	L. Bennet: Maternal glucocorticoids: timing is everything for the fetal brain	120P

Symposium: A vignette of TRP ion channel physiology
Chair: Gary Housley

16:30	L. Birnbaumer: TRPC channels: An overview	121P
16:50	G.J. Barritt: Multiple roles for transient receptor potential (TRP) non-selective cation channels in liver function	125P
17:15	G.Y. Rychkov: TRPM2 channels in oxidative stress-induced cell death	126P
17:40	N.W. Bunnett: Proteolytic regulation of TRP channels: implications for pain and neurogenic inflammation	127P
18:05	S.L. Sandow: Myoendothelial microdomains and TRPC3: anatomical links to function	129P

Free Communications: ASB Young Investigator & Spectroscopy
Chairs: Jamie Vandenberg & Frances Separovic

16:30	D.R. Whelan: Quantification and detection of DNA in eukaryotic cells using Fourier transform infrared spectroscopy	130P
16:45	T.D.M. Bell: Super-resolution imaging of cells using a home built dSTORM microscope costing less than A$100k	131P
17:00	T. Holm: dSTORM super-resolution made cheap and easy	132P
17:15	M.-A. Sani: Antimicrobial peptide activity in a competitive lipid environment	133P
17:30	C.G. Cranfield: Tethered Bilayer Lipid Membranes (tBLMs) to measure pore formation by antimicrobial peptide (AMP) insertion	134P
17:45	P.S. Tan: Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels	135P
18:00	T.A. Hilder: Characterizing various inward rectifier potassium channels	136P
18:15	R.J. Clarke: Kinetic comparisons of heart and kidney Na⁺,K⁺-ATPases	137P

Free Communications - Muscle Metabolism/Signalling
Chair: Matthew Watt

16:30	A.J. Hoy: Regulation of plasma ceramide levels with fatty acid oversupply - evidence that the liver detects and secretes de novo synthesized ceramide	138P
16:45	S. Lamon: Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis	139P
17:00	J.G. Ryall: A switch in metabolism underlies the initiation of MyoD transcription in satellite cells	140P
17:15	R. Koopman: Glycine, a pharmaco-nutrient that protects muscle cells from cachectic stimuli in vitro and in vivo	141P
17:30	V.C. Foletta: Suppression of NDRG2, a novel PGC-1α and PGC-1β target gene, contributes to the metabolic profile and protein synthesis rates of skeletal muscle cells	142P
17:45	D.J. Ham: Citrulline protects muscle cells from cachectic stimuli and preserves protein metabolism in vitro	143P
18:00	S. Trajanovska: Role of glycogen depletion in muscle fatigue	144P
18:15	C.W. Gray: Local sensitivity analysis of GLUT4 translocation in response to insulin	145P

17:00

17:30

18:00

18:30

19:00

19:30

Student Member Function - BBQ in the Whitehouse

Tuesday 4th December 2012

Mathews A

Mathews B

Mathews C

Mathews D

08:30

AuPS Plenary Lecture - Scandinavian Exchange Lecturer - Prof Håkan Westerblad

08:30

H. Westerblad: Muscle fatigue

146P

09:00

09:30

Morning tea

10:00

Symposium: Calcium signalling in microdomains essential to normal cell function
Chair: Bradley Launikonis

10:00	I.F. Smith: Imaging the motility of inositol trisphosphate receptors in intact mammalian cells using single particle tracking photoactivated localization microscopy (sptPALM)	147P
10:30	I.D. Jayasinghe: Three-dimensional analysis of the tubular networks in mammalian and amphibian skeletal muscle fibres	148P
11:00	B.S. Launikonis: Specialization of the skeletal muscle junctional membranes allow rapid activation of store-operated calcium entry, tightly controlled by [Ca²⁺]_SR	149P
11:30	P. Thorn: Focal secretion of insulin within intact islets of langerhans	150P

Symposium: Science at the high performance computing frontier
Chair: Adam Hill

10:00	E. Afgan: Genomics Virtual Laboratory	151P
10:30	B. Corry: Long time scale molecular simulations for understanding ion channel function	153P
11:00	P.M.F. Nielsen: Sharing physiological models	154P
11:30	A. Sadrieh: Massive parallelization of cardiac simulations using unconventional processing architectures	155P

Free communications - Transporters
Chair: Tim Murphy

10:00	R.J. Cater: Mapping the chloride permeation pathway of a human glutamate transporter	156P
10:15	A.J. Scopelliti: Molecular determinants for functional differences between the neutral amino acid transporter ASCT1 and acidic amino acid transporters of the EAAT family	157P
10:30	N.L. Absalom: γ hydroxybutyrate activates specific GABA_A receptor subtypes	158P
10:45	J.E. Carland: Oleoyl L-carnitine inhibits glycine transport by GLYT2	159P
11:00	R.M. Ryan: Using N-modified aspartate analogues to probe the ‘open-to-inside’ structure of the bacterial aspartate transporter, Glt_Ph	160P
11:15	B.C. McIlwain: Conformational dynamics of an archaeal aspartate transporter are determined by the lipid bilayer	161P
11:30	K.E. Polglaze: Benzamil, but not triamterene, reduces mechanosensitive 5-HT release from EC cells of guinea pig intestine	162P
11:45	S. Senadheera: Enhanced T-type calcium channel function, but not L-type or TRPC3 channels, augments uteroplacental arterial vascular tone in late pregnancy	163P

10:30

11:00

11:30

12:00

Posters and Lunch - ASB AGM (Mathews 312) - PSNZ AGM (Mathews 125)
Presenting authors of posters on even numbered boards in attendance.

12:30

13:00

13:30

Symposium: Muscular adaptations to exercise: mechanisms at play
Chair: David Simar

13:30	R. Barres: Adaptations to exercise: the role of epigenetic changes	164P
14:00	B.E. Kemp: AMPK signaling and exercise	165P
14:30	J.A. Hawley: Sending the message: Training-nutrient interactions to stimulate mitochondrial biogenesis	166P
15:00	J.E. Sharman: Exercise central haemodynamics: mechanisms and relation to end organ damage	167P

Symposium: Integrative physiology of the heart
Chairs: Bruce Smaill & Jamie Vandenberg

13:30	D.S. Loiselle: Multi-scale cardiac energetics	168P
13:50	L.M.D. Delbridge: Cardiac ischemia - different contexts and different consequences	169P
14:10	M.L. Trew: Cardiomyocyte group architecture and electrical activation pathways in the heart	170P
14:30	A.P. Hill: Computational analysis of the contribution of ionic conductances to ECG parameters	171P

Free communications - Molecular Dynamics
Chair: Toby Allen

13:30	S. Kuyucak: Rational drug design from toxins - how rational can one get?	172P
13:45	R. Chen: Binding of scorpion toxins to the voltage sensors of Na⁺ channels: molecular dynamics studies	173P
14:00	D. Gordon: Brownian dynamics simulation of ion channel block by polypeptide toxins	174P
14:15	M. Thomas: Biological channel mimics for use as desalination membranes	175P
14:30	H. Yu: Catalysis in silico	176P
14:45	M.L. O'Mara: The effect of ATP binding on the conformation of P-glycoprotein	177P
15:00	Z. Jia: The effect of environment on the recognition and binding of vancomycin to native and resistance forms of lipid II	178P
15:15	T.W. Allen: Long molecular dynamics simulations to explore ion channel function	179P

14:00

14:30

15:00

15:30

Afternoon tea

16:00

Free communications - Gene for Speed
Chair: Peter Houweling

16:00	N. Eynon: Overcoming the barrier of sample size: The ACTN3 R577X polymorphism across three groups of elite European athletes	180P
16:15	F. Garton: Deficiency of a fast twitch muscle fibre protein alters muscle adaptation in response to denervation and immobilization	181P
16:30	M.W. Hogarth: α-Actinin-3: a novel genetic modifier of Duchenne muscular dystrophy	182P
16:45	S.I. Head: Alterations in Ca²⁺ transients and SR function in isolated fast fibres from α-actinin-3-deficient speed gene knockout mice	183P
17:00	P.J. Houweling: Metabolic consequences of α-actinin-3 deficiency – more than a structural muscle protein!	184P
17:15	M. Kreissl: Mutations in the α-tropomyosin-slow gene (TPM3) cause sarcomeric dysfunction in slow muscle fibres	185P

Free Communications - Cardiac Physiology
Chair: Nicole Beard

16:00	A.F. Dulhunty: Functional analyses of a cluster of CCD mutations reveals a gating module within TM6 of RyR1	186P
16:15	K. Walweel: Regulation of human RYR2 by intracellular Ca²⁺ and Mg²⁺	187P
16:30	J. Li: Adrenergic stimulation increases RYR2 activity via intracellular Ca²⁺ and Mg²⁺ regulation	188P
16:45	D. Mehra: Role of cardiac Na⁺ channel blockers and Mg²⁺ in inhibiting the cardiac calcium release channel	189P
17:00	J. Liu: Store-operated calcium entry activity revealed by confocal live cell calcium imaging in isolated mouse pacemaker cells	190P
17:15	A. Gogoi: Autonomic functions and serum leptin levels in normal and obese, a comparative study	191P

PSNZ - John Hubbard and Mary Bullivant Student Prize Competition

16:00	Peter Hunter: John Hubbard Prize
16:05	J.-C. Han: Does the heart really operate at 'isoefficiency'?	192P
16:30	Kirk Hamilton: Mary Bullivant Prizes
16:35	H.P.A. Thaung: Sympathetic modulation of cardiac function in diabetes - in vivo and ex vivo study	193P
17:00	S. Fan: Inflammation of the proximal colon of IL10^−/− mice induced by Helicobacter typhlonius infection reduces anion secretion and expression of the NaHCO₃ cotransporter, NBCe1	194P

16:30

17:00

17:30

18:00

Conference Dinner and Awards

18:30

19:00

19:30

20:00

20:30

21:00

21:30

22:00

22:30

Wednesday 5th December 2012

Mathews A

Mathews B

Mathews C

Mathews D

09:00

Invited Lecture - Prof Lutz Birnbaumer

09:00

L. Birnbaumer: TRPC channels: on-going discovery of molecular physiological function in relation to store operated Ca²⁺ entry and Orai proteins

195P

09:30

10:00

Morning tea

10:30

Symposium: Brain dysfunction and translational neurophysiology
Chairs: Andrew Moorhouse & Arun Krishnan

10:35	A. Yamanaka: Optogenetical approach to reveal the regulatory mechanism of instinctive behaviors by the hypothalamic neurons	196P
10:55	J. Nabekura: Glia and neuron interactions: their role in synapse remodeling in vivo	197P
11:15	A.J. Moorhouse: Membrane transporters regulating inhibitory neurotransmitter signaling in health and disease	198P
11:30	R. Rajan: Traumatic brain injury and sensory cortex: using barrel cortex to understand functional changes in the injured brain	199P
11:45	D. Burke: Excitability and action potential in human axons	200P
12:05	M.C. Kiernan: Central assessment of motor dysfunction using transcranial magnetic stimulation	201P

Symposium: Autonomic physiology - nutrient sensing in the GI tract
Chair: Paul Bertrand

10:30	H.E. Raybould: Nutrient-sensing in the GI tract: fat, the gut microbiota and obesity	202P
11:15	R.L. Young: Dysregulation of intestinal glucose sensing and transport in critical illness	203P
11:40	P.P. Bertrand: Iron sensing by the intestine: A new model for iron-induced changes to GI motility	204P
12:05	C. Feinle-Bisset: Nutrient sensing in the human gastrointestinal lumen - role in appetite regulation and implications for obesity	205P

Symposium: Skeletal muscle in health and disease
Chair: Gordon Lynch

10:30	H. Westerblad: Mitochondrial myopathies	206P
11:00	E. Hardeman: Insights into and therapies for nemaline myopathy	207P
11:30	K.T. Murphy: Tackling muscle wasting in cancer	208P
12:00	G. Ravenscroft: Uncovering the genetics of neuromuscular foetal akinesias using next generation sequencing	209P

11:00

11:30

12:00

12:30

Lunch - AuPS AGM

13:00

13:30

14:00

Symposium: Developments in auditory and vestibular physiology
Chair: Ramesh Rajan

14:00	A.W. Gummer: Nanomechanical mechanisms of cochlear amplification	210P
14:20	G.D. Housley: Neurohumoral mechanisms for regulating sound transduction	211P
14:40	R.B. Patuzzi: Spreadsheet analysis of ion transport in epithelia	212P
14:55	P. J. Blamey: Factors affecting clinical outcomes in adult patients with cochlear implants	213P
15:15	A.M. Brichta: The other part of the ear – a ‘balanced’ view	214P
15:35	I.S. Curthoys: The sensitive response of irregular otolithic vestibular afferents to bone conducted vibration and air conducted sound underpins fast, simple, safe clinical testing of otolithic function	215P

Symposium: Ion Channels as drug targets
Chairs: Trevor Lewis & Joe Lynch

14:00	D. Julius: Exploiting toxins to probe pain pathways	216P
14:40	G.F. King: Spider-venom peptides that target the human Na_v1.7 channel: potential analgesics for the treatment of chronic pain	217P
15:00	R.S. Norton: Conotoxins targeting voltage-gated sodium channels: harnessing nature’s analgesics	218P
15:20	M. Chebib: Modulation of Cys-loop receptors to address CNS disorders	219P
15:40	A. Keramidas: Correlating functional models of channel activation with subunit specific GABA_A receptors	220P

Free Communications - Muscle Diseases
Chair: Stewart Head

14:00	J.L. Chen: Targeting activin to counteract muscle wasting and cachexia	221P
14:15	B.P. Frankish: Calpain-3 deficiency results in the perturbation of specific Ca²⁺-handling proteins in skeletal muscle of mice	222P
14:30	T.R. Cully: Adeno-associated virus directed expression of Orai1 to examine store operated calcium entry in wild-type and dystrophic skeletal muscle	223P
14:45	T.D. Colgan: Combinatorial gene therapy using AAV technology to treat Duchenne muscular dystrophy	224P
15:00	T. Kennedy: Altered expression of heat shock proteins in Duchenne muscular dystrophy	225P
15:15	A. Cheng: Time-course of decline in the size of neuromuscular synaptic contacts with sedentary aging in mice	226P
15:30	P.W. Sheard: A new view of fibre type transformations in elderly skeletal muscles	227P
15:45	M. Morsch: Patient autoantibodies reveal the role of muscle specific kinase in maintaining the mature neuromuscular junction	228P
16:00	K. Swiderski: Endogenous phosphorylation of the dystrophin protein modulates protein function	229P

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16:30

Afternoon tea and Drinks - Closing Reception and Awards

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